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The Microbiome Lifeline: How Can Data and Digital Tools Help Us Prevent Autoimmunity

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Content and Visual Design by Tiffany Simms

As numerous as the stars in the sky, the ecosystem inside our bodies, gives hope to the lonely voices of autoimmune disease.

DrBonnie360 presents the microbiome lifeline at Cambridge HealthTech Institute's 23rd International Molecular Med Tri-Con. Showing Data and Digital Health is the glue that brings together research, clinical care, patients, and businesses, DrBonnie360 effectively tosses a lifeline across the autoimmune abyss.

Published in: Health & Medicine
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The Microbiome Lifeline: How Can Data and Digital Tools Help Us Prevent Autoimmunity

  1. 1. The Microbiome Lifeline How Can Data and Digital Tools Help Us Prevent Autoimmunity Bonnie Feldman, DDS, MBA – Your Autoimmunity Connection www.drbonnie360.com | @DrBonnie360
  2. 2. A New Ecosystem: The Body’s Microbial Garden @DrBonnie360
  3. 3. Convergence @DrBonnie360
  4. 4. Microbiota Meets Big Data: The Human Microbiome Project DOI: 10.1038/nrg3785 @DrBonnie360
  5. 5. Data and Digital Tools DOI: http://dx.doi.org/10.1016/j.tem.2015.09.011 @DrBonnie360
  6. 6. Metabalomics and Metabolic Network Modeling DOI: http://dx.doi.org/10.1016/j.atg.2016.02.001 @DrBonnie360
  7. 7. Modeling and Interactions of Gut Microbiome DOI: http://dx.doi.org/10.3389/fgene.2015.00219 @DrBonnie360
  8. 8. What Characterizes the Microbiome
  9. 9. The Gut is Where It’s At Organ of Immunity DOI: 10.1038/nri3430 @DrBonnie360
  10. 10. The Gut is Where It’s At Brain-Gut Axis DOI: 10.1038/nrn3346 @DrBonnie360
  11. 11. Location Matters DOI: 10.1038/ajgsup.2012.4 @DrBonnie360
  12. 12. DOI: 10.3389/fcimb.2012.00104 @DrBonnie360 A Changing Microbiome
  13. 13. What is Leaky Gut? DOI:10.1038/ni.2611 @DrBonnie360
  14. 14. 100+ 16% 10 diseases US population Top leading cause of death in women less than 64 yrs An Invisible Epidemic @DrBonnie360
  15. 15. The Microbiome in Autoimmunity @DrBonnie360
  16. 16. Leaky Gut and Celiac Disease DOI:10.1038/nrgastro.2013.141 @DrBonnie360
  17. 17. Microbiome in Inflammatory Bowel Disease DOI:10.1038/nrgastro.2015.34 @DrBonnie360
  18. 18. Diversity Matters in Inflammatory Bowel Disease DOI:10.1038/ajgsup.2012.4 @DrBonnie360
  19. 19. Microbiome in Rheumatoid Arthritis DOI:10.1038/nrrheum.2011.121 @DrBonnie360
  20. 20. Microbiome in Oral Health DOI:10.1016/j.imlet.2014.08.017 @DrBonnie360
  21. 21. DOI:10.1016/j.cell.2015.11.001 @DrBonnie360
  22. 22. Company Indication What How Open Biome Therapeutic - Oral & Fecal Transplant Nonprofit Stool Bank & Research Platform eliminates practical barriers to Fecal Microbiota Transplants (FMT) & provide tailored fecal microbiota preparations to bioinformatics/analytical services -Donor Selection; characterize with molecular biomarkers, cross-sectional data, & statistical tools to predict which donors are well suited. -Maintenance Therapy; oral capsules to deliver & explore long-term management of chronic diseases uBiome Crowdsourced Database Equip individuals with the tools needed to learn about bacteria within their bodies -Send sample kits & surveys to collect microbiomes for analysis. -Use NIH human microbiome project to sequence DNA & ID each strain -Compare with library & compile results Global Crowdscience Comes to the Microbiome
  23. 23. DOI:10.1038/nbt.2548 Medicines from Microbiota @DrBonnie360
  24. 24. Company Indication What How AOBiome Therapeutic - Topical Skin Advance the science of Ammonia Oxidizing Bacteria (AOB) to restore the skin’s microbiome -Topical therapeutic & consumer product of AOB to reintroduce Nitrosomonas to skin’s bacterial flora & restore Nitric Oxide balance Enterome Diagnostics & Therapeutic Inflammatory Bowel Disease - Crohn’s & Ulcerative Colitis Quantitative Metagenomics Platform (QMP) & Functional Metagenomics Platform (FMP) to support personalized medicine for microbiome-related diseases -QMP uses total fecal bacterial gene to characterize personal metagenome with disease phenotype & ID biomarkers -FMP screen genomic/metagenomic libraries for dis & dev of new drugs/targets Miomics Bio- Therapeutics Therapeutic - Oral Autoimmune Disease - RA & MS Oral biologicals to rebalance a microbiota towards a standard microbiota. -Research GI inhabitan commensal
  25. 25. Company Indication What How Osel Therapeutic - Topical Women’s Health “Live Biotherapeutic Products” (LBP) focusing on women’s health (GU & GI) -Library of proprietary human bacterial strains -Screening methods to ID strains w/ unique protective properties -Produce stable high quality LBP from selected strains Second Genome Therapeutic - Oral Crohn’s Disease Microbiome Modulating Discovery Platform (MMDP) ID key microbial community members/activities/metaboli tes & assay for modulatory potential against host targets -Measure & ID changes in the microbial community composition/function/signaling in health or diseased states w/ MMDP -Generation & eval of small molecules/peptide biologic/bacterial strains that modulate microbe-microbe & microbe-human interactions Seres Therapeutics Therapeutic - Topical Dysbiosis, Ulcerative Colitis Propritary Microbiome Therapeutics Platform (PMTP) & Ecobiotic drugs to reestablish a healthy microbiome -Computational approaches & PMTP to ID organismal/functional networks of microbial communities, & determine which organisms work together best with disease microbiome to restore function
  26. 26. Company Indication What How Synlogic Therapeutic Rare Genetic Metabolic Disorders & IBD Synthetic Biotics engineered probiotic bacteria -Platform that engineers new metabolic function into the microbiome Vedanta Biosciences Therapeutic Autoimmune Modulate pathways of interaction between human microbiome & host immune sys. To induce tolerance & restore intestinal homeostasis -Study mucosal immunology to produce drug based on a proprietary consortia of potent regulatory T cell- inducing Clostridium bacteria Whole Biome Diagnostics & Therapeutic Metabolic Syndrome Proprietary discovery platform for targeted equilibration of the microbiome. Focus on metabolic syndrome -Target novel symbiotic functionality inherent in the human-microbial interface with a microbiome diagnostic discovery platform
  27. 27. • Autoimmune Disease: An Invisible Epidemic http://bit.ly/1m0ttsl • The Serious Health Concern All 20-somethings Should Know About http://bit.ly/R9cEgp • Decoding Autoimmunity – a Summary of the State of the Art http://bit.ly/1knzaAQ • The Lonely Voices of Autoimmune Disease via Youtube http://bit.ly/X41mMv • Believe It or Not – The Real Voices of Autoimmunity http://bit.ly/20xRCXO Your Autoimmunity Exploration
  28. 28. Exploring The Microbiome Lifeline • Fasano, Alessio. “Leaky Gut and Autoimmune Diseases.” Clinical Reviews in Allergy & Immunology 42.1 (2012) : 71–8. <http://www.ncbi.nlm.nih.gov/pubmed/22109896>. • Gomez, Andres, David Luckey, and Veena Taneja. “The Gut Microbiome in Autoimmunity: Sex Matters.”Clinical Immunology 159.2 (2015) : 154–162. <http://www.sciencedirect.com/science/article/pii/S1521661615001576>. • Kamdar, K et al. “Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.” Cell Host & Microbe 19.1 (2016) : 21-31. <http://www.cell.com/cell-host-microbe/pdfExtended/S1931-3128(15)00498-9>. • McLean, Mairi et al. “Does the Microbiota Play a Role in the Pathogenesis of Autoimmune Diseases?” Gut 64.2 (2014) : gutjnl–2014–308514. <http://gut.bmj.com/content/early/2014/11/28/gutjnl-2014-308514>. • Waldor, Matthew et al. “Where next for Microbiome Research?” PLoS Biology 13.1 (2015) : e1002050. <http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002050>. • Wu, Hao, Valentina Tremaroli, and Fredrik Bäckhed. “Linking Microbiota to Human Diseases: A Systems Biology Perspective.” Trends in Endocrinology & Metabolism 26.12 (2015) : 758-770. <http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00194-0>. Autoimmunity and the Microbiome @DrBonnie360
  29. 29. The Microbiome and Inflammatory Bowel Disease • De Souza, Heitor, and Claudio Fiocchi. “Immunopathogenesis of IBD: Current State of the Art.” Nature Reviews Gastroenterology & Hepatology (2015) : 13-27 <http://www.ncbi.nlm.nih.gov/pubmed/26627550>. • Sartor, R. Balfour. “The Intestinal Microbiota in Inflammatory Bowel Disease.” Nestle Nutrition Institute Workshop Series 79 (2014) : 29–39.<https://uncch.pure.elsevier.com/en/publications/the-intestinal-microbiota- in-inflammatory-bowel-diseases>. • Sartor, RB, and SK Mazmanian. “Intestinal Microbes in Inflammatory Bowel Diseases.” The American Journal of Gastroenterology … (2012) : 15-21. <http://www.nature.com/ajgsup/journal/v1/n1/abs/ajgsup20124a.html>. • Wlodarska, Marta, Aleksandar Kostic, and Ramnik Xavier. “An Integrative View of Microbiome-Host Interactions in Inflammatory Bowel Diseases.” Cell Host & Microbe 17.5 (2015) : 577-591. <http://www.cell.com/cell-host-microbe/abstract/S1931-3128(15)00166-3>. @DrBonnie360
  30. 30. The Microbiome and Periodontal Disease • Costalonga, M, and MC Herzberg. “The Oral Microbiome and the Immunobiology of Periodontal Disease and Caries.” Immunology Letters 162.2 (2014) : 22-38. <http://www.sciencedirect.com/science/article/pii/S0165247814001874>. Rheumatoid Arthritis Systemic Lupus Erythematosus • Scher, JU, and SB Abramson. “The Microbiome and Rheumatoid Arthritis.” Nature Reviews Rheumatology 7 (2011) : 569-578. <http://www.nature.com/nrrheum/journal/v7/n10/abs/nrrheum.2011.121.html>. • Mu, Q, H Zhang, and XM Luo. “SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?” Frontiers in Immunology (2015) : n. pag. <http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663251/>. @DrBonnie360
  31. 31. Prevention – Diet, Food, & Nutrition • Tilg, H, and AR Moschen. “Food, Immunity, and the Microbiome.” Gastroenterology 148.6 (2015) : 1107-1119. <http://www.sciencedirect.com/science/article/pii/S0016508515000128>. • Zeevi et al. “Personalized Nutrition by Prediction of Glycemic Responses.” Cell. 163.5 (2015) : 1079-1094. <http://www.cell.com/abstract/S0092-8674(15)01481-6>. • Zmora, N et al. “Taking It Personally: Personalized Utilization of the Human Microbiome in Health and Disease.” Cell Host & Microbe 19.1 (2016) : 12-20. <http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)00508-9.pdf>. Prevention – Prebiotics & Probiotics • Hemarajata, P, and J Versalovic. “Effects of Probiotics on Gut Microbiota: Mechanisms of Intestinal Immunomodulation and Neuromodulation.” Therapeutic Advances in Gastroenterology. (2012) : 39-51. <http://tag.sagepub.com/content/early/2012/09/24/1756283X12459294.abstract>. • Petschow, B et al. “Probiotics, Prebiotics, and the Host Microbiome: The Science of Translation.” Annals of the New York Academy of Sciences (2013) : 1-17. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.12303/full>. @DrBonnie360
  32. 32. The Microbiome Lifeline +1.310.666.5312 drbonnie360@gmail.com www.drbonnie360.com @DrBonnie360 www.facebook.com/YourAutoimmunityConnection Bonnie Feldman, DDS, MBA DrBonnie360 is helping companies and entrepreneurs counteract the autoimmune epidemic. Through consulting, market research, writing and speaking, she works with teams using data and digital tools to reshape research, diagnosis, treatment and prevention of autoimmune disease.

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