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Trust Your Gut: Data and Digital Tools for the Microbiome - An Emerging Field in Autoimmune Disease

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Joining Discovery on Target 2016 in Boston, for Targeting the Microbiome, DrBonnie presents new discoveries in research, technology, and upcoming companies. Most importantly, DrBonnie360 focuses on the gut as an organ of immunity and its possible relations to autoimmune disease.

Topics include: Brain-Gut Axis, Locality, The Leaky Gut, Microbial Composition, Dysbiosis, Oral Microbiome, Personalizing Nutrition, Crowdscience, and Medicines from the Microbiome.

Company Summary Tables: Information in order of Indication, What, and How.

Published in: Health & Medicine
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Trust Your Gut: Data and Digital Tools for the Microbiome - An Emerging Field in Autoimmune Disease

  1. 1. Trust Your Gut Second Annual Targeting the Microbiome September 20-21, 2016 Bonnie Feldman DDS, MBA @DrBonnie360 Your Autoimmunity Connection Data and Digital Tools for the Microbiome: An Emerging Field in Autoimmune Disease
  2. 2. Trust Your Gut +1.310.666.5312 drbonnie360@gmail.com www.drbonnie360.com @DrBonnie360 www.facebook.com/YourAutoimmunityConnection Bonnie Feldman, DDS, MBA DrBonnie360’s mission is to create a digitally connected world of personalized care for autoimmune patients. We consult with start-up companies and entrepreneurs who are bringing new products and services that will improve research, diagnosis, and treatment for autoimmunity
  3. 3. The Road to Today
  4. 4. 2008 2012 2015 2016 The NIH Human Microbiome Project is established Public Curiosity Ignites Scientific American publishes an interactive human microbiome infographic Microbiome exhibit opens to the public The Secret World Inside You The White House announces the National Microbiome Intiative Advances in research begin to show connections to autoimmunity @DrBonnie360
  5. 5. An Invisible Epidemic @DrBonnie360 ~50 Million Americans have an autoimmune disease DOUBLED < 6% of NIH Funding goes to Autoimmunity Source: http://bit.ly/1m0ttsl http://bit.ly/1B57pNb incidence rate in children under 10 with IBD in other words, More than Cancer + Heart Disease combined 1 in 6 Americans Population of 25 states!
  6. 6. Is Your Gut Friend or Foe?
  7. 7. The Gut is Where It’s At Brain-Gut Axis DOI: 10.1038/nrn3346 @DrBonnie360
  8. 8. DOI: 10.1038/ajgsup.2012.4 @DrBonnie360 Location Matters
  9. 9. Changing with Age DOI: 10.1038/nm.4142 @DrBonnie360
  10. 10. Oral Diseases 26 APR 2016 DOI: 10.1111/odi.12472 http://onlinelibrary.wiley.com/doi/10.1111/odi.12472/full#odi12472-fig-0002 CLINICAL PRESENTATION @DrBonnie360 Triggering Autoimmunity
  11. 11. DOI:10.1038/ni.2611 @DrBonnie360 When Things Go Wrong The Leaky Gut
  12. 12. The Leaky Gut in Celiac Disease DOI: 10.3390/nu7085314
  13. 13. DOI:10.1038/nrgastro.2015.34 @DrBonnie360 A Life Balance Inflammatory Bowel Disease
  14. 14. DOI:10.1038/ajgsup.2012.4 @DrBonnie360 Diversity Matters Inflammatory Bowel Disease
  15. 15. DOI:10.1038/nrrheum.2011.121 @DrBonnie360 Beyond the Gut Dysbiosis May Affect Other Areas Rheumatoid Arthritis
  16. 16. Beyond the Gut Dysbiosis & Rheumatoid Arthritis DOI:10.1038/nm.3916 @DrBonnie360
  17. 17. Beyond the Gut Dysbiosis & Lupus @DrBonnie360 DOI:10.1128/mBio.01548-14
  18. 18. Beyond the Gut Microbe Composition & Multiple Sclerosis @DrBonnie360 DOI: 10.1038/ncomms12015
  19. 19. DOI:10.1016/j.imlet.2014.08.017 @DrBonnie360 The Oral Microbiome Dental Caries & Periodontal Disease
  20. 20. Caring for your Microbiome Your Personal Microbial Garden
  21. 21. A Tailor-Made Personalizing Nutrition DOI:10.111/nyas.13118 @DrBonnie360
  22. 22. DOI:10.1016/j.cell.2015.11.001 @DrBonnie360 Tailor-Made Personalizing Nutrition
  23. 23. Company IndicaKon What How Open Biome TherapeuKc - Oral & Fecal Transplant Nonprofit Stool Bank & Research Pla5orm eliminates pracKcal barriers to Fecal Microbiota Transplants (FMT) & provide tailored fecal microbiota preparaKons to bioinformaKcs/ analyKcal services -Donor SelecKon; characterize with molecular biomarkers, cross-secKonal data, & staKsKcal tools to predict which donors are well suited. -Maintenance Therapy; oral capsules to deliver & explore long-term management of chronic diseases uBiome Crowdsourced Database Equip individuals with the tools needed to learn about bacteria within their bodies -Send sample kits & surveys to collect microbiomes for analysis. -Use NIH human microbiome project to sequence DNA & ID each strain -Compare with library & compile results Tailor-Made Global Crowdscience for the Microbiome
  24. 24. DOI:10.1038/nbt.2548 @DrBonnie360 Tailor- Made Medicines From Microbiota
  25. 25. Company IndicaKon What How AOBiome TherapeuKc - Topical Skin Advance the science of Ammonia Oxidizing Bacteria (AOB) to restore the skin’s microbiome -Topical therapeuKc & consumer product of AOB to reintroduce Nitrosomonas to skin’s bacterial flora & restore Nitric Oxide balance Enterome DiagnosKcs & TherapeuKc Inflammatory Bowel Disease - Crohn’s & UlceraKve ColiKs QuanDtaDve Metagenomics Pla5orm (QMP) & FuncDonal Metagenomics Pla5orm (FMP) to support personalized medicine for microbiome-related diseases -QMP uses total fecal bacterial gene to characterize personal metagenome with disease phenotype & ID biomarkers -FMP screen genomic/metagenomic libraries for dis & dev of new drugs/ targets Miomics Bio- TherapeuKcs TherapeuKc - Oral Autoimmune Disease - RA & MS Oral biologicals to rebalance a microbiota towards a standard microbiota. -Research GI inhabitan commensal
  26. 26. Company IndicaKon What How Osel TherapeuKc - Topical Women’s Health “Live BiotherapeuDc Products” (LBP) focusing on women’s health (GU & GI) -Library of proprietary human bacterial strains -Screening methods to ID strains w/ unique protecKve properKes -Produce stable high quality LBP from selected strains Second Genome TherapeuKc - Oral Crohn’s Disease Microbiome ModulaDng Discovery Pla5orm (MMDP) ID key microbial community members/acKviKes/ metabolites & assay for modulatory potenKal against host targets -Measure & ID changes in the microbial community composiKon/funcKon/ signaling in health or diseased states w/ MMDP -GeneraKon & eval of small molecules/ pepKde biologic/bacterial strains that modulate microbe-microbe & microbe- human interacKons Seres TherapeuKcs TherapeuKc - Topical Dysbiosis, UlceraKve ColiKs Propritary Microbiome TherapeuDcs Pla5orm (PMTP) & EcobioDc drugs to reestablish a healthy microbiome -ComputaKonal approaches & PMTP to ID organismal/funcKonal networks of microbial communiKes, & determine which organisms work together best with disease microbiome to restore funcKon
  27. 27. Company IndicaKon What How Synlogic TherapeuKc Rare GeneKc Metabolic Disorders & IBD SyntheDc BioDcs engineered probioKc bacteria -Plahorm that engineers new metabolic funcKon into the microbiome Vedanta Biosciences TherapeuKc Autoimmune Modulate pathways of interacKon between human microbiome & host immune sys. To induce tolerance & restore intesKnal homeostasis -Study mucosal immunology to produce drug based on a proprietary consorKa of potent regulatory T cell- inducing Clostridium bacteria Whole Biome DiagnosKcs & TherapeuKc Metabolic Syndrome Proprietary discovery pla5orm for targeted equilibraKon of the microbiome. Focus on metabolic syndrome -Target novel symbioKc funcKonality inherent in the human-microbial interface with a microbiome diagnosKc discovery plahorm
  28. 28. •  Autoimmune Disease: An Invisible Epidemic http://bit.ly/1m0ttsl •  The Serious Health Concern All 20- somethings Should Know About http://bit.ly/R9cEgp •  Decoding Autoimmunity – a Summary of the State of the Art http://bit.ly/1knzaAQ •  The Lonely Voices of Autoimmune Disease via Youtube http://bit.ly/X41mMv •  Believe It or Not – The Real Voices of Autoimmunity http://bit.ly/20xRCXO Your Autoimmunity Exploration
  29. 29. Exploring The Microbiome Lifeline •  Fasano, Alessio. “Leaky Gut and Autoimmune Diseases.” Clinical Reviews in Allergy & Immunology 42.1 (2012) : 71–8. <http://www.ncbi.nlm.nih.gov/pubmed/22109896>. •  Gomez, Andres, David Luckey, and Veena Taneja. “The Gut Microbiome in Autoimmunity: Sex Matters.”Clinical Immunology 159.2 (2015) : 154–162. < http://www.sciencedirect.com/science/article/pii/S1521661615001576>. •  Kamdar, K et al. “Genetic and Metabolic Signals during Acute Enteric Bacterial Infection Alter the Microbiota and Drive Progression to Chronic Inflammatory Disease.” Cell Host & Microbe 19.1 (2016) : 21-31. <http://www.cell.com/cell-host-microbe/pdfExtended/S1931-3128(15)00498-9>. •  McLean, Mairi et al. “Does the Microbiota Play a Role in the Pathogenesis of Autoimmune Diseases?” Gut 64.2 (2014) : gutjnl–2014–308514. < http://gut.bmj.com/content/early/2014/11/28/gutjnl-2014-308514>. •  Waldor, Matthew et al. “Where next for Microbiome Research?” PLoS Biology 13.1 (2015) : e1002050. <http://journals.plos.org/plosbiology/article?id=10.1371/journal.pbio.1002050>. •  Wu, Hao, Valentina Tremaroli, and Fredrik Bäckhed. “Linking Microbiota to Human Diseases: A Systems Biology Perspective.” Trends in Endocrinology & Metabolism 26.12 (2015) : 758-770. <http://www.cell.com/trends/endocrinology-metabolism/abstract/S1043-2760(15)00194-0>. Autoimmunity and the Microbiome @DrBonnie360
  30. 30. The Microbiome and Inflammatory Bowel Disease •  De Souza, Heitor, and Claudio Fiocchi. “Immunopathogenesis of IBD: Current State of the Art.” Nature Reviews Gastroenterology & Hepatology (2015) : 13-27 < http://www.ncbi.nlm.nih.gov/pubmed/26627550>. •  Sartor, R. Balfour. “The Intestinal Microbiota in Inflammatory Bowel Disease.” Nestle Nutrition Institute Workshop Series 79 (2014) : 29–39. <https://uncch.pure.elsevier.com/en/publications/the-intestinal-microbiota-in-inflammatory- bowel-diseases>.   •  Sartor, RB, and SK Mazmanian. “Intestinal Microbes in Inflammatory Bowel Diseases.” The American Journal of Gastroenterology … (2012) : 15-21. < http://www.nature.com/ajgsup/journal/v1/n1/abs/ajgsup20124a.html>. •  Wlodarska, Marta, Aleksandar Kostic, and Ramnik Xavier. “An Integrative View of Microbiome- Host Interactions in Inflammatory Bowel Diseases.” Cell Host & Microbe 17.5 (2015) : 577-591. <http://www.cell.com/cell-host-microbe/abstract/S1931-3128(15)00166-3>. @DrBonnie360
  31. 31. The Microbiome and Periodontal Disease •  Costalonga, M, and MC Herzberg. “The Oral Microbiome and the Immunobiology of Periodontal Disease and Caries.” Immunology Letters 162.2 (2014) : 22-38. <http://www.sciencedirect.com/science/article/pii/S0165247814001874>. Rheumatoid Arthritis Systemic Lupus Erythematosus •  Scher, JU, and SB Abramson. “The Microbiome and Rheumatoid Arthritis.” Nature Reviews Rheumatology 7 (2011) : 569-578. < http://www.nature.com/nrrheum/journal/v7/n10/abs/nrrheum.2011.121.html>. •  Mu, Q, H Zhang, and XM Luo. “SLE: Another Autoimmune Disorder Influenced by Microbes and Diet?” Frontiers in Immunology (2015) : n. pag. < http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4663251/>. @DrBonnie360
  32. 32. Prevention – Diet, Food, & Nutrition •  Tilg, H, and AR Moschen. “Food, Immunity, and the Microbiome.” Gastroenterology 148.6 (2015) : 1107-1119. < http://www.sciencedirect.com/science/article/pii/S0016508515000128>. •  Zeevi et al. “Personalized Nutrition by Prediction of Glycemic Responses.” Cell. 163.5 (2015) : 1079-1094. <http://www.cell.com/abstract/S0092-8674(15)01481-6>. •  Zmora, N et al. “Taking It Personally: Personalized Utilization of the Human Microbiome in Health and Disease.” Cell Host & Microbe 19.1 (2016) : 12-20. <http://www.cell.com/cell-host-microbe/pdf/S1931-3128(15)00508-9.pdf>. Prevention – Prebiotics & Probiotics •  Hemarajata, P, and J Versalovic. “Effects of Probiotics on Gut Microbiota: Mechanisms of Intestinal Immunomodulation and Neuromodulation.” Therapeutic Advances in Gastroenterology. (2012) : 39-51. <http://tag.sagepub.com/content/early/2012/09/24/1756283X12459294.abstract>. •  Petschow, B et al. “Probiotics, Prebiotics, and the Host Microbiome: The Science of Translation.” Annals of the New York Academy of Sciences (2013) : 1-17. < http://onlinelibrary.wiley.com/doi/10.1111/nyas.12303/full>. @DrBonnie360
  33. 33. •  2008 = Human Microbiome Project. hlp://hmpdacc.org/overview/about.php •  2012 = ScienKfic American, explore the human microbiome (interacKve) hlp://www.scienKficamerican.com/arKcle/microbiome-graphic- explore-human-microbiome/ •  2015 = American Museum of Natural History •  exhibit: The Secret World Inside You hlp://www.amnh.org/calendar/the-secret-world-inside-you •  info: Meet your Microbiome hlp://www.amnh.org/explore/science-topics/health-and-our-microbiome/meet-your-microbiome •  2016 = hlps://www.whitehouse.gov/the-press-office/2016/05/12/fact-sheet-announcing-naKonal-microbiome-iniKaKve

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