The document discusses the ISA (Investigation/Study/Assay) framework for enabling data reuse and reproducibility in bioscience research. The ISA framework provides a generic format for rich experimental descriptions and an infrastructure of open source software tools. It aims to minimize the burden of reporting, curating, sharing data and metadata from bioscience experiments to enable comprehension, reuse of data, and reproducibility. The framework promotes community engagement to develop community standards and document use cases.

1. Embedding
underpinning
mechanisms
for
data
reuse
and
reproducibility
in
bioscience
The
ISA
Exemplar
(Inves=ga=on/Study/Assay)
-­‐behind
the
PDF-­‐
Alejandra
González-­‐Beltrán,
PhD
Oxford
e-­‐Research
Centre,
University
of
Oxford,
UK
Beyond
the
PDF
2,
Amsterdam,
Netherlands,
March
20th
2013

2. Source
of
the
figure:
EBI
website
Bioscience
Mul=ple
domains
Mul=ple
communi=es
Mul=ple
technologies
Mul=ple
data
types
Mul=ple
data
formats
Mul=ple
data
repositories
…
Community
engagement
ISA
infrastructure
Generic
format
for
Open
source
rich
experimental
soVware
tools
descrip=ons

3. Minimise
the
burden
and
provide
tools
and
incen=ves
for
repor=ng,
cura=ng,
sharing
data
and
metadata
of
bioscience
experiments
to
enable
the
comprehension,
re-­‐use
of
data
in
subsequent
inves=ga=ons
and
reproducibility
of
bioscience

4. Community
engagement
community
standards
use
cases

5. Community
engagement
community
standards
use
cases

6. Community
engagement
community
standards
use
cases

7. Community
engagement
community
standards
use
cases

8. Experimental
descrip=on
provenance/aZribu=on
tracking
aggrega=on:
workflow
publica=ons,
data
samples
characteris=cs
community
standards
experimental
design
+
sta=s=cal
ontology
methods
annota=ons
…
cura=on
at
source
incremental
across
the
research
cycle
(from
planning/grant
wri=ng
up
to
manuscripts
publica=on
and
beyond)

9. collaborate
query
visualize
store
filter
share
create
analyse
curate
submit
research
objects
nanopub
share
query
integrate
link
infer

10. research
objects

11. g
n
u nderlyin
links
betwee ds
and
ho
d ata/met
pub lica=ons
research
objects

12. Follow
us:
@isatools
@biosharing
Find
us:
isa-­‐tools.org
isacommons.org
biosharing.org