antibiotics

6. The international unit of penicillin is the
specific penicillin activity contained in 0.6
mg of the crystalline sodium salt of
penicillin G. One milligram of pure
penicillin G sodium thus equals 1667
units; 1.0 mg of pure penicillin G
potassium represents 1595 units. The
dosage and the antibacterial potency of
the semisynthetic penicillins are

7. Natural penicillins
• Penicillin V
Semi-synthetics
penicillins
• Ampicillin
• Amoxicillin
Aminopenicillins
• Oxacillin, Dicloxacillin
• Cloxacillin, Methicillin
Penicillinase resistant
penicillins
• Carboxypenicillins
• Ureidopenicillins
Broad spectrum
penicillins

8. Mainly against Gram +ve & less on Gram –ve
bacteria.
 Gram +ve & Gram –ve Cocci
 Gram +ve bacilli & some Gram –ve Bacilli
 Streptococcus spp
 Staphylococcus spp
 Spirochetes – Trepenoma palladium
 Neisseria gonorrhoeae
 Pseudomonas spp
 Meningococcus
 E.coli, Klebsiella spp

14. Oral
route
Small
IM
route
Small
IV route
Large
IV route
Penicillin V or
Benzyl
penicillin
PPF +
Benzyl
penicillin
Benzyl
penicillin
Benzyl
penicillin
250-500mg or
4-5lakh units
per day
6 + 2lakh units
per day
1 – 2 mega
units every
6 hrs
1 -2 mu
Every 2hrs for
max 24mu

15.  streptococcal infections
pneumonia – R 1/R 2 for 4 days.
osteomyelitis-
Emphysema - R 3/R 4 for 2 – 4 weeks
pericarditis -
meningitis – R3/R4 for 10 – 14 days
 streptococcal pyogenes infections
Pharyngitis – R1/R2 for 7 – 10 days
A O M – R1/R2 for 2 weeks
 Staphylococcal infection like Osteomyelitis – R3/R4 for 2 – 4 weeks
 S T D’s like
Uncomplicated Gonorrhoea – R3/R4 stat dose
complicated – R3/R4 for 14 days
syphillis - R3/R4 stat dose exactly 4.8 mu or weekly once 3 times