2. Objectives
• Introduce basic concepts of
pharmacokinetics/pharmacodynamics of antimicrobials
• Describe oral bioavailability of antimicrobials
• Illustrate the concept of time-dependent antimicrobials
and describe optimizing the use of beta-lactam
antibiotics using prolonged infusion.
2
21. Review: Pharmacology for Clinicians
Drug
Dose
Duration
Route
prescription
.............
.............
.............
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22. Review: Pharmacology for Clinicians
Drug
Dose
Duration
Route
prescription
.............
.............
.............
Highly bioavailable oral
antibiotics are those that
achieve serum concentrations
comparable to antibiotics
administered intravenously.
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23. Review: Pharmacology for Clinicians
Drug
Dose
Duration
Route
prescription
.............
.............
.............
Patients receiving IV
antimicrobials can often be
switch to oral antimicrobials to
complete a course of therapy.
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24. Review: Pharmacology for Clinicians
Drug
Dose
Duration
Route
prescription
.............
.............
.............
PK/PD can optimize use of
antimicrobials
24