Patients and healthcare providers interested in non-addictive, pain management options that do not cause ulcers, GI bleeds or cardiovascular issues are encouraged to learn more about the medical food Theramine. Theramine is a viable pain management option for patients over the age of 65 or who have a history of liver, kidney or cardiovascular disease. Theramine is a also a treatment option for providers interested in shifting their patients away from narcotic or anti-epileptic pain medications.

1. Responsible Pain Management
Theramine®

2. Better health through medical foods
How Does Chronic Pain Affect the Body?
Chronic pain disrupts homeostasis
and can change the way the brain
communicates with the body.
• Change in Amino Acid Levels
• Change in Nutrient Levels
• Imbalance of Neurotransmitters
• Miscommunication Between Cells
Over time, a sustained imbalance can
prolong and amplify pain, rendering
many treatments ineffective.
2

3. Better health through medical foods
How Can Theramine Improve Pain Management?
Theramine®
 Provides the “fuel” required to
manage the increased metabolic
demands of pain.
 Improve concentrations of the key
amino acids and nutrients required
to make the neurotransmitters
responsible for dampening pain
signals and reducing inflammation
 Restore homeostasis to the central
and peripheral nervous systems
3

4. Better health through medical foods
Pain Management Reinvented
Drugs are designed to treat the symptoms of pain, Theramine
addresses the increased nutritional requirements of pain.
Pain alters metabolic rates, accelerating the rate that amino
acids and neurotransmitters are consumed by the body to
manage the pain process.
Nutritional deficiencies that develop over time can prolong
and amplify pain and inflammation.
Theramine improves the amino acid levels required to
restore nervous system balance and improve pain
management.
4

5. Better health through medical foods
Theramine as a Frontline Therapy
• Effective Standalone Therapy
• Effective Adjunct Therapy
• No Severe Side Effects
• No Drug Half Life
• Amino Acid Based
• Rapid Uptake and Utilization
• Multiple Double Blind Studies
• No Known Contraindications
5

6. Better health through medical foods
6
Improve Pain Management
Theramine® is intended for the dietary
management of pain syndromes that include:
• Acute Pain
• Chronic Pain
• Fibromyalgia
• Neuropathic Pain
• Inflammatory Pain
Recommended Dosing:
2 capsules twice daily

7. Better health through medical foods
7
In a 28 day double-blind, randomized, controlled, multicenter trial of 127 subjects with chronic
established back pain, Theramine proved more effective than naproxen at reducing pain. Subjects
taking Theramine as an adjunct to low dose naproxen, experienced a statistically significant reduction
in pain compared to once daily naproxen (250mg)1 .
1. Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back
Pain”; American Journal of Therapeutics; 2012 108-114
Pain Management: Theramine® vs. Naproxen
2.95
-44
-65
-80
-70
-60
-50
-40
-30
-20
-10
0
10
Percent(%)
Reduction of Pain - Roland Morris Index
Naproxen Theramine Both
p<0.05
n=126

8. Better health through medical foods
8
In a 28 day double-blind, randomized, controlled, multicenter trial of 127 subjects, Theramine
proved more effective than ibuprofen at reducing pain in patients with back pain. Subjects taking
Theramine as an adjunct to low dose ibuprofen, experienced a statistically significant reduction in
pain compared to once daily ibuprofen (400mg) .
Pain Management: Theramine® vs. Ibuprofen
0.73
-50.3
-63.1-70
-60
-50
-40
-30
-20
-10
0
10
Percent(%)
Reduction of Pain - Roland-Morris Index
Ibuprofen n = 43 Theramine n = 41 Combination n = 38
p<0.01

9. Better health through medical foods
1. Shell, et al.,“A Double-Blind Controlled Trial of a Single Dose Naproxen and an Amino Acid Medical Food Theramine for the Treatment of Low Back
Pain”; American Journal of Therapeutics; 2012 108-114
In this double-blind multicenter trial examining the efficacy of Theramine for pain management,
a marked decrease in CRP was measured among subjects taking Theramine compared to subjects
taking naproxen (250mg) once daily.1
9
Theramine® vs. Naproxen: Inflammation Reduction
184.5
-16.7
-78.6-100
-50
0
50
100
150
200
250
Percent(%)
Change in CRP Levels
Naproxen Theramine Both
p<0.01
n=127

10. Better health through medical foods
In this double-blind multicenter trial of 127 subjects with chronic established back pain, a marked
decrease in the inflammatory marker C-Reactive Protein was measured among subjects taking
Theramine compared to subjects taking ibuprofen (400mg) once daily.
10
Theramine® vs. Ibuprofen: Inflammation Reduction
60.1
-47.05
-35.99
-60
-40
-20
0
20
40
60
80
Percent(%)
Change in CRP Levls
Ibuprofen n = 43 Theramine n = 41 Combination n = 38
p<0.01

11. Better health through medical foods
Why is Theramine® a Good Choice?
• No reported side effects in over 40 million administrations*
• No reported GI bleeds
• No reported adverse CV effects
• Non-addictive
• Effective Pain Medication
• Reduces chronic back pain2
• Reduces inflammation2
1. * administrations is defined as number of pills sold since 2004
2. Shelll WE; Pavlik St; Roth B; Silver M; Breitstein M; May L; Silver D “ Reduction in Pain and Inflammation Associated with Chronic Low Back Pain with the use of the Medical Food
Theramine” American Journal of Therapeutics 2014.
11
• Replace or Augment NSAID Therapies
• NSAIDs contraindicated in high risk patients
• Replace or Reduce Narcotic Pain Meds
• Dose titration
• Dose replacement

12. Better health through medical foods
For More Information
Visit www.tmedpharma.com
12