This document discusses key concepts in organizational structure and design. It defines differentiation as the process of allocating people and resources to tasks and establishing relationships to achieve goals. As organizations grow in size and complexity, managers must decide how to control and coordinate activities through differentiation. The challenges are managing differentiation to achieve goals and balancing specialization with integration to promote cooperation. Other concepts covered include centralization versus decentralization of decision-making, standardization versus mutual adjustment of behaviors, and mechanistic versus organic structures.