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Biotechnology Weekend for Teachers Bill Hall University of Delaware February, 2006

What is Biotechnology? ,[object Object],[object Object],[object Object],[object Object]

Traditional Biotechnology ,[object Object],[object Object],[object Object]

Traditional Biotechnology ,[object Object],[object Object]

Modern Biotechnology ,[object Object],[object Object],The Delaware Biotechnology Institute

BC Biotechnology ,[object Object],[object Object],[object Object],[object Object],[object Object]

BC Biotechnology ,[object Object],[object Object]

Traditional Biotechnology ,[object Object],[object Object],Roman Wine bottle 550 AD

BC ,[object Object],[object Object],[object Object],[object Object]

AD: before 20 th Century ,[object Object],1663 – Cells described by Hooke; Antonie van Leeuwenhoek discovers protozoa & bacteria. 1797 – Edward Jenner innoculates a child with a viral vaccine -

1800s ,[object Object],[object Object]

Pasteurization ,[object Object],[object Object]

1800s ,[object Object],[object Object],[object Object],[object Object]

First half of the 20 th century ,[object Object],[object Object],[object Object],[object Object],[object Object]

First half of the 20 th century ,[object Object]

Origin of term ,[object Object],[object Object]

First half of the 20 th century ,[object Object],[object Object]

1950 to 1960 ,[object Object],[object Object],[object Object],[object Object],Barbara McClintock James Watson & Francis Crick

1970s 1975 - Colony hybridization and Southern blotting are developed for detecting specific DNA sequences. Simply a way to determine genomes. 1973 – Cohen & Boyer perform the first successful recombinant DNA experiment using bacterial genes. Dr. Stanly Cohen (left) and Dr. Herbert Boyer

1970s ,[object Object],[object Object],[object Object]

1980 ,[object Object],[object Object]

1980s ,[object Object],[object Object],[object Object],[object Object],Wakame, the first mouse cloned

1980s ,[object Object],Humulin--synthetic insulin

1980s ,[object Object],[object Object],The first genetically engineered human vaccine, Chiron's Recombivax HB, is approved for the prevention of hepatitis B.

1980s ,[object Object],http://www.ornl.gov/sci/techresources/Human_Genome/home.shtml

1980s ,[object Object],[object Object],[object Object],Blastula

1990s ,[object Object],[object Object],The BCRA1 molecule: Linked to breast cancer

1994 - The first full gene sequence of Calgene's Flavr Savr tomato, engineered to resist rotting, is approved for sale. Before Flavr Savr tomatoes were picked green and shipped.

1990s 1995 - First full gene sequence of a living organism other than a virus is completed for the bacterium Haemophilus influenzae. Humans have 25,000 to 30,000 genes Fruit fly 13,000 Estimated that 265 to 400 needed for viable life form We now know the complete DNA sequences for about a dozen bacteria Bacteria seem to need about 500 to 5000 genes to conduct their lives

1990s ,[object Object],[object Object],Jeff Getty recieves baboon bone marrow transplant

1990s ,[object Object],[object Object],[object Object],[object Object]

2000 and Beyond ,[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],2000 and Beyond

2000 and Beyond "Golden Rice," modified to make vitamin A, promises to help third-world countries alleviate blindness.

2000 and Beyond ,[object Object]

2000 and Beyond ,[object Object],[object Object],[object Object],[object Object]

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