Avicenna Laser Technology, Inc., founded in 2002, specializes in developing high power therapeutic laser systems for medical use, achieving FDA clearance as the first 'class IV' therapeutic laser. Their technology is based on extensive research and aims to facilitate deep tissue healing, pain management, and improved metabolic activity through precise energy delivery. Training and comprehensive protocols accompany their laser systems to ensure optimal medical outcomes and address various musculoskeletal and neuropathic conditions.

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3. Avicenna Laser Technology, Inc. was founded in 2002 by Bruce R. Coren, DVM, MS and James Ohneck with the intent to develop a therapeutic laser system capable of delivering healing laser energy to depth’s never before achieved and to offer physician's of all medical disciplines the capability to heal injuries previously refractive to traditional medical care. In December of 2003 Avicenna was granted a 510-k and became the first “Class IV” Therapeutic laser to cleared by the FDA

4. The Avicenna laser was designed from the ground up to be a therapeutic medical laser. It was developed using research by our own biomedical engineers and clinicians as well as collaboration with a major medical school and university optics department. We investigated important criteria such as wavelength, power and power density, optics and beam delivery in order to afford the greatest penetration and delivery of a therapeutic dose capable of stimulating tissue healing in deep seated pathologies. All of our lasers have there own research to support our claims as well as being tested in our patient treatment and R&D center. No other laser manufacturer can make that statement. They typically use studies done with other lasers and then make a great leap of faith to make the claims they do without any of their own research. The world of laser therapy is unfortunately buyer beware!

5. LASER— an acronym for: L ight A mplification by S timulated E mission of R adiation

6. Surgical Lasers: Are used to cut, coagulate, and evaporate tissues. This type of laser replaces the scalpel of the surgeon.

7. Therapeutic Lasers: Are used for the stimulation of cell function. The biological effect is photochemical not thermal, as is the case with surgical lasers.

8. Pain Management Specialists, Orthopedists, Neurologists, Interventional Pain Management Doctors, Physical Medicine and Rehab, Physiatrists and Family Practice Physicians Chiropractors and Physical Therapists Podiatrists, Naturopaths and DOM’s MLB, NBA, NFL and College Sports Teams Medical Colleges The United States Military and VA Hospitals Veterinarians –Equine and Small Animal

9. Energy has the capability to penetrate into tissue to varying depths-depending on its corresponding wavelength and power (examples: Electromagnetic spectrum-X-Ray) Surgical Laser Beam- Infrared energy collimated to a fine beam causes tissue destruction Therapeutic Laser Beam- dispersal of same energy causes tissue stimulation

10. Laser therapy aims to bio-stimulate injured and dysfunctional tissues. Clinical studies and trials of Class III & IV laser technology indicate the following beneficial effects of light therapy on tissues and cells.

11. Chromophores are components of molecules which absorb light. The stimulation of chromophores on mitochondrial membranes incites the production of ATP. Leading to a biological cascade of events.

12. Increased Growth factor response within cells and tissue as a result of increased ATP and protein synthesis. Accelerated cell reproduction and growth leading to faster repair of damaged tissues. Increased metabolic activity- via increase in enzyme outputs, oxygen and nutrient availability.

13. Faster Wound Healing- Laser significantly increases fibroblast and collagen production which are essential for tissue repair. Improved Vascular Activity- Increased capillary production leads to faster wound closure. Greater Tensile Strength – Surgical repaired wounds heal with greater tensile strength, including skin, tendon, ligament and fascia. Scar Tissue Reduction- Wounds heal with less scar tissue formation.

14. PRE-LASER AFTER TWO TREATMENTS

15. Anti-inflammatory via an anti-edemic effect as it causes vasodilatation and activation of the lymphatic drainage system.

16. Via increased endorphin release. Anti-inflammatory via less edema as a result of lymphatic system activation and less swelling. Via Suppression of nociceptors.

17. Strengthening the immune system response via increasing levels of lymphocyte activity and through a newly researched mechanism termed photo-modulation of blood. Documented evidence of Tumor size reduction in animals. Mechanism of action unknown.

18. Improved Nerve Function via increased nerve cell reconnections Trigger Point Resolution Acupuncture Point Stimulation Dermatology, Respiratory, GI and OB-GYN cases also being treated by numerous Avicenna clinicians in the field. (Corporately We stick to neuromusculoskeletal and would healing claims.)

19. Accelerated Tissue Repair and Cell Growth Faster wound Healing Reduced Fibrous (Scar) Tissue Formation Anti-Inflammation Anti-Pain (Analgesia) Improved Vascular Activity Increased Metabolic Activity Improved Nerve Function Immunoregulation Trigger Point Resolution and Acupuncture Pt. Stimulation

20. Safety protocols must ensure sufficient precautions are taken to protect the health and safety of employees and patients .

21. Therapeutic Energy = Measured in Joules Energy Output is based on lasers power output 1 Watt = 1 Joule / Second Laser therapy is a positive form of energy medicine When you treat a patient with a therapeutic laser there is a measurable dosage to every treatment

22. Class IIIa = lasers 1 to 5mw of power (laser pointers) Class IIIb = lasers 6 to 500mw in power (typical cold laser you read about) Class IV = lasers above 500mw of power Avicenna = 12,000mw maximum output

23. Although all therapeutic lasers bio-stimulate tissue, that is where the similarities end. Laser Therapy is all about Physics!

24. As light energy hits the surface of the skin and subsequent deeper layers, some of it is scattered and some of it is absorbed At each tissue interface less energy is available to pass further through to the next layer because of the effects of absorption, reflectance and transmission

26. Low melanin, low water, low hemoglobin

27. 65% of laser energy is absorbed in the skin and subcutaneous tissue layers with the following having a high affinity for absorption: Hemoglobin in blood Melanin in skin, hair, moles, etc. Water (present in all biological tissue) In order to overcome those factors one most start with large quantities of energy

28. Prime Determinants of Laser Penetration and Concomitant Tissue Stimulation are: Power – measured in Watts or milliwatts Wavelength – measured in nanometers Power Density – measured in mw / cm2 Frequency – continuous wave versus pulsing

29. Approximately 65% of the energy delivered is lost in the epidermis If you don’t start with enough energy there will not be enough to stimulate cell healing If you do not have sustained power density over a long enough period of time treatments may be ineffective Too much power density can also be detrimental (surgical lasers that have been converted to therapy lasers.) Collimated beam vs. Divergent Beam

30. A laser with two or more wavelengths only has the ability to penetrate as deep as each individual wavelengths allows Lasers that pulse or have a high duty cycle coupled with multiple wavelengths of energy emission will not penetrate as deep as CW lasers of a single wavelength Continuous wave lasers = 100% duty cycle, laser is always delivering energy which is needed to overcome absorption in the superficial layers

31. In Laser Medicine 1 + 1 Does not = 2 Dual wavelength lasers only penetrate as deep as each wavelength will go individually. The penetration is not additive so there is no real benefit to this scenario. It is more advantageous to have one wavelength of greater power that stimulates cell metabolism and tissue regeneration at all tissues in its pathway. We knew this going into the formation of our laser system unlike our competitors who relied on other laser manufacturers incorrect theory of wavelength and biostimulation.

32. In order to get penetration you must create significant energy density to overcome absorption in the superficial layers of the skin. With low power density and even with pulsed class iv lasers it is like pouring small amounts of water onto a large sponge (the dermis and subcutaneous tissues) and expecting the water to leak through. In order to to do so you must saturate the superficial layers of the sponge- with enough water-energy to soak the sponge, so as you pour more water-energy over the sponge it will start to penetrate or leak through. This it what is needed and why it is important to deliver the energy in a continuous manner. Low power or pulsed class iv lasers just cannot provide the energy necessary to overcome the absorptive capabilities of the superficial skin layers and that is why they fail to deliver a positive outcome when trying to reach deep seated pathologies.

33. 49-73 mw/cm 2 for cell stimulation 1 EFFECTS OF INFRARED LASER EXPOSURE IN A CELLULAR MODEL OF WOUND HEALING Mark D. Skopin and Scott C. Molitor, Department of Bioengineering, University of Toledo, Toledo OH

34. Tissue Layer Max Power (mw/cm2) Epidermis 206 Dermis Layer 182 Dermis Plexus Super. 135 2nd Dermis Layer 115 Dermis Plexus Prof. 93 Muscle Tissue 9.7 Power Setting 5 Watts, 3.0cm spot size, 980nm (This is a snapshot in time. Calculated using computer models by U of Toledo)

35. Duty Cycle – 100% Laser is firing continuously Duty Cycle – 50% Laser is firing 50% of the time. This will not only cut energy delivery but it will also affect ability to penetrate. Pulsing – Lasers that pulse also do not emit continuous energy Avicenna is 100% continuous wave energy

38. Under-dosage – The typical low level or cold laser does not deliver enough energy to adequately stimulate deep seated inflammatory conditions Under penetration - The typical low level or cold laser does not concentrate the laser energy sufficiently to allow for adequate penetration Wrong Diagnosis – This typically occurs when doctors are treating image studies and not the patient. It is paramount that a proper orthopedic and neurologic exam is performed!

40. High Power Therapeutic Laser Medicine is a new discipline in Neuromusculoskeletal Medicine created by Avicenna Laser Technology’s Team of Physicians It revolves around using the Avicenna High Power Laser in conjunction with numerous areas of medicine such as:

41. High Power Laser Therapy Non-surgical orthopedics Neurology Foot pathology Biomechanics, gait and kinetic chain dysfunction Orthotic intervention All of the above are critical components in achieving a successful outcome.

42. Avicenna’s goal has always been to build the most efficacious laser available to deliver the best outcomes. Our lasers are built from the ground up and are designed to get patients who have failed traditional therapy better Our competitors lasers are built based on economic factors There is a hugh difference between making a patient feel better vs. actually getting them better. There are no shortcuts to treating real pathologies

43. Higher the power output of laser energy The Greater The Penetration The Faster the Therapeutic Outcome The Quicker the Patient Returns to Normal This is one of the reasons we developed our new technology the AVI HPLL-12

44. Relieve Pain and Reduce Inflammation Promote Tissue Healing Minimize Side Effects Restore Active Range of motion

45. Laser vs. Standard Modalities You May Have Used to Treat Patients with in the Past

46. Disc Pathologies, Spinal Stenosis, Radicular Pain, spondylolesthesis, and sacroiliac dysfunction Failed surgical back syndrome Accelerated Post Surgical, Soft and hard Tissue healing Arthritis (Degenerative Joint Disease) Foot Pain and Neuropathies Muscle, Ligament and Tendon Injuries Ulcerations and Open Wounds

47. Decreased inflammation of disc, nerve roots and the cauda equine Increase microcirculation of spinal structures Accelerate healing of annular defects Decreased formation of abnormal/non functional scar tissue Decreased scar tissue and non-osseous hypertrophic changes Reduce pain associated with prolotherapy injection Decrease or even eliminate need for epidurals

48. Decreased inflammation of nerve tissue Accelerated Reinervation of nerve fibers Increase blood flow and microcirculation of tissue structures Accelerate healing of open wounds Decreased formation of abnormal/non-functional scar tissue

49. Increase synovial fluid and cartilage production Increase collagen and fibroblast production Increase osteoblastic activity and fracture healing Decreased bony edema – osteochondral bone bruise Decrease in pain associated with epidural, prolotherapy or other invasive injections

50. Assessment of Laser Therapy for Late Postoperative Pain after Lumbar Fusion Surgery and For Pain And Wound Healing After Acute Traumatic Injury - Preliminary Results Ashok Biyani, MD Martin Skie, MD Despina Ciocanel, MD

51. Cornell University – Weill College of Medicine Investigating the Effect of the AVI-HP 7.5 Therapeutic Laser on Post Thoracotomy Syndrome

52. Avicenna clinicians all subscribe to the theory of EBM Clinicians measures results with outcome assessment tools: Pressure Algometer Inclinometer , Goniometer Thermal Imaging and Doppler Studies VAS, PDQ – Pain Disability Questionnaire These tools are vital to document outcomes which ultimately lead to adequate reimbursement

53. Introduction to Laser Medicine Pathologies of the Lumbar Spine Pathologies of the Cervical Spine Peripheral Neuropathy Peripheral Entrapment Syndromes Upper Extremity Pathologies Lower Extremity Pathologies Kinetic Chain Dysfunction Orthotic Fabrication

54. Developed by Clinicians for Clinicians Proprietary to AVI HP –7.5 and AVI HPLL-12 Utilizes Texas Back Institute Protocols in conjunction with laser Will not work for LLLT or other Low Power Lasers as they cannot create significant power (energy density) to over come tissue saturation to reach deep structures in the disc, joint or areas of deep seated inflammation

55. Profound anti-inflammatory and analgesic effects Pain relief typically immediate Non-invasive and no side effects Profound tissue regeneration of all tissue types Overall contraindications minimal

56. Avicenna's training incorporates the teachings of multiple disciplines including non-surgical orthopedics, physical medicine and rehab, neurology, podiatry, bio-mechanics and kinetic chain dysfunction. Combined with our revolutionary technology we have brought to the field of medicine a new discipline: "High Power Therapeutic Laser Medicine” Regardless of your medical discipline or level of experience we will train you to outperform anything in medicine when it comes to treating neuromusculoskeletal pain. The training you will receive will not only be second to none it also includes unlimited phone consultation services! As good as our laser is, without proper training you may fail when treating difficult conditions With our training, when it comes to pain management you will now be able to outperform anything in medicine, safely and without the potential for side-effects.

57. Avicenna’s goal has always been to build the most efficacious laser available to deliver the best outcomes. Our lasers are built from the ground up and are designed to get patients who have failed traditional therapy better Our competitors lasers are built based on economic factors There is a huge difference between making a patient feel better vs. actually getting them better. There are no shortcuts to treating real pathologies

58. A technological advancement in energy output and delivery The AVI HPLL-12 is the world’s most powerful and advanced therapeutic laser system But: As good as this technology is, without the appropriate training when it comes to treating medical failures your results will be marginal at best As a physician based company we have treated or will know how to treat any condition you are confronted with the ultimate result being a better outcome With the superior training and clinical support we provide physicians the above goal will readily be achieved

60. Clinical Training which includes basic training, lumbar spine, foot pathologies and peripheral neuropathy to quickly generate cash flow Custom Website from Avicenna Template with SEO Custom brochure and business card from Avicenna Templates Custom ads made using Avicenna templates Custom Seminar Power Points using Avicenna templates Help set up internal and external marketing plan Help with setting up seminars including advertising, choosing location, negotiation for venue Weekly financial consultations to discuss income and marketing strategies Money back guarantee Training your employee’s to sell cash

61. www.AvicennaLaser.com 888-Avi-Laser – info@avicennalaser.com