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Fluid/Lytes/Minerals/Renal 
(General Key Points) 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
· Diuretics  fluid loss via urine output 
· Major uses of diuretics include prevention of renal failure and 
management of hypertension. 
· Most diuretics work by blocking reabsorption of Na+ and Cl-; the more 
ion absorption blocked, the more fluid that is lost. 
· Potassium is necessary for nerve impulse conduction and regulation of 
acid-base balance. 
· Calcium is critical to normal metabolic processes of the heart, nerves, 
muscles, bones, and coagulation. 
· Mineral supplements tend to cause GI distress and should be administered 
with a full glass of water or with meals.
High Ceiling Loop Diuretics 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: 
Proto: furosemide (Lasix) — Others: ethacrynic acid (Edcrin), 
bumetanide (Bumex), Torsemide (Demadex) 
· In  Loop of Henle to block reabsorption of Na+/Cl-/H2O  Extensive diuresis. 
Therapeutic Uses: · Pulmonary edema d/t heart failure 
· Works well with renal impairment · Hypercalcemia r/t stone formation 
· Reserved for conditions unresponsive to other diuretics (e.g. edema d/t liver, 
cardiac or renal disease; hypertension) 
Adverse Effects: · Dehydration ( output < 30 mL/hr) · Hypotension 
· Ototoxic – furosemide (temp); ethacrynic acid (permanent) -  other ototoxics 
· Hypokalemia · Hyperglycemia, hyperuricemia,  [Ca2+], [Mg2+] 
Contraindications/Precautions: ♀ (C) · Caution ĉ diabetes, gout 
Interactions: · Digoxin toxicity r/t K+ · NSAIDs blunt diuretic effect 
· Antihypertensives – Additive hypotensive effect · [Li] d/t diuresis 
Education: · Daily weights · Infuse slowly (20 mg/min) 
· K+ foods (avocado, strawberry, banana, potato, spinach, tomato, meat, carrots) 
·  Mg2+ signs: muscle twitch and tremor
Thiazide Diuretics 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: 
Proto: hydrochlorothiazide (HydroDIURIL) — Others: 
chlorothiazide (Diuril), indapamide 
· In early DCT to block Na+/Cl-/H2O reabsorption – promote diuresis when renal 
function is not impaired. 
Therapeutic Uses: · 1st choice essential hypertension 
· Edema of mild-to-moderate heart failure and liver/kidney disease. 
Adverse Effects: · Dehydration · Hypokalemia · Hyperglycemia 
Contraindications/Precautions: ♀ (B) ·  breastfeeding 
· Caution ĉ renal impairment – may not be effective 
Interactions: · Digoxin toxicity d/t K+ · Antihypertensives: Additive effect 
·  lithium levels · NSAIDs blunt diuretic effect 
Education: · Alternate day dosing can  electrolyte imbalances 
·  K+ foods (avocado, strawberry, banana, potato, spinach, tomato, meat)
K+-Sparing Diuretics 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: 
Proto: spironolactone (Aldactone) — Others: triamterene 
(Dyrenium), amiloride (Midamore) 
· Block aldosterone action resulting in K+ retention and Na+/H2O excretion. 
Therapeutic Uses: · Combined with other diuretics for K+-sparing effect 
· Heart failure · Blocks aldosterone in hyperaldosteronism 
Adverse Effects: · Hyperkalemia (insulin injection drives K+ back into cell) 
· Endocrine effects: Irregular menses or impotence 
Contraindications/Precautions: ♀ (_) · 
· 
Interactions: · ACE inhibitors (lisinopril)   hyperkalemia 
· K+ supplements   hyperkalemia 
Education: · Triamterene may color urine blue
Osmotic Diuretics 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: Proto: mannitol (Osmitrol) — Others: urea, glycerin, isosorbide 
·  blood osmolality thus attracting fluid (e.g. 3rd spacing, CSF, intraocular) 
Therapeutic Uses: ·  ICP ·  intraocular pressure (IOP) 
· Prevent renal failure in hypovolemic shock or severe hypotension. 
· Promote Na+ retention and H2O excretion in hyponatremia and fluid V excess 
Adverse Effects: · Heart failure / pulmonary edema 
· Renal failure (urine < 30 mL/hr, creatinine > 1.2 mg/dL, BUN > 20 mg/dL 
· Fluid and electrolyte imbalance 
Contraindications/Precautions: ♀ (_) · 
· Lasix complements through renal excretion of fluid drawn by osmotics. 
Education: · Most effective given as a bolus · Use filter to prevent crystals 
· Monitor serum osmolarity and every 6 hours / urine osmolarity daily
Phosphate Binders 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: 
Proto: aluminum hydroxide gel (Amphojel) — Others: calcium 
carbonate (Tums, OsCal), aluminum carbonate gel (Basaljel) 
· Bind intestinal phosphate that is excreted in the feces 
Therapeutic Uses: · Antacid 
·  hyperphosphatemia (>4.5mg/dL) in end-stage renal disease 
Adverse Effects: · Constipation · Hypophosphatemia (<3mg/dL) 
Contraindications/Precautions: ♀ (_) · 
· CI: hypophosphatemia / bowel obstruction / pregnant or breastfeeding 
Interactions: · Alter absorption of many medications. Do not administer other 
medications concurrently with Amphojel. 
Education: · Give with first bite of food to absorb phosphate in food 
· Avoid  PO4 foods: (dairy, fish, pork, nuts, whole-grains)
Kayexalate 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: Proto: Sodium Polystyrene (Kayexalate) 
· Promotes K+ excretion and Na+ absorption, primarily in large intestine 
Therapeutic Uses: · Treat hyperkalemia 
Adverse Effects: · Electrolyte (Ca2+, K+, Na+, Mg2+) imbalance 
Contraindications/Precautions: ♀ (_) · 
Interactions: · Ca2+- or Mg2+-containing antacids or laxatives may  efficacy 
· Digoxin and K+-sparing diuretics should undergo frequent K+ monitoring 
Education: · Given orally or rectally · Mix with juice 
· Retain enema for 30-60 minutes; irrigate ĉ non-Na+-containing solution
K+ Supplements 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: 
Proto: Potassium Chloride (K-Dur) — Others: 
K+ gluconate, K+ phosphate, K+ bicarbonate 
· K+ is essential for nerve conduction, muscle excitability, and acid/base balance 
Therapeutic Uses: · Hypokalemia · K+-sparing diuretics 
· K+ loss d/t excessive/prolonged diarrhea, vomiting, GI fistulas, drainage 
Adverse Effects: · GI distress (take with water or meals) 
· GI ulceration (do not dissolve / take with water or meals) 
· Hyperkalemia (rare ĉ oral) – signs = bradycardia, hypotension, ECG Δ 
Contraindications/Precautions: ♀ (_) · Severe renal disease 
· Hypoaldosteronism creates risk for hyperkalemia 
Interactions: · 
· Concurrent use of K+-sparing diuretics (spironolactone) or ACE inhibitors 
(lisinopril) increases risk of hyperkalemia. 
Education: · Never give IV push · Use infusion pump 
· Assess site for irritation, phlebitis, infiltration – d/c immediately if present 
· Dilute to no more than 40 mEq/L || give no faster than 10 mEq/hr.
Mg2+ Sulfate 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: Proto: Mag. sulfate — Others: mag. gluconate, mag. hydroxide 
· Mg2+ activates many intracellular enzymes, helps regulate muscle contraction and 
blood coagulation 
Therapeutic Uses: · Hypomagnesemia (< 1.3 mEq/L) 
· Oral doses for mild cases / parenteral doses for severe cases. 
Adverse Effects: · Neuromuscular blockade and respiratory depression (IV 
· Diarrhea administration requires careful monitoring of patient.) 
Contraindications/Precautions: ♀ (B) · 
· Caution ĉ AV block, rectal bleeding, nausea/vomiting, abdominal pain, renal, and 
cardiac disease. 
Interactions: · MgSO4  absorption of tetracyclines 
Education: · Monitor serum Ca2+, Mg2+, PO4 
- · Mg2+ WNL 
· 1.3-2.1 
mEq/L 
· Assess for depressed or absent deep tendon reflex as a sign of 
toxicity. Calcium gluconate is given for MgSO4 toxicity.
Sodium Bicarbonate 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: Proto: Sodium Bicarbonate 
· Systemic alkalinizer used to correct metabolic acidosis (pH < 7.35) 
Therapeutic Uses: · Acidosis d/t diabetes, cardiac arrest, or vascular collapse 
· Given orally as an antacid · Raise urinary pH to enhance renal excretion 
· Raise urinary pH to enhance renal excretion in salicylate overdose 
Adverse Effects: · Na+ overload (>145 mEq/L) · Renal calculi (> 1500 cc/day) 
· Alkalosis (pH > 7.45) (tachycardia, irritability, twitching) 
Contraindications/Precautions: ♀ (_) · Unsuitable as antacid b/c short-acting 
· Caution ĉ hypertension, ♥ failure, kidney disease 
Interactions: · Corticosteroids   K+,  Na+ · Many IV incompatibilities 
· Pseudoephedrine, quinidine   effects of these 
· Lithium, salicylates, benzodiazepines   effects of these 
Education: · Confirm acidosis by ABG
Calcium Supplements 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: Proto: Calcium citrate — Others: Ca2+ carbonate, Ca2+ acetate 
· Required for normal musculoskeletal, neurological, and cardiovascular function 
Therapeutic Uses: · 
· Hypocalcemia or deficiencies of PTH, vitamin D, or dietary calcium 
Adverse Effects: · 
· Hypercalcemia – tachycardia,  BP, muscle weakness, constipation. 
Contraindications/Precautions: ♀ (_) · 
· CI: hypercalcemia, bone tumors, and hyperparathyroidism 
Interactions: · Glucocorticoids  Ca2+absorption · 
·  absorption of Tetracyclines, thyroxine · Thiazides   hypercalcemia 
· IV Ca2+ precipitates with phosphates, carbonates, sulfates, and tartrates 
· Digoxin + IV Ca2+  severe bradycardia 
Education: · IV injections at 0.5-2 mL/min · Ca2+ WNL = 9-10.5 mg/dL
Selective Estrogen Receptor 
Modifiers 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: Proto: raloxifene (Evista)— Others: tamoxifen citrate (Nolvadex) 
· Endogenous estrogen in bone, lipid metabolism, and blood coagulation 
·  osteoclast activity   bone 
· resorption. 
 plasma cholesterol 
· Antagonist to estrogen on breast and endometrial tissue 
Therapeutic Uses: · Postmenopausal osteoporosis ·  risk of breast cancer 
Adverse Effects: · Hot flashes ·  risk of PE and DVT  Keep active 
Contraindications/Precautions: ♀ (X) · CI: Hx of venous thromboses 
Interactions: · None 
Education: 
· Sufficient calcium / vitamin D to PTH 
release and   Ca2+ release from bones 
Ca2+ WNL 
9-10.5 mg/dL
Bisphosphonates 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: 
Proto: alendronate (Fosamax) 
Others: ibandronate (Boniva), risedronate (Actonel) 
·  number and action of osteoclasts   bone resorption 
Therapeutic Uses: · ♂/♀ osteoporosis · 
· Paget’s disease and hypercalcemia of malignancy 
Adverse Effects: · Esophagitis  full glass of H2O and upright for 30 min 
·  risk for hyperparathyroidism @  doses in Paget’s disease 
Contraindications/Precautions: ♀ (C) · CI: Esophageal disorders, GERD 
Interactions: · 
· Ca2+supplements, antacids, OJ, & caffeine all  alendronate absorption 
Education: · Take first thing in AM, with  H2O 
· Sufficient Ca2+ / vitamin D to PTH release and   Ca2+ release from bones 
· Encourage weight-bearing exercise (30-40 min/day)
Calcitonin – Salmon 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
Expected Action: Proto: calcitonin salmon (Fortical, Miacalcin) 
·  osteoclasts bone resorption ·  tubular resorption of calcium 
Therapeutic Uses: · Postmenopausal osteoporosis and Paget’s disease 
· Hypercalcemia due to hyperparathyroidism and cancer 
Adverse Effects: · Intranasal: dryness and irritation 
· IM/SC: site inflammatory response · Self-limiting nausea 
Contraindications/Precautions: ♀ (C) · CI: Hypersensitivity to fish protein 
Interactions: ·  serum lithium · 
Education: · Keep container upright · Alternate nostrils daily 
· Check for Chvostek’s or Trousseau’s signs for hypocalcemia 
· Sufficient Ca2+ / vitamin D to PTH release and   Ca2+ release from bones
Normal Lab Values 
N203 
ATI (Unit 9) 
Fluids/Lytes/Minerals/Renal -
· RBC=4.7-6.1 x 1012/L · WBC = 5-10 x 109/L · PLT = 150-400 x 109/L 
· PO2=75-100 mm Hg · PCO2=34-45 mm Hg · pH = 7.35-7.45 
· Hgb=14-18 g/dL · Hct=42-52% · PT=11-12.5 s · PTT=60-70 s 
· Na+=135-145 mEq/L · Cl-=100-108 mEq/L · Ca2+=9-10.5 mg/dL 
· K+=3.5-5 mEq/L · PO4 
3-=3-4.5 mg/dL · Mg2+=1.6-2.6 mg/dL 
· · · 
· Prot=6-8 g/dL · Creatinine=0.6-1.5 mg/dL · BUN=3.6-7.1 mmol/L 
Neu=55-70% 
(2,500-8,000) 
Lym=20-40% 
(1,000-4,000) 
Mon=2-8% 
(100-700) 
Eos=1-4% 
(50-500) 
·

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Ati flash cards 09, medications affecting fluid, electrolytes, minerals, and renal

  • 1. Fluid/Lytes/Minerals/Renal (General Key Points) N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 2. · Diuretics  fluid loss via urine output · Major uses of diuretics include prevention of renal failure and management of hypertension. · Most diuretics work by blocking reabsorption of Na+ and Cl-; the more ion absorption blocked, the more fluid that is lost. · Potassium is necessary for nerve impulse conduction and regulation of acid-base balance. · Calcium is critical to normal metabolic processes of the heart, nerves, muscles, bones, and coagulation. · Mineral supplements tend to cause GI distress and should be administered with a full glass of water or with meals.
  • 3. High Ceiling Loop Diuretics N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 4. Expected Action: Proto: furosemide (Lasix) — Others: ethacrynic acid (Edcrin), bumetanide (Bumex), Torsemide (Demadex) · In  Loop of Henle to block reabsorption of Na+/Cl-/H2O  Extensive diuresis. Therapeutic Uses: · Pulmonary edema d/t heart failure · Works well with renal impairment · Hypercalcemia r/t stone formation · Reserved for conditions unresponsive to other diuretics (e.g. edema d/t liver, cardiac or renal disease; hypertension) Adverse Effects: · Dehydration ( output < 30 mL/hr) · Hypotension · Ototoxic – furosemide (temp); ethacrynic acid (permanent) -  other ototoxics · Hypokalemia · Hyperglycemia, hyperuricemia,  [Ca2+], [Mg2+] Contraindications/Precautions: ♀ (C) · Caution ĉ diabetes, gout Interactions: · Digoxin toxicity r/t K+ · NSAIDs blunt diuretic effect · Antihypertensives – Additive hypotensive effect · [Li] d/t diuresis Education: · Daily weights · Infuse slowly (20 mg/min) · K+ foods (avocado, strawberry, banana, potato, spinach, tomato, meat, carrots) ·  Mg2+ signs: muscle twitch and tremor
  • 5. Thiazide Diuretics N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 6. Expected Action: Proto: hydrochlorothiazide (HydroDIURIL) — Others: chlorothiazide (Diuril), indapamide · In early DCT to block Na+/Cl-/H2O reabsorption – promote diuresis when renal function is not impaired. Therapeutic Uses: · 1st choice essential hypertension · Edema of mild-to-moderate heart failure and liver/kidney disease. Adverse Effects: · Dehydration · Hypokalemia · Hyperglycemia Contraindications/Precautions: ♀ (B) ·  breastfeeding · Caution ĉ renal impairment – may not be effective Interactions: · Digoxin toxicity d/t K+ · Antihypertensives: Additive effect ·  lithium levels · NSAIDs blunt diuretic effect Education: · Alternate day dosing can  electrolyte imbalances ·  K+ foods (avocado, strawberry, banana, potato, spinach, tomato, meat)
  • 7. K+-Sparing Diuretics N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 8. Expected Action: Proto: spironolactone (Aldactone) — Others: triamterene (Dyrenium), amiloride (Midamore) · Block aldosterone action resulting in K+ retention and Na+/H2O excretion. Therapeutic Uses: · Combined with other diuretics for K+-sparing effect · Heart failure · Blocks aldosterone in hyperaldosteronism Adverse Effects: · Hyperkalemia (insulin injection drives K+ back into cell) · Endocrine effects: Irregular menses or impotence Contraindications/Precautions: ♀ (_) · · Interactions: · ACE inhibitors (lisinopril)   hyperkalemia · K+ supplements   hyperkalemia Education: · Triamterene may color urine blue
  • 9. Osmotic Diuretics N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 10. Expected Action: Proto: mannitol (Osmitrol) — Others: urea, glycerin, isosorbide ·  blood osmolality thus attracting fluid (e.g. 3rd spacing, CSF, intraocular) Therapeutic Uses: ·  ICP ·  intraocular pressure (IOP) · Prevent renal failure in hypovolemic shock or severe hypotension. · Promote Na+ retention and H2O excretion in hyponatremia and fluid V excess Adverse Effects: · Heart failure / pulmonary edema · Renal failure (urine < 30 mL/hr, creatinine > 1.2 mg/dL, BUN > 20 mg/dL · Fluid and electrolyte imbalance Contraindications/Precautions: ♀ (_) · · Lasix complements through renal excretion of fluid drawn by osmotics. Education: · Most effective given as a bolus · Use filter to prevent crystals · Monitor serum osmolarity and every 6 hours / urine osmolarity daily
  • 11. Phosphate Binders N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 12. Expected Action: Proto: aluminum hydroxide gel (Amphojel) — Others: calcium carbonate (Tums, OsCal), aluminum carbonate gel (Basaljel) · Bind intestinal phosphate that is excreted in the feces Therapeutic Uses: · Antacid ·  hyperphosphatemia (>4.5mg/dL) in end-stage renal disease Adverse Effects: · Constipation · Hypophosphatemia (<3mg/dL) Contraindications/Precautions: ♀ (_) · · CI: hypophosphatemia / bowel obstruction / pregnant or breastfeeding Interactions: · Alter absorption of many medications. Do not administer other medications concurrently with Amphojel. Education: · Give with first bite of food to absorb phosphate in food · Avoid  PO4 foods: (dairy, fish, pork, nuts, whole-grains)
  • 13. Kayexalate N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 14. Expected Action: Proto: Sodium Polystyrene (Kayexalate) · Promotes K+ excretion and Na+ absorption, primarily in large intestine Therapeutic Uses: · Treat hyperkalemia Adverse Effects: · Electrolyte (Ca2+, K+, Na+, Mg2+) imbalance Contraindications/Precautions: ♀ (_) · Interactions: · Ca2+- or Mg2+-containing antacids or laxatives may  efficacy · Digoxin and K+-sparing diuretics should undergo frequent K+ monitoring Education: · Given orally or rectally · Mix with juice · Retain enema for 30-60 minutes; irrigate ĉ non-Na+-containing solution
  • 15. K+ Supplements N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 16. Expected Action: Proto: Potassium Chloride (K-Dur) — Others: K+ gluconate, K+ phosphate, K+ bicarbonate · K+ is essential for nerve conduction, muscle excitability, and acid/base balance Therapeutic Uses: · Hypokalemia · K+-sparing diuretics · K+ loss d/t excessive/prolonged diarrhea, vomiting, GI fistulas, drainage Adverse Effects: · GI distress (take with water or meals) · GI ulceration (do not dissolve / take with water or meals) · Hyperkalemia (rare ĉ oral) – signs = bradycardia, hypotension, ECG Δ Contraindications/Precautions: ♀ (_) · Severe renal disease · Hypoaldosteronism creates risk for hyperkalemia Interactions: · · Concurrent use of K+-sparing diuretics (spironolactone) or ACE inhibitors (lisinopril) increases risk of hyperkalemia. Education: · Never give IV push · Use infusion pump · Assess site for irritation, phlebitis, infiltration – d/c immediately if present · Dilute to no more than 40 mEq/L || give no faster than 10 mEq/hr.
  • 17. Mg2+ Sulfate N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 18. Expected Action: Proto: Mag. sulfate — Others: mag. gluconate, mag. hydroxide · Mg2+ activates many intracellular enzymes, helps regulate muscle contraction and blood coagulation Therapeutic Uses: · Hypomagnesemia (< 1.3 mEq/L) · Oral doses for mild cases / parenteral doses for severe cases. Adverse Effects: · Neuromuscular blockade and respiratory depression (IV · Diarrhea administration requires careful monitoring of patient.) Contraindications/Precautions: ♀ (B) · · Caution ĉ AV block, rectal bleeding, nausea/vomiting, abdominal pain, renal, and cardiac disease. Interactions: · MgSO4  absorption of tetracyclines Education: · Monitor serum Ca2+, Mg2+, PO4 - · Mg2+ WNL · 1.3-2.1 mEq/L · Assess for depressed or absent deep tendon reflex as a sign of toxicity. Calcium gluconate is given for MgSO4 toxicity.
  • 19. Sodium Bicarbonate N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 20. Expected Action: Proto: Sodium Bicarbonate · Systemic alkalinizer used to correct metabolic acidosis (pH < 7.35) Therapeutic Uses: · Acidosis d/t diabetes, cardiac arrest, or vascular collapse · Given orally as an antacid · Raise urinary pH to enhance renal excretion · Raise urinary pH to enhance renal excretion in salicylate overdose Adverse Effects: · Na+ overload (>145 mEq/L) · Renal calculi (> 1500 cc/day) · Alkalosis (pH > 7.45) (tachycardia, irritability, twitching) Contraindications/Precautions: ♀ (_) · Unsuitable as antacid b/c short-acting · Caution ĉ hypertension, ♥ failure, kidney disease Interactions: · Corticosteroids   K+,  Na+ · Many IV incompatibilities · Pseudoephedrine, quinidine   effects of these · Lithium, salicylates, benzodiazepines   effects of these Education: · Confirm acidosis by ABG
  • 21. Calcium Supplements N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 22. Expected Action: Proto: Calcium citrate — Others: Ca2+ carbonate, Ca2+ acetate · Required for normal musculoskeletal, neurological, and cardiovascular function Therapeutic Uses: · · Hypocalcemia or deficiencies of PTH, vitamin D, or dietary calcium Adverse Effects: · · Hypercalcemia – tachycardia,  BP, muscle weakness, constipation. Contraindications/Precautions: ♀ (_) · · CI: hypercalcemia, bone tumors, and hyperparathyroidism Interactions: · Glucocorticoids  Ca2+absorption · ·  absorption of Tetracyclines, thyroxine · Thiazides   hypercalcemia · IV Ca2+ precipitates with phosphates, carbonates, sulfates, and tartrates · Digoxin + IV Ca2+  severe bradycardia Education: · IV injections at 0.5-2 mL/min · Ca2+ WNL = 9-10.5 mg/dL
  • 23. Selective Estrogen Receptor Modifiers N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 24. Expected Action: Proto: raloxifene (Evista)— Others: tamoxifen citrate (Nolvadex) · Endogenous estrogen in bone, lipid metabolism, and blood coagulation ·  osteoclast activity  bone · resorption.  plasma cholesterol · Antagonist to estrogen on breast and endometrial tissue Therapeutic Uses: · Postmenopausal osteoporosis ·  risk of breast cancer Adverse Effects: · Hot flashes ·  risk of PE and DVT  Keep active Contraindications/Precautions: ♀ (X) · CI: Hx of venous thromboses Interactions: · None Education: · Sufficient calcium / vitamin D to PTH release and  Ca2+ release from bones Ca2+ WNL 9-10.5 mg/dL
  • 25. Bisphosphonates N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 26. Expected Action: Proto: alendronate (Fosamax) Others: ibandronate (Boniva), risedronate (Actonel) ·  number and action of osteoclasts  bone resorption Therapeutic Uses: · ♂/♀ osteoporosis · · Paget’s disease and hypercalcemia of malignancy Adverse Effects: · Esophagitis  full glass of H2O and upright for 30 min ·  risk for hyperparathyroidism @  doses in Paget’s disease Contraindications/Precautions: ♀ (C) · CI: Esophageal disorders, GERD Interactions: · · Ca2+supplements, antacids, OJ, & caffeine all  alendronate absorption Education: · Take first thing in AM, with  H2O · Sufficient Ca2+ / vitamin D to PTH release and  Ca2+ release from bones · Encourage weight-bearing exercise (30-40 min/day)
  • 27. Calcitonin – Salmon N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 28. Expected Action: Proto: calcitonin salmon (Fortical, Miacalcin) ·  osteoclasts bone resorption ·  tubular resorption of calcium Therapeutic Uses: · Postmenopausal osteoporosis and Paget’s disease · Hypercalcemia due to hyperparathyroidism and cancer Adverse Effects: · Intranasal: dryness and irritation · IM/SC: site inflammatory response · Self-limiting nausea Contraindications/Precautions: ♀ (C) · CI: Hypersensitivity to fish protein Interactions: ·  serum lithium · Education: · Keep container upright · Alternate nostrils daily · Check for Chvostek’s or Trousseau’s signs for hypocalcemia · Sufficient Ca2+ / vitamin D to PTH release and  Ca2+ release from bones
  • 29. Normal Lab Values N203 ATI (Unit 9) Fluids/Lytes/Minerals/Renal -
  • 30. · RBC=4.7-6.1 x 1012/L · WBC = 5-10 x 109/L · PLT = 150-400 x 109/L · PO2=75-100 mm Hg · PCO2=34-45 mm Hg · pH = 7.35-7.45 · Hgb=14-18 g/dL · Hct=42-52% · PT=11-12.5 s · PTT=60-70 s · Na+=135-145 mEq/L · Cl-=100-108 mEq/L · Ca2+=9-10.5 mg/dL · K+=3.5-5 mEq/L · PO4 3-=3-4.5 mg/dL · Mg2+=1.6-2.6 mg/dL · · · · Prot=6-8 g/dL · Creatinine=0.6-1.5 mg/dL · BUN=3.6-7.1 mmol/L Neu=55-70% (2,500-8,000) Lym=20-40% (1,000-4,000) Mon=2-8% (100-700) Eos=1-4% (50-500) ·