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Asthma – Symptoms and
Treatment
Case History
• 57 year old female
• 1 day history of shortness of breath and chest
tightness
• Started at 5pm
• No cough / coryzal symptoms
• Called 999 at 9pm – unable to speak on phone
Past medical history and drug history
• Asthma since young child
• Previous hospital admission aged 4/5
• No ITU admissions
• Hayfever, slight eczema
• Drugs: Salbutamol 2 puffs PRN inhaler
• Beclometasone 2 puffs BD inhaler (non-concordant)
• Stopped attending asthma clinics
• Allergies: penicillin (rash)
Social and family history
• Lives with partner
• Two dogs – don’t trigger asthma
• Non-smoker
On admission
• Nebulisers in ambulance: salbutamol 5mg, ipratropium
500 micrograms
• Peak flow 300 before nebs, 400 after nebs (best 600)
• ABG on air: pO2 10.0, pCO2 4.4, lactate 3.5, base
excess 1.9, H+ 37.4
• Bloods: Hb 13.9, WCC 12.6, Urea 6.2, Creat 94, K+ 3.4,
Na+ 140
• ECG: sinus rhythm 90bpm
• Obs: temp 36.6, pulse 109, bp 147/78, RR 21, SaO2
95% on air
Severity of exacerbation
Moderate Severe Life threatening
Able to talk Cannot complete
sentences in one breath
Silent chest, feeble
respiratory effort,
cyanosis
RR <25 RR ≥25 Hypotension,
bradycardia, arrthymia,
exhaustion, agitation
Pulse <110 Pulse ≥110
SaO2 ≥ 92% SaO2 < 92% SaO2 < 92%
PEFR > 50% predicted PEFR 33-50% PEFR <33%
Based on BTS/SIGN guidelines
Severe exacerbation (PEFR 50%)
Examination and management
• On examination: no use of accessory muscles
• Expansion symmetrical
• Percussion resonant
• Reduced air entry throughout
• Inhaler technique assessed: good technique
• Started prednisolone 40mg for 5 days
Ideas/concerns/expectations
• Wishes asthma would go away – only ‘niggle’
in life at the moment
• Copes with it
• Would like further training – plans to reattend
asthma clinics
• Treatment: Discharged same day with home
nebs and asthma nurse follow-up
Pathophysiology of asthma
• Bronchial inflammation
• Eosinophilic infiltration
• Airway remodelling
• Bronchial hyperresponsiveness
• Airflow limitation
• Thick mucus production
Clinical features
• Cough
• Dyspnoea
• Wheeze – diffuse, polyphonic
• Diurnal variation
• Variable symptoms
• Many triggers
• Other atopic features
Investigations
• PEFR – diurnal variation
• Bloods – infective exacerbations
• Cultures
• CXR – often normal
• Spirometry – bronchodilator responsiveness
- methacholine/histamine challenge
- low FEV1/FVC
Treatment - acute
• Oxygen
• Salbutamol – b2 agonist
• Ipratropium – anticholinergic
• Steroids
• If severe consider IV aminophylline (caution in
pregnancy)/magnesium/ITU – need senior
advice
Treatment – chronic asthma
• Step 1 - Inhaled SABA
• Step 2 - Inhaled steroid 200-800 mcg/day
(start at 400 mcg)
• Step 3 – Inhaled LABA
• Step 4 – Increase steroid/add 4th drug
• Step 5 - Oral steroids
Which of these people have or had asthma?
Answers
• Answer: Bottom left and Top right: Antonio
Vivaldi and Bill Clinton
• Photos from www.wikipedia.org

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Asthma

  • 1. Asthma – Symptoms and Treatment
  • 2. Case History • 57 year old female • 1 day history of shortness of breath and chest tightness • Started at 5pm • No cough / coryzal symptoms • Called 999 at 9pm – unable to speak on phone
  • 3. Past medical history and drug history • Asthma since young child • Previous hospital admission aged 4/5 • No ITU admissions • Hayfever, slight eczema • Drugs: Salbutamol 2 puffs PRN inhaler • Beclometasone 2 puffs BD inhaler (non-concordant) • Stopped attending asthma clinics • Allergies: penicillin (rash)
  • 4. Social and family history • Lives with partner • Two dogs – don’t trigger asthma • Non-smoker
  • 5. On admission • Nebulisers in ambulance: salbutamol 5mg, ipratropium 500 micrograms • Peak flow 300 before nebs, 400 after nebs (best 600) • ABG on air: pO2 10.0, pCO2 4.4, lactate 3.5, base excess 1.9, H+ 37.4 • Bloods: Hb 13.9, WCC 12.6, Urea 6.2, Creat 94, K+ 3.4, Na+ 140 • ECG: sinus rhythm 90bpm • Obs: temp 36.6, pulse 109, bp 147/78, RR 21, SaO2 95% on air
  • 6. Severity of exacerbation Moderate Severe Life threatening Able to talk Cannot complete sentences in one breath Silent chest, feeble respiratory effort, cyanosis RR <25 RR ≥25 Hypotension, bradycardia, arrthymia, exhaustion, agitation Pulse <110 Pulse ≥110 SaO2 ≥ 92% SaO2 < 92% SaO2 < 92% PEFR > 50% predicted PEFR 33-50% PEFR <33% Based on BTS/SIGN guidelines Severe exacerbation (PEFR 50%)
  • 7. Examination and management • On examination: no use of accessory muscles • Expansion symmetrical • Percussion resonant • Reduced air entry throughout • Inhaler technique assessed: good technique • Started prednisolone 40mg for 5 days
  • 8. Ideas/concerns/expectations • Wishes asthma would go away – only ‘niggle’ in life at the moment • Copes with it • Would like further training – plans to reattend asthma clinics • Treatment: Discharged same day with home nebs and asthma nurse follow-up
  • 9. Pathophysiology of asthma • Bronchial inflammation • Eosinophilic infiltration • Airway remodelling • Bronchial hyperresponsiveness • Airflow limitation • Thick mucus production
  • 10. Clinical features • Cough • Dyspnoea • Wheeze – diffuse, polyphonic • Diurnal variation • Variable symptoms • Many triggers • Other atopic features
  • 11. Investigations • PEFR – diurnal variation • Bloods – infective exacerbations • Cultures • CXR – often normal • Spirometry – bronchodilator responsiveness - methacholine/histamine challenge - low FEV1/FVC
  • 12. Treatment - acute • Oxygen • Salbutamol – b2 agonist • Ipratropium – anticholinergic • Steroids • If severe consider IV aminophylline (caution in pregnancy)/magnesium/ITU – need senior advice
  • 13. Treatment – chronic asthma • Step 1 - Inhaled SABA • Step 2 - Inhaled steroid 200-800 mcg/day (start at 400 mcg) • Step 3 – Inhaled LABA • Step 4 – Increase steroid/add 4th drug • Step 5 - Oral steroids
  • 14. Which of these people have or had asthma?
  • 15. Answers • Answer: Bottom left and Top right: Antonio Vivaldi and Bill Clinton • Photos from www.wikipedia.org