Are Aging and Heart Failure Similar Syndromes of Sympathetic Dysregulation?

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Heart failure (HF) is a growing epidemic affecting over 4.8 million Americans, with 400,000 new cases diagnosed annually. The aging population is a major contributing factor, as both aging and HF are associated with sympathetic nervous system (SNS) dysregulation. However, most research on the mechanisms of SNS dysregulation in HF has used young rat models, without considering potential differences in aged HF rats. This study aims to test the hypothesis that aging and HF are not similar syndromes of SNS dysregulation, by measuring SNS responses to acute heat stress in young HF rats compared to aged HF and aged sham HF rats. Preliminary results suggest aged HF rats can be used in neurophysiological studies to better understand potential

Health & Medicine Technology

Are Aging and Heart Failure Similar Syndromes of Sympathetic Dysregulation? Anthony Garcia

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Prevalence of Heart Failure By Age and Gender (NHANES: 1999-2004). Source: NCHS and NHLBI.

The Aging Population: Persons 65 Years or Older (Actual and Estimated) US Census Bureau, Population Division, Interim State Population Projections. 2005.

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This document summarizes key points about the relationship between sleep and cardio-metabolic disease: - Sleep disturbances are linked to increased risk of cardiovascular diseases like hypertension, coronary heart disease, and stroke through physiological mechanisms like increased sympathetic nervous system activity and inflammation. - Common sleep disorders like sleep apnea and insomnia have been associated with adverse cardio-metabolic outcomes in numerous epidemiological studies and meta-analyses. - Beyond traditional sleep metrics like the apnea-hypopnea index, newer markers of sleep disruption and hypoxic burden may better predict cardiovascular risk. - There are opportunities to develop precision sleep medicine approaches to identify at-risk populations and new targets for intervention to improve population cardiovascular health.

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Neonatal encephalopathy is a clinical syndrome in newborns associated with hypoxic-ischemic injury to the brain near the time of birth. It is characterized by difficulties with maintaining respiration, hypotonia, altered consciousness, depressed reflexes, and sometimes seizures. Risk factors include complications of pregnancy, issues during labor and delivery, and problems with the placenta or umbilical cord. An evaluation includes the baby's history and exam findings as well as imaging studies, EEG, and laboratory tests to assess organ function and rule out other conditions. Management focuses on treatment of seizures and supportive care, with cooling therapy in moderate to severe cases aiming to reduce brain injury.

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1) Neuroimaging studies of schizophrenia have found reductions in gray matter volume in brain regions like the left superior temporal gyrus, hippocampus, and amygdala. 2) White matter abnormalities have also been found in fiber tracts like the corpus callosum, uncinate fasciculus, and inferior fronto-occipital fasciculus in patients with schizophrenia. 3) Studies of first-episode patients suggest these changes may occur within the first year of illness, especially in auditory processing regions of the superior temporal gyrus.

How chronic inflammation in rheumatoid arthritis affects brain pre

vinay tuteja

Rheumatoid arthritis is an inflammatory disease that can affect multiple systems beyond the joints. While joint involvement is most common, the disease may also impact the brain through several mechanisms. Chronic systemic inflammation from rheumatoid arthritis is associated with increased levels of pro-inflammatory cytokines that can impact cognition. Several studies have found evidence of cognitive impairment in 30-70% of rheumatoid arthritis patients involving domains like attention, memory and flexibility. Brain imaging of patients has shown signs of hypoperfusion and increased white matter lesions that correlate with cognitive dysfunction. Higher inflammation levels are also linked to changes in functional and structural brain networks that relate to increased fatigue, pain and cognitive problems in rheumatoid arthritis. Effectively treating the inflammatory components of the disease may

Ojchd.000549

crimsonpublishersOJCHD

This document discusses a study of 72 patients with bradycardia. Autonomic nervous system testing revealed autonomic dysfunction in most patients, with increased vagal tone being the most common finding present in 83.3% of patients. Several autonomic syndromes were also identified, with postural orthostatic tachycardia syndrome being present in 34.7% of patients. Treatment targeting the identified autonomic abnormalities improved symptoms in most patients. The study demonstrates that autonomic nervous system testing can help explain causes of bradycardia when clinical exams are otherwise normal.

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This document discusses the role of functional imaging like PET and SPECT in evaluating patients for epilepsy surgery. It provides information on: 1) When epilepsy surgery evaluation is performed for drug-resistant epilepsy cases. PET and SPECT can help identify the seizure focus when MRI and EEG findings are inconclusive. 2) PET typically shows hypometabolism in the seizure focus interictally and hypermetabolism ictally and postictally. Specific PET tracers can provide data on neurotransmitter systems that may be involved. 3) PET and SPECT findings like hypometabolism or hypoperfusion in the seizure focus can help lateralize and localize the epileptogenic zone to

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