Africa RISING conducted systems research at sites in Ghana, Ethiopia, Malawi, and Tanzania to identify options for sustainable intensification of crop and livestock production. The research evaluated interventions to improve productivity, nutrition, natural resource management, and household incomes. Farm types were defined in each country based on characteristics like household endowments. Integrated research approaches included crop-livestock trials, testing intercropping systems, and intensifying maize-groundnut-pigeon pea systems. Partnering with development organizations helped scale technologies to more households. Lessons indicated a need for more whole-systems and gender-sensitive research, cross-disciplinary linkages, and innovation platforms to enhance communications and impact.