Indian mackerel
The Indian mackerel belongs to the family scombridae and order perciformes .
It is commonly found in the Indian and west pacific oceans, and their surrounding seas.
Marine, pelagic –neritic, oceanodromous.
Depth range 20-90m.
It is an important food fish .
CAGE CULTURE OF FISH THEIR TREND,STATUS AND PRODUCTION Ashish sahu
Cage culture is an aquaculture production system where fish are held in Cage. Cage culture of fish utilizes existing water resources but encloses the fish in a cage which allows water to pass freely through the enclosures and the surrounding water body. Cages are used to culture several types of shell fish and finfish species in fresh, brackish and marine waters. Cages in freshwaters are used for food fish culture and for fry to fingerling rearing.
In 1950s modern cage culture began with the initiation of production of synthetic materials for cage construction. Fish production in cages became highly popular among the small or limited resource farmers who are looking for alternatives to traditional agricultural crops. The mesh size of the cage is kept smaller than the fish body. In India cage culture have been attempted first for Air breathing fish. Cage mesh netting made from synthetic material that can resist decomposition in water for a long period of time. Cage are used to culture several type of shell fish and fin fishes in fresh , brackish and marine water. Cage in fresh water are used for food fish culture and for fry to fingerling rearing. Cages are generally small, ranging in freshwater reservoirs from 1 square meter (m2) to 500 m2.
Definition –
Cage culture is a system in which the cultured Fish 0r animal are enclosed from all side allowing water to pass freely through the enclosures and the surrounding water body.
HISTORY-
Cage culture seem to have developed around 200 year ago in Cambodia where fisherman used to keep clarias spp. And some other fishes in bamboo made cage. Cage culture is traditional in part of Indonesia also attempted for the first time in air breathing fishes in swamp for raising major carp in running water in the river, Yamuna and Ganga at Allahabad and for raising Common carp , Catla , Silver carp, Rohu , Snakehead and Tilapia in still water body of Karnataka. In India sea cage start in 2007 for culture sea bass at Vishakhapatnam by CMFRI. anchored in streams which are practically open sewers. Common carp , where cage are in the southern USA. Around 80 species are being culture in cage. In India cage culture was initially culture in bamboo cage is practice in west java, since early 1940. Modern cage culture in open water bodies probably originated in Japan in early 1950. According to FAO cage culture is being practiced in more than 62 countries and has a become high tech business in developed countries such as floating and submerged cage culture of Salmonids in Norway, Canada and Scotland, Tuna and Yellowtails in Japan , Chinese carp in China, and catfish.
Indian mackerel
The Indian mackerel belongs to the family scombridae and order perciformes .
It is commonly found in the Indian and west pacific oceans, and their surrounding seas.
Marine, pelagic –neritic, oceanodromous.
Depth range 20-90m.
It is an important food fish .
CAGE CULTURE OF FISH THEIR TREND,STATUS AND PRODUCTION Ashish sahu
Cage culture is an aquaculture production system where fish are held in Cage. Cage culture of fish utilizes existing water resources but encloses the fish in a cage which allows water to pass freely through the enclosures and the surrounding water body. Cages are used to culture several types of shell fish and finfish species in fresh, brackish and marine waters. Cages in freshwaters are used for food fish culture and for fry to fingerling rearing.
In 1950s modern cage culture began with the initiation of production of synthetic materials for cage construction. Fish production in cages became highly popular among the small or limited resource farmers who are looking for alternatives to traditional agricultural crops. The mesh size of the cage is kept smaller than the fish body. In India cage culture have been attempted first for Air breathing fish. Cage mesh netting made from synthetic material that can resist decomposition in water for a long period of time. Cage are used to culture several type of shell fish and fin fishes in fresh , brackish and marine water. Cage in fresh water are used for food fish culture and for fry to fingerling rearing. Cages are generally small, ranging in freshwater reservoirs from 1 square meter (m2) to 500 m2.
Definition –
Cage culture is a system in which the cultured Fish 0r animal are enclosed from all side allowing water to pass freely through the enclosures and the surrounding water body.
HISTORY-
Cage culture seem to have developed around 200 year ago in Cambodia where fisherman used to keep clarias spp. And some other fishes in bamboo made cage. Cage culture is traditional in part of Indonesia also attempted for the first time in air breathing fishes in swamp for raising major carp in running water in the river, Yamuna and Ganga at Allahabad and for raising Common carp , Catla , Silver carp, Rohu , Snakehead and Tilapia in still water body of Karnataka. In India sea cage start in 2007 for culture sea bass at Vishakhapatnam by CMFRI. anchored in streams which are practically open sewers. Common carp , where cage are in the southern USA. Around 80 species are being culture in cage. In India cage culture was initially culture in bamboo cage is practice in west java, since early 1940. Modern cage culture in open water bodies probably originated in Japan in early 1950. According to FAO cage culture is being practiced in more than 62 countries and has a become high tech business in developed countries such as floating and submerged cage culture of Salmonids in Norway, Canada and Scotland, Tuna and Yellowtails in Japan , Chinese carp in China, and catfish.
Introduction of Fish and Fisheries of India.
• Freshwater Fish: Fish that spend most or all of their life in freshwaters, such as rivers and lakes, having a salinity of less than 0.5 ppt. Around 40% of all known species of
fish are found in freshwater.
They may be divided into Coldwater Fish (5-20 °C); examples: Mahseer, Trout, etc., and Warmwater Fish (25 35 °C); example: Carps, Catfish, Snakeheads, Featherbacks, etc.
• Brackishwater Fish: Fish that can tolerate a wide range of salinity (0.5 30.0 ppt)
and live in backwaters, estuaries and coastal waters.
Example: Mullet, Milkfish, Seabass, Pearlspot, Mudskipper, etc.
• Marine Fish: Fish that spend most or all of their life in seawater, such as Seas and
Oceans, having salinity above 30 ppt. There are about 240 species contributing to
the marine fisheries. Example: Sardines, Mackerel, Ribbonfish, Anchovies, Grouper, Cobia, Tuna, etc.
Trawl nets and bottom seines possess an initial selectiveness owing to their particular design and mode of operation. A mesh size limitation would vary considerably in effect from one type of trawl net to another. It is important therefore to consider gear selectivity and performance before we begin to think of mesh sizes and their effect.
Take a herring vinge trawl for example and two other bottom other trawls like the granton trawl and the shrimp trawl. All use otter boards, all are on the sea bed throughout the duration of the tow and all have the same basic structure of wings, square, bellies, bag and cod end. But their performances differ as much as those of a racing car, a truck and a tractor. All three nets could be fishing in the same area, yet the vinge trawl might take only herring, the granton trawl only demersal fish and the shrimp trawl primarily shrimp or prawn. Mesh size has little to do with this species selection. It is a function of other aspects of gear performance - speed of tow, headline height, ground contact, flow of water through the body of the net, otter door spread, length of ground-cables, and so on. The vinge trawl would have the smallest mesh in the cod end, yet it would take no cod, haddock or shrimp. The shrimp or prawn trawl would have a smaller mesh than the granton trawl yet it would capture only a small proportion of the bigger fish the granton trawl would take. To imagine that in these cases the size of mesh controls the size of fish caught would be as simplistic as to think that the respective speeds of the racing car, truck and tractor were determined by the size of their wheels.
In contrast to the trawls designed to capture one species or group of species, there are the multi-species trawls or combination trawls which take a great variety of fish. The North Sea prawn and fish trawl is a combination net designed to capture Nephrops norvegicus or Norway prawns, plus demersal fish like cod, haddock, skate, monks, plaice and lemon sole. Most bottom trawls in the tropics and sub-tropics are multi-species trawls taking fish which vary greatly from each other in size and shape. There is no common selectivity factor and no common minimum size or length for the various species. For these fisheries, a mesh regulation is at best an inadequate means of reducing juvenile mortality. It can be aimed only at the smallest of the main commercial species.
Shrimp farming in India, till 2009, was synonymous with the mono culture of tiger shrimp, Penaeus monodon. About 1,90,000 ha brackishwater area have been developed for shrimp culture in the country spread over all the coastal states. Since 1995 culture of P monodon is affected by White Spot Syndrome Virus (WSSV) and the development of shrimp farming has become stagnant.
Most of the Southeast Asian countries like Thailand, Vietnam, Indonesia were also culturing P. monodon and since 2001-02 onwards most of them have shifted to culture of exotic Whiteleg shrimp,Litopenaeus vannamei because of the availability of Specific Pathogen Free (SPF) and Specific Pathogen Resistant (SPR) broodstock. In India, Pilot-scale introduction of L.vannamei was initiated in 2003 and after a risk analysis study large-scale introduction has been permitted in 2009.
All the freshwater prawns that have been cultured so far belong to the genus Macrobrachium , Bate 1868, the largest genus of the family Palaemonidae. About 200 species have been described, almost all of which live in freshwater at least for part of their life.
The giant river prawn, Macrobrachium rosenbergii , was one of the first species to become scientifically known , the first recognizable illustration appearing in 1705. The nomenclature of freshwater prawns, both on a generic and a species level has had quite a muddled history. In the past, generic names have included Cancer (Astacus) and Palaemon. Previous names of M. rosenbergii have included Palaemon carcinus, P. dacqueti and P. rosenbergii ( De Man 1879) became universally accepted.
Reproduction is a fundamental biological process which enables continuation of species. In fisheries biology, reproduction assumes greater significance to understand sexual
dimorphism, process of maturation, size or age of maturity, breeding season, spawning area, sexual segregation, migration, fecundity, embryonic and larval development and
recruitment. Most of the management strategies in capture fisheries are based on reference points that are the manifestations of reproductive biology. In aquaculture,
knowledge of reproductive biology of a fish is essential for hatchery production of fish feeds.
,
Nazmul Haque Syekat
At what age does a fish attain a maturity
What is the perfect catchable or mark able size of the fish
It helps to calculate the life span and longevity of fish
It enables to estimate and compare growth rates of fish in different waters.
Good or bad growth can point out the suitability for rearing and stocking purposes
The timing of spawning migration of given species can be worked out .
Introduction of Fish and Fisheries of India.
• Freshwater Fish: Fish that spend most or all of their life in freshwaters, such as rivers and lakes, having a salinity of less than 0.5 ppt. Around 40% of all known species of
fish are found in freshwater.
They may be divided into Coldwater Fish (5-20 °C); examples: Mahseer, Trout, etc., and Warmwater Fish (25 35 °C); example: Carps, Catfish, Snakeheads, Featherbacks, etc.
• Brackishwater Fish: Fish that can tolerate a wide range of salinity (0.5 30.0 ppt)
and live in backwaters, estuaries and coastal waters.
Example: Mullet, Milkfish, Seabass, Pearlspot, Mudskipper, etc.
• Marine Fish: Fish that spend most or all of their life in seawater, such as Seas and
Oceans, having salinity above 30 ppt. There are about 240 species contributing to
the marine fisheries. Example: Sardines, Mackerel, Ribbonfish, Anchovies, Grouper, Cobia, Tuna, etc.
Trawl nets and bottom seines possess an initial selectiveness owing to their particular design and mode of operation. A mesh size limitation would vary considerably in effect from one type of trawl net to another. It is important therefore to consider gear selectivity and performance before we begin to think of mesh sizes and their effect.
Take a herring vinge trawl for example and two other bottom other trawls like the granton trawl and the shrimp trawl. All use otter boards, all are on the sea bed throughout the duration of the tow and all have the same basic structure of wings, square, bellies, bag and cod end. But their performances differ as much as those of a racing car, a truck and a tractor. All three nets could be fishing in the same area, yet the vinge trawl might take only herring, the granton trawl only demersal fish and the shrimp trawl primarily shrimp or prawn. Mesh size has little to do with this species selection. It is a function of other aspects of gear performance - speed of tow, headline height, ground contact, flow of water through the body of the net, otter door spread, length of ground-cables, and so on. The vinge trawl would have the smallest mesh in the cod end, yet it would take no cod, haddock or shrimp. The shrimp or prawn trawl would have a smaller mesh than the granton trawl yet it would capture only a small proportion of the bigger fish the granton trawl would take. To imagine that in these cases the size of mesh controls the size of fish caught would be as simplistic as to think that the respective speeds of the racing car, truck and tractor were determined by the size of their wheels.
In contrast to the trawls designed to capture one species or group of species, there are the multi-species trawls or combination trawls which take a great variety of fish. The North Sea prawn and fish trawl is a combination net designed to capture Nephrops norvegicus or Norway prawns, plus demersal fish like cod, haddock, skate, monks, plaice and lemon sole. Most bottom trawls in the tropics and sub-tropics are multi-species trawls taking fish which vary greatly from each other in size and shape. There is no common selectivity factor and no common minimum size or length for the various species. For these fisheries, a mesh regulation is at best an inadequate means of reducing juvenile mortality. It can be aimed only at the smallest of the main commercial species.
Shrimp farming in India, till 2009, was synonymous with the mono culture of tiger shrimp, Penaeus monodon. About 1,90,000 ha brackishwater area have been developed for shrimp culture in the country spread over all the coastal states. Since 1995 culture of P monodon is affected by White Spot Syndrome Virus (WSSV) and the development of shrimp farming has become stagnant.
Most of the Southeast Asian countries like Thailand, Vietnam, Indonesia were also culturing P. monodon and since 2001-02 onwards most of them have shifted to culture of exotic Whiteleg shrimp,Litopenaeus vannamei because of the availability of Specific Pathogen Free (SPF) and Specific Pathogen Resistant (SPR) broodstock. In India, Pilot-scale introduction of L.vannamei was initiated in 2003 and after a risk analysis study large-scale introduction has been permitted in 2009.
All the freshwater prawns that have been cultured so far belong to the genus Macrobrachium , Bate 1868, the largest genus of the family Palaemonidae. About 200 species have been described, almost all of which live in freshwater at least for part of their life.
The giant river prawn, Macrobrachium rosenbergii , was one of the first species to become scientifically known , the first recognizable illustration appearing in 1705. The nomenclature of freshwater prawns, both on a generic and a species level has had quite a muddled history. In the past, generic names have included Cancer (Astacus) and Palaemon. Previous names of M. rosenbergii have included Palaemon carcinus, P. dacqueti and P. rosenbergii ( De Man 1879) became universally accepted.
Reproduction is a fundamental biological process which enables continuation of species. In fisheries biology, reproduction assumes greater significance to understand sexual
dimorphism, process of maturation, size or age of maturity, breeding season, spawning area, sexual segregation, migration, fecundity, embryonic and larval development and
recruitment. Most of the management strategies in capture fisheries are based on reference points that are the manifestations of reproductive biology. In aquaculture,
knowledge of reproductive biology of a fish is essential for hatchery production of fish feeds.
,
Nazmul Haque Syekat
At what age does a fish attain a maturity
What is the perfect catchable or mark able size of the fish
It helps to calculate the life span and longevity of fish
It enables to estimate and compare growth rates of fish in different waters.
Good or bad growth can point out the suitability for rearing and stocking purposes
The timing of spawning migration of given species can be worked out .
Importance of Fish meal for a healthy lifeSreekkuttan89
The Kerala State Co-operative Federation for FisheriesDevelopment Ltd.(Matsyafed), was established on the 19th of March 1984. Registered as a Co-operative Apex Federation of primary level cooperative societies, this organization has never looked back and is still growing incessantly.
A short description about catla fish.presentation on catla fish.which scientific name is catla catla,cyprinus catla & gibelion catla.this fish is very important for aquaculture.the growth rate is high and culture system of this fish is very easy.This freshwater fish has a good market demand also.
The most important omega-3 fatty acids in seafood are eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). All seafood contains omega-3 fatty acids, but oily fish such as salmon, sardines, trout, Atlantic and Pacific mackerel, and herring are especially rich sources of EPA and DHA.
In this PPT/PDF we have research and created details report of best Fish & Seafood with Nutritional Benefits.
The Most Nutritious And Safest Fish
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5 Atlantic Pollock https://bradleysfish.com/product/pollock/
6 Spiny Lobster https://bradleysfish.com/product/lobster-550-650g-raw/
7 European Anchovy https://bradleysfish.com/product/anchovies-xlarge-1kg/
8 Atlantic Herring https://bradleysfish.com/product/herrings-whole/
9 Sockeye Salmon https://bradleysfish.com/product/sockeye-salmon-fillets-1kg-bag/
10 Pacific Wild Oysters https://bradleysfish.com/product/oyster/
11 Bluefish
12 Wild Rainbow Trout https://bradleysfish.com/product/trout/
13 Squid https://bradleysfish.com/product/squid-rings/
14 Mussels https://bradleysfish.com/product/whole-cooked-mussels/
15 Blue Crab https://bradleysfish.com/product/crab-raw-15kg-bulk/
16 Gray and Red Snapper https://bradleysfish.com/product/red-snapper-portions/
17 Wild Striped Bass https://bradleysfish.com/product/striped-bass-fillets-2-x-170-225geach/
18 Black Sea Bass https://bradleysfish.com/product/seabass-fillets-350-450gram/
19 Skipjack Tuna https://bradleysfish.com/product/tuna-loins-1kg/
20 Perch https://bradleysfish.com/product/nile-perch-fillets/
21 Dungeness Crab https://bradleysfish.com/product/crab-raw-15kg-bulk/
22 Wild Eastern Oysters https://bradleysfish.com/product/oyster/
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
2. Ray-finned fishes belonging to family
Salmonidae
Native to Atlantic and Pacific oceans
These are Anadromous
Species: to mention a few
• Salmo salar (a.k.a. Atlantic Salmon):
used worldwide for aquaculture
• Eleutheronema tetradactylum (a.k.a.
Rawas): Indian species of Salmon
3.
4. On an average the farmed Salmon can weigh
upto 4 kgs; although wild salmons up to 36 kgs.
have been reported.
Carotenoid pigment gives the mean orange – red
color
Can be sold in cans, or smoked, etc.
Not only does it look amazing and tastes
delicious, it is also healthy
5. salmon is considered to be healthy due to:
• fish's high protein
• high omega-3 fatty acids
• high vitamin D content
• cholesterol (23–214 mg/100g)
Although PCB, dioxin (contaminants)
contents are high in farmed salmon,
according to a 2006 study published in the
Journal of the American Medical
Association, the benefits of eating even
farmed salmon far outweigh any risks
imposed by contaminants.
6. It’s a $ 10 Billion industry worldwide
Hatcheries (Ranching): eggs are hatched in a
facility and then released in the wild once
they are old enough.
Aquaculturing:
1. Extensive (ponds): relatively natural with
low produce
2. Intensive (artificial facility): more produce
but needs stricter monitoring
7. Salmon feeds a lot: 2–4 kg of wild-caught fish are
needed to produce 1 kg of salmon
Parasites: sea lice, etc.
Heavy use of antibiotics
Contaminants: Heavy metal, PCB, dioxins, etc.
Not eco-friendly: impacts the local ecology, and
affects the wild population of salmon as well.
8. Applied fisher science, by S. M. Shafi
https://agriculture.indiabizclub.com/info/agricultur
e_types/fish_farming_/_aquaculture
https://en.wikipedia.org/wiki/Salmon#Species
https://en.wikipedia.org/wiki/Eleutheronema_tetra
dactylum