An educational PDF describing how to interpret Chest X-Ray. Common chest diseases radiographs are explained. An informative and useful material for every physician and medical student.
An educational PDF describing how to interpret Chest X-Ray. Common chest diseases radiographs are explained. An informative and useful material for every physician and medical student.
From Dr Ng Kian Seng:"Please send this out to all those coming, it is just a revision of the fundamentals. I dont intend to go through this at the workshop.
I will go straight to the Systematic Reading of the Chest Radiographs. It will take only 10 minutes to run through this powerpoint, so please run through it before coming."
From Dr Ng Kian Seng:"Please send this out to all those coming, it is just a revision of the fundamentals. I dont intend to go through this at the workshop.
I will go straight to the Systematic Reading of the Chest Radiographs. It will take only 10 minutes to run through this powerpoint, so please run through it before coming."
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
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micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
1. APPROACH TO CXR
DR MD MAMUNUZZAMAN
MBBS, MD ( CARDIOLOGY )
ASST. PROF. CARDIOLOGY
2.
3. Before interpreting CXR, assessment of x-ray is necessary , either its of diagnostic
quality or not.
a) Quality assessment of film-
Check label : Patients name, right/left, dextrocardia or not, either PA/AP view
Exposure quality : On a high quality radiograph, the vertebral bodies should just
be visible through the heart. If the vertebral bodies are not visible and resulting
‘whiter film’ are said to be ‘overcalling’ of pathology ( less photon passed /
inadequate exposure). If the film appears too ‘black’, then too many photons have
resulted in overexposure of the x-ray film. This ‘blackness’ results in pathology
being less conspicuous and may lead to ‘undercalling’.
4. • Most cxrs are taken in a PA position; that is, the patient stands in front of the
x-ray film cassette with their chest against the cassette and their back to the
radiographer. The x-ray beam passes through the patient from back to front (ie,
PA) onto the film. The heart and mediastinum are thus closest to the film and
therefore not magnified. When an x-ray is taken in an AP position, such as when
the patient is unwell in bed, the heart and mediastinum are distant from the
cassette and are therefore subject to x-ray magnification. As a result it is very
difficult to make an accurate assessment of the cardiomediastinal contour on an
AP film.
7. This patient is rotated to the left. Note
the spinous process is close to the
right clavicle and the left lung is
‘blacker’ than the right, due to the
rotation.
8. Adequacy of inspiratory effort :
Presence of visible six anterior ribs/ ten posterior
ribs indicates an adequate inspiratory effort.
Fewer than six anterior ribs indicates poor inspiratory
effort, whereas more than six anterior ribs indicate
hyper-expanded lungs.
IF A POOR INSPIRATORY EFFORT IS MADE OR IF THE CXR IS TAKEN
IN EXPIRATION,
Then several potentially spurious findings can result:
Apparent cardiomegaly, hilar abnormalities, mediastinal
contour abnormalities and the lung parenchyma tends to
appear of increased density, ie. ‘White lung’.
9. An example of poor inspiratory effort.
Shows : cardiomegaly, a mass at the
aortic arch and patchy opacification in
both lower zones.
Same patient following an adequate inspiratory
effort. The CXR now appears normal.
10. c) Review of important anatomy
- Heart and mediastinum
1. Assessment of heart size :
2. Assessment of cardiomediastinal contour
3. Assessment of hilar region
4. Assessment of trachea
5. Evaluation of mediastinal compartment
11. 1. Assessment of heart size :
The cardiothoracic ratio should be less than 0.5.
i.e. A/B <0.5.
A cardiothoracic ratio of greater than 0.5 (in a
good quality film) - suggests cardiomegaly.
12. 2. Assessment of cardiomediastinal
contour
• Right side: SVC , RA
• Anterior aspect: RV
• Cardiac apex: LV
• Left side: LV, left atrial appendage,
pulmonary trunk, aortic arch.
13. 3. Assessment of hilar region ( Above-
downward: bronchus, artery ,vein)
• Both hilar should be concave. This results from
the superior pulmonary vein crossing the lower
lobe pulmonary artery. The point of intersection
is known as the hilar point (HP).
• Both hilar should be of similar density.
• The left hilum is usually superior to the right by
up to 1
cm.
14.
15. 4. Assessment of trachea
• The trachea is placed usually just to the right of the
midline, but can be pathologically pushed or pulled to
either side, providing indirect support for an
underlying abnormality.
• The right wall of the trachea should be clearly seen as
the so-called right para-tracheal stripe.
• The para-tracheal stripe is visible by virtue of the
silhouette sign : air within the tracheal lumen and
adjacent right lung apex outline the soft tissue-
density tracheal wall.
• Loss or thickening of the para-tracheal stripe intimates
adjacent pathology.
• The trachea is shown in its normal position, just to the
right of centre.
16. 5. Evaluation of mediastinal compartment
• It is useful to consider the contents of
the mediastinum as belonging to three
compartments:
• Anterior mediastinum: Anterior to the
pericardium and trachea.
• Middle mediastinum: Between the
anterior and posterior mediastinum.
• Posterior mediastinum: Posterior to the
pericardial surface.
17.
18. LUNGS AND PLEURA
• LOBAR ANATOMY :
• Right lung : upper lobe, middle lobe
and lower lobe
• Left lung : Upper lobe; this contains
the lingula ( anatomically part of
upper lobe but functionally a separate
lobe ), and lower lobe
19. PLEURAL ANATOMY
There are two layers of pleura: the parietal pleura and
the visceral pleura. The parietal pleura lines the
thoracic cage and the visceral pleura surrounds the
lung. Both of these layers come together to form
reflections which separate the individual lobes. These
pleural reflections are known as fissures.
20. On the right there is an oblique
and horizontal fissure; the right
upper lobe sits above the
horizontal fissure (HF), the right
lower lobe behind the oblique
fissure (OF) and the middle lobe
between the two.
On the left, an oblique fissure
separates the upper and lower
lobes.
Left lateral view
Right lateral view
21. DIAPHRAGMS
ASSESSMENT OF THE DIAPHRAGMS :
Highest point of right diaphragm – 1 to 1.5 cm
higher than left diaphragm.
Both costophrenic angles should be clear and
sharply visible.
22.
23. The ‘curvature’ of both hemidiaphragms should be assessed to identify
diaphragmatic flattening. The highest point of a hemidiaphragm should be at
least 1.5 cm above a line drawn from the cardiophrenic to the costophrenic angle.
24. BONES AND SOFT TISSUES
ASSESSMENT OF BONES AND SOFT TISSUES
Look at every ribs ( from anterior to posterior
), the clavicles and the shoulder joints. Look
for soft tissue shadows ( eg,- mastectomy )
and try to scrutinizes structures in ‘hidden
area’.
25. After scrutinising the bones and soft tissues,
remember to look for
Pathology in the ‘hidden areas’.
- The lung apices
- Look ‘behind’ the heart
- Under the diaphragms
Hidden areas of CXR
26. A BRIEF LOOK AT THE LATERAL CXR
IMPORTANT ANATOMY RELATING TO THE LATERAL CXR
Key points
- There should be a decrease in density from
superior to inferior in the posterior
mediastinum.
- The retrosternal airspace should be of the
same density as the retrocardiac airspace.
29. The outline of the left hemidiaphragm stops at the posterior
heart border. Air in the gastric fundus is seen below the left
hemidiaphragm.
The right hemidiaphragm is usually ‘higher’ than the left.
The outline of the right can be seen extending from the
posterior to anterior chest wall.
30. UNDERSTANDING THE SILHOUETTE SIGN
The silhouette sign, first described by felson in 1950, is a means of detecting and localising
abnormalities within the chest.
In order for any object to appear radiographically distinct on a CXR, it must be of a different
radiographic density to that of an adjacent structure. Broadly speaking only four different
radiographic densities are detectable on a plain radiograph: air, fat, soft tissue and bone (i.e.
Calcium). If two soft tissue densities lie adjacent to each other, they will not be visible separately
(e.g. The left and right ventricles). If however two such densities are separated by air, the
boundaries of both will be seen.
31. The silhouette sign has two uses: it can localise abnormalities on a frontal CXR without the aid of a
lateral view. For example, if a mass lies adjacent to, and obliterates the outline of, the aortic arch,
then the mass lies posteriorly against the arch (which represents the posteriorly placed arch and
descending aorta). If the outline of the arch and of the mass are seen separately, then the mass lies
anteriorly. The loss of the outline of the hemidiaphragm, heart border or other structures suggests
that there is soft tissue shadowing adjacent to these, such as lung consolidation.