The document discusses various types of anemia including their causes, symptoms, diagnostic tests, and treatment. It covers iron deficiency anemia, thalassemia, sickle cell anemia, hereditary spherocytosis, megaloblastic anemia, and aplastic anemia. The key signs and findings for each type are outlined along with recommended treatment approaches.
Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
Dr. Sachin Verma is a young, diligent and dynamic physician. He did his graduation from IGMC Shimla and MD in Internal Medicine from GSVM Medical College Kanpur. Then he did his Fellowship in Intensive Care Medicine (FICM) from Apollo Hospital Delhi. He has done fellowship in infectious diseases by Infectious Disease Society of America (IDSA). He has also done FCCS course and is certified Advance Cardiac Life support (ACLS) and Basic Life Support (BLS) provider by American Heart Association. He has also done a course in Cardiology by American College of Cardiology and a course in Diabetology by International Diabetes Centre. He specializes in the management of Infections, Multiorgan Dysfunctions and Critically ill patients and has many publications and presentations in various national conferences under his belt. He is currently working in NABH Approved Ivy super-specialty Hospital Mohali as Consultant Intensivists and Physician.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
MANAGEMENT OF ATRIOVENTRICULAR CONDUCTION BLOCK.pdfJim Jacob Roy
Cardiac conduction defects can occur due to various causes.
Atrioventricular conduction blocks ( AV blocks ) are classified into 3 types.
This document describes the acute management of AV block.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
2. Anemia is present when the hemoglobin level is more two standard deviations below
the mean for child age and sex.
According to third NATIONAL FAMILY HEALTH SURVEY (NHFS3), 79% of Indian
children have anemia, including 71% of urban children and 84% of rural areas.
Anemia refers to reduction in oxygen carrying capacity of blood leading to tissue
hypoxia.
Decreased production and increased breakdown of RBC can lead to anemia
3.
4. • The 2 major categories are decreased production and increased destruction or
loss.
• Decreased RBC production may be a consequence of ineffective erythropoiesis or a
complete or relative failure of erythropoiesis
• Increased destruction or loss may be secondary to hemolysis, sequestration, or
bleeding.
• The peripheral blood reticulocyte percentage or absolute number will help to
make a distinction between the 2 physiologic categories.
5. • The normal reticulocyte percentage of total RBCs during most of childhood is
approximately 1%, with an absolute reticulocyte count of 25,000-75,000/mm3.
6. 1. SIZE
NORMOCYTE – NORMAL SIZE ( MCV = 75FL )
MICROCYTE. – SMALL SIZE ( MCV <75 FL )
MACROCYTE – LARGE CELLS ( MCV > 105 FL )
2. SHAPES
ANISOCYTOSIS – variation in size
POIKILOCYTOSIS – variation in shape
SPHEROCYTE – small round cells.
8. Pallor – in nail beds, oral mucous membrane and conjunctiva.
Fatigue & generalized muscular weakness
Anorexia, irritability & inadequate school performance
Dysnoea on excertion, palpitation , tachycardia
Nervous system symptoms include dizziness , headache,humming in
ears,tinnitus,lack of concentration.
9. . 1. AGE
. Neonate – neonatal blood loss, fetomaternal hemorrhage, haemolytic disorders.
CHILDHOOD 6m-2yr = nutritional anemia
After 4-6m beta thalassemia
Adolescent growth spurt,menstruating & pregnant teens
. 2. SEX
⚫ X linked diseases will be seen in male
⚫ include G6PD deficiency and PK deficiency
. 3. FAMILY HISTORY
⚫ all hemoglobinopathies and thalassemia syndromes are inherited in AUTOSOMAL
DOMINANT condition.
• Spherocytosis is inherited as autosomal dominant
10. 4. DIET HISTORY
⚫Iron deficiency develops when there is poor breast fooding and improper time
and quality of weaning food, both of which are exaggerated by bottle feeding
⚫Pica is both an effect and a cause of iron deficiency besides seen in lead pisoning
⚫ Megaloblastic anemia is due to folate deficiency is common in those villagers
who consume a lot of goat milk
5.DRUG HISTORY
.
11. -7. INFECTION AND INFESTATION HISTORY
⚫ G6PD deficiency induced hemolysis can be precipitated by many inf. And drugs to
treat such inf.
⚫ Hemolysis could also be induced by malaria.
⚫Bone marrow suppression can occur following many viral infections, kala Azar,
fulminant sepsis or drugs
⚫ Nutritional anemia can be precipitated by worms due to worms due to
malabsorption, nutrients deficiency and micro bleeding especially in hook worm
infestations.
12. Dysmorphic features – congenital hypoplastic anemia and chronic haemolytic
anemia
Jaundice. - hemolysis
Tongue( atrophy of papillae)
Purpura or bleeding – thrombocytopenia
Kilonychia – severe iron defeciency
Lymhadenopathy – leukaemia and lymphoma
Splenomegaly – hemolysis, leukaemia and lymphoma
13. CBC ( hb, hematocrit, MCV, MCH,MCHC,TLC, DLC,platelets )
Peripheral blood film (microcytic, normocytic, macrocytic)
Reticulocyte count – high (hemolysis), low (hypoplastic)
ESR ,CRP( CHRONIC DISEASE AND INFLAMMATION)
Serum ferritin, serum iron
Hemoglobin electrophoresis ( hemoglobinopathies )
Bone marrow examination ( leukemia )
14.
15. Decrease in total iron body content severe enough to diminish erythropoiesis.
Laboratory diagnosis:
Periheral smear: microcytic,hypochromic red cells with
anisocytosis,poikilocytosis ,increased RDW
MCV,MCHC reduced
Serum iron ,serum ferritin reduced,TIBC increased
16. TREATMENT
Oral iron 3-6 mg/kg/day,should be taken on empty stomach or in between meals.
Parenteral iron : indications-
1. Intolerance to oral iron
2. Malabsortive states
3. Ongoing blood loss
Total dose (mg)=(target Hb-actual Hb)x weight in kgx2.4+[15xweight(kg)]
17. Laboratory findings
Hb level ranges from 2-8g/dl
MCV & MCH significantly low
Reticulocyte count elevated to 5-8%
PS shows hypochromasia,microcytosis
Polychromatophilia, nucleated RBCs,basophilic stippling
HPLC shows absence of HbA & high levels of HbF,elevated HbA2
18. MANAGEMENT
Genetic counselling
Hematopoietic stem cell transplantation
Blood transfusion at an early age
Chelation therapy for accumulated iron overload.
Normal diet with following suplements- folic acid small doses of ascorbic acid (vit
C) & alpha –tocopherol(vit E).
19. Laboratory findings
Anemia & thrombocytosis are common
Leukocytosis
On PS sickle shaped cells,target cells found
Presence of Howell-Jolly bodies indicates functional asplenia.
Indirect bilirubin elevated due to hemolysis.
Hemoglobin electrophoresis.
20. Management
Hospital management:
Hydration & analgesia
Blood transfusion in aplastic &
sequestration crisis.
Oxygen supplementation in hypoxia
Intubation & mechanical ventilation
if CVA has occurred.
Preventive care:
Penicillin or Amoxicillin prophylaxis
until 5 yrs.
Pneumococcal,meningococcal &
hemophilus vaccines
Lifelong folate supplements
Hydroxyurea,10-15mg/kg /day
Genetic counseling
21.
22. Laboratory findings:
Anemia is normocytic normochromic
Increased reticulocyte count
Spherocytes & nucleated red cells in PS
Positive direct coombs test
Increased lactic dehydrogenase,indirect & total biliruin,aspartate
aminotranserase & urinary uroilinogen
23. MANAGEMENT
Supportive care
Prednisolone 1mg/kg for 4 weeks,tapered over 4-6 months.
In severe cases immunosuppressive agents like corticosteroids, aathioprine
,cyclosporines are used.
Intravenous immunoglobulins ,splenectomy or hematopoetic stem cell
transplantation can be done in refractory cases.
24.
25. Laboratory findings
CBC shows macrocytosis and cytopenias,hypersegmented neutrophils.
Reticulocyte count
Serum b12 and folate level
Bone marrow cellular & show RBC precursor nuclear-cytoplasmic asynchrony.
Serum chemistry :elevated LDH & bilirubin.
26. TREATMENT
Folate supplementation,1-5mg/day for 3-4 weeks.
Parenteral vit B12 1mg IM
In patients with pernicious anemia & malabsorptive states vit B12 1mg IM daily
for 2 weeks then weekly until the hemocrit value & monthly for life.
Dietary counselling
27. Hematopoietic stem cells are damaged by various mechanisms:
1. Acquired stem cell injury from viruses ,toxins or chemicals
2. Abnormal cellular control of hematopoiesis
3. Abnormal marrow environment
4. Immunologic suppression of hematopoiesis
5. Mutation in genes resulting in inherited bone marrow failure
28. Laboratory findings
Pancytopenia
PS shows macrocytic anemia
,thrombocytopenia & agranulocytosis
Corrected reticulocyte count <1%
indicates reduced RBC production.
Bone marrow aspirate & biopsy
shows reduced cellularity.
Management
Supportive care: packed red cells for
anemia,platelets for
thrombocytopenia & antibiotics for
infection
HSCT is the only curative therapy.