Apoptosis is a form of programmed cell death that removes unwanted or damaged cells from multicellular organisms. It involves the activation of caspase proteins that trigger an orderly breakdown of the cell's contents. Apoptosis is important for development, tissue homeostasis, and defense against infection and cancer by eliminating infected, damaged, or unnecessary cells.
Apoptosis is a
-pathway of cell death that is
-induced by an internally regulated program
-in which cells destined to die activate intrinsic enzymes that --degrade the cells’ own nuclear DNA and also nuclear and cytoplasmic proteins
-With minimal host reaction.
Characterization and the Kinetics of drying at the drying oven and with micro...Open Access Research Paper
The objective of this work is to contribute to valorization de Nephelium lappaceum by the characterization of kinetics of drying of seeds of Nephelium lappaceum. The seeds were dehydrated until a constant mass respectively in a drying oven and a microwawe oven. The temperatures and the powers of drying are respectively: 50, 60 and 70°C and 140, 280 and 420 W. The results show that the curves of drying of seeds of Nephelium lappaceum do not present a phase of constant kinetics. The coefficients of diffusion vary between 2.09.10-8 to 2.98. 10-8m-2/s in the interval of 50°C at 70°C and between 4.83×10-07 at 9.04×10-07 m-8/s for the powers going of 140 W with 420 W the relation between Arrhenius and a value of energy of activation of 16.49 kJ. mol-1 expressed the effect of the temperature on effective diffusivity.
Apoptosis is a
-pathway of cell death that is
-induced by an internally regulated program
-in which cells destined to die activate intrinsic enzymes that --degrade the cells’ own nuclear DNA and also nuclear and cytoplasmic proteins
-With minimal host reaction.
Characterization and the Kinetics of drying at the drying oven and with micro...Open Access Research Paper
The objective of this work is to contribute to valorization de Nephelium lappaceum by the characterization of kinetics of drying of seeds of Nephelium lappaceum. The seeds were dehydrated until a constant mass respectively in a drying oven and a microwawe oven. The temperatures and the powers of drying are respectively: 50, 60 and 70°C and 140, 280 and 420 W. The results show that the curves of drying of seeds of Nephelium lappaceum do not present a phase of constant kinetics. The coefficients of diffusion vary between 2.09.10-8 to 2.98. 10-8m-2/s in the interval of 50°C at 70°C and between 4.83×10-07 at 9.04×10-07 m-8/s for the powers going of 140 W with 420 W the relation between Arrhenius and a value of energy of activation of 16.49 kJ. mol-1 expressed the effect of the temperature on effective diffusivity.
Epcon is One of the World's leading Manufacturing Companies.EpconLP
Epcon is One of the World's leading Manufacturing Companies. With over 4000 installations worldwide, EPCON has been pioneering new techniques since 1977 that have become industry standards now. Founded in 1977, Epcon has grown from a one-man operation to a global leader in developing and manufacturing innovative air pollution control technology and industrial heating equipment.
Top 8 Strategies for Effective Sustainable Waste Management.pdfJhon Wick
Discover top strategies for effective sustainable waste management, including product removal and product destruction. Learn how to reduce, reuse, recycle, compost, implement waste segregation, and explore innovative technologies for a greener future.
Altered Terrain: Colonial Encroachment and Environmental Changes in Cachar, A...PriyankaKilaniya
The beginning of colonial policy in the area was signaled by the British annexation of the Cachar district in southern Assam in 1832. The region became an alluring investment opportunity for Europeans after British rule over Cachar, especially after the accidental discovery of wild tea in 1855. Within this historical context, this study explores three major stages that characterize the evolution of nature. First, it examines the distribution and growth of tea plantations, examining their size and rate of expansion. The second aspect of the study examines the consequences of land concessions, which led to the initial loss of native forests. Finally, the study investigates the increased strain on forests caused by migrant workers' demands. It also highlights the crucial role that the Forest Department plays in protecting these natural habitats from the invasion of tea planters. This study aims to analyze the intricate relationship between colonialism and the altered landscape of Cachar, Assam, by means of a thorough investigation, shedding light on the environmental, economic, and societal aspects of this historical transformation.
Artificial Reefs by Kuddle Life Foundation - May 2024punit537210
Situated in Pondicherry, India, Kuddle Life Foundation is a charitable, non-profit and non-governmental organization (NGO) dedicated to improving the living standards of coastal communities and simultaneously placing a strong emphasis on the protection of marine ecosystems.
One of the key areas we work in is Artificial Reefs. This presentation captures our journey so far and our learnings. We hope you get as excited about marine conservation and artificial reefs as we are.
Please visit our website: https://kuddlelife.org
Our Instagram channel:
@kuddlelifefoundation
Our Linkedin Page:
https://www.linkedin.com/company/kuddlelifefoundation/
and write to us if you have any questions:
info@kuddlelife.org
Willie Nelson Net Worth: A Journey Through Music, Movies, and Business Venturesgreendigital
Willie Nelson is a name that resonates within the world of music and entertainment. Known for his unique voice, and masterful guitar skills. and an extraordinary career spanning several decades. Nelson has become a legend in the country music scene. But, his influence extends far beyond the realm of music. with ventures in acting, writing, activism, and business. This comprehensive article delves into Willie Nelson net worth. exploring the various facets of his career that have contributed to his large fortune.
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Introduction
Willie Nelson net worth is a testament to his enduring influence and success in many fields. Born on April 29, 1933, in Abbott, Texas. Nelson's journey from a humble beginning to becoming one of the most iconic figures in American music is nothing short of inspirational. His net worth, which estimated to be around $25 million as of 2024. reflects a career that is as diverse as it is prolific.
Early Life and Musical Beginnings
Humble Origins
Willie Hugh Nelson was born during the Great Depression. a time of significant economic hardship in the United States. Raised by his grandparents. Nelson found solace and inspiration in music from an early age. His grandmother taught him to play the guitar. setting the stage for what would become an illustrious career.
First Steps in Music
Nelson's initial foray into the music industry was fraught with challenges. He moved to Nashville, Tennessee, to pursue his dreams, but success did not come . Working as a songwriter, Nelson penned hits for other artists. which helped him gain a foothold in the competitive music scene. His songwriting skills contributed to his early earnings. laying the foundation for his net worth.
Rise to Stardom
Breakthrough Albums
The 1970s marked a turning point in Willie Nelson's career. His albums "Shotgun Willie" (1973), "Red Headed Stranger" (1975). and "Stardust" (1978) received critical acclaim and commercial success. These albums not only solidified his position in the country music genre. but also introduced his music to a broader audience. The success of these albums played a crucial role in boosting Willie Nelson net worth.
Iconic Songs
Willie Nelson net worth is also attributed to his extensive catalog of hit songs. Tracks like "Blue Eyes Crying in the Rain," "On the Road Again," and "Always on My Mind" have become timeless classics. These songs have not only earned Nelson large royalties but have also ensured his continued relevance in the music industry.
Acting and Film Career
Hollywood Ventures
In addition to his music career, Willie Nelson has also made a mark in Hollywood. His distinctive personality and on-screen presence have landed him roles in several films and television shows. Notable appearances include roles in "The Electric Horseman" (1979), "Honeysuckle Rose" (1980), and "Barbarosa" (1982). These acting gigs have added a significant amount to Willie Nelson net worth.
Television Appearances
Nelson's char
WRI’s brand new “Food Service Playbook for Promoting Sustainable Food Choices” gives food service operators the very latest strategies for creating dining environments that empower consumers to choose sustainable, plant-rich dishes. This research builds off our first guide for food service, now with industry experience and insights from nearly 350 academic trials.
2. Apoptosis
• Apoptosis is a form of programmed cell death, or
“cellular suicide.” It is different from necrosis, in
which cells die due to injury.
• Apoptosis is an orderly process in which the cell’s
contents are packaged into small packets of
membrane for “garbage collection” by immune cells.
• Apoptosis removes cells during development,
eliminates potentially cancerous and virus-infected
cells, and maintains balance in the body.
3. Why do multicellular organisms need to
regulate the death of their cells?
To allow body structures to grow and develop correctly.
To remove body structures that are no longer required.
To regulate the sizes of cell populations in adult bodies cell proliferation
must be balanced with cell death.
This allows organisms to precisely control the sizes of their tissues and
organs.
To prevent cells from surviving in environments where they should not be
present.
To kill cells that have been infected by pathogens.
To prevent the survival of cells with damaged DNA (these have the
potential to become cancerous).
To eliminate white blood cells that would produce an immune response to
the body’s own cells.
9. Why do multicellular organisms need to
regulate the death of their cells?
• To kill cells that have been infected by
pathogens.
• To prevent the survival of cells with damaged
DNA (these have the potential to become
cancerous).
• To eliminate white blood cells that would
produce an immune response to the body’s own
cells.
10.
11. Apoptosis compared to necrosis: What
happens to the cell when it dies?
Feature Apoptosis Necrosis
Regulated by organism Yes: involves a series of
enzyme-controlled reactions
No: can occur as a result
of injury
DNA broken down Yes Only after cell has lysed
Cell membrane
disintegration
No Yes
Nuclear membrane
broken down
Yes No
Number of cells affected May be single cells Usually sheets of cells
Energy requirement ATP dependent (active
process)
Energy input not required
(passive process)
Fate of dead cells Ingested by neighbouring cells
or phagocytes
Ingested by phagocytes
Leakage of cell contents No Yes
End point Cell fragments into smaller
bodies
Lysis of whole cell
12. The mechanism of apoptosis
1. Activation of procaspase proteins
Active
caspase B
Active
caspase A
Inactive
procaspase
Prodomain
13. The mechanism of apoptosis
2. Caspase activation cascade
Active
caspase A
Active caspase B
Active caspase C
14. The mechanism of apoptosis
3. Caspases are proteinases: they cleave key cell
proteins
Inactive
DNAse
Active
DNAse
Nuclear
lamins
Fragmented
nuclear lamins
Gelsolin Actin-digesting enzyme
Caspase activity
15. The mechanism of apoptosis
4. Caspase activity results in the controlled destruction
of the cell
Active DNAse
Breakdown of
nuclear DNA
Fragmented nuclear
lamins
Disassembly
of nucleus
Actin-digesting enzyme Disassembly of
cytoskeleton
16. Initiation of apoptosis: the death signal
• Adaptor proteins cause initiator procaspases to
cluster together.
• Clustering induces a conformational change that
activates the procaspases.
Caspase activation Caspase
cascade
17. Intracellular death signals
• Mitochondrion-mediated pathway
1. Damaged mitochondrion
3. Caspase
cascade
2. Cytochrome C
protein released
20. Extracellular death signals: survival
factors
• Animal cells undergo apoptosis if they are deprived of
survival factors released by other cells.
• This ensures that cells only survive in locations where
they are needed, when they are needed.
• The default program for most cells is suicide!
21. Extracellular death signals: inhibitory
signal proteins
- Some signal proteins oppose the effects of
growth factors and survival factors. They can
inhibit the growth of organs by stimulating
apoptosis.
- For example, mouse limb formation (see earlier
images D, E, F and G).
22. Extracellular death signals
• Body cells infected with certain pathogens,
eg some viruses, present fragments of
antigenic proteins on surface receptor
proteins on their cell membranes.
23.
24. Extracellular death signals
• Activated killer T lymphocytes can
recognise body cells displaying antigens.
The lymphocytes bind surface receptor
proteins on the target cell and trigger
apoptosis.
30. What could be the consequence of
impaired apoptosis to:
(a) the affected cell?
(b) the organism containing the
affected cell?
31. Cancer
• The development of some forms of leukemia is
promoted by the loss of control of apoptosis.
• Mutations to the DNA of B lymphocytes can
cause them to produce abnormally large
quantities of a protein that inhibits apoptosis.
• p53 is a cancer-critical gene.
32. 3. Inhibition of
procaspase
activation
4. Cell develops
resistance to
apoptosis
5. Survival of B
lymphocytes that would
normally have died
1. Chromosome
translocation
2. Over-expression
of a regulatory
protein
Editor's Notes
http://jmg.bmj.com/content/41/1/60.full.
Development of mouse limb depends on apoptosis. D–G indicate sequential passage of time.
http://upload.wikimedia.org/wikipedia/commons/a/ae/Metamorphosis_frog_Meyers.png
a: tadpole; b: tadpole with hind limbs developing; c: tadpole with four limbs and tail; d: froglet with tail reabsorbed into body; e: froglet
Liver removed during autosopy with tumours present.
File:Secondary_tumor_deposits_in_the_liver_from_a_primary_cancer_of_the_pancreas
Wikicommons
Cytotoxic (killer) T cell on left. Cell infected with virus on right.
http://media-1.web.britannica.com/eb-media/35/21135-004-6CF60E1F.jpg
Procaspases are examples of proenzymes.
Spot the paradox (how is caspase A activated?).
Amplification of response. Still a paradox (what activates caspase A?).
Students predict the effects of caspase activity on the cell.
Next question: what activates the adaptor proteins?
http://upload.wikimedia.org/wikipedia/commons/b/bb/P53.png
p53 protein is a gene regulatory protein.
Genes code for proteins that belong to the Bcl-2 family (role = regulation of procaspases). The proteins produced as a result of p53 activity promote the release of cytochrome c from mitochondria.
Proteasome = large proteolytic enzyme complex in cytosol. Responsible for degrading proteins that have been labelled for destruction.
http://ars.sciencedirect.com/content/image/1-s2.0-S1286457904002369-fx1.jpg