The Catholic Church responded to the Protestant Reformation through reforms initiated by Pope Paul III from 1534-1549. He appointed reform-minded clergy and established organizations like the Roman Inquisition to investigate heresy and enforce doctrine. The Council of Trent from 1545-1563 upheld traditional Catholic teachings while implementing reforms for clergy like requiring residence in their dioceses and suppressing pluralism. New religious orders like the Jesuits were founded and used education to spread Catholic messages and restore Catholicism throughout Europe and the world.