Using healthcare data - context & considerations for collecting, cleansing, analyzing, and displaying geospatial and temporal data, with a focus on Propeller Health's program in Louisville, KY.
Discovery of Drug and Introduction to Clinical Trial_Katalyst HLSKatalyst HLS
Introduction to Discovery of Drug and Introduction to Clinical Trials in Pharmaceuticals, Bio-Pharmaceuticals, Medical Devices, Cosmeceuticals and Foods.
Farmakokinetik klinik digoksin, pengaruh kondisi dan keadaan penyakit gagal ginjal, hati, gagal jantung dan obesitas pada parameter farmakokinetik dan pengaturan dosis digoksin
Discovery of Drug and Introduction to Clinical Trial_Katalyst HLSKatalyst HLS
Introduction to Discovery of Drug and Introduction to Clinical Trials in Pharmaceuticals, Bio-Pharmaceuticals, Medical Devices, Cosmeceuticals and Foods.
Farmakokinetik klinik digoksin, pengaruh kondisi dan keadaan penyakit gagal ginjal, hati, gagal jantung dan obesitas pada parameter farmakokinetik dan pengaturan dosis digoksin
Public Device & Biopharma Ophthalmology Company Showcase - pSividaHealthegy
Public Device & Biopharma Ophthalmology Company Showcase - pSivida at OIS@AAO 2016.
Presenter:
Nancy Lurker, President & CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Product Development Ecosystems: Defining Your Value in the Digital AgeDesign World
Medical device developers look to solve problems in healthcare with a product or service. But for some, that’s where they stop short. It is critical that medtech developers move beyond a single solution into thinking holistically about the care environment, the various motivations of users and stakeholders, and the opportunities to connect to a larger view of healthcare. Understanding the ecosystem opportunity opens the path to successful product development in the digital age. Designers need to understand how their piece of the jigsaw puzzle fits to ensure the products offering is effective and successful.
This webinar features a real-world expertise from Gecko Healthcare and the design firm that partnered in the commercialization of Gecko’s CareTRx.
Watch the webinar: http://www.medicaldesignandoutsourcing.com/product-development-ecosystems-defining-value-digital-age/
18 Interesting Health Technology StartupsGary Monk
An overview of 18 interesting health technology startups. Some are more successful than others, some are in a relatively crowded space. Slides contain an overview and insights into these emerging healthtech companies
SensorThings API Webinar - #1 of 4 - IntroductionSensorUp
OGC SensorThings API Get Started Series #1 of 4. (Nov 26 2015)
Video here: http://youtube.com/watch?v=4RgE01Xvps0
#2: OGC SensorThings Data Model and Common Control Information (Dec 3rd 2015)
#3: Connect and Manage Your Sensors with OGC SensorThings API (Dec 10th 2015)
#4: Query and Analytics with SensorThings API (Dec 17th 2015)
Cohero health - Gamification in healthcare - Manu Melwin Joymanumelwin
The consequences of forgetting to take one’s medication can be particularly dire for young asthma patients. But thanks to Cohero Health, there is now an app called Asthma Hero to help young patients stay on schedule.
How to Use Data to Improve Patient Safety: A Two-Part DiscussionHealth Catalyst
As healthcare organizations continue to experience expenses growing faster than revenues, value based care, and consumer transparency of costs and quality, patient safety will be an important determinant of success. This session will describe the sociotechnical attributes of a safe system, the challenges, the barriers and opportunities, and how to use data and your culture of safety as a powerful tool to drive down adverse events.
Attendees will learn:
Why patient safety and quality are important.
How data can help improve patient safety.
The history of patient safety and where we are today.
What components make up a safety analytics culture.
How the internal safety culture directly impacts patient safety metrics.
To describe basic guidelines for improving a safety culture with analytics.
Working the Science and Regulations Harder to Win Your Drug and Device CasesSara Dunlap
This webinar will teach critical scientific principles related to the regulatory framework as they pertain to drug and medical device litigation for seasoned in house and outside counsel alike. Examples of topics that will be covered include safety signaling and pharmacovigilance, epidemiological and randomized controlled trial study design, risk management principles, causality assessment, and the strategic role of regulatory guidelines and compliance.
Public Device & Biopharma Ophthalmology Company Showcase - pSividaHealthegy
Public Device & Biopharma Ophthalmology Company Showcase - pSivida at OIS@AAO 2016.
Presenter:
Nancy Lurker, President & CEO
Powered by:
Healthegy
For more ophthalmology innovation
Visit us at www.ois.net
Product Development Ecosystems: Defining Your Value in the Digital AgeDesign World
Medical device developers look to solve problems in healthcare with a product or service. But for some, that’s where they stop short. It is critical that medtech developers move beyond a single solution into thinking holistically about the care environment, the various motivations of users and stakeholders, and the opportunities to connect to a larger view of healthcare. Understanding the ecosystem opportunity opens the path to successful product development in the digital age. Designers need to understand how their piece of the jigsaw puzzle fits to ensure the products offering is effective and successful.
This webinar features a real-world expertise from Gecko Healthcare and the design firm that partnered in the commercialization of Gecko’s CareTRx.
Watch the webinar: http://www.medicaldesignandoutsourcing.com/product-development-ecosystems-defining-value-digital-age/
18 Interesting Health Technology StartupsGary Monk
An overview of 18 interesting health technology startups. Some are more successful than others, some are in a relatively crowded space. Slides contain an overview and insights into these emerging healthtech companies
SensorThings API Webinar - #1 of 4 - IntroductionSensorUp
OGC SensorThings API Get Started Series #1 of 4. (Nov 26 2015)
Video here: http://youtube.com/watch?v=4RgE01Xvps0
#2: OGC SensorThings Data Model and Common Control Information (Dec 3rd 2015)
#3: Connect and Manage Your Sensors with OGC SensorThings API (Dec 10th 2015)
#4: Query and Analytics with SensorThings API (Dec 17th 2015)
Cohero health - Gamification in healthcare - Manu Melwin Joymanumelwin
The consequences of forgetting to take one’s medication can be particularly dire for young asthma patients. But thanks to Cohero Health, there is now an app called Asthma Hero to help young patients stay on schedule.
How to Use Data to Improve Patient Safety: A Two-Part DiscussionHealth Catalyst
As healthcare organizations continue to experience expenses growing faster than revenues, value based care, and consumer transparency of costs and quality, patient safety will be an important determinant of success. This session will describe the sociotechnical attributes of a safe system, the challenges, the barriers and opportunities, and how to use data and your culture of safety as a powerful tool to drive down adverse events.
Attendees will learn:
Why patient safety and quality are important.
How data can help improve patient safety.
The history of patient safety and where we are today.
What components make up a safety analytics culture.
How the internal safety culture directly impacts patient safety metrics.
To describe basic guidelines for improving a safety culture with analytics.
Working the Science and Regulations Harder to Win Your Drug and Device CasesSara Dunlap
This webinar will teach critical scientific principles related to the regulatory framework as they pertain to drug and medical device litigation for seasoned in house and outside counsel alike. Examples of topics that will be covered include safety signaling and pharmacovigilance, epidemiological and randomized controlled trial study design, risk management principles, causality assessment, and the strategic role of regulatory guidelines and compliance.
Wide adoption of smartphones and availability of low-cost sensors has resulted in seamless and continuous monitoring of physiology, environment, and public health notifications. However, personalized digital health and patient empowerment can become a reality only if the complex multisensory and multimodal data is processed within the patient context. Contextual processing of patient data along with personalized medical knowledge can lead to actionable information for better and timely decisions. We present a system called kHealth capable of aggregating multisensory and multimodal data from sensors (passive sensing) and answers to questionnaire (active sensing) from patients with asthma. We present our preliminary data analysis comprising data collected from real patients highlighting the challenges in deploying such an application. The results show strong promise to derive actionable information using a combination of physiological indicators from active and passive sensors that can help doctors determine more precisely the cause, severity, and control level of asthma. Information synthesized from kHealth can be used to alert patients and caregivers for seeking timely clinical assistance to better manage asthma and improve their quality of life.
Paper: http://www.knoesis.org/library/resource.php?id=2153
Citation:
Pramod Anantharam, Tanvi Banerjee, Amit Sheth, Krishnaprasad Thirunarayan, Surendra Marupudi, Vaikunth Sridharan, Shalini G. Forbis, Knowledge-driven Personalized Contextual mHealth Service for Asthma Management in Children , IEEE 4th International Conference on Mobile Services, June 27 - July 2, 2015, New York, USA.
Cognitive Computing: Company presentation by Avner Halperin, Co-Founder & CEO of EarlySense at the NOAH Conference 2019 in Tel Aviv, Hangar 11, 10-11 April 2019.
Mobile Health at Ochsner: The Apple HealthKit and Epic EMR IntegrationRahlyn Gossen
These slides are from the April 2, 2015 meeting of Health 2.0 New Orleans with special guest Jonathan Wilt, the Assistant Vice President of the Center for Innovation at Ochsner Health System. Jonathan spoke about Ochsner's Health System's integration of Apple HealthKit with the Epic EMR.
Audio is here: http://www.youtube.com/watch?v=UsSKui7m4VY
Empowering ACOs: Leveraging Quality Management Tools for MIPS and BeyondHealth Catalyst
Join us as we delve into the crucial realm of quality reporting for MSSP (Medicare Shared Savings Program) Accountable Care Organizations (ACOs).
In this session, we will explore how a robust quality management solution can empower your organization to meet regulatory requirements and improve processes for MIPS reporting and internal quality programs. Learn how our MeasureAble application enables compliance and fosters continuous improvement.
Global launch of the Healthy Ageing and Prevention Index 2nd wave – alongside...ILC- UK
The Healthy Ageing and Prevention Index is an online tool created by ILC that ranks countries on six metrics including, life span, health span, work span, income, environmental performance, and happiness. The Index helps us understand how well countries have adapted to longevity and inform decision makers on what must be done to maximise the economic benefits that comes with living well for longer.
Alongside the 77th World Health Assembly in Geneva on 28 May 2024, we launched the second version of our Index, allowing us to track progress and give new insights into what needs to be done to keep populations healthier for longer.
The speakers included:
Professor Orazio Schillaci, Minister of Health, Italy
Dr Hans Groth, Chairman of the Board, World Demographic & Ageing Forum
Professor Ilona Kickbusch, Founder and Chair, Global Health Centre, Geneva Graduate Institute and co-chair, World Health Summit Council
Dr Natasha Azzopardi Muscat, Director, Country Health Policies and Systems Division, World Health Organisation EURO
Dr Marta Lomazzi, Executive Manager, World Federation of Public Health Associations
Dr Shyam Bishen, Head, Centre for Health and Healthcare and Member of the Executive Committee, World Economic Forum
Dr Karin Tegmark Wisell, Director General, Public Health Agency of Sweden
R3 Stem Cells and Kidney Repair A New Horizon in Nephrology.pptxR3 Stem Cell
R3 Stem Cells and Kidney Repair: A New Horizon in Nephrology" explores groundbreaking advancements in the use of R3 stem cells for kidney disease treatment. This insightful piece delves into the potential of these cells to regenerate damaged kidney tissue, offering new hope for patients and reshaping the future of nephrology.
Navigating Challenges: Mental Health, Legislation, and the Prison System in B...Guillermo Rivera
This conference will delve into the intricate intersections between mental health, legal frameworks, and the prison system in Bolivia. It aims to provide a comprehensive overview of the current challenges faced by mental health professionals working within the legislative and correctional landscapes. Topics of discussion will include the prevalence and impact of mental health issues among the incarcerated population, the effectiveness of existing mental health policies and legislation, and potential reforms to enhance the mental health support system within prisons.
CHAPTER 1 SEMESTER V PREVENTIVE-PEDIATRICS.pdfSachin Sharma
This content provides an overview of preventive pediatrics. It defines preventive pediatrics as preventing disease and promoting children's physical, mental, and social well-being to achieve positive health. It discusses antenatal, postnatal, and social preventive pediatrics. It also covers various child health programs like immunization, breastfeeding, ICDS, and the roles of organizations like WHO, UNICEF, and nurses in preventive pediatrics.
Deep Leg Vein Thrombosis (DVT): Meaning, Causes, Symptoms, Treatment, and Mor...The Lifesciences Magazine
Deep Leg Vein Thrombosis occurs when a blood clot forms in one or more of the deep veins in the legs. These clots can impede blood flow, leading to severe complications.
CRISPR-Cas9, a revolutionary gene-editing tool, holds immense potential to reshape medicine, agriculture, and our understanding of life. But like any powerful tool, it comes with ethical considerations.
Unveiling CRISPR: This naturally occurring bacterial defense system (crRNA & Cas9 protein) fights viruses. Scientists repurposed it for precise gene editing (correction, deletion, insertion) by targeting specific DNA sequences.
The Promise: CRISPR offers exciting possibilities:
Gene Therapy: Correcting genetic diseases like cystic fibrosis.
Agriculture: Engineering crops resistant to pests and harsh environments.
Research: Studying gene function to unlock new knowledge.
The Peril: Ethical concerns demand attention:
Off-target Effects: Unintended DNA edits can have unforeseen consequences.
Eugenics: Misusing CRISPR for designer babies raises social and ethical questions.
Equity: High costs could limit access to this potentially life-saving technology.
The Path Forward: Responsible development is crucial:
International Collaboration: Clear guidelines are needed for research and human trials.
Public Education: Open discussions ensure informed decisions about CRISPR.
Prioritize Safety and Ethics: Safety and ethical principles must be paramount.
CRISPR offers a powerful tool for a better future, but responsible development and addressing ethical concerns are essential. By prioritizing safety, fostering open dialogue, and ensuring equitable access, we can harness CRISPR's power for the benefit of all. (2998 characters)
How many patients does case series should have In comparison to case reports.pdfpubrica101
Pubrica’s team of researchers and writers create scientific and medical research articles, which may be important resources for authors and practitioners. Pubrica medical writers assist you in creating and revising the introduction by alerting the reader to gaps in the chosen study subject. Our professionals understand the order in which the hypothesis topic is followed by the broad subject, the issue, and the backdrop.
https://pubrica.com/academy/case-study-or-series/how-many-patients-does-case-series-should-have-in-comparison-to-case-reports/
2. Propeller Health
• Founded in 2010
• Located in Madison, WI
and San Francisco, CA
• FDA 510(k) cleared
• 25+ commercial programs
• Validated in 12 clinical studies
totaling over 1,200 patients
4. Cost of asthma & COPD
Asthma & COPD are the 5th and 6th most expensive diseases in the US
5. Disease management has not changed in decades
Daily diaries and paper-based action plans add burden &
complexity and are rarely used by patients.
6. Real-time data can help detect exacerbations
• Half of patients who go to ED have had symptoms for > 4
days
• With real-time data, we can intervene early while outpatient
treatment is still an option
8. Digital interventions improve adherence
Significant literature supports the use of SMS and audiovisual
reminders to improve adherence to inhaled controller
medications
10. Sensors measure symptoms & track symptoms
Rescue
Used to address symptoms
when they occur unexpectedly –
among the most important
markers of impairment & risk
Controller / maintenance
Should be used regularly to
minimize or eliminate symptoms
by addressing underlying
pathophysiology
12. 1:38:08
PM PST
Pollen Count 5.2
AQI 102
N47o 34.4452. W110o77.8257
2 inhalations of ProAir (120mcg)
20 seconds apart
Winds from SW, 13mph
And attaches meta
data to each
actuation
13. Multi-faceted approach to improving adherence
• Non-adherence is complex and multi-dimensional
• Improving adherence requires an equally multi-dimensional solution
14. Rules driven notifications & alerts
Goal is to give users small bits of actionable, personalized
feedback to foster self-management, without increasing the effort
required of users
• Passive
• Feed of personalized insights
• Personalized encouragement
• Triggered questions & surveys
• Messaging from Care Team
16. Retain Users
Enroll Users● Intercept during
normal clinical care
● Telephone to schedule visit
● Email marketing
● Direct mail
● Online targeted marketing
● Incentives
● Partnership
● In person (face-to-face)
● On telephone
● Online self-enrollment
● Hardware
● Software
● CSS Team
Experiments every step of the way
30. Data are the backbone of value-based care
Better data are needed to
understand what happens to
patients in between physician
visits
• to effectively manage care
• to improve outcomes
• to prove effectiveness
36. • Enacted August 21, 1996
• 4 key components, including: administrative simplification
• Administrative simplification, including: privacy & security
standards
Health Insurance Portability and Accountability Act
Privacy standards
• Protected Health
Information (PHI)
• Covered entities
• Routine purposes
Security standards
• Administrative: Policies, training, etc.
• Physical: unauthorized intrusion, etc.
• Technical: encryption, etc.
37. Once information is de-identified, it is no longer subject to the
privacy regulation restrictions.
De-identification
Statistical de-identification
• Statistical expert confirms
that data could not
reasonably be re-identified
• Documentation & results of
all statistical tests &
analyses
Safe Harbor Guidelines
Removal of 18 personal
identifiers that constitute
Personally identifiable
information (PII).
1. Names
2. Geo-specificity < than state
3. All dates (birth, death, doc visits, etc.)
4. Telephone numbers
5. Fax numbers
6. Email addresses
7. Social security #s
8. Medical record #s
9. Health plan #s
10. Account #s
11. License #s
12. Vehicle identifiers
13. Device identifiers
14. URLs
15. IP addresses
16. Biometric identifiers
17. Full face photography
18. Any other uniquely identifying #
40. Clinical trials
Series of statistically instrumented experiments to prove safety
& efficacy of treatments, devices, and medical strategies
Development process – medical devices
41. Propeller clinical trials design
500-1,000 enrolled
Intervention
Control
6-12 month study period,
with quarterly assessments of control
Randomization
Sensor +
intervention
Sensor + no
intervention
Primary outcomes
Asthma control
Poorly controlled
Not well controlled
Well controlled
Inhaler use
Rescue inhaler
Controller inhaler
44. Case study: Propeller Health in Louisville, Kentucky
“One of the top 20 “most challenging
places to live with asthma in the US.”
- Asthma & Allergy Foundation of America, 2014
45. Snapshot of Louisville health
• 1 in 3 adults in Louisville are overweight or obese
- Increased risk for high blood pressure, diabetes, some
cancers, arthritis / joint pain
• 25% of Louisville adults still use tobacco products
- Increased risk for lung disease, cancer, heart attack and stroke,
and poor wound healing
• Louisville’s rate of deaths for heart disease, cancer, diabetes,
stroke are higher than the death rates for Kentucky and the
US
46. Why do this study?
Asthma hospitalizations in Jefferson County, 2011
Data like this has many problems:
• Based on healthcare utilization
• Retrospective, time lags
• Aggregated, low spatial resolution
47. Louisville study design
Enrollment begins
Baseline data collection for 1 month
instrumentation with sensors, but no access to data
Intervention period & data collection for 12 months
5,430 unique rescue inhaler events recorded
27,197 person-days of data
49. Temporal data Air quality index
(Levels of health
concern)
Numerical
value
Meaning
Good 0 to 50 Air quality is considered satisfactory & poses
little or no risk
Moderate 51 to 100 Air quality is acceptable, but for some
pollutants there may be risk for unusually
sensitive groups
Unhealthy for
sensitive groups
101 to 150 Members of sensitive groups may experience
health effects
Unhealthy 151 to 200 Everyone may begin to experience health
effects
Very unhealthy 201 to 300 Health warnings of emergency conditions
Hazardous 301 to 500 Health alerts: everyone may experience serious
health effects
58. Geospatial data
• Usually latitude, longitude
• A shapefile is an vector data storage format for storing
the location, shape, and attributes of geographic features
• Projections matter!
This slide has an
animation.
61. World Geodetic System, 1984 – WGS 84
• Standard for use in cartography and navigation, including GPS
• Coordinate origin at the Earth’s center of mass
• Meridian of zero longitude is ~336 feet east of Greenwich
• Originally developed by the Department of Defense in 1966
• Default projection for Tableau & QGIS
79. Spatial predictors we explored
• Exposures
• Proximity to emission sources, industrial areas, power plants, active mines
• Transportation infrastructure
• High density traffic areas
• Land use
• Impervious surface (%)
• “Greenness” and tree canopy
• Proximity to green spaces & parks
• Neighborhood
• Socioeconomic measures: household income, educational attainment,
property values, property age, crime rates
• Population density
• Study factors
• # of users enrolled per zip
81. Ecological niche modeling
1. Geo-reference inhaler use points
2. GIS of environmental variables
3. Extract environmental data at each point
4. Build model against background sample of
pseudo-absences
5. Model calibration & selection (AUC, cross-
validation with test data, etc.)
6. Probability distribution based on environmental
suitability
7. Assessment of environmental
variable contributions
8. Extrapolate into new
environmental or geographic space
9. Test with additional data
87. Current AIR Louisville emphases
• Improved data & sampling
• More analyses, guided closely by city needs
• More transparency & public awareness with open data portal
105. Louisville is one of the top 20
most difficult places to live
with asthma in the US.
AIR Louisville enrolled 300
residents to track their asthma
rescue inhaler use with
Propeller Health sensors.
AIR Louisville collected data on citizens’ inhaler use for 12 months
Here’s what we learned…
We learned a lot about how
Louisville residents experience
asthma symptoms and use
their inhalers.
Only 31% of asthma attacks
occur in homes.
People use inhalers more
when it is hot outside.
Weed, pollen and mold
significantly increase asthma
risk.
Wind clears the air and
reduces asthma attacks.
When pollution levels are high,
people have more asthma
symptoms.
Strong city partnerships are
key to a successful program.
People use rescue inhalers
more on weekdays than on
weekends.
Trees provide a protective
effect for asthma attacks
(especially evergreens).
A 10% reduction in particulate
matter could mean a 27%
reduction in asthma risk.
Blue dot = inhaler signal
This slide has an
animation.
106. In Mayor Fischer’s own words
This slide has an
animation.
https://youtu.be/iiaTPV09vBE?t=6m27s