This document discusses tuberculosis (TB) and anti-TB drugs. It defines TB as an infectious lung disease caused by Mycobacterium tuberculosis that can affect any part of the body but mainly the lungs. It classifies TB as pulmonary or extrapulmonary and lists common symptoms like cough, chest pain, weight loss, and fever. The document also categorizes anti-TB drugs, describes the mechanism of action of isoniazid, and notes its pharmacokinetics and potential adverse effects like liver damage and hepatotoxicity.

1. ANTI- T.B. DRUGS
By Rahul Sharma

2. Tuberculosis is an
infectious disease caused
by “Mycobacterium
Tuberculosis”.

3. T.B. can effect any
part of body but it
is mainly infection
of lungs.

4. CLASSIFICATION
PULMONARY T.B. Extrapulmonary T.B.
❏ Primary Disease
❏ Secondary Disease
❏ Lymph node T.B.
❏ Skeletal T.B.
❏ GIT T.B.
❏ Pleural T.B.
❏ Less common T.B.

5. ● Peristant cough(2-3 weeks long)
● Chest Pain
● Loss of weight
● Evening Fever
● Night Sweats
● Fatigue
● Urine Discoloration
SYMPTOMS

6. Classification of Anti - T.B. Drugs

7. MOA
Isoniazid(Prodrug)
Active Form
Inhibit Mycohlic acid Synthesis
Destruction of Cell Wall

8. PHARMACOKINECTIC
● Taken orally .
● Absorption is reduced due to fatty diet.
● Easily cross BBB and Placenta.
● Metabolized by acetylation.
● Excreted through urine (75%-95%).
● t half-: 1-4 hours.

9. Adverse
Effects
➢ Hepatotoxicity
➢ Liver damage
➢ SLE(Systemic lopus erythematosus)

10. THANK
YOU