There are two pathways for antigen processing and presentation: the cytosolic pathway and the endocytic pathway. The cytosolic pathway uses MHC class I to process endogenous proteins from within cells. It involves marking proteins with ubiquitin and degrading them in proteasomes to generate peptides, which are then transported into the ER by TAP for loading onto MHC class I. The endocytic pathway uses MHC class II to process exogenous proteins endocytosed by antigen presenting cells. The proteins are degraded within lysosomes, and peptides displace the CLIP region of invariant chain to bind MHC class II for presentation. Antigen presentation leads to cross-talk between immune cells that stimulates an adaptive immune response.