This document provides an overview of various classes of antibiotics, including their mechanisms of action, uses, and side effects. It covers beta-lactam antibiotics like penicillins and cephalosporins, tetracyclines, sulfonamides, chloramphenicol, and more. Classification of antibiotics is discussed based on mechanisms, spectra of activity, and types of organisms targeted. Factors affecting antibiotic choice and concepts like combined antibiotic use and drug resistance are also summarized.
The document discusses anti-infective agents, which are drugs designed to selectively target and kill invading microorganisms without harming the host's cells. It provides a brief history of anti-infective development and outlines several mechanisms of action, including interfering with bacterial cell wall synthesis, protein synthesis, and DNA synthesis. The document also discusses anti-infective classification, acquiring resistance, treatment considerations, antibiotic classes, and specific aminoglycoside antibiotics.
This document discusses several classes of anti-infective drugs including penicillins, cephalosporins, aminoglycosides, macrolides, clindamycin, vancomycin, and carbapenems. It covers the pharmacokinetics, pharmacodynamics, uses, drug interactions and adverse effects of these drug classes. The classes of anti-infective drugs are compared in terms of their mechanisms of action, antimicrobial spectra, and indications for use. Factors involved in selecting an appropriate antimicrobial agent are also reviewed.
This document provides an overview of antimicrobial agents and antibiotics. It discusses the germ theory of disease, the timeline of antibiotic discovery, and classifications of antimicrobial agents. It describes different types of antimicrobial therapy including prophylaxis, empirical, and definitive therapy. Key concepts covered include bacteriostatic vs bactericidal agents, minimum inhibitory concentration, and principles of antibiotic dosing. The document also addresses factors influencing antimicrobial choice, problems with antimicrobial use including resistance, and Schedule HX regulations in India.
1. The document discusses the use of antibiotics in treating periodontal diseases. It outlines various antibiotics including tetracyclines, metronidazole, penicillins, and cephalosporins that can be used systemically or locally as adjuncts to scaling and root planing.
2. No single ideal antibiotic exists for treating all periodontal pathogens due to variations in bacterial species involved and development of resistance. Combinations of antibiotics like metronidazole and amoxicillin are effective against many anaerobes.
3. Factors in selecting an antibiotic include the disease treated, antibiotic spectrum of activity, side effects, dosage, and minimizing development of bacterial resistance. Proper
This document defines key terms related to antimicrobial drugs and provides guidance on their appropriate use. It discusses:
1. Common types of antimicrobial drugs including antibacterial, antiviral, antifungal, and antiparasitic.
2. Characteristics of broad and narrow spectrum antibacterials.
3. Mechanisms of action for killing or inhibiting bacterial growth.
4. Examples of common antibiotics and their indications.
5. Factors to consider when selecting an antibiotic for odontogenic infections.
This document discusses antibiotics prescribing for dentistry. It defines antibiotics and describes how penicillin was discovered by accident. It outlines the risks of antibiotic use including drug resistance, superinfection, toxicity and allergies. Benefits include preventing and spreading of infection. Antibiotics are classified based on their mode of action and therapeutic spectra. Various antibiotics are discussed in terms of their pharmacodynamics, mechanisms of action, indications and principles of use. Factors that influence dosing like renal function are also covered.
2. Choice and combined use of Anti-microbial agentsJagirPatel3
This document discusses factors that influence the choice and combined use of antimicrobial agents (AMAs). It notes that empiric therapy is sometimes necessary before laboratory results are available. When selecting AMAs, clinicians must consider the activity of the agent against the suspected organism, site of infection, administration route, metabolism/excretion, treatment duration, frequency, toxicity, cost, and local resistance rates. Combining AMAs can achieve synergism, broaden antimicrobial spectrum, reduce toxicity, prevent resistance emergence, and treat mixed infections, but may also increase adverse effects, resistance, costs, and superinfections if not used rationally.
1. Antibiotics are chemical substances produced by microorganisms like fungi, actinomycetes and bacteria that suppress or destroy other microorganisms.
2. Alexander Fleming discovered penicillin in 1929 after noticing that a mold growing in one of his petri dishes had prevented bacteria from growing nearby. Penicillin revolutionized medicine as the first widely used antibiotic.
3. Antibiotic resistance has become a major problem as bacteria have increasingly developed resistance, even to formerly powerful antibiotics like penicillin. Proper antibiotic stewardship including only using antibiotics when necessary and completing prescribed treatment courses can help address this growing threat.
The document discusses anti-infective agents, which are drugs designed to selectively target and kill invading microorganisms without harming the host's cells. It provides a brief history of anti-infective development and outlines several mechanisms of action, including interfering with bacterial cell wall synthesis, protein synthesis, and DNA synthesis. The document also discusses anti-infective classification, acquiring resistance, treatment considerations, antibiotic classes, and specific aminoglycoside antibiotics.
This document discusses several classes of anti-infective drugs including penicillins, cephalosporins, aminoglycosides, macrolides, clindamycin, vancomycin, and carbapenems. It covers the pharmacokinetics, pharmacodynamics, uses, drug interactions and adverse effects of these drug classes. The classes of anti-infective drugs are compared in terms of their mechanisms of action, antimicrobial spectra, and indications for use. Factors involved in selecting an appropriate antimicrobial agent are also reviewed.
This document provides an overview of antimicrobial agents and antibiotics. It discusses the germ theory of disease, the timeline of antibiotic discovery, and classifications of antimicrobial agents. It describes different types of antimicrobial therapy including prophylaxis, empirical, and definitive therapy. Key concepts covered include bacteriostatic vs bactericidal agents, minimum inhibitory concentration, and principles of antibiotic dosing. The document also addresses factors influencing antimicrobial choice, problems with antimicrobial use including resistance, and Schedule HX regulations in India.
1. The document discusses the use of antibiotics in treating periodontal diseases. It outlines various antibiotics including tetracyclines, metronidazole, penicillins, and cephalosporins that can be used systemically or locally as adjuncts to scaling and root planing.
2. No single ideal antibiotic exists for treating all periodontal pathogens due to variations in bacterial species involved and development of resistance. Combinations of antibiotics like metronidazole and amoxicillin are effective against many anaerobes.
3. Factors in selecting an antibiotic include the disease treated, antibiotic spectrum of activity, side effects, dosage, and minimizing development of bacterial resistance. Proper
This document defines key terms related to antimicrobial drugs and provides guidance on their appropriate use. It discusses:
1. Common types of antimicrobial drugs including antibacterial, antiviral, antifungal, and antiparasitic.
2. Characteristics of broad and narrow spectrum antibacterials.
3. Mechanisms of action for killing or inhibiting bacterial growth.
4. Examples of common antibiotics and their indications.
5. Factors to consider when selecting an antibiotic for odontogenic infections.
This document discusses antibiotics prescribing for dentistry. It defines antibiotics and describes how penicillin was discovered by accident. It outlines the risks of antibiotic use including drug resistance, superinfection, toxicity and allergies. Benefits include preventing and spreading of infection. Antibiotics are classified based on their mode of action and therapeutic spectra. Various antibiotics are discussed in terms of their pharmacodynamics, mechanisms of action, indications and principles of use. Factors that influence dosing like renal function are also covered.
2. Choice and combined use of Anti-microbial agentsJagirPatel3
This document discusses factors that influence the choice and combined use of antimicrobial agents (AMAs). It notes that empiric therapy is sometimes necessary before laboratory results are available. When selecting AMAs, clinicians must consider the activity of the agent against the suspected organism, site of infection, administration route, metabolism/excretion, treatment duration, frequency, toxicity, cost, and local resistance rates. Combining AMAs can achieve synergism, broaden antimicrobial spectrum, reduce toxicity, prevent resistance emergence, and treat mixed infections, but may also increase adverse effects, resistance, costs, and superinfections if not used rationally.
1. Antibiotics are chemical substances produced by microorganisms like fungi, actinomycetes and bacteria that suppress or destroy other microorganisms.
2. Alexander Fleming discovered penicillin in 1929 after noticing that a mold growing in one of his petri dishes had prevented bacteria from growing nearby. Penicillin revolutionized medicine as the first widely used antibiotic.
3. Antibiotic resistance has become a major problem as bacteria have increasingly developed resistance, even to formerly powerful antibiotics like penicillin. Proper antibiotic stewardship including only using antibiotics when necessary and completing prescribed treatment courses can help address this growing threat.
This document provides an introduction to principles of anti-microbial therapy. It discusses key topics including:
- Sir Alexander Fleming's discovery of penicillin in 1928.
- The definition of chemotherapy and agents used to treat infections and cancer.
- Factors considered in selecting appropriate anti-microbial agents, including the infecting organism, site of infection, and patient factors.
- Mechanisms of anti-microbial resistance that can develop, including genetic alterations in microbes and changes in target sites or drug accumulation.
- Complications of anti-microbial therapy like hypersensitivity, direct toxicity, and superinfections.
Antimicrobial in dentistry practice - dental pharmacologyTaha Hussein Kadi
This document discusses antimicrobial agents used for dental infections. It defines antibiotics, bactericidal agents, and bacteriostatic agents. It discusses factors in choosing antibiotics like cost and patient adherence. It describes stages of infection and organisms involved. It provides dosing guidelines for common antibiotics used like penicillin, amoxicillin, clindamycin, metronidazole, erythromycin, and azithromycin. It also discusses antifungal agents like nystatin, miconazole, and systemic azoles. Clinical case studies are presented on management of periodontitis, abscesses, and pseudomembranous colitis.
This document provides an overview of antibiotic use in oral and maxillofacial surgery. It begins with the history and introduction of antibiotics, followed by classifications based on type of organism, mechanism of action, chemical structure, and spectrum of activity. Principles of antibiotic therapy are discussed, including determining infection severity, evaluating host defenses, and choosing appropriate antibiotics. Common oral infections and their typical microorganisms are listed. Guidelines for antibiotic selection include empirically treating typical odontogenic infections, obtaining cultures in specific situations, and using narrow-spectrum antibiotics when possible.
Dr. V.RAMKUMAR discusses various classes of antibiotics including their mechanisms of action, spectra of activity, indications for use, and side effects. The document covers penicillins, cephalosporins, macrolides, tetracyclines, aminoglycosides, and other classes of antibiotics. It provides detailed information on commonly used antibiotics within each class.
Antibiotics and antimicrobial agents can be classified based on their chemical structure, mechanism of action, spectrum of activity, and source. Beta-lactams like penicillins, cephalosporins, carbapenems, and monobactams as well as glycopeptides inhibit bacterial cell wall synthesis. Aminoglycosides, macrolides, lincosamides, streptogramins, tetracyclines, phenicols, and oxazolidinones inhibit protein synthesis in bacteria. Odontogenic infections are usually mixed aerobic-anaerobic infections involving streptococci and require broad spectrum antibiotics like amoxicillin that cover both gram-positive and gram-negative organisms
This document discusses antibiotic use in dentistry. It covers principles of therapy and antibiotic selection including using the most specific antibiotic, proper administration, and patient monitoring. It then describes common antibiotic classes used in dentistry like beta-lactams (penicillins, cephalosporins), tetracyclines, vancomycin, macrolides, nitroimidazoles, and quinolones. It provides examples of antibiotics used to treat maxillofacial infections and conditions. Finally, it discusses antibiotic prophylaxis for dental procedures in patients with conditions like cardiac abnormalities or compromised immunity.
This document discusses different types of antibiotics, including their definitions, indications, mechanisms of action, and resistance. It describes several classes of antibiotics: beta-lactams like penicillin and cephalosporin which inhibit bacterial cell wall synthesis; aminoglycosides which have nephrotoxicity risks; macrolides like erythromycin which are bacteriostatic; tetracyclines which can discolor teeth and bones; and metronidazole which is effective against anaerobic bacteria. Each antibiotic class has different spectrums of activity, mechanisms of action, pharmacokinetics, uses, and potential adverse effects. Precise indications and risks are outlined to help guide appropriate clinical antibiotic selection and
This document discusses antimicrobial therapy for orofacial infections. It covers topics such as selecting and initiating antibiotic regimens, empiric vs definitive therapy, bactericidal vs bacteriostatic drugs, common classes of antibiotics including penicillins, cephalosporins, aminoglycosides, and their mechanisms of action. It also discusses factors to consider like host characteristics, microbiology diagnosis, oral vs intravenous routes, adverse effects, and treating device-associated infections.
This document discusses various antimicrobial drugs used in dentistry, including antibacterials, antifungals, and antivirals. It defines key terms and outlines the mechanisms of action, indications, and common examples of different classes of antimicrobials. Factors influencing treatment choices are described, such as infection type, resistance patterns, and patient factors. Guidelines are provided for administration, treatment duration, and addressing treatment failure.
Brief information about Tuberculosis, drugs used for its treatment including recent advances and drug regimen for patients of different categories of TB suggested by WHO (DOTS therapy) including national and international programes for preventing TB.
Chemotherapy describes different types of chemotherapy agents including antibiotics, antifungals, and antineoplastics. It discusses penicillin antibiotics in depth, describing their mechanisms of action, classifications as narrow or broad spectrum, examples of each type, and mechanisms of bacterial resistance. Key points covered include how penicillins work by inhibiting bacterial cell wall synthesis, classifications such as aminopenicillins and antipseudomonal penicillins, and common combinations with beta-lactamase inhibitors.
ANTIBIOTICS IN ORAL & MAXILLOFACIAL SURGERYankitaraj63
This document provides an overview of antibiotics used in oral and maxillofacial surgery. It begins with an introduction to antibiotics and their history. It then discusses various ways antibiotics can be classified including by chemical structure, mechanism of action, and spectrum of activity. Key principles for choosing and administering antibiotics are outlined. Common adverse reactions and antibiotic resistance are also reviewed. The document concludes with references. It provides a comprehensive but concise review of important antibiotics and concepts related to their use in oral and maxillofacial surgery.
This document summarizes various types of antimicrobials including their classification based on chemical structure and mechanism of action. It describes how antimicrobials work by inhibiting processes like cell wall synthesis or protein synthesis. It also discusses problems that can arise with antimicrobial use like toxicity, hypersensitivity reactions, drug resistance through mutation or gene transfer, and superinfections. Antimicrobials are obtained from fungi, bacteria, and actinomycetes.
1. Fungal infections are common in immunocompromised patients and those taking immunosuppressive drugs. They are harder to treat than bacterial infections.
2. There are two main types of fungal infections - superficial infections affecting the skin and mucous membranes, and deep infections affecting internal organs like the lungs and brain.
3. Major antifungal drug classes include azoles like fluconazole and itraconazole, polyenes like amphotericin B, and allylamines like terbinafine. They work by disrupting the fungal cell membrane or inhibiting fungal enzyme activity.
This document discusses antibiotic use in dentistry and provides details on penicillin antibiotics. It describes the classes of anti-infective drugs and their mechanisms of action, including inhibition of bacterial cell wall biosynthesis, protein synthesis, and DNA synthesis. It also discusses the spectrum of activity of antibiotics as either narrow or broad-spectrum. Common adverse drug reactions include nephrotoxicity, gastrointestinal toxicity, central nervous system toxicity, and hypersensitivity. Specific details are provided on the classes of penicillin antibiotics, their mechanisms of action, spectrum of activity, pharmacokinetics, clinical uses, and adverse effects.
This document provides an overview of antibiotics, including:
1) It outlines the objectives of classifying commonly used antibiotics into six major classes, understanding their mechanisms of action, clinical uses, and side effects.
2) It summarizes the key characteristics and clinical uses of beta-lactams, aminoglycosides, fluoroquinolones, macrolides, tetracyclines, glycopeptides, and metronidazole.
3) It emphasizes the importance of considering pharmacokinetics and the site of infection when selecting an antibiotic to ensure it reaches the infection.
An antifungal medication is a pharmaceutical fungicide used to treat and prevent mycoses such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. Such drugs are usually obtained by a doctor's prescription, but a few are available OTC (over-the-counter).
Antifungals work by exploiting differences between mammalian and fungal cells to kill the fungal organism with fewer adverse effects to the host. Unlike bacteria, both fungi and humans are eukaryotes. Thus, fungal and human cells are similar at the biological level. This makes it more difficult to discover drugs that target fungi without affecting human cells. As a consequence, many antifungal drugs cause side-effects. Some of these side-effects can be life-threatening if the drugs are not used properly.
The document discusses various classes of antimicrobial agents including their classification, mechanisms of action, spectra of activity, and examples. It covers antibiotics such as penicillin, cephalosporins, aminoglycosides, and macrolides. It also addresses antimicrobial resistance, rational antibiotic usage, and combination therapy.
Tuberculosis is caused by Mycobacterium tuberculosis and is one of the world's most deadly infectious diseases. It primarily affects the lungs but can spread throughout the body. First line drugs used to treat tuberculosis include isoniazid, rifampin, pyrazinamide, and ethambutol. Isoniazid and rifampin are the most effective. Treatment requires combination drug therapy for an extended period of time to address both actively growing and dormant bacilli. Short course multidrug regimens introduced by the WHO have improved treatment completion rates. Problems in tuberculosis chemotherapy include the slow growth of mycobacteria and risk of resistance development with single drug therapy.
1. Antimicrobial agents include substances that kill or inhibit the growth of microorganisms such as bacteria, fungi, and protozoa. They are commonly classified based on their mechanism of action and spectrum of activity.
2. Antimicrobial resistance can develop through natural resistance, mutation, or gene transfer between microorganisms. It is important to select the right antimicrobial agent, use the proper dose for sufficient duration, and consider combination therapy to prevent resistance.
3. Superinfections can sometimes occur during antimicrobial therapy due to elimination of normal protective flora. Probiotics and prudent antimicrobial use can help reduce this risk.
This document discusses chemotherapy and provides classifications of antibiotics. It focuses on penicillin, describing its discovery in 1928 by Alexander Fleming, that it is derived from the fungus Penicillium notatum, and that penicillins are usually bactericidal and effective against fast-growing bacteria. The document outlines penicillin's mechanism of action in inhibiting bacterial cell wall synthesis, its common indications for gram-positive infections, dosing guidelines, contraindications, adverse effects and drug interactions. Nursing responsibilities are also mentioned, including assessing for allergies and monitoring for signs of reaction.
This document provides an introduction to principles of anti-microbial therapy. It discusses key topics including:
- Sir Alexander Fleming's discovery of penicillin in 1928.
- The definition of chemotherapy and agents used to treat infections and cancer.
- Factors considered in selecting appropriate anti-microbial agents, including the infecting organism, site of infection, and patient factors.
- Mechanisms of anti-microbial resistance that can develop, including genetic alterations in microbes and changes in target sites or drug accumulation.
- Complications of anti-microbial therapy like hypersensitivity, direct toxicity, and superinfections.
Antimicrobial in dentistry practice - dental pharmacologyTaha Hussein Kadi
This document discusses antimicrobial agents used for dental infections. It defines antibiotics, bactericidal agents, and bacteriostatic agents. It discusses factors in choosing antibiotics like cost and patient adherence. It describes stages of infection and organisms involved. It provides dosing guidelines for common antibiotics used like penicillin, amoxicillin, clindamycin, metronidazole, erythromycin, and azithromycin. It also discusses antifungal agents like nystatin, miconazole, and systemic azoles. Clinical case studies are presented on management of periodontitis, abscesses, and pseudomembranous colitis.
This document provides an overview of antibiotic use in oral and maxillofacial surgery. It begins with the history and introduction of antibiotics, followed by classifications based on type of organism, mechanism of action, chemical structure, and spectrum of activity. Principles of antibiotic therapy are discussed, including determining infection severity, evaluating host defenses, and choosing appropriate antibiotics. Common oral infections and their typical microorganisms are listed. Guidelines for antibiotic selection include empirically treating typical odontogenic infections, obtaining cultures in specific situations, and using narrow-spectrum antibiotics when possible.
Dr. V.RAMKUMAR discusses various classes of antibiotics including their mechanisms of action, spectra of activity, indications for use, and side effects. The document covers penicillins, cephalosporins, macrolides, tetracyclines, aminoglycosides, and other classes of antibiotics. It provides detailed information on commonly used antibiotics within each class.
Antibiotics and antimicrobial agents can be classified based on their chemical structure, mechanism of action, spectrum of activity, and source. Beta-lactams like penicillins, cephalosporins, carbapenems, and monobactams as well as glycopeptides inhibit bacterial cell wall synthesis. Aminoglycosides, macrolides, lincosamides, streptogramins, tetracyclines, phenicols, and oxazolidinones inhibit protein synthesis in bacteria. Odontogenic infections are usually mixed aerobic-anaerobic infections involving streptococci and require broad spectrum antibiotics like amoxicillin that cover both gram-positive and gram-negative organisms
This document discusses antibiotic use in dentistry. It covers principles of therapy and antibiotic selection including using the most specific antibiotic, proper administration, and patient monitoring. It then describes common antibiotic classes used in dentistry like beta-lactams (penicillins, cephalosporins), tetracyclines, vancomycin, macrolides, nitroimidazoles, and quinolones. It provides examples of antibiotics used to treat maxillofacial infections and conditions. Finally, it discusses antibiotic prophylaxis for dental procedures in patients with conditions like cardiac abnormalities or compromised immunity.
This document discusses different types of antibiotics, including their definitions, indications, mechanisms of action, and resistance. It describes several classes of antibiotics: beta-lactams like penicillin and cephalosporin which inhibit bacterial cell wall synthesis; aminoglycosides which have nephrotoxicity risks; macrolides like erythromycin which are bacteriostatic; tetracyclines which can discolor teeth and bones; and metronidazole which is effective against anaerobic bacteria. Each antibiotic class has different spectrums of activity, mechanisms of action, pharmacokinetics, uses, and potential adverse effects. Precise indications and risks are outlined to help guide appropriate clinical antibiotic selection and
This document discusses antimicrobial therapy for orofacial infections. It covers topics such as selecting and initiating antibiotic regimens, empiric vs definitive therapy, bactericidal vs bacteriostatic drugs, common classes of antibiotics including penicillins, cephalosporins, aminoglycosides, and their mechanisms of action. It also discusses factors to consider like host characteristics, microbiology diagnosis, oral vs intravenous routes, adverse effects, and treating device-associated infections.
This document discusses various antimicrobial drugs used in dentistry, including antibacterials, antifungals, and antivirals. It defines key terms and outlines the mechanisms of action, indications, and common examples of different classes of antimicrobials. Factors influencing treatment choices are described, such as infection type, resistance patterns, and patient factors. Guidelines are provided for administration, treatment duration, and addressing treatment failure.
Brief information about Tuberculosis, drugs used for its treatment including recent advances and drug regimen for patients of different categories of TB suggested by WHO (DOTS therapy) including national and international programes for preventing TB.
Chemotherapy describes different types of chemotherapy agents including antibiotics, antifungals, and antineoplastics. It discusses penicillin antibiotics in depth, describing their mechanisms of action, classifications as narrow or broad spectrum, examples of each type, and mechanisms of bacterial resistance. Key points covered include how penicillins work by inhibiting bacterial cell wall synthesis, classifications such as aminopenicillins and antipseudomonal penicillins, and common combinations with beta-lactamase inhibitors.
ANTIBIOTICS IN ORAL & MAXILLOFACIAL SURGERYankitaraj63
This document provides an overview of antibiotics used in oral and maxillofacial surgery. It begins with an introduction to antibiotics and their history. It then discusses various ways antibiotics can be classified including by chemical structure, mechanism of action, and spectrum of activity. Key principles for choosing and administering antibiotics are outlined. Common adverse reactions and antibiotic resistance are also reviewed. The document concludes with references. It provides a comprehensive but concise review of important antibiotics and concepts related to their use in oral and maxillofacial surgery.
This document summarizes various types of antimicrobials including their classification based on chemical structure and mechanism of action. It describes how antimicrobials work by inhibiting processes like cell wall synthesis or protein synthesis. It also discusses problems that can arise with antimicrobial use like toxicity, hypersensitivity reactions, drug resistance through mutation or gene transfer, and superinfections. Antimicrobials are obtained from fungi, bacteria, and actinomycetes.
1. Fungal infections are common in immunocompromised patients and those taking immunosuppressive drugs. They are harder to treat than bacterial infections.
2. There are two main types of fungal infections - superficial infections affecting the skin and mucous membranes, and deep infections affecting internal organs like the lungs and brain.
3. Major antifungal drug classes include azoles like fluconazole and itraconazole, polyenes like amphotericin B, and allylamines like terbinafine. They work by disrupting the fungal cell membrane or inhibiting fungal enzyme activity.
This document discusses antibiotic use in dentistry and provides details on penicillin antibiotics. It describes the classes of anti-infective drugs and their mechanisms of action, including inhibition of bacterial cell wall biosynthesis, protein synthesis, and DNA synthesis. It also discusses the spectrum of activity of antibiotics as either narrow or broad-spectrum. Common adverse drug reactions include nephrotoxicity, gastrointestinal toxicity, central nervous system toxicity, and hypersensitivity. Specific details are provided on the classes of penicillin antibiotics, their mechanisms of action, spectrum of activity, pharmacokinetics, clinical uses, and adverse effects.
This document provides an overview of antibiotics, including:
1) It outlines the objectives of classifying commonly used antibiotics into six major classes, understanding their mechanisms of action, clinical uses, and side effects.
2) It summarizes the key characteristics and clinical uses of beta-lactams, aminoglycosides, fluoroquinolones, macrolides, tetracyclines, glycopeptides, and metronidazole.
3) It emphasizes the importance of considering pharmacokinetics and the site of infection when selecting an antibiotic to ensure it reaches the infection.
An antifungal medication is a pharmaceutical fungicide used to treat and prevent mycoses such as athlete's foot, ringworm, candidiasis (thrush), serious systemic infections such as cryptococcal meningitis, and others. Such drugs are usually obtained by a doctor's prescription, but a few are available OTC (over-the-counter).
Antifungals work by exploiting differences between mammalian and fungal cells to kill the fungal organism with fewer adverse effects to the host. Unlike bacteria, both fungi and humans are eukaryotes. Thus, fungal and human cells are similar at the biological level. This makes it more difficult to discover drugs that target fungi without affecting human cells. As a consequence, many antifungal drugs cause side-effects. Some of these side-effects can be life-threatening if the drugs are not used properly.
The document discusses various classes of antimicrobial agents including their classification, mechanisms of action, spectra of activity, and examples. It covers antibiotics such as penicillin, cephalosporins, aminoglycosides, and macrolides. It also addresses antimicrobial resistance, rational antibiotic usage, and combination therapy.
Tuberculosis is caused by Mycobacterium tuberculosis and is one of the world's most deadly infectious diseases. It primarily affects the lungs but can spread throughout the body. First line drugs used to treat tuberculosis include isoniazid, rifampin, pyrazinamide, and ethambutol. Isoniazid and rifampin are the most effective. Treatment requires combination drug therapy for an extended period of time to address both actively growing and dormant bacilli. Short course multidrug regimens introduced by the WHO have improved treatment completion rates. Problems in tuberculosis chemotherapy include the slow growth of mycobacteria and risk of resistance development with single drug therapy.
1. Antimicrobial agents include substances that kill or inhibit the growth of microorganisms such as bacteria, fungi, and protozoa. They are commonly classified based on their mechanism of action and spectrum of activity.
2. Antimicrobial resistance can develop through natural resistance, mutation, or gene transfer between microorganisms. It is important to select the right antimicrobial agent, use the proper dose for sufficient duration, and consider combination therapy to prevent resistance.
3. Superinfections can sometimes occur during antimicrobial therapy due to elimination of normal protective flora. Probiotics and prudent antimicrobial use can help reduce this risk.
This document discusses chemotherapy and provides classifications of antibiotics. It focuses on penicillin, describing its discovery in 1928 by Alexander Fleming, that it is derived from the fungus Penicillium notatum, and that penicillins are usually bactericidal and effective against fast-growing bacteria. The document outlines penicillin's mechanism of action in inhibiting bacterial cell wall synthesis, its common indications for gram-positive infections, dosing guidelines, contraindications, adverse effects and drug interactions. Nursing responsibilities are also mentioned, including assessing for allergies and monitoring for signs of reaction.
New microsoft power point presentationwria zangana
This document discusses the use of antibiotics, both systemic and local, in the treatment of periodontal disease. It outlines several antibiotics commonly used systemically, including tetracyclines, metronidazole, penicillins, cephalosporins, clindamycin, ciprofloxacin, and macrolides. It notes their mechanisms of action, effectiveness against various bacteria, recommended dosages, and potential side effects. The document also discusses using antibiotics in combination or sequentially, as periodontal infections often involve multiple bacteria. Finally, it mentions the benefits of local antibiotic delivery directly into periodontal pockets to treat target bacteria while avoiding systemic side effects.
Chemotherapeutic drugs work by disrupting cells through various mechanisms like interfering with membranes, DNA, RNA, or essential nutrients. There are several classes of chemotherapeutic drugs including antimicrobials against bacteria, viruses, fungi and parasites. Antibiotics can be further classified based on their mechanism of action such as cell wall inhibitors like penicillins and cephalosporins, or protein synthesis inhibitors like tetracyclines. Other classes of antibiotics include aminoglycosides, macrolides and fluoroquinolones. Drugs used to treat tuberculosis also work through multi-drug combinations over long periods. Care must be taken with antibiotic use and sensitivity testing done to minimize resistance and side effects.
The document discusses various protein synthesis inhibitors including aminoglycosides, tetracyclines, chloramphenicol, macrolides, clindamycin, streptogramins, and oxazolidinones. It describes the stages of protein synthesis, mechanisms of action, antimicrobial spectra, resistance mechanisms, pharmacokinetics, clinical uses, and toxicities of each class of inhibitors.
The document discusses various protein synthesis inhibitors including aminoglycosides, tetracyclines, chloramphenicol, macrolides, clindamycin, streptogramins, and oxazolidinones. It describes the stages of protein synthesis, mechanisms of action, antimicrobial spectra, resistance mechanisms, pharmacokinetics, clinical uses, and toxicities of each class of inhibitors.
The document discusses various protein synthesis inhibitors including aminoglycosides, tetracyclines, chloramphenicol, macrolides, clindamycin, streptogramins, and oxazolidinones. It describes the stages of protein synthesis, mechanisms of action, antimicrobial spectra, resistance mechanisms, pharmacokinetics, clinical uses, and toxicities of each class of inhibitors.
The document discusses various antifungal drugs used to treat fungal infections. It describes different types of fungal infections including superficial infections affecting the skin and mucous membranes, and deep infections affecting internal organs. It then classifies and describes several classes of antifungal drugs including antifungal antibiotics like amphotericin B and nystatin, azoles like imidazoles and triazoles, flucytosine, and squalene epoxidase inhibitors. It provides details on mechanisms of action, pharmacokinetics, clinical uses, and adverse effects of specific antifungal drugs.
CHEMOTHERAPY_RDP_GENERAL PRINCIPLES OF CHEMOTHERAPY.pdfrishi2789
1. Chemotherapy involves using drugs to treat infectious diseases or malignancies by preferentially killing microorganisms or cancer cells with minimal damage to host tissues. Antimicrobial agents include those obtained from bacteria, fungi, and actinomycetes.
2. Antimicrobial drugs can be classified based on their chemical structure, mechanism of action, type of organism targeted, and spectrum of activity. They may be bacteriostatic or bactericidal.
3. Issues that can arise with antimicrobial use include toxicity, hypersensitivity reactions, and development of resistance via mutation or gene transfer between microorganisms.
The document discusses various aspects of antimicrobial drugs and antibiotic resistance. It defines key terms like antimicrobials, antibiotics, and describes different classes of antibiotics including their mechanisms of action and examples. It discusses factors that influence the effectiveness of antibiotics like spectrum of activity, toxicity and resistance development. It differentiates between acquired and intrinsic antibiotic resistance, and lists factors like overuse/misuse of drugs, poor infection control and inappropriate antibiotic usage as major causes of acquired antibiotic resistance.
The document discusses antimicrobial agents and mechanisms of resistance. It covers several topics:
1. Definitions and classifications of antibiotics based on chemical structure, source, mechanism of action, and spectrum.
2. Mechanisms of antibiotic resistance in bacteria including production of enzymes to destroy drugs and genetic/non-genetic resistance.
3. Approaches to address rising antibiotic resistance such as appropriate use and preventing overprescription.
This document provides an overview of aminoglycoside antibiotics, including their classification, mechanism of action, antibacterial spectrum, pharmacokinetics, resistance, and adverse effects. Aminoglycosides are obtained from Streptomyces and Micromonospora bacteria and interfere with bacterial protein synthesis. They are effective against many gram-negative bacteria but not gram-positive or anaerobic species. Due to poor absorption, aminoglycosides must be administered parenterally. They have concentration-dependent bacterial killing and a post-antibiotic effect. Adverse effects include ototoxicity, nephrotoxicity, and neuromuscular blockade. Common aminoglycosides discussed are streptomycin, gent
This document provides definitions and information about chemotherapy and antimicrobial agents. It discusses the history of chemotherapy beginning with Paul Ehrlich and the discovery of penicillin. It then classifies antibiotics according to spectrum of activity, type of action, organisms targeted, mechanism of action, chemical structure, and source. The document discusses drug resistance, combination therapy, chemoprophylaxis, superinfection, and principles of rational antibiotic use. It emphasizes the importance of proper antibiotic selection, dosage, duration and monitoring treatment to improve outcomes and reduce drug resistance.
Antifungal drugs work by targeting differences in the cell wall and membrane compositions of fungi compared to human cells. Azoles like fluconazole and itraconazole inhibit fungal ergosterol synthesis while amphotericin B binds to ergosterol in the membrane. Topical antifungals like nystatin and tolnaftate treat superficial infections while systemic drugs like fluconazole and terbinafine treat deep infections. These drugs have various mechanisms of action and are used to treat a wide range of fungal infections based on their spectra, pharmacokinetics and safety profiles.
Antifungal drugs work by targeting differences between fungal and human cell membranes and metabolism. Azoles like fluconazole inhibit ergosterol synthesis while polyenes like amphotericin B bind to ergosterol in the fungal cell membrane. Topical antifungals like nystatin and tolnaftate treat superficial infections while systemic drugs like fluconazole and itraconazole treat deep infections. Common adverse effects include nausea, liver toxicity, and drug interactions. The choice of antifungal depends on the infecting organism, infection severity, and route of administration needed.
This document discusses different classifications and mechanisms of antimicrobial agents. It describes how antibiotics can be classified based on their chemical structure, source, mechanism of action, spectrum of activity, and mode of action. The main mechanisms of antibiotic resistance are discussed, including production of enzymes to destroy antibiotics and alterations to cell membranes or metabolic pathways. Approaches to addressing resistance include proper antibiotic usage and selection based on accurate diagnosis and susceptibility testing.
This document summarizes various antibiotics including penicillin, cephalosporins, macrolides, lincosamides, glycopeptides, tetracyclines, aminoglycosides, fluoroquinolones, and lipopeptides. It describes the mechanisms of action, common uses, and side effects for each class. Nursing interventions are also provided for assessing allergies, monitoring potential toxicities, and ensuring proper administration of antibiotics.
This document discusses chemotherapy and anti-bacterial drugs. It defines chemotherapy as using specific chemicals to treat diseases like cancer or infections caused by bacteria, viruses, fungi or protozoa. It describes different types of chemotherapy and anti-bacterial agents, how they work, examples of commonly used drugs, their mechanisms of action, side effects and clinical uses. The principles of chemotherapy and classification and mechanisms of several classes of anti-bacterial drugs are explained in detail.
The document discusses various topics related to chemotherapy in infectious diseases including:
1. It defines chemotherapy as using chemicals to treat diseases caused by microorganisms. Antimicrobials kill or inhibit microorganism growth.
2. Antibiotics are a type of antimicrobial but not all antimicrobials are antibiotics. The first antibiotic, penicillin, was discovered by Alexander Fleming.
3. Antimicrobials can be classified based on their source, chemical structure, mechanism of action, and spectrum of activity.
4. Combination antimicrobial therapy and issues of antimicrobial resistance are also discussed.
The document is a general + dental quiz containing multiple choice and fill in the blank questions about various topics related to Kerala history, geography, Olympics, and dentistry. Some questions ask about the location of a statue, the name of rivers that converge in Muvattupuzha, the Olympic medal winner from Kerala, dental tools, and materials used in dentistry like plaster of Paris.
1. The dentist logo represents primary teeth as it contains 20 berries within the symbol.
2. In the movie Masters, the main character calls his dentist friend to seek whether children in a juvenile home are actually juveniles or not, relating dentistry to dental age estimation.
3. The orange chromide fish known as Pallathi acts as a cleaner fish for the popular fish Karimeen/Green chromide by removing parasites in a symbiotic relationship.
This document discusses different surgical airway techniques that can be used when endotracheal intubation fails or is not possible. It describes needle cricothyrotomy with translaryngeal jet ventilation, cricothyrotomy, and tracheostomy. In emergency situations, cricothyrotomy is preferred over tracheostomy due to its faster speed and lower risks. However, cricothyrotomy should be avoided in children younger than 10-12 years due to the small size of the cricoid cartilage and higher complication rates. The document provides details on how to perform each technique and notes important pediatric considerations for surgical airways.
The document reports on a case study of a 65-year-old male patient who presented with diffuse erythematous patches on the hard palate and grooves that bled upon probing, and was diagnosed with oral erythroplasia based on a positive toluidine blue staining test and histological examination showing epithelial atrophy and mild dysplasia. Oral erythroplasia is a potentially malignant disorder strongly associated with tobacco and alcohol use that requires surgical excision due to its high risk of transforming into carcinoma.
This document discusses oroantral fistula, which is an abnormal communication between the oral cavity and maxillary sinus. It defines oroantral fistula and describes its symptoms and investigations. It then discusses management approaches for early and delayed cases, including closure techniques like buccal and palatal flaps. Post-operative care including antibiotics, analgesics and nasal decongestants are also summarized. Surgical procedures for treating oroantral fistula include palatal rotational flaps, buccal flaps, and combined buccal and palatal flaps.
The document describes the Atraumatic Restorative Technique (ART), which is a minimally invasive dental procedure for managing tooth decay. ART involves removing decayed tooth material using hand instruments only, without anesthesia or drilling, and then restoring the cavity with adhesive materials like glass ionomer cement. The key principles of ART are preserving tooth structure, minimizing trauma, and using materials that bond chemically to tooth surfaces. ART has advantages like pain reduction, lower costs, and improved access for patients who cannot access traditional dental care. The document outlines the indications, contraindications, procedure steps, advantages, and limitations of the ART approach.
The document discusses impacted third molars, including their definition, etiology, indications for removal, classifications, clinical examination, radiographic analysis, and surgical management techniques. Impaction occurs due to local factors like lack of space or chronic inflammation, as well as systemic factors like rickets. Indications for removal include pericoronitis, dental caries, and orthodontic reasons. Surgical techniques involve raising a mucoperiosteal flap, removing bone, elevating the tooth, potentially sectioning it, debriding the socket, and closing the wound.
Pit and fissures on teeth are prone to harboring microbes that can cause dental caries. Sealants are protective coatings that are applied to pits and fissures to prevent caries by physically blocking them. There are different types of sealants that are made from various materials like dimethacrylates or glass ionomer cement. Application involves cleaning, etching, rinsing and drying the tooth surface before carefully applying the sealant. Factors like the operator's skill, type of sealant used and maintenance affect how long sealants are retained and prevent caries. Sealants have been shown to be cost effective in reducing dental treatment needs when applied selectively based on caries risk.
Biomechanics in Orthodontic tooth movementsAswanth E.P
1) Orthodontic treatment is based on applying prolonged pressure to teeth to induce bone remodeling and tooth movement using biomechanical principles.
2) Key biomechanical concepts include forces, moments, centers of resistance and rotation, and different types of tooth movement such as tipping, translation, and rotation.
3) Proper application of these concepts through different force systems allows the orthodontist to design effective treatment plans to efficiently correct malocclusions.
This document summarizes the development of the face and palate and discusses cleft lip and cleft palate. It begins with the development of the frontonasal process and maxillary processes which form the upper lip. The palate develops from the primary palate formed by the frontonasal process and secondary palate formed by the palatal processes. Cleft lip is a split in the upper lip caused by failure of fusion of the maxillary process. Cleft palate is a split in the palate allowing communication between the oral and nasal cavities. Types of clefts and classification are described along with incidence, etiology, and problems associated with cleft disorders.
The document discusses a general quiz with questions about various topics and their answers. It includes questions about euthanasia and Aruna Shanbaug's case (X and Y), the town of Bekal in Kerala (X), the symbol of the American Dental Association (X and Y being 32 and 20), the raga Darbari (X), the life of Mata Hari (X), the collar bone (X), the clouded leopard (X), the Tamil poem Thiruppavai (X), the art of Madhubani paintings (X), the character found in the KFC logo (X), the practice of Ochirakali in Kerala (X), the name of
It is simple 20 : 20 Quiz prepard for UP & HS .Which is my 1st attempt as a Quiz Master.But,I have a Quiz CLub On FB .If u like qstns log on :https://www.facebook.com/pages/Goals-quiz-club/1417549768500265?ref=hl
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Does Over-Masturbation Contribute to Chronic Prostatitis.pptxwalterHu5
In some case, your chronic prostatitis may be related to over-masturbation. Generally, natural medicine Diuretic and Anti-inflammatory Pill can help mee get a cure.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
2. Contents
Introduction
Classification of AMAs
Factors affecting choice
of AMAs
Combined use of antibiotics
Drug resistance
Beta lactam aantibiotics
a)Penicillins
b)Cephalosporins
Tetracyclines
Sulfonamides
a)Cotrimoxazole
b)Quinolones
Macrolides
Aminoglycosides
Antibiotic prophylaxis
Conclusion
Reference
3. INTRODUCTION
Antibiotics are substances produced by
microorganisms which are selectively supress the
growth or kill other microorganisms at low
concentrations.
Chemotherapy is the treatment of systemic infections
with specific drugs that selectively supress the infecting
microorganism without significanly affecting the host.
Appropriate choice of drugs are important in any
treatment and its prognosis.
4. Classification
1)Based on mechanism of action
a)Inhibit cell wall synthesis : Penicillins,cephalosporins
b)Inhibit protein synthesis : Tetracyclins,Chloramphynicol
c)Inhibit DNA gyrase : Fluoroquinolones
d)Interfere DNA synthesis : Acyclovir
e)Causing misreading of mRNA &
affect permiability : Aminoglycosides
2)Based on spectrum of activity
a)Narrow Spectrum : Penicillin G,Streptomycin
b)Broad spectrum : Tetracyclins,Chloramphinicol
5. 3)Based on type of action
a)Primarily bacteriostatic : Tetracyclines,Chloramphinicol
b)Primarily bacteriocidal : Penicillins,Cephalosporins
4)Based on type of organisms against which
primarily active
a)Antibacterials: Penicillins,Aminoglycocides
b)Antifungal : Ketoconazole,Amphotericin B
c)Antiviral : Acyclovir,Zidovudine
6. Factors affecting choice of AMA’s
1)Patient factors :
Age
Renal & hepatic function
Local factors like :
a)Presence of pus & secretions
b)Presence of necrotic material/foreign body
c)pH
Drug allergy
Impaired host defence
7. Pregnancy
All AMAs should be avoided due to risk of foetus.
Penicillins,cephalosporins &erythromycin are safe.
Tetracycline contraindicated-Pancreatitis & kidney damage
in mother and teeth & bone deformities in children.
Aminoglycosides causes foetal ear damage.
Genetic factors
Sulfonamides,fluoroquinolones carry risk of producing
haemolysis in G6PD deficient patient.
8. 2)Drug factors
Spectrum of activity
For definitive treatment – Narrow spectrum & for
emperical – broad spectrum
Type of activity
Acute infection resolve faster with cidal than with
static,as the cidal drug reduces the number of bacteria at
the site of infection while static only prevent the increase
in the number.
Sensitivity of organism
Relative toxicity-less toxic preferred(i.e beta lactam over
aminoglycosides)
9. Route of administration
Penicillin G have to be given by injection (20-24MU
daily)
For less severe infections, oral antibiotic is
preferrable.But for serious infection like meningitis
parenteral would be more reliable.
Cost
10. Combined use of antibiotics :
1)To achieve synergism :
Synergism(supra additive effect),additive action,
antagonism may be observed when 2 AMAs used together.
If MIC of one AMA is reduced in presence
of other– Synergism
11. 2)To reduce severity / incidence of adverse effects
Needed for AMAs with low safety margin
Amphotericin B + rifampin : the latter is not themselves
antifungal but enhance action of amphotericin B.
3)To prevent emergence of resistance
4)To broaden the spectrum of antibiotic
a)Treatment of mixed infection
b)Initial treatment of severe infections
12. Disadvantages :
Toxicity of one agent may enhanced by another.
Increased chances of super infections
High cost of therapy
Emergence of resistance
13. Drug Resistance
1)Natural resistance :
Develop due to lack of metabolic processes or the
target site which is affected by the particular drug.
Eg : gram negative bacilli are unaffected by penicillin G
2)Acquired resistance :
Arise due to use of an AMA over a period of time.
Eg : Gonococci develop resistance to penicillin.
14. Resistance may develop by :
a)Mutation
a1)Single step – E coli to rifampin
a2)Multiple step – Staphy. to rifampin
b)Gene transfer
b1)Conjugation - E coli to streptomycin
b2)Transduction – Resistance of stph.aureus
b3)Transformation – Pneumococci resistance to penicillin G
15. Beta lactam Antibiotics
Penicillins
1st antibiotic to be used clinically in 1941.
Antibiotics having a beta lactam ring.
2 major groups include penicillins & cephalosporins.
Mechanism of action :
Interfere the synthesis of bacterial cell wall.
Bacterial cell wall has crosslinked peptidoglycans, which
provide rigidity & stability to cell wall.
Beta lactam antibiotics inhibit the transpeptidase-
cross linking doesn’t take place.
16.
17. Such bacteria which divide in presence of beta lactam
antibiotic produce cell wall deficient forms.
They swell & burst –Bacterial lysis.
Preparations of Penicillin G
Duration of action of PnG increased by combining it
with poorly water soluble compounds like procaine,
benzathine..which are referred as repository penicllins.
Dose
Adult-500mg - t.i.d
Pediatric -250mg - t.i.d
18. Uses of penicillin G
Vincent angina,necrotizing gingivitis
Penumococcal infections-pnuemonia, meningitis
Diphtheria
Syphilis
Streptococcal infections-pharyngitis, rheumatic fever…
19. Adverse effects :
Local irritancy like pain at i.m injection site,nausea
on oral ingestion…
Direct toxicity to brain manifests as mental confusion,
convulsions & coma.
Hypersensitivity reactions
Jarisch – Herxheimer reaction :
Penicillin injection in syphilitic patient may produce
shivering,fever,myalgia…due to sudden release of
spirochetal lytic products.
20. Limitations of Penicillin G
1)Acid labile-orally not well effective
2)Short duration of action
3)Narrow spectrum of activity
4)Destroyed by penicillinase enzyme.
Classification of penicillins
a)Natural penicillins : Penicillin G,
Procain penicillin(0.6-1.2 MU),
benzathine penicillin(0.6-2.4 MU)
(PENIDURE).
22. B4)beta lactamase inhibitors – Clavulanic acid
It has beta lactam ring but no antibacterial activity of
its own.
Clavulanic acid combine with amoxicillin which have
similar half life (AUGMENTIN-
250mg amoxicillin+ 125 mg clavulanic acid)
Bact.fragilis not responsive to amoxicillin alone but inhibited
by combination.
Addition of Clavulanic acid re-establishes the activity of
amoxicillin against beta lactamase producing Staph.aureus.
It can be used in Skin & soft tissue infections ,Gonorrhoea
25. Uses :
1st generation – Cefazolin(ORIZOLIN) 1 g i.m / i.v ,30 min
before used for prophylaxis of bacterial endocarditis
before dental procedures & also used in odentogenic
infections.
2nd generation – Cefaclor(KEFLOR) -250mg useful in
orodental infections.
3rd generation – Used in severe gram negative
infections like community acquired pneumonia,
typhoid fever, gonorrhoea…
Adverse effects
Hypersensitivity
GIT disturbances-diarrhoea, vomiting…
Pain at site of infection.
26. Tetracyclines
Class of antibiotics having nucleus of 4 cyclic rings.
Mechanism of action
:
They are primarily
bacteriostatic
They inhibit protein
synthesis by binding to 30S
ribosome .
Thus interfere the binding
of aminoacyl tRNA to the
acceptor site of mRNA
28. Adverse effects
Irritative effects – nausea,vomiting,diarrhoea
Liver damage - In pregnant women may precipitate
acute hepatic necrosis.
All tetracyclines except doxycycline,accumulate &
enhance renal failure.
Phototoxicity – Sunburn like skin lesions on exposed parts.
Teeth & bones – Calcium-tetracycline chelate may get
deposited in teeth & bone.
If given during pregnancy,brown discoloration of
deciduous teeth,which become susceptible to caries.
Hypersensitivity reactions
Superinfection eg-pseudomonas enterocolitis
29. Chloramphenicol
Broad spectrum antibiotic but use is limited due
to its dangerous side effect – bone marrow supression
Mechanism of action
Bind reversibly to 50S ribosomal subunits-prevent
peptide bond formation-thus inhibit protein synthesis.
Uses
Never use it for minor infections or those of unknown
etiology or infections treatable by other safer AMAs
30. Daily dose not exceed 2-3 g & duration of therapy
to be <2 weeks.
Typhoid fever
Bacterial meningitis – In combination with ampicillin.
Intraocular infections
Anaerobic infections – caused by B.fragilis
Adverse effects
Bone marrow supression
1)Dose depent reversible supression-anaemia,leucocytopenia
2)Idiosyncratic nondose related aplastic anaemia-fetal.
Gray baby syndrome in neonates-Due to reduced
degradation in liver-skin appears ashengray colour.
Hypersensitivity reactions
31. Sulphonamides
1st AMAs effective against pyogenic bacterial infections.
Bacteriostatic
Classification :
1)Short acting – Sulfadiazine-0.5g tab q.i.d
2)Intermediate acting – Sulfamethoxazole-1 g BD
3)Long acting – Sulfadoxine.
Mechanism of action
PABA is a Component of folic acid,which is
produced by the bacteria & needed
for growth and multiplication of bacteria
Sulfonamides are structural analogous of PABA.
32. As the human cell not produce folic acid,but utilize it,
They are unaffected by sulfonamides.
Pus & tissue extracts contains purines & thymidine
which decrease bacterial requirement for FA & antagonize
the sulfonamide action.
Sulfonamide may itself get incorporated to
form an altered folate which is metabolically
injurious.
Thus they inhibit bacterial folate synthesis-
FA not formed-bacteriostatic effect.
33.
34. Doses
Sulfadiazine – 500mg –QID
Sulfamethoxazole – 1g- BD
Uses
Sodium salt of sulphacetamide used topically for
treatment of ophthalmic infections.
Silver sulfadiazine used topically for preventing
infection of burn wound.
Combined with trimethaprim,sulfamethoxazole is
used in many infections.
With pyrimethamine, certain sulfonamides are used for
malaria.
35. Adverse affects
Nausea,vomiting,epigastric pain
Hypersensiticity reactions
Hepatitis
Kernicterus in newborn
Cotrimoxazole is the fixed dose combination of
trimethoprim and sulfamethoxazole.
Optimum synergic effect seen at concentration ratio
20 : 1 (Sulphamethoxazole : Trimethoprim)
Used in UTI infections,Bronchitis,Typhoid fever…
Adverse effects are Skin rashes,GIT disturbances
Cotrimoxazole
36. Individually both sulfonamide & Trimethoprim are
bacteriostatic.But the combination become bactericidal
against many organisms.
37. Quinolones
1st quinolone nalidixic acid is a urinary antiseptic.
Fluoroquinolones are fluorinated analogoues of
nalidixic acid.
Classification :
1st generation fluoroquinolones – Ciprofloxacin,ofloxacin
2nd generation fluoroquinolones – Levofloxacin , moxifloxacin
Mechanism of action
They inhibit bacterial DNA synthesis – bactericidal.
They inhibit DNA gyrase thus blocking DNA replication
in gram negative bacteria.
38. Uses
Ofloxacin used in TB,leprosy
Moxifloxacin & levofloxacin are used in community
acquired pneumonia
UTI
Bacterial diarrhoea
Ciprofloxacin is the preffered drug for treatment
of typhoid fever
Chancroid
Adverse effects
Nausea,vomiting
Headache,insomnia,convulsions
Hypersensitivity reactions
39. Macrolids
Antibiotics having macrocyclic lactone ring with
attached sugers.
Erythromycin is the 1st member discovered.
Safer to use in pregnancy.
Mechanism of action
They are bacteriostatic at low and cidal at high
concentrations.
They inhibit protein synthesis by binding with 50S
subunit of ribosome.
Activity enhanced in alkaline medium.
40. Dose
Erithromycin : 250-500mg – oral – q.i.d
Clarithromycin (CLARIBID): 250 mg – b.d
Azithromycin(AZITHRAL) : 500mg - o.d
Uses
Alternative to penicillin to treat orodental infections.
Prophylaxis of dental infections –gingivitis, peridontitis…
Drug of choice in : pneumonial infections, chlamydal
Infections,diphtheria,pertussis…
42. Aminoglycosides
They have amino groups linked glycosidically to 2 or
more aminosugar residues.
Classification :
1)Systemic – Streptomycin,gentamycin,amikacin
2)Topical – Neomycin,framycetin.
Mechanism of action
They inhibit protein synthesis –bactericidal.
Streptomycin binds to 30S ribosomes but other
aminoglycosides bind to additional sites on 50S
subunit,as well as to 30S-50S interface.
43. Uses
Streptomycin is a 1st line drug in TB.
Gentamycin used in aerobic gram negative bacillary
infections.
Neomycin used only for local effect.
Adverse effects
Ototoxicity
Nephrotoxicity
Hypersensitivity reactions
Neuromuscular blocking effect
45. Conclusion
Antibiotics exert their action by various methodes
which include ; inhibition of cell wall synthesis,Inhibit
protein synthesis…
AMAs used in combinations to obtain better results.
Selection of drug,dose,freequency of taking are all
affect the net result.
GIT problems,hypersensutuvity,toxicity are most
frequently encountered adverse effects.
Accuarate drug choice is important for better
treatment and prognosis.
46. Reference
1) Essentials of medical pharmacology : 7th edition , by
K.D.TRIPATHI
2) Pharmacology for dentistry : 3rd edition ;by Tara V
Shanbhag,Smita Shenoy,Veena Nayak