Chemotherapeutic drugs work by disrupting cells through various mechanisms like interfering with membranes, DNA, RNA, or essential nutrients. There are several classes of chemotherapeutic drugs including antimicrobials against bacteria, viruses, fungi and parasites. Antibiotics can be further classified based on their mechanism of action such as cell wall inhibitors like penicillins and cephalosporins, or protein synthesis inhibitors like tetracyclines. Other classes of antibiotics include aminoglycosides, macrolides and fluoroquinolones. Drugs used to treat tuberculosis also work through multi-drug combinations over long periods. Care must be taken with antibiotic use and sensitivity testing done to minimize resistance and side effects.
this slides includes overview of antimicrobial drugs, their classifications, antimicrobial resistance, adverse effects and toxicity, choice of antimicrobial drugs and its uses
this slides includes overview of antimicrobial drugs, their classifications, antimicrobial resistance, adverse effects and toxicity, choice of antimicrobial drugs and its uses
antibiotics are necessary to treat infections and chemotherapeutic agents are also used for this purpose. Chemotherapeutic agents are also used in the treatment of cancers. These therapeutic agents have limitations, specific action and a set mode of action. We can say that they are selective. The antibiotics are natural as well as synthetic in nature and have specificity for action against the microorganisms. Chemotherapeutic agents are chemical in nature and are synthesised in labs. They are less selective in action.
Microbiology is the study of microorganisms.
The overall theme of the Microbiology course is to study the relationship between microbes and our lives.
Microorganisms (microbes) are organisms that are too small to be seen with the unaided eye, and usually require a microscope to be seen.
This relationship involves harmful effects such as diseases and food spoilage as well as many beneficial effects.
Chemotherapy is a type of cancer treatment that uses one or more anti-cancer drugs as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent, or it may aim to prolong life or to reduce symptom
antibiotics are necessary to treat infections and chemotherapeutic agents are also used for this purpose. Chemotherapeutic agents are also used in the treatment of cancers. These therapeutic agents have limitations, specific action and a set mode of action. We can say that they are selective. The antibiotics are natural as well as synthetic in nature and have specificity for action against the microorganisms. Chemotherapeutic agents are chemical in nature and are synthesised in labs. They are less selective in action.
Microbiology is the study of microorganisms.
The overall theme of the Microbiology course is to study the relationship between microbes and our lives.
Microorganisms (microbes) are organisms that are too small to be seen with the unaided eye, and usually require a microscope to be seen.
This relationship involves harmful effects such as diseases and food spoilage as well as many beneficial effects.
Chemotherapy is a type of cancer treatment that uses one or more anti-cancer drugs as part of a standardized chemotherapy regimen. Chemotherapy may be given with a curative intent, or it may aim to prolong life or to reduce symptom
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Honest Reviews of Tim Han LMA Course Program.pptxtimhan337
Personal development courses are widely available today, with each one promising life-changing outcomes. Tim Han’s Life Mastery Achievers (LMA) Course has drawn a lot of interest. In addition to offering my frank assessment of Success Insider’s LMA Course, this piece examines the course’s effects via a variety of Tim Han LMA course reviews and Success Insider comments.
2024.06.01 Introducing a competency framework for languag learning materials ...Sandy Millin
http://sandymillin.wordpress.com/iateflwebinar2024
Published classroom materials form the basis of syllabuses, drive teacher professional development, and have a potentially huge influence on learners, teachers and education systems. All teachers also create their own materials, whether a few sentences on a blackboard, a highly-structured fully-realised online course, or anything in between. Despite this, the knowledge and skills needed to create effective language learning materials are rarely part of teacher training, and are mostly learnt by trial and error.
Knowledge and skills frameworks, generally called competency frameworks, for ELT teachers, trainers and managers have existed for a few years now. However, until I created one for my MA dissertation, there wasn’t one drawing together what we need to know and do to be able to effectively produce language learning materials.
This webinar will introduce you to my framework, highlighting the key competencies I identified from my research. It will also show how anybody involved in language teaching (any language, not just English!), teacher training, managing schools or developing language learning materials can benefit from using the framework.
Francesca Gottschalk - How can education support child empowerment.pptxEduSkills OECD
Francesca Gottschalk from the OECD’s Centre for Educational Research and Innovation presents at the Ask an Expert Webinar: How can education support child empowerment?
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
The French Revolution, which began in 1789, was a period of radical social and political upheaval in France. It marked the decline of absolute monarchies, the rise of secular and democratic republics, and the eventual rise of Napoleon Bonaparte. This revolutionary period is crucial in understanding the transition from feudalism to modernity in Europe.
For more information, visit-www.vavaclasses.com
Palestine last event orientationfvgnh .pptxRaedMohamed3
An EFL lesson about the current events in Palestine. It is intended to be for intermediate students who wish to increase their listening skills through a short lesson in power point.
Biological screening of herbal drugs: Introduction and Need for
Phyto-Pharmacological Screening, New Strategies for evaluating
Natural Products, In vitro evaluation techniques for Antioxidants, Antimicrobial and Anticancer drugs. In vivo evaluation techniques
for Anti-inflammatory, Antiulcer, Anticancer, Wound healing, Antidiabetic, Hepatoprotective, Cardio protective, Diuretics and
Antifertility, Toxicity studies as per OECD guidelines
1. Chemotherapeutic Drugs
Chemotherapy is the term originally used to describe the use of drugs that are 'selectively toxic' to invading micro-
organisms while having minimal effects on the host. The term also embraces the use of drugs that target tumors.
Mechanism of action of chemotherapeutic drugs
Chemotherapeutic drugs can affect cells by disrupting the cell membrane, interfering with DNA synthesis, altering RNA,
or blocking the use of essential nutrients.
2. Chemotherapy includes:
1. Antimicrobial agents: e.g. antibacterial (antibiotics), antiviral and antifungal.
2. Antiparasitic agents: antihelminthic and antiprotozoal.
3. Anticancer chemotherapy.
Antibiotics
bactericidal: substance that causes the death of bacteria.
bacteriostatic: substance that prevents the replication of bacteria.
spectrum: range of bacteria against which an antibiotic is effective (e.g., broad-spectrum antibiotics are effective against a
wide range of bacteria).
3. Classification of antibiotics
Antibiotics can be classified according to the mechanism of action into cell wall inhibitors,
inhibitors of protein synthesis, Quinolones, folic acid inhibitors and antimycobacterium.
Cell Wall Inhibitors
Cell wall inhibitors are antimicrobial drugs selectively interfere with synthesis of the bacterial
cell wall.
I. Penicillins:
Classification:
•Penicillin G (benzylpenicillin): Spectrum: gram-positive and gram-negative cocci, gram-
positive bacilli, and spirochetes.
•Penicillin V: has a spectrum similar to that of penicillin G and is more acid-stable than
penicillin G.
•Antistaphylococcalpenicillins: Methicillin,nafcillin,oxacillin and dicloxacillin are
penicillinase-resistant penicillins.
4. •Extended-spectrum penicillins: Ampicillin and amoxicillin have an
antibacterial spectrum similar to that of penicillin G.
•Antipseudomonalpenicillins:Carbenicillin,ticarcillin, and piperacillin are
called antipseudomonalpenicillins because of their activity against P.
aeruginosa.
Clinical uses :
• Bacterial meningitis (e.g. caused by Neisseria meningitidis,
Streptococcus pneumoniae): benzylpenicillin.
•Bone and joint infections (e.g. with Staphylococcus aureus): flucloxacillin.
5. Skin and soft tissue infections (e.g. with Strep. pyogenes or Staph. aureus): benzylpenicillin, flucloxacillin.
Pharyngitis (from Strep. pyogenes): phenoxylmethylpenicillin.
Otitis media (organisms commonly include Strep. pyogenes, Haemophilusinfluenzae): amoxicillin.
Bronchitis (mixed infections common): amoxicillin.
Pneumonia: amoxicillin.
Urinary tract infections (e.g. with Escherichia coli): amoxicillin.
Gonorrhea: amoxicillin.
Syphilis: procaine benzylpenicillin.
Endocarditis (e.g. with Strep. viridans or Enterococcus faecalis).
Adverse effects
Hypersensitivity, Diarrhea, Nephritis, Neurotoxicity.
Hematologic toxicities: Decreased coagulation may be observed with the antipseudomonal and, to some extent,
with penicillin G. Additional toxicities include eosinophilia.
6. II.Cephalosporins
Are β-lactam antibiotics that are closely related both structurally and functionally to the penicillins.
Clinical uses :
Septicaemia.
Pneumonia caused by susceptible organisms.
Meningitis.
Biliary tract infection.
Urinary tract infection.
Sinusitis.
Adverse effects
- Hypersensitivity reactions, very similar to those seen with penicillin.
- Nephrotoxicity, and diarrhea.
7. Antimicrobial agents that interfere
with the synthesis or action of folate
I. Sulfonamides
The action of a sulfonamide is to inhibit growth of the bacteria, not to kill them; that is to say, it is bacteriostatic rather than
bactericidal.
Clinical uses of sulfonamides
Combined with trimethoprim (co-trimoxazole) for Pneumocystis carinii.
Combined with pyrimethamine for drug-resistant malaria and for toxoplasmosis.
In inflammatory bowel disease: sulfasalazine (sulfapyridine-aminosalicylate combination) is used.
For infected burns (silver sulfadiazine).
For some sexually transmitted infections (e.g. trachoma).
For respiratory infections.
For acute urinary tract infection.
Typhoid fever.
8. Side effects:
- Mild to moderate side effects include nausea and vomiting, headache and mental depression. Cyanosis caused by
methaemoglobinaemia may occur.
- Serious adverse effects necessitating cessation of therapy include hepatitis, hypersensitivity reactions (rashes,
fever, anaphylactoid reactions), bone marrow depression and crystalluria. This last effect results from the
precipitation of acetylated metabolites in the urine.
9. II.Trimethoprim.
Trimethoprim is active against most common bacterial pathogens, and it is bacteriostatic too. It is sometimes
given as a mixture with sulfamethoxazole in a combination called co-trimoxazole.
Side effects
- Nausea, vomiting, blood disorders and skin rashes.
- Folate deficiency, with resultant megaloblasticanaemia.
10. Antimicrobial agents affecting bacterial protein synthesis
I.Tetracyclines
- Tetracyclines are broad-spectrum antibiotics against Gram-positive and Gram-negative bacteria, Mycoplasma,
Rickettsia, Chlamydia spp., spirochaetes and some protozoa (e.g. amoebae).
- Examples: tetracycline, doxycycline and minocycline.
Clinical uses:
Rickettsial and chlamydial infections, brucellosis, anthrax, mycoplasma and leptospira, mixed respiratory tract infections ,
chronic bronchitis and acne.
11. Adverse effects:
- Gastrointestinal caused initially by direct irritation and later by modification of the gut flora.
- Yellow discoloration of teeth in children.
- They should not be given to children, pregnant women or nursing mothers.
- Hepatotoxicity.
- Phototoxicity (sensitization to sunlight).
- High doses of tetracyclines may result in renal damage and disturbances of the bone marrow.
12. II. Chloramphenicol
Antibacterial spectrum
Chloramphenicol has a wide spectrum of antimicrobial activity, including Gram-negative and Gram-positive
organisms and rickettsiae. It is bacteriostatic for most organisms but kills H. influenzae.
Therapeutic uses:
Infections caused by Haemophilus influenzae resistant to other drugs.
Meningitis in patients in whom penicillin cannot be used.
It is also safe and effective in bacterial conjunctivitis (given topically).
It is effective in typhoid fever.
13. Adverse effects:
Depression of the bone marrow.
Chloramphenicol should also be used with great care in newborns, it can result in the 'grey baby syndrome'-
vomiting, diarrhoea, flaccidity, low temperature and an ashen-grey colour-which carries 40% mortality.
Hypersensitivity reactions
Gastrointestinal disturbances secondary to alteration of the intestinal microbial flora.
14. III.Aminoglycosides
The main agents are gentamicin, streptomycin, amikacin, tobramycin and neomycin.
Antibacterial spectrum
The aminoglycosides are effective against many aerobic Gram-negative and some Gram-positive organisms they are most
widely used against Gram-negative enteric organisms and in sepsis.
Adverse effects:
Ototoxicity and nephrotoxicity .
A rare but serious toxic reaction is paralysis caused by neuromuscular blockade.
15. IV.Macrolides
Examples: Azithromycin,erythromycin and Clarithromycin
Spectrum: Narrow spectrum (like penicillin G).
Therapeutic uses:
Replace penicillin in case of penicillin allergy.
Syphilis and gonorrhoeae.
Toxoplasmosis and chlamydial infection in pregnancy.
Adverse effects:
GIT disturbances.
Hepatotoxicity.
16. FLUOROQUINOLONES
The fluoroquinolones include the broad-spectrum agents ciprofloxacin, levofloxacin, ofloxacin, norfloxacin and moxifloxacin, as
well as a narrow-spectrum drug used in urinary tract infections-nalidixic acid.
Mechanism of action: Bactericidal through inhibition of nucleic acid synthesis.
Spectrum: Broad spectrum.
Clinical uses:
Complicated urinary tract infections.
Respiratory infections in patients with cystic fibrosis.
Invasive external otitis ('malignant otitis') caused by P.aeruginosa.
Chronic Gram-negative bacillary osteomyelitis.
Eradication of Salmonella typhi in carriers.
Gonorrhea
Bacterial prostatitis
Cervicitis Anthrax .
17. Adverse effects
- Gastrointestinal disorders and skin rashes.
- Arthropathy has been reported in young individuals.
- Central nervous system symptoms-headache and dizziness-have occurred, convulsions associated with central
nervous system pathology or concurrent use of theophylline or a non-steroidal anti-inflammatory drug.
Contraindications:
- There is a clinically important interaction between ciprofloxacin and theophylline may lead to theophylline
toxicity in asthmatics treated with the fluoroquinolones.
- Not used in pregnancy, lactation and children less than 18 years.
18. Drugs used to treat T.B. (Tuberculosis)
- First-line drugs: isoniazid, rifampicin, rifabutin,, ethambutol and pyrazinamide.
- Some second-line drugs available are: capreomycin, cycloserine, streptomycin (rarely used now in the
UK), clarithromycin, and ciprofloxacin.
- These are used to treat infections likely to be resistant to first-line drugs, or when the first-line agents
have to be abandoned because of adverse reactions.
- Treatment begins by using three drugs of the first line for 3 months, then two antituberculous drugs for
6 months (may reach up to 1-5 years).
19. Precautions during antibiotic therapy:
1. Sensitivity test should be done before each injection of pencillin.
2. If there is drug allergy, treat it with H1 blockers (antihistaminic), cortisone IV and adrenaline IM.
3. Oral penicillins must be given 1 hour before or after meals.
4. Don’t give cephalosporine to penicillin sensitive patients.
5. Culture and sensitivity test is an accurate guide for successful treatment.
6. Don’t give tetracycline during pregnancy, lactation and in early years of life.
7. Don’t give sulphonamide during 1st months of life.
8. Kidney function tests should be done during aminoglycosides treatment to avoid nephrotoxicity.
9. Total and deferential leucocytic count is important during chloramphenicol therapy to avoid bone marrow depression.
10. Highly nutritious diet is important during treatment of T.B.
20. Antiviral Drugs
Viruses are small (usually in the range 20-30 nm) infective agents that are incapable of reproduction outside their host
cells. Viruses are generally characterized either as DNA or RNA viruses depending on the nature of their nucleic acid
content.
Antiviral drugs
I.Nucleoside reverse transcriptase inhibitors
Example: Zidovudine, lamivudine
Therapeutic uses:
Treatment of reterovirus infection, mainly HIV.
Adverse effects
- Gastrointestinal disturbances including nausea, vomiting, abdominal pain and diarrhea.
- Central nervous system and related effects including headache, insomnia and dizziness, and neuropathy,
musculoskeletal and dermatological effects including fatigue, myalgia, arthralgia, rash, urticaria and fever.
- Blood disorders including anemia, neutropenia and thrombocytopenia metabolic effects.
21. II. Non-nucleoside reverse transcriptase inhibitors
nevirapine and efavirenz.
Therapeutic uses
Treatment of HIV, generally in combination.
Adverse effects
- Dermatological effects including rash and urticaria.
- Central nervous system and related effects including fatigue, headache, sleep disturbances, depression and
dizziness.
- Gastrointestinal disturbances including nausea, vomiting, abdominal pain and diarrhea.
- Blood disorders including anemia, neutropenia and thrombocytopenia.
- Metabolic effects including pancreatitis, raised cholesterol, liver dysfunction and lipodystrophy.
22. III.Protease inhibitors
Protease inhibitors: amprenavir, atazanavir, indinavir, lopinavir, nelfinavir, ritonavir, saquinavir.
Therapeutic uses
Treatment of HIV, generally and other retrovirals.
IV.DNA polymerase inhibitors: aciclovir ,cidofovir, famciclovir, foscarnet ,ganciclovir, idoxuridine, penciclovir.
Therapeutic uses :
Treatment:
Herpes (genital herpes, mucocutaneous herpes and herpes encephalitis), cytomegalovirus,Varicella zoster infections
(chickenpox, shingles), or hepatitis C and respiratory syncitial virus infections.
Prophylactically:
Patients who are to be treated with immunosuppressant drugs or radiotherapy and who are at risk of herpesvirus infection owing
to reactivation of a latent virus.
Individuals who suffer from frequent recurrences of genital infection with herpes simplex virus.
23. Adverse effects
Acyclovir: minimal local inflammation can occur during intravenous injection if there is extravasation of the
solution. Renal dysfunction, nausea and headache can occur and, rarely, encephalopathy .
Ganciclovir: has serious side actions, including bone marrow depression and potential carcinogenicity, and is
consequently used only for life- or sight-threatening cytomegalovirus infections in patients who are
immunocompromised. Oral administration can be used for maintenance therapy in AIDS patients.
24. V.Inhibitors of HIV fusion with host cells: enfurvitide
Therapeutic uses
Treatment of HIV and other retrovirals.
VI.Inhibitors of viral coat disassembly and neuraminidase inhibitors: amantadine, oseltamivir, zanamivir,
Influenza A or A and B.
VII. Immunomodulators: interferon-α
Therapeutic uses
Treatment of he`patitis B and C, herpes and respiratory syncitial virus.
25. Antifungal Drugs
Amphotericin B, ketoconazole, fluconazole and terbinafine are systemic antifungal drugs
used for treatment of local and systemic fungal infections and for prophylaxis of fungal
infection during immunosuppression. All systemic antifungal drugs are contraindicated
in liver diseases.
26. Antiparasitic Agents
Anthelminthic drugs
The substituted benzimidazoles.
This group of broad-spectrum agents includes mebendazole, tiabendazole and albendazole.
It is generally given as a single dose for threadworm, and twice daily for 3 days for hookworm
and roundworm infestations.
Spectrum: Ascaris, Ancylostoma, Enterobius.
Side effects: are few with albendazole, or mebendazole,, although gastrointestinal
disturbances can occasionally occur.
28. Antiprotozoal drugs
Amoebiasis
Amoebiasis is caused by infection with Entamoebahistolytica, which causes dysentery and liver abscesses. The
organism may be present in motile invasive form or as a cyst. The main drugs are as follow:
Metronidazole
Given orally.Active against the invasive form in gut and liver but not the cysts.
Side effects: The drug has a metallic, bitter taste in the mouth gastrointestinal disturbances, central nervous system
(CNS) symptoms (dizziness, headache, sensory neuropathies). Metronidazole, should not be used in pregnancy.
Uses:
- Amebiasis.
- Giardiasis.
- Trichmonas vaginalis.
29. Diloxanide is given orally with no serious side effects. It is active, while
unabsorbed, against the non-invasive form in the gastrointestinal tract.
Hepatic amebiasis: Metronidazole + chloroquine.
Cystic amebiasis: Diloxanide furate.