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ANTI PROTOZOAL DRUGS
By
Dr. Nidhi Gupta
MM College of Pharmacy
MM (Deemed to be University), Mullana,
Ambala
ANTI AMOEBIC DRUGS
TISSUE AMOEBICIDES:
I. Both intestinal &
extraintestinal
Alkaloid:
• Emetine,
Nitroimidazole
• Metronidazole
• Tinidazole
dehydroemetine
II. Extraintestinal only :
Chloroquine
• Orindazole
Cont...
III. LUMINALAMOEBICIDES:
• Amide : Diloxanide Furate
• 8-hydroxyquinolines: Quinidochlor,
Iodoquinol.
• Antibiotics : Tetracyclines
METRONIDAZOLE
• Metronidazole – prototype of
Nitroimidazole (1959)
• First introduced for trichomoniasis.
• Higher Amoebicidal activity and Anti
Anerobic Activity (Bacteriocidal activity)
• Antiamoebic drugs : these are the drug
which are active against the protozoan
infection especially Entamoeba histalytica .
ANAEROBIC ORGANISM
METRONIDAZOLE
(PRODRUG)
NITRO GROUP REDUCTION BY
NITRO REDUCTASE ENZYME IN ANAEROBES
INHIBITS AMOEBIC DNA SYNTHESIS
AMOEBICIDAL EFFECT
ACTIVE METABOLITE(CYTOTOXIC)
Adverse Effects...
• Metallic taste, anorexia, nausea, and
abdominal cramps, dryness of mouth,
seizures .
MEDICAL USES –
• Amoebiasis
• Giardiasis
• Trichomoniasis
• Anaerobic infections : oral infections, post
operative infection.
• Helicobacter pylori

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Anti Protozoal final.pptx

  • 1. ANTI PROTOZOAL DRUGS By Dr. Nidhi Gupta MM College of Pharmacy MM (Deemed to be University), Mullana, Ambala
  • 2. ANTI AMOEBIC DRUGS TISSUE AMOEBICIDES: I. Both intestinal & extraintestinal Alkaloid: • Emetine, Nitroimidazole • Metronidazole • Tinidazole dehydroemetine II. Extraintestinal only : Chloroquine • Orindazole
  • 3. Cont... III. LUMINALAMOEBICIDES: • Amide : Diloxanide Furate • 8-hydroxyquinolines: Quinidochlor, Iodoquinol. • Antibiotics : Tetracyclines
  • 4.
  • 5.
  • 6. METRONIDAZOLE • Metronidazole – prototype of Nitroimidazole (1959) • First introduced for trichomoniasis. • Higher Amoebicidal activity and Anti Anerobic Activity (Bacteriocidal activity) • Antiamoebic drugs : these are the drug which are active against the protozoan infection especially Entamoeba histalytica .
  • 7. ANAEROBIC ORGANISM METRONIDAZOLE (PRODRUG) NITRO GROUP REDUCTION BY NITRO REDUCTASE ENZYME IN ANAEROBES INHIBITS AMOEBIC DNA SYNTHESIS AMOEBICIDAL EFFECT ACTIVE METABOLITE(CYTOTOXIC)
  • 8. Adverse Effects... • Metallic taste, anorexia, nausea, and abdominal cramps, dryness of mouth, seizures .
  • 9. MEDICAL USES – • Amoebiasis • Giardiasis • Trichomoniasis • Anaerobic infections : oral infections, post operative infection. • Helicobacter pylori