This document summarizes several anthelmintic drugs used to treat parasitic worm infections. It describes the mechanism of action, pharmacokinetics, indications, side effects, and cautions for albendazole, diethylcarbamazine, ivermectin, mebendazole, piperazine, pyrantel pamoate, thiabendazole, bithionol, and praziquantel.
Ms. Mandakini Sampat Holkar provides an overview of anthelmintic drugs used to treat helminth infections. Helminths are parasitic worms that infect humans. Anthelmintics work by stunning or killing helminths and include benzimidazoles like albendazole and mebendazole, piperazines like diethylcarbamazine, and others such as ivermectin, praziquantel, and pyrantel. The document then describes the mechanisms of action of several anthelmintics, including how they disrupt helminth cell membranes, nerve function, or other key processes to paralyze or kill the parasites.
This document discusses demulcents and expectorants used to treat cough. Demulcents soothe irritated throat tissues to provide relief from dry coughs. Expectorants are thought to increase or thin bronchial secretions to facilitate coughing them up. The document classifies and describes various demulcents like lozenges and cough drops. It also discusses expectorant types including those that enhance bronchial secretions like potassium citrate and those that are mucolytics like bromhexine. It then covers antitussive drug classes including opioids like codeine, non-opioids like noscapine, and various antitussive combinations and their uses, mechanisms, dosages, and side effects.
Antiprotozoal drugs are a class of medication used to treat infections caused by protozoa, which are single-cell organisms that belong to the type of parasites. Protozoal infections occur throughout the world and are a major cause of morbidity and mortality in some regions such as Africa and South-East Asia.
This document provides information on various gentamicin injection products available in Pakistan made by different pharmaceutical companies. It discusses gentamicin's mechanism of action as an aminoglycoside antibiotic that inhibits protein synthesis in bacteria. It also provides dosing, administration, contraindications and precautions for gentamicin treatment. The document then shifts to discussing cloxacillin products in Pakistan and information about cloxacillin as a penicillinase-resistant penicillin antibiotic.
TO STUDY THE RECALLED DRUG RANITIDINE HYDROCHLORIDES IN DIFFERENT FORMULATIONS. Shantanu Kumar Singh
The document discusses Ranitidine Hydrochloride, a commonly used drug classified as a histamine H2-receptor antagonist. It provides details on Taj Pharmaceuticals, an Indian company that manufactures and distributes Ranitidine in various formulations. The document covers the mechanism of action, indications, contraindications, pharmacokinetics and other clinical information about Ranitidine.
This document summarizes a lecture on anthelminthic and anti-protozoal drugs. It discusses how these drugs work, how they are classified based on the organisms they target, and provides examples of specific drugs. Key drugs discussed are albendazole and metronidazole. Albendazole works by paralyzing helminths through binding to microtubule proteins. Metronidazole kills protozoa by interfering with their energy production. Both drugs are generally well tolerated though can cause gastrointestinal side effects.
This document discusses mucolytic drugs, which are used to thin mucus in the respiratory tract. It classifies common mucolytics - bromhexine, ambroxol, and acetylcysteine. It describes their mechanisms of action, dosages, and nursing responsibilities when administering them. Mucolytics work by breaking down mucus polymers to decrease viscosity and make mucus easier to cough up or suction out of the airways. Nurses should prepare for suctioning, encourage fluid intake, and maintain patients' airways when using mucolytics to treat respiratory disorders associated with excessive mucus production.
COMT is an enzyme that breaks down catecholamines like dopamine and norepinephrine. It is produced in the brain and liver. COMT inhibitors prevent the breakdown of levodopa, increasing its availability to treat Parkinson's disease. Common COMT inhibitors include entacapone, opicapone, and tolcapone. COMT inhibitors reduce "off time" for Parkinson's patients but can cause side effects like nausea, low blood pressure, and liver damage with tolcapone.
Ms. Mandakini Sampat Holkar provides an overview of anthelmintic drugs used to treat helminth infections. Helminths are parasitic worms that infect humans. Anthelmintics work by stunning or killing helminths and include benzimidazoles like albendazole and mebendazole, piperazines like diethylcarbamazine, and others such as ivermectin, praziquantel, and pyrantel. The document then describes the mechanisms of action of several anthelmintics, including how they disrupt helminth cell membranes, nerve function, or other key processes to paralyze or kill the parasites.
This document discusses demulcents and expectorants used to treat cough. Demulcents soothe irritated throat tissues to provide relief from dry coughs. Expectorants are thought to increase or thin bronchial secretions to facilitate coughing them up. The document classifies and describes various demulcents like lozenges and cough drops. It also discusses expectorant types including those that enhance bronchial secretions like potassium citrate and those that are mucolytics like bromhexine. It then covers antitussive drug classes including opioids like codeine, non-opioids like noscapine, and various antitussive combinations and their uses, mechanisms, dosages, and side effects.
Antiprotozoal drugs are a class of medication used to treat infections caused by protozoa, which are single-cell organisms that belong to the type of parasites. Protozoal infections occur throughout the world and are a major cause of morbidity and mortality in some regions such as Africa and South-East Asia.
This document provides information on various gentamicin injection products available in Pakistan made by different pharmaceutical companies. It discusses gentamicin's mechanism of action as an aminoglycoside antibiotic that inhibits protein synthesis in bacteria. It also provides dosing, administration, contraindications and precautions for gentamicin treatment. The document then shifts to discussing cloxacillin products in Pakistan and information about cloxacillin as a penicillinase-resistant penicillin antibiotic.
TO STUDY THE RECALLED DRUG RANITIDINE HYDROCHLORIDES IN DIFFERENT FORMULATIONS. Shantanu Kumar Singh
The document discusses Ranitidine Hydrochloride, a commonly used drug classified as a histamine H2-receptor antagonist. It provides details on Taj Pharmaceuticals, an Indian company that manufactures and distributes Ranitidine in various formulations. The document covers the mechanism of action, indications, contraindications, pharmacokinetics and other clinical information about Ranitidine.
This document summarizes a lecture on anthelminthic and anti-protozoal drugs. It discusses how these drugs work, how they are classified based on the organisms they target, and provides examples of specific drugs. Key drugs discussed are albendazole and metronidazole. Albendazole works by paralyzing helminths through binding to microtubule proteins. Metronidazole kills protozoa by interfering with their energy production. Both drugs are generally well tolerated though can cause gastrointestinal side effects.
This document discusses mucolytic drugs, which are used to thin mucus in the respiratory tract. It classifies common mucolytics - bromhexine, ambroxol, and acetylcysteine. It describes their mechanisms of action, dosages, and nursing responsibilities when administering them. Mucolytics work by breaking down mucus polymers to decrease viscosity and make mucus easier to cough up or suction out of the airways. Nurses should prepare for suctioning, encourage fluid intake, and maintain patients' airways when using mucolytics to treat respiratory disorders associated with excessive mucus production.
COMT is an enzyme that breaks down catecholamines like dopamine and norepinephrine. It is produced in the brain and liver. COMT inhibitors prevent the breakdown of levodopa, increasing its availability to treat Parkinson's disease. Common COMT inhibitors include entacapone, opicapone, and tolcapone. COMT inhibitors reduce "off time" for Parkinson's patients but can cause side effects like nausea, low blood pressure, and liver damage with tolcapone.
This document discusses emetics, which induce vomiting, and antiemetics, which prevent vomiting. It describes the physiology of vomiting including the vomiting center and chemoreceptor trigger zone in the brain. It explains the mechanisms and sites of action of various classes of antiemetic drugs including antihistamines, 5-HT3 receptor antagonists, dopamine antagonists, cannabinoids, glucocorticoids, and others. It provides details on specific antiemetic drugs like metoclopramide, ondansetron, dexamethasone, and their indications, mechanisms, pharmacokinetics and adverse effects.
Tuberculosis is caused by Mycobacterium tuberculosis and was once incurable but now treatable with anti-tubercular drugs. These drugs are classified as primary/standard or secondary/reserve drugs and include isoniazid, rifampicin, streptomycin, pyrazinamide, ethambutol, para-aminosalicylic acid, thiacetazone, capreomycin, kanamycin, ethionamide, and cycloserine. The primary drugs are bactericidal while the secondary drugs treat multi-drug resistant strains. A standard short-term regimen involves taking isoniazid, rifampicin, ethambutol, and pyrazinamide daily for 2 months
This document discusses anti helminthic drugs used to treat helminth infections. It begins by introducing helminths and the prevalence of helminthiasis globally and in developing countries. It then discusses the classification of helminths and the pharmacological targets of antihelminthic drugs. The document proceeds to describe several classes of antihelminthic drugs in detail, including their mechanisms of action, adverse effects, contraindications, and uses for treating specific helminth infections. Key drugs discussed include mebendazole, albendazole, pyrantel pamoate, diethylcarbamazine, ivermectin, and praziquantel. In the end, the document
Broad Spectrum Antibiotic:Tetracycline,four cyclic rings,Physicochemical Properties,Classification-According to source and Based on Duration of action ,Mechanism of action-30S ribosomes ,Inhibit protein synthesis,Antimicrobial spectrum
Resistance
Adverse effects
Precautions,Uses by snehal chakorkar
This document classifies and describes various anticancer drugs, including cytotoxic drugs like alkylating agents, platinum coordination drugs like cisplatin, antimetabolites, microtubule damaging agents like vincristine and vinblastine, topoisomerase inhibitors, antibiotics, targeted drugs, hormonal drugs, and miscellaneous drugs. It provides details on the mechanisms of action, uses, doses, and common side effects of representative drugs from each class, such as how cisplatin causes DNA cross-linking, how vinca alkaloids inhibit microtubule assembly, and how paclitaxel and docetaxel inhibit beta-tubulin.
1) Aminoglycosides are polybasic amino groups linked glycosidically to aminosugar compounds. They are highly water soluble and excreted unchanged in urine.
2) They are bactericidal, inhibiting protein synthesis by binding to the 30S/50S interface of bacterial ribosomes. This causes misreading of mRNA and nonfunctional protein formation.
3) Common adverse effects include ototoxicity (hearing loss) and nephrotoxicity. Individual drugs vary in their specific toxicities.
This document provides information on various anthelmintic drugs used to treat helminth infections. It discusses the classification, mechanisms of action, pharmacokinetics, efficacy, and side effects of common anthelmintics including mebendazole, albendazole, thiabendazole, pyrantel pamoate, piperazine, diethyl carbamazine citrate, and ivermectin. The document aims to educate on the treatment of helminth infections through different anthelmintic drug options.
Levofloxacin is the isolated levo isomer of ofloxacin, which allows for once daily dosing. It has superior efficacy to other fluoroquinolones like ofloxacin and ciprofloxacin. Levofloxacin achieves high concentrations in tissues and body fluids, making it effective against common pathogens causing respiratory, urinary, skin and soft tissue infections. It demonstrates rapid bactericidal activity and lower resistance development compared to other fluoroquinolones. Guidelines recommend levofloxacin as first-line therapy for various infections.
This document discusses drugs for cough. It begins by describing the mechanism and causes of cough. Cough can be voluntary or reflexive, and has afferent and efferent pathways involving various nerves. Causes include upper respiratory infections, pneumonia, and other conditions. The document then classifies drugs for cough into four main categories: pharyngeal demulcents to soothe the throat; expectorants to increase or thin mucus; antitussives to suppress coughing; and bronchodilators to relieve cough caused by bronchospasm. Specific drugs and combinations are provided as examples for each category. The document concludes by describing specific treatments for cough based on its underlying cause.
Rifampicin is an antibiotic used to treat tuberculosis and other bacterial infections. It works by inhibiting bacterial RNA polymerase. Common forms include capsules, syrup, ointment, and intravenous powder. Rifampicin must be taken regularly as part of a combination drug regimen to prevent drug resistance and is commonly used with isoniazid, ethambutol, pyrazinamide, and streptomycin to treat tuberculosis. Common side effects include nausea, vomiting, headache, and liver dysfunction. Due to interactions with many other drugs, patients should notify their provider of all medications.
This document discusses various anthelmintic drugs used to treat helminth infections. It describes the major classes of helminths that infect humans including nematodes, trematodes, and cestodes. It provides details on common anthelmintic drugs for each class, including their mechanisms of action, indications, dosages, and side effects. Key anthelmintic drugs discussed are mebendazole, albendazole, pyrantel, praziquantel, diethylcarbamazine, and ivermectin.
The document discusses proton pump inhibitors (PPIs), which are drugs that reduce gastric acid production by inhibiting proton pumps in the stomach. It outlines the five main PPI agents, how PPIs work by irreversibly binding to and inactivating the proton pump, and their indications and uses for conditions like peptic ulcers and gastroesophageal reflux disease. Triple therapy combining a PPI with antibiotics is also described as a treatment approach for Helicobacter pylori-associated peptic ulcers.
Antiemetics are drugs that prevent nausea and vomiting. They work by blocking receptors in the vomiting center of the brain such as H1 receptors, muscarinic receptors, dopamine D2 receptors, and 5-HT3 receptors. Common antiemetics include antihistamines like cyclizine for motion sickness, scopolamine for motion sickness, phenothiazines like prochlorperazine for chemotherapy induced vomiting, and 5-HT3 receptor antagonists like ondansetron for chemotherapy and radiation induced vomiting. The document discusses the mechanisms and uses of various classes of antiemetic drugs for conditions like morning sickness, motion sickness, vertigo, and vomiting caused by chemotherapy, radiation, or other illnesses.
The document discusses various drugs that affect the gastrointestinal system, including those used to treat peptic ulcer disease, constipation, diarrhea, and vomiting. It describes factors that increase or decrease acid secretion in the stomach, and drugs that inhibit acid production such as H2 receptor antagonists and proton pump inhibitors. It also discusses treatments for Helicobacter pylori infection, as well as laxatives, antidiarrheal agents, and antiemetic drugs.
Antiprotozoal agents is a class of pharmaceuticals used in treatment of protozoan infection. Protozoans have little in common with each other and so agents effective against one pathogen may not be effective against another
The current presentation include mechanism involved in emesis and pharmacology of different emetics used clinically.
Reference: Essentials of Medical Pharmacology, Sixth Edition, K D Tripathi.
This document discusses drugs that affect the gastrointestinal system. It covers topics including peptic ulcer disease, constipation, diarrhea, vomiting, and digestion. It describes factors that increase or decrease acidity in peptic ulcer disease. It then summarizes different drug classes used to treat peptic ulcers, constipation, diarrhea, vomiting, and digestive issues. These include H2 receptor antagonists, proton pump inhibitors, anticholinergics, prostaglandin analogs, antacids, antibiotics, laxatives, antidiarrheals, antiemetics, and digestion aids.
Fluoroquinolones are a class of broad-spectrum antibacterial agents derived from nalidixic acid. They work by inhibiting bacterial DNA gyrase and topoisomerase IV, blocking DNA synthesis. Resistance can occur via mutations in the quinolone binding region of these target enzymes or changes in bacterial permeability. Fluoroquinolones are classified into generations based on spectrum of activity and are well-absorbed orally with varying tissue distribution and drug interactions. Adverse effects include gastrointestinal, central nervous system, and musculoskeletal issues. Ciprofloxacin and levofloxacin are two commonly used fluoroquinolones with activity against both gram-negative and gram-positive pathogens.
In here I am talking about Amainoglycosides, its classification, mechanism of action, adverse effect, clinical uses of aminoglycoside, Pharmacokinetics..
The document discusses various anthelmintic drugs used to treat helminth infections in animals. It provides details on the mechanisms of action, pharmacokinetics, clinical uses, adverse effects and contraindications of commonly used anthelmintics including albendazole, mebendazole, thiabendazole, pyrantel pamoate, piperazine, niclosamide, diethylcarbamazine, ivermectin, and bithionol. These drugs act by paralyzing or killing intestinal worms and parasites through various mechanisms such as inhibiting microtubule synthesis, interfering with metabolism, or increasing chloride influx in parasites.
This document summarizes various antiparasitic drugs used to treat helminth infections. It discusses the classes of drugs used to treat roundworms, flukes, and tapeworms which include albendazole, mebendazole, praziquantel, diethylcarbamazine, ivermectin, and others. For each drug, it describes the absorption, distribution, metabolism, excretion, mechanisms of action, dosages, efficacy, adverse effects, and other important details. The document provides a comprehensive overview of the available pharmacological options for treating the most common parasitic worm infections.
This document discusses emetics, which induce vomiting, and antiemetics, which prevent vomiting. It describes the physiology of vomiting including the vomiting center and chemoreceptor trigger zone in the brain. It explains the mechanisms and sites of action of various classes of antiemetic drugs including antihistamines, 5-HT3 receptor antagonists, dopamine antagonists, cannabinoids, glucocorticoids, and others. It provides details on specific antiemetic drugs like metoclopramide, ondansetron, dexamethasone, and their indications, mechanisms, pharmacokinetics and adverse effects.
Tuberculosis is caused by Mycobacterium tuberculosis and was once incurable but now treatable with anti-tubercular drugs. These drugs are classified as primary/standard or secondary/reserve drugs and include isoniazid, rifampicin, streptomycin, pyrazinamide, ethambutol, para-aminosalicylic acid, thiacetazone, capreomycin, kanamycin, ethionamide, and cycloserine. The primary drugs are bactericidal while the secondary drugs treat multi-drug resistant strains. A standard short-term regimen involves taking isoniazid, rifampicin, ethambutol, and pyrazinamide daily for 2 months
This document discusses anti helminthic drugs used to treat helminth infections. It begins by introducing helminths and the prevalence of helminthiasis globally and in developing countries. It then discusses the classification of helminths and the pharmacological targets of antihelminthic drugs. The document proceeds to describe several classes of antihelminthic drugs in detail, including their mechanisms of action, adverse effects, contraindications, and uses for treating specific helminth infections. Key drugs discussed include mebendazole, albendazole, pyrantel pamoate, diethylcarbamazine, ivermectin, and praziquantel. In the end, the document
Broad Spectrum Antibiotic:Tetracycline,four cyclic rings,Physicochemical Properties,Classification-According to source and Based on Duration of action ,Mechanism of action-30S ribosomes ,Inhibit protein synthesis,Antimicrobial spectrum
Resistance
Adverse effects
Precautions,Uses by snehal chakorkar
This document classifies and describes various anticancer drugs, including cytotoxic drugs like alkylating agents, platinum coordination drugs like cisplatin, antimetabolites, microtubule damaging agents like vincristine and vinblastine, topoisomerase inhibitors, antibiotics, targeted drugs, hormonal drugs, and miscellaneous drugs. It provides details on the mechanisms of action, uses, doses, and common side effects of representative drugs from each class, such as how cisplatin causes DNA cross-linking, how vinca alkaloids inhibit microtubule assembly, and how paclitaxel and docetaxel inhibit beta-tubulin.
1) Aminoglycosides are polybasic amino groups linked glycosidically to aminosugar compounds. They are highly water soluble and excreted unchanged in urine.
2) They are bactericidal, inhibiting protein synthesis by binding to the 30S/50S interface of bacterial ribosomes. This causes misreading of mRNA and nonfunctional protein formation.
3) Common adverse effects include ototoxicity (hearing loss) and nephrotoxicity. Individual drugs vary in their specific toxicities.
This document provides information on various anthelmintic drugs used to treat helminth infections. It discusses the classification, mechanisms of action, pharmacokinetics, efficacy, and side effects of common anthelmintics including mebendazole, albendazole, thiabendazole, pyrantel pamoate, piperazine, diethyl carbamazine citrate, and ivermectin. The document aims to educate on the treatment of helminth infections through different anthelmintic drug options.
Levofloxacin is the isolated levo isomer of ofloxacin, which allows for once daily dosing. It has superior efficacy to other fluoroquinolones like ofloxacin and ciprofloxacin. Levofloxacin achieves high concentrations in tissues and body fluids, making it effective against common pathogens causing respiratory, urinary, skin and soft tissue infections. It demonstrates rapid bactericidal activity and lower resistance development compared to other fluoroquinolones. Guidelines recommend levofloxacin as first-line therapy for various infections.
This document discusses drugs for cough. It begins by describing the mechanism and causes of cough. Cough can be voluntary or reflexive, and has afferent and efferent pathways involving various nerves. Causes include upper respiratory infections, pneumonia, and other conditions. The document then classifies drugs for cough into four main categories: pharyngeal demulcents to soothe the throat; expectorants to increase or thin mucus; antitussives to suppress coughing; and bronchodilators to relieve cough caused by bronchospasm. Specific drugs and combinations are provided as examples for each category. The document concludes by describing specific treatments for cough based on its underlying cause.
Rifampicin is an antibiotic used to treat tuberculosis and other bacterial infections. It works by inhibiting bacterial RNA polymerase. Common forms include capsules, syrup, ointment, and intravenous powder. Rifampicin must be taken regularly as part of a combination drug regimen to prevent drug resistance and is commonly used with isoniazid, ethambutol, pyrazinamide, and streptomycin to treat tuberculosis. Common side effects include nausea, vomiting, headache, and liver dysfunction. Due to interactions with many other drugs, patients should notify their provider of all medications.
This document discusses various anthelmintic drugs used to treat helminth infections. It describes the major classes of helminths that infect humans including nematodes, trematodes, and cestodes. It provides details on common anthelmintic drugs for each class, including their mechanisms of action, indications, dosages, and side effects. Key anthelmintic drugs discussed are mebendazole, albendazole, pyrantel, praziquantel, diethylcarbamazine, and ivermectin.
The document discusses proton pump inhibitors (PPIs), which are drugs that reduce gastric acid production by inhibiting proton pumps in the stomach. It outlines the five main PPI agents, how PPIs work by irreversibly binding to and inactivating the proton pump, and their indications and uses for conditions like peptic ulcers and gastroesophageal reflux disease. Triple therapy combining a PPI with antibiotics is also described as a treatment approach for Helicobacter pylori-associated peptic ulcers.
Antiemetics are drugs that prevent nausea and vomiting. They work by blocking receptors in the vomiting center of the brain such as H1 receptors, muscarinic receptors, dopamine D2 receptors, and 5-HT3 receptors. Common antiemetics include antihistamines like cyclizine for motion sickness, scopolamine for motion sickness, phenothiazines like prochlorperazine for chemotherapy induced vomiting, and 5-HT3 receptor antagonists like ondansetron for chemotherapy and radiation induced vomiting. The document discusses the mechanisms and uses of various classes of antiemetic drugs for conditions like morning sickness, motion sickness, vertigo, and vomiting caused by chemotherapy, radiation, or other illnesses.
The document discusses various drugs that affect the gastrointestinal system, including those used to treat peptic ulcer disease, constipation, diarrhea, and vomiting. It describes factors that increase or decrease acid secretion in the stomach, and drugs that inhibit acid production such as H2 receptor antagonists and proton pump inhibitors. It also discusses treatments for Helicobacter pylori infection, as well as laxatives, antidiarrheal agents, and antiemetic drugs.
Antiprotozoal agents is a class of pharmaceuticals used in treatment of protozoan infection. Protozoans have little in common with each other and so agents effective against one pathogen may not be effective against another
The current presentation include mechanism involved in emesis and pharmacology of different emetics used clinically.
Reference: Essentials of Medical Pharmacology, Sixth Edition, K D Tripathi.
This document discusses drugs that affect the gastrointestinal system. It covers topics including peptic ulcer disease, constipation, diarrhea, vomiting, and digestion. It describes factors that increase or decrease acidity in peptic ulcer disease. It then summarizes different drug classes used to treat peptic ulcers, constipation, diarrhea, vomiting, and digestive issues. These include H2 receptor antagonists, proton pump inhibitors, anticholinergics, prostaglandin analogs, antacids, antibiotics, laxatives, antidiarrheals, antiemetics, and digestion aids.
Fluoroquinolones are a class of broad-spectrum antibacterial agents derived from nalidixic acid. They work by inhibiting bacterial DNA gyrase and topoisomerase IV, blocking DNA synthesis. Resistance can occur via mutations in the quinolone binding region of these target enzymes or changes in bacterial permeability. Fluoroquinolones are classified into generations based on spectrum of activity and are well-absorbed orally with varying tissue distribution and drug interactions. Adverse effects include gastrointestinal, central nervous system, and musculoskeletal issues. Ciprofloxacin and levofloxacin are two commonly used fluoroquinolones with activity against both gram-negative and gram-positive pathogens.
In here I am talking about Amainoglycosides, its classification, mechanism of action, adverse effect, clinical uses of aminoglycoside, Pharmacokinetics..
The document discusses various anthelmintic drugs used to treat helminth infections in animals. It provides details on the mechanisms of action, pharmacokinetics, clinical uses, adverse effects and contraindications of commonly used anthelmintics including albendazole, mebendazole, thiabendazole, pyrantel pamoate, piperazine, niclosamide, diethylcarbamazine, ivermectin, and bithionol. These drugs act by paralyzing or killing intestinal worms and parasites through various mechanisms such as inhibiting microtubule synthesis, interfering with metabolism, or increasing chloride influx in parasites.
This document summarizes various antiparasitic drugs used to treat helminth infections. It discusses the classes of drugs used to treat roundworms, flukes, and tapeworms which include albendazole, mebendazole, praziquantel, diethylcarbamazine, ivermectin, and others. For each drug, it describes the absorption, distribution, metabolism, excretion, mechanisms of action, dosages, efficacy, adverse effects, and other important details. The document provides a comprehensive overview of the available pharmacological options for treating the most common parasitic worm infections.
Action of anticholinergics on Genito-urinary SystemJasleenrait
It describes the action of Anticholinergics on the genitourinary system. Detailed description of each anticholinergic drug is given .
they can be given in urinary incontinence.
This document discusses anti-helminthic drugs used to treat parasitic worm infections. It defines anti-helminthics as drugs that expel or kill parasitic worms without significantly damaging the host. The document describes common helminth infections, classifies anti-helminthic drugs by mode of action and type of infection treated, and provides details on commonly used drugs including Albendazole, Mebendazole, Levamisole, and Pyrantel pamoate. It explains the mechanisms of action, therapeutic uses, dosages, and adverse effects of these anti-helminthic drugs.
This document provides information on various antihelmintic drugs used to treat helminth infections. It discusses the epidemiology of soil-transmitted helminth infections and mechanisms of action of different classes of antihelmintics. Key drugs discussed include mebendazole, albendazole, ivermectin, praziquantel, diethylcarbamazine, and piperazine. Each drug's indications, mechanisms of action, pharmacokinetics, clinical uses, and adverse effects are summarized.
Ethosuximide is effective against absence seizures by reducing T-type calcium currents in thalamic neurons. It has a narrow clinical use and is preferred over lamotrigine for absence seizures. Common side effects include nausea, vomiting, and abdominal pain.
Valproic acid is effective against absence seizures and generalized tonic-clonic seizures. It acts by blocking sodium channels, facilitating GABA synthesis, and inhibiting GABA degradation. Common side effects are nausea, vomiting, and sedation. Hepatotoxicity and teratogenic effects are important toxicities.
Benzodiazepines like diazepam and lorazepam are highly effective for stopping status epilepticus.
Introduction
Classification of Helminthiasis
Classification of Anthelmintics Drugs
Mebendazole
Albendazole
Pyrentel pamoate
Peperazine
Levamisole
Praziquantel
Niclosamide
Ivermectin
Diethylcarbamazine
Helminthiasis, also known as worm infection, is any macroparasitic disease of humans and other animals in which a part of the body is infected with parasitic worms, known as helminths. There are numerous species of these parasites, which are broadly classified into tapeworms, flukes, and roundworms.
The helminths worms are macroscopic, multicellular organisms having their own digestive, excretory, reproductive and nervous system. The helminths could be nemathelminths (round bodied worms) or platyhelminths (flat bodied worms).
Nematodes (round worms) are long, round bodied segmented worms that are tapered at both ends . In festation occurs if the embryonated eggs or tissues of infested host contain larva of the nematode.
MALARIA
It is an infectious disease of humans caused by parasitis protozoans belonging to the genus plasmodium.
It is endemic in most parts of India and other tropical countries.
As per WHO, malaria causes one death every minute globally and about 40,000 annual deaths in India.
The disease is transmitted by the bite of an infected female Anopheles mosquito.
Four species of protozoa plasmodium can cause malaria which are P. falciparum, P. vivax, P. ovale and P. malariae.
INTRODUCTION
These are the drugs which are used for the treatment, prophylaxis and prevention of relapses of malaria.
The treatment of malaria is available since 17 century. During those times, the bark of Cinchona tree was used in the crude form.
Later in 1820, quinine was isolated from the bark.
Since 1920, quinine and other drugs are commercially available in the market
OBJECTIVES IN USE OF ANTIMALARIAL DRUGS
The various objectives are:
To prevent clinical attack of malaria.
To treat clinical attack of malaria.
To completely eradicate the parasite from the patient’s body.
To cut down human to mosquito transmission.
THERAPEUTIC CLASSIFICATION
1. CAUSAL PROPHYLACTICS: (Destroy parasite in liver cells and prevent invasion of erythrocytes)
e.g. primaquine, pyrimethamine
2.BLOOD SCHIZONTOCIDES SUPPRESIVES (destroy parasites in the RBC and terminate clinical attacks of malaria): e.g. chloroquine, quinine, mefloquine, halofantrine, pyrimethamine
3. TISSUE SCHIZONTOCIDES used to prevent relapse: act vivax and P. ovale that produce replapses. E.g. primaquine
4. GAMETOCIDAL DRUGS: primaquine, chloroquine, quinine.
1. CHLOROQUINE
It acts as erythrocytic schizontocide against all species of plasmodia.
The parasite disappears from peripheral blood in 1-3 days. It control the clinical attacks of malaria within 1-2 days.
It doesn’t have any gametocidal activity.
It is bitter in taste, so patient should be advised ‘not to chew the tablet’ it is used for the treatment of malaria during pregnancy: no teratogenic effects have been reported.
MECHANISM OF ACTION
Its gets concentrated in the infected RBCs and then is actively taken up by the susceptible plasmodia.
The chloroquine binds to the heme and forms chloroquine heme complex.
Complex inhibits the formation of hemozoin and also damages the Plasmodium memberane
PHARMACOKINETICS
It is well absorbed orally.
50% of the drug is plasma protein bound, gets concentrated in liver, spleen, kidneys, lungs, skin and leukocytes.
The plasma half life is 3-10 days, whereas the terminal half life is 1-2 months. On prolonged use, it gets accumulated selectively in the retina and causes ocular toxicity.
It is partially metabolized in liver and slowly excreted in urine.
INDICATIONS ADVERSE EFFECTS
Clinical drug of choice for malaria.
Extraintestinal amoebiasis.
Rheumatoid arthritis
Infectious mononucleosis.
Mil
1. Anthelmintic drugs act by paralyzing, damaging, or interfering with the metabolism of parasitic worms. They are used to treat infections caused by a variety of parasites that can infect the intestines, tissues, or bloodstream.
2. Albendazole and mebendazole are broad-spectrum oral anthelmintics commonly used to treat infections caused by roundworms, hookworms, pinworms, tapeworms, and others. They work by inhibiting microtubule synthesis in parasites.
3. Other anthelmintics include pyrantel pamoate, piperazine, niclosamide, diethylcarbamazine, ivermectin, and bith
This document provides information on the pharmacological management of helminthic infections. It discusses the characteristics of ideal anthelmintic drugs and then describes several individual drugs, including their mechanisms of action, uses, dosages, and side effects. The drugs covered include albendazole, mebendazole, pyrantel, diethylcarbamazine, ivermectin, praziquantel, and others. The goal of anthelmintic treatment is elimination of parasites from the host and control of infection spread.
Anthelmintic.
According to the syllabus based on “PHARMACY COUNCIL OF INDIA”
“I Dedicate this work to all the
Students , Pharmacy Faculty & Family Members .”
Anthelmintic are the drugs that either KILL [vermicide] or Expel [vermifuge] infesting Helminths.
The choice of drug for each worm infestation is based not only on Efficacy, but also on Lack of Side effects/ Toxicity, Ease of administration [preferably single dose] & low cost.
Development of resistance has not been a problem in the clinical use of Anthelmintic.
Anthelmintic drugs are used to kill or expel parasitic worms. Common anthelmintics discussed include mebendazole, albendazole, pyrantel pamoate, piperazine, levamisole, diethylcarbamazine citrate, ivermectin, niclosamide, and praziquantel. These drugs have different mechanisms of action and are used to treat a variety of helminth infections that are prevalent globally, especially in developing areas with poorer hygiene. Common side effects include gastrointestinal upset.
Anthelmintics drugs classification,history,mechanism of action and adverse ef...Muhammad Amir Sohail
Helminths infect billions worldwide and effective drugs are available to treat most infections. However, drug costs are high. Mass treatment programs by WHO and governments have significantly reduced some infections. Anthelmintics expel or kill parasitic worms. They work by inhibiting worm metabolism or muscle paralysis. Common anthelmintic drugs include albendazole, mebendazole, pyrantel, and ivermectin. Praziquantel is effective against most flukes and schistosomes by increasing calcium permeability in the worm's tegument. While treatments are generally well tolerated, anthelmintic resistance has emerged as a threat to future control of parasitic worms.
This document summarizes anthelmintic drugs used to treat helminthiasis. It discusses the major classes of anthelmintics including benzimidazoles (albendazole, mebendazole), piperazines (piperazine citrate), ivermectin, and praziquantel. For each drug, it outlines the mechanism of action, clinical uses, pharmacokinetics, contraindications, and adverse effects. The document provides an overview of the most common helminth infections (roundworms, hookworms, tapeworms, flukes) and highlights the anthelmintics recommended for treating different parasitic infections.
Pharmacotherapy of Antihelminthic agentsManoj Kumar
1. Helminths, or worms, infect over 1/3 of the world's population and are most common in developing countries with poor sanitation. They are usually transmitted through feces and cause symptoms like anemia, diarrhea, abdominal pain, and organ damage.
2. The main drug classes used to treat helminth infections are benzimidazoles like mebendazole and albendazole, which inhibit polymerization of beta-tubulin in parasites. Other drugs include pyrantel pamoate, diethylcarbamazine, and ivermectin.
3. While effective, these drugs can cause side effects like nausea, vomiting, rash, and alopec
Clinical Pharmacology of the Anthelmintic Drugs.pptNorhanKhaled15
This document summarizes several anthelmintic drugs including albendazole, bithionol, diethylcarbamazine, and ivermectin. It provides information on the chemistry, pharmacokinetics, anthelmintic actions, clinical uses, adverse reactions, and contraindications for each drug. Albendazole is the drug of choice for many intestinal helminth infections. Bithionol is used for fascioliasis and paragonimiasis. Diethylcarbamazine treats filariasis and loiasis. Ivermectin is primarily used for strongyloidiasis and onchocerciasis. Each drug requires careful administration and monitoring for
This document discusses the pathophysiology of epilepsy and drugs used to treat it. It begins by defining seizures as transient alterations in behavior due to abnormal neuronal firing. Epilepsy is characterized by unpredictable seizures. Several types of seizures are described including partial and generalized seizures. Common anti-seizure drugs are discussed along with their mechanisms of action, clinical uses, pharmacokinetics, and side effects. These include GABA analogues like gabapentin, tiagabine, and vigabatrin. Glutamate analogues like felbamate and perampanel are also covered. Calcium channel blockers, sodium channel blockers, and other broad spectrum drugs and their roles in epilepsy treatment are summarized.
- Anthelmintic drugs are used to treat helminth (parasitic worm) infections which affect over two billion people worldwide.
- Some common anthelmintic drug classes include benzimidazoles (e.g. mebendazole, albendazole), piperazines, and avermectins (e.g. ivermectin).
- Mebendazole and albendazole are good choices for treating roundworm, hookworm, pinworm and whipworm infections. Praziquantel is used for tapeworm infections while ivermectin is effective for strongyloidiasis.
This document discusses various antifungal drugs, their mechanisms of action, and clinical uses. It describes how caspofungin inhibits fungal cell wall synthesis, while amphotericin B and nystatin bind to ergosterol in the fungal cell membrane. Azoles like ketoconazole, fluconazole and itraconazole inhibit ergosterol synthesis. 5-flucytosine inhibits fungal nucleic acid synthesis. It also discusses the antifungals' mechanisms of action, pharmacokinetics, clinical indications, resistance and adverse effects. Superficial and systemic fungal infections are outlined.
Promoting Wellbeing - Applied Social Psychology - Psychology SuperNotesPsychoTech Services
A proprietary approach developed by bringing together the best of learning theories from Psychology, design principles from the world of visualization, and pedagogical methods from over a decade of training experience, that enables you to: Learn better, faster!
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kol...rightmanforbloodline
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Versio
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
TEST BANK For An Introduction to Brain and Behavior, 7th Edition by Bryan Kolb, Ian Q. Whishaw, Verified Chapters 1 - 16, Complete Newest Version
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
1. Lecturer: Dr. F. Deane
Student : Shenellie Harry
Course : Pharmacology
Class : MD5
2. • Anthelmintic drugs are aimed at metabolic targets that
are present in the parasite but either are absent from or
have different characteristics than those of the host.
• Most anthelmintics target eliminating the organisms from
the host, as well as controlling spread of infections
3.
4. • Albendazole is a benzimidazole carbamate.
• Benzimidazoles are thought to act against nematodes by
inhibiting microtubule synthesis.
5. Administered orally.
It is erratically absorbed and then rapidly undergoes first-pass
metabolism in the liver to the active metabolite albendazole sulfoxide.
It reaches variable maximum plasma concentrations about 3 hours
after a 400-mg oral dose, and its plasma half-life is 8–12 hours.
The sulfoxide is mostly protein-bound, distributes well to tissues, and
enters bile, cerebrospinal fluid, and hydatid cysts.
Albendazole metabolites are excreted in the urine.
7. • threadworm infections,
• filariasis,
• both visceral and cutaneous larva migrans.
• Albendazole is also used in hydatid disease and is active
against the pork tapeworm in the larval stage
(cysticercosis).
10. • The drug should not be given to patients with known
hypersensitivity to other benzimidazole drugs or to those
with cirrhosis.
11. • Diethylcarbamazine, a synthetic piperazine derivative, is
marketed as a citrate salt.
• Diethylcarbamazine immobilizes microfilariae and alters
their surface structure, displacing them from tissues and
making them more susceptible to destruction by host
defense mechanisms.
12. It is rapidly absorbed from the gastrointestinal tract; after a 0.5
mg/kg dose, peak plasma levels are reached within 1–2 hours.
The plasma half-life is 2–3 hours in the presence of acidic urine
but about 10 hours if the urine is alkaline.
The drug rapidly equilibrates with all tissues except fat.
It is excreted, principally in the urine, as unchanged drug and
the N-oxide metabolite.
13. Eye worm
disease (loa loa).
Brugia malayi
Wucheria
bancrofti ,
Diethylcarbamazine
is the drug of choice
for several filarial
infections including
those caused by:
16. Caution is advised when
using diethylcarbamazine
in patients with
hypertension or renal
disease
17. • Ivermectin, a semisynthetic macrocyclic lactone, is a
mixture of avermectin B 1a and B 1b . It is derived from
the soil actinomycete Streptomyces avermitilis .
• Ivermectin appears to paralyze nematodes and
arthropods by intensifying γ-aminobutyric acid (GABA)–
mediated transmission of signals in peripheral nerves.
18. Administered orally
The drug is rapidly absorbed, reaching maximum
plasma concentrations 4 hours after a 12 mg dose.
The drug has a wide tissue distribution and a
volume of distribution of about 50 L. Its half-life is
about 16 hours.
Excretion of the drug and its metabolites is almost
exclusively in the feces.
22. • It is best to avoid concomitant use of ivermectin with
other drugs that enhance GABA activity, eg, barbiturates,
benzodiazepines, and valproic acid.
• Ivermectin should not be used during pregnancy. Safety
in children younger than 5 years has not been
established.
•
23. • Mebendazole probably acts by inhibiting microtubule
synthesis; the parent drug appears to be the active form.
• Efficacy of the drug varies with gastrointestinal transit
time, with intensity of infection, and perhaps with the
strain of parasite. The drug kills hookworm, ascaris, and
trichuris eggs.
24. Less than 10% of orally administered mebendazole is absorbed.
The absorbed drug is protein-bound (> 90%), is rapidly converted to
inactive metabolites (primarily during its first pass in the liver), and has
a half-life of 2–6 hours.
It is excreted mostly in the urine, principally as decarboxylated
derivatives.
In addition, a portion of absorbed drug and its derivatives are excreted
in the bile. Absorption is increased if the drug is ingested with a fatty
meal.
25. Mebendazole is a
primary drug for
treatment of
ascariasis and for
pinworm and
whipworm infections.
Mebendazole has
also been used as a
backup drug in
visceral larval
migrans.
Less than 10% of the
drug is absorbed
systemically after
oral use, and this
portion is
metabolized rapidly
by hepatic enzymes.
Plasma levels may
be decreased by
carbamazepine or
phenytoin and
increased by
cimetidine.
27. • Contraindicated in pregnancy.
• It should be used with caution in children younger than 2
years of age because of limited experience and rare
reports of convulsions in this age group.
28. • Piperazine is an alternative for the treatment of
ascariasis, with cure rates over 90% when taken for 2
days, but it is not recommended for other helminth
infections.
• Piperazine is available as the hexahydrate and as a
variety of salts.
29. • It is readily absorbed, and maximum plasma levels are
reached in 2–4 hours.
• Most of the drug is excreted unchanged in the urine in 2–
6 hours, and excretion is complete within 24 hours.
• For ascariasis, the dosage of piperazine (as the
hexahydrate) is 75 mg/kg (maximum dose, 3.5 g) orally
once daily for 2 days.
• For heavy infections, treatment should be continued for
3–4 days or repeated after 1 week.
30. • Nausea, vomiting, diarrhea, abdominal pain, dizziness,
and headache.
• Neurotoxicity and allergic reactions are rare.
• Piperazine compounds should not be given to women
during pregnancy, to patients with impaired renal or
hepatic function, or to those with a history of epilepsy or
chronic neurologic disease.
•
31. • Pyrantel pamoate is a tetrahydropyrimidine derivative.
• Pyrantel is effective against mature and immature forms
of susceptible helminths within the intestinal tract but not
against migratory stages in the tissues or against ova.
• The drug is a neuromuscular blocking agent that causes
release of acetylcholine and inhibition of cholinesterase;
this results in paralysis of worms, which is followed by
expulsion.
•
32. • It is poorly absorbed from the gastrointestinal tract and
active mainly against luminal organisms.
• Peak plasma levels are reached in 1–3 hours.
• Over half of the administered dose is recovered
unchanged in the faeces.
33. • Pyrantel pamoate has wide activity against nematodes
killing adult worms in the colon but not the eggs.
• It is a drug of choice for hookworm and roundworm
infections and an alternative drug for pinworms.
35. • Pyrantel should be used with caution in patients with liver
dysfunction, because low, transient aminotransferase
elevations have been noted in a small number of
patients.
36. • Thiabendazole is a benzimidazole compound. Although it
is a chelating agent that forms stable complexes with a
number of metals, including iron, it does not bind calcium.
• The drug has ovicidal effects against some parasites.
37. Thiabendazole is rapidly absorbed after ingestion.
With a standard dose, drug concentrations in plasma peak within 1–2
hours; the half-life is 1.2 hours.
The drug is almost completely metabolized in the liver to the 5-hydroxy
form; 90% is excreted in the urine in 48 hours, largely as the
glucuronide or sulfonate conjugate.
Thiabendazole can also be absorbed from the skin
38. • Thiabendazole is an alternative drug in strongyloidiasis
and trichinosis (adult worms).
• The drug has anti-inflammatory and immunorestorative
actions in the host.
39. dizziness, anorexia,
nausea, vomiting.
epigastric pain,
abdominal
cramps,
diarrhea, pruritus,
headache,
drowsiness,
and
neuropsychiatric
symptoms.
Irreversible liver
failure and fatal
Stevens-Johnson
syndrome have
been reported.
40.
41. Bithionol is an alternative to triclabendazole for the treatment of
fascioliasis (sheep liver fluke). Bithionol is also an alternative drug in
the treatment of pulmonary paragonimiasis.
After ingestion, bithionol reaches peak blood levels in 4–8 hours.
Excretion appears to be mainly via the kidney.
For treatment of paragonimiasis and fascioliasis, the dosage of
bithionol is 30–50 mg/kg in two or three divided doses, given orally
after meals on alternate days for 10–15 doses.
For pulmonary paragonimiasis, cure rates are over 90%. For cerebral
paragonimiasis, repeat courses of therapy may be necessary.
42. • Diarrhoea, abdominal cramps, anorexia, nausea,
vomiting, dizziness, and headache.
• Skin rashes may occur after a week or more of therapy,
suggesting a reaction to antigens released from dying
worms.
• Bithionol should be used with caution in children younger
than 8 years of age because there has been limited
experience in this age group.
•
43. • Praziquantel is a synthetic isoquinoline-pyrazine
derivative.
• Praziquantel appears to increase the permeability of
trematode and cestode cell membranes to calcium,
resulting in paralysis, dislodgement, and death.
44. It is rapidly absorbed, with a bioavailability of about 80% after oral administration. Peak
serum concentrations are reached 1–3 hours after a therapeutic dose.
Cerebrospinal fluid concentrations of praziquantel reach 14–20% of the drug’s plasma
concentration. About 80% of the drug is bound to plasma proteins.
Most of the drug is rapidly metabolized to inactive mono- and polyhydroxylated products
after a first pass in the liver. The half-life is 0.8–1.5 hours.
Excretion is mainly via the kidneys (60–80%) and bile (15–35%).
Plasma concentrations of praziquantel increase when the drug is taken with a high-
carbohydrate meal or with cimetidine; bioavailability is markedly reduced with some
antiepileptics (phenytoin, carbamazepine) or with corticosteroids.
45. Headache, dizziness and drowsiness, malaise, and less frequently,
gastrointestinal irritation, skin rash, and fever.
Neurologic effects can occur in the treatment of neurocyticercosis
including intracranial hypertension and seizures.
Corticosteroid therapy reduces the risk of the more serious
reactions.
Praziquantel is contraindicated in ocular cysticercosis.
46. Metrifonate, an organophosphate compound, is rapidly absorbed after
oral administration.
The mode of action is thought to be related to cholinesterase inhibition.
This inhibition temporarily paralyzes the adult worms, resulting in their
shift from the bladder venous plexus to small arterioles of the lungs,
where they are trapped, encased by the immune system, and die.
The drug is not effective against S haematobium eggs; live eggs
continue to pass in the urine for several months after all adult worms
have been killed.
47. • After the standard oral dose, peak blood levels are
reached in 1–2 hours; the half-life is about 1.5 hours.
• Clearance appears to be through nonenzymatic
transformation to dichlorvos, its active metabolite.
• Metrifonate and dichlorvos are well distributed to the
tissues and are completely eliminated in 24–48 hours.
48. • In the treatment of S haematobium , an oral dose of
7.5–10 mg/kg is given three times at 14-day intervals.
• Cure rates on this schedule are 44–93%, with marked
reductions in egg counts in those not cured.
49. • Nausea and vomiting, diarrhea, abdominal pain,
bronchospasm, headache, sweating, fatigue, weakness,
dizziness, and vertigo.
• These symptoms may begin within 30 minutes and
persist up to 12 hours.
50. Oxamniquine, a semisynthetic tetrahydroquinoline.
Oxamniquine is active against both mature and immature stages of S mansoni but does
not appear to be cercaricidal.
The mechanism of action is unknown. Contraction and paralysis of the worms results in
detachment from terminal venules in the mesentery and transit to the liver, where many
die; surviving females return to the mesenteric vessels but cease to lay eggs.
Strains of S mansoni in different parts of the world vary in susceptibility. Oxamniquine
has been effective in instances of praziquantel resistance.
51. • Oxamniquine is readily absorbed orally; it should be
taken with food.
• Its plasma half-life is about 2.5 hours.
• The drug is extensively metabolized to inactive
metabolites and excreted in the urine—up to 75% in the
first 24 hours.
52. • Dizziness is a common adverse effect (no driving for 24
h); headache, gastrointestinal irritation, and pruritus may
also occur.
• Reactions to dying parasites include eosinophilia,
urticaria, and pulmonary infiltrates.
• It is not advisable to use the drug in pregnancy or in
patients with a history of seizure disorders.
53.
54. • Niclosamide is a salicylamide derivative.
• Adult worms (but not ova) are rapidly killed, presumably
due to inhibition of oxidative phosphorylation or
stimulation of ATPase activity.
•
55. • It appears to be minimally absorbed from the
gastrointestinal tract—neither the drug nor its metabolites
have been recovered from the blood or urine.
56. • Niclosamide is an alternative drug to praziquantel for
infections caused by beef, pork, and fish tapeworm.
• It is not effective in cysticercosis (for which albendazole
or praziquantel is used) or hydatid disease caused by
Echinococcus granulosus (for which albendazole is
used). Scoleces and cestode segments are killed, but
ova are not.
• Niclosamide is effective in the treatment of infections
from small and large intestinal flukes.
57. • Gastrointestinal distress, headache, rash, and fever.
Some of these effects may result from systemic
absorption of antigens from disintegrating parasites.
• Ethanol consumption should be avoided for 24–48 h
Albendazole is administered on an empty stomach when used against intraluminal parasites but with a fatty meal when used against tissue parasites.
1. increased with a fatty meal.
W hen used for 1–3 days, albendazole is nearly free of significant adverse effects.
Less common problems are epigastric pain, abdominal cramps, diarrhea, pruritus, headache, drowsiness, and neuropsychiatric symptoms. Irreversible liver failure and fatal Stevens-Johnson syndrome have been reported