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Anoxic brain injury and neurological braindeath 
: Information for patients and families 
Vancouver General Hospital Intensive Care Unit 
Myp Sekhon MD 
Clinical Instructor, Staff Intensivist 
Vancouver General Hospital 
Division of Critical Care Medicine 
University of British Columbia
Outline 
Definition 
Etiologies 
Imaging 
Management 
Prognosis 
Braindeath 
Definition 
Anoxic brain injury occurs when the brain does not receive 
enough oxygen to stay alive. Most commonly, this scenario 
happens after the heart stops pumping (a “cardiac arrest”).
Outline 
Definition 
Etiologies 
Imaging 
Management 
Prognosis 
Braindeath 
What causes the heart to stop 
beating? 
An abnormal rhythm (electrical abnormality) of the heart 
can stop it from beating 
Depending on the type of electrical abnormality, the 
problem might be inside the heart or another problem in the 
body causing the heart to stop 
An investigation will be conducted to find the underlying 
problem, if possible
Outline 
Definition 
Etiologies 
Imaging 
Management 
Prognosis 
Braindeath 
What happens to the brain after a 
cardiac arrest? 
The brain is the most important organ in the body 
Unfortunately, the brain does not have a storage of energy 
If it stops receiving blood flow and oxygen from the heart / 
lungs, it will start to become irreversibly damaged after 
only 
4 minutes without blood supply 
If blood flow (delivery of oxygen) is not restored, the brain 
will start to die and it can become very swollen
Outline 
Definition 
Etiologies 
Imaging 
Management 
Prognosis 
Braindeath 
How do we know the brain is 
damaged? 
We use multiple methods of assessment to determine the 
severity of brain injury after a cardiac arrest: 
•Clinical examination 
•History – initial abnormal rhythm, duration without 
blood supply, if the patient received immediate CPR 
etc. 
•CT scans 
•Tests measuring the electrical activity of the brain
If blood is restored to the brain (heart re-started) then our 
focus is optimize the delivery of oxygen to the brain 
This is achieved by: 
•Maintain blood pressure with medications to allow the 
heart to pump blood to the brain 
•We control the temperature of the body – this is done 
to prevent a fever which make the brain use more 
oxygen and potentially cause more injury 
•We used sedation medications to “rest” the brain and 
allow time for healing. This is usually for 24-48 hours. 
Outline 
Definition 
Etiologies 
Imaging 
Management 
Prognosis 
Braindeath 
How do we treat patients with brain 
damage after a cardiac arrest?
Outline 
Definition 
Etiologies 
Imaging 
Management 
Prognosis 
Braindeath 
Prognosis? 
The prognosis of most patients is poor (~50-70%). 
Predictors of poor outcome include: 
•Older age 
•Multiple previous diseases (heart disease, diabetes, 
kidney disease, lung disease etc) 
•Long duration of cardiac arrest 
•Unwitnessed cardiac arrest 
•Poor clinical examination (we will help with this)

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Anoxic brain injury and braindeath info for patient's families

  • 1. Anoxic brain injury and neurological braindeath : Information for patients and families Vancouver General Hospital Intensive Care Unit Myp Sekhon MD Clinical Instructor, Staff Intensivist Vancouver General Hospital Division of Critical Care Medicine University of British Columbia
  • 2. Outline Definition Etiologies Imaging Management Prognosis Braindeath Definition Anoxic brain injury occurs when the brain does not receive enough oxygen to stay alive. Most commonly, this scenario happens after the heart stops pumping (a “cardiac arrest”).
  • 3. Outline Definition Etiologies Imaging Management Prognosis Braindeath What causes the heart to stop beating? An abnormal rhythm (electrical abnormality) of the heart can stop it from beating Depending on the type of electrical abnormality, the problem might be inside the heart or another problem in the body causing the heart to stop An investigation will be conducted to find the underlying problem, if possible
  • 4. Outline Definition Etiologies Imaging Management Prognosis Braindeath What happens to the brain after a cardiac arrest? The brain is the most important organ in the body Unfortunately, the brain does not have a storage of energy If it stops receiving blood flow and oxygen from the heart / lungs, it will start to become irreversibly damaged after only 4 minutes without blood supply If blood flow (delivery of oxygen) is not restored, the brain will start to die and it can become very swollen
  • 5. Outline Definition Etiologies Imaging Management Prognosis Braindeath How do we know the brain is damaged? We use multiple methods of assessment to determine the severity of brain injury after a cardiac arrest: •Clinical examination •History – initial abnormal rhythm, duration without blood supply, if the patient received immediate CPR etc. •CT scans •Tests measuring the electrical activity of the brain
  • 6. If blood is restored to the brain (heart re-started) then our focus is optimize the delivery of oxygen to the brain This is achieved by: •Maintain blood pressure with medications to allow the heart to pump blood to the brain •We control the temperature of the body – this is done to prevent a fever which make the brain use more oxygen and potentially cause more injury •We used sedation medications to “rest” the brain and allow time for healing. This is usually for 24-48 hours. Outline Definition Etiologies Imaging Management Prognosis Braindeath How do we treat patients with brain damage after a cardiac arrest?
  • 7. Outline Definition Etiologies Imaging Management Prognosis Braindeath Prognosis? The prognosis of most patients is poor (~50-70%). Predictors of poor outcome include: •Older age •Multiple previous diseases (heart disease, diabetes, kidney disease, lung disease etc) •Long duration of cardiac arrest •Unwitnessed cardiac arrest •Poor clinical examination (we will help with this)