SAP R3, S4 HANA, FIORI
Give your workforce the knowledge and skills they need to meet your strategic goals– with a full suite of software training and education courses and certifications designed to help you maximize the power of your SAP solutions. We can help you create a comprehensive training plan, manage your talent, empower end users with training courses which drive greater proficiency across your organization.
Zabeel offers the following courses in SAP.
• SAP FINANCE AND CONTROLLING- FICO
• SAP MATERIALS MANAGEMENT - MM
• SAP HUMAN CAPITAL MANAGEMENT - HCM/HR
• SAP PRODUCTION PLANNING
• SAP PLANT MAINTAINENCE
• SAP LOGISTICS
• SAP QUALITY MANAGEMENT
• SAP ABAP - PROGRAMMING MODULE
• SAP SALES AND DISTRIBUTION - SD
• SAP CUSTOMER SERVICE – CS
• SAP S4 HANA (SIMPLE FINANCE, SIMPLE LOGISTICS, ABAP,SUCCESS FACTORS)
• SAP FIORI
SAP R3, S4 HANA, FIORI
Give your workforce the knowledge and skills they need to meet your strategic goals– with a full suite of software training and education courses and certifications designed to help you maximize the power of your SAP solutions. We can help you create a comprehensive training plan, manage your talent, empower end users with training courses which drive greater proficiency across your organization.
Zabeel offers the following courses in SAP.
• SAP FINANCE AND CONTROLLING- FICO
• SAP MATERIALS MANAGEMENT - MM
• SAP HUMAN CAPITAL MANAGEMENT - HCM/HR
• SAP PRODUCTION PLANNING
• SAP PLANT MAINTAINENCE
• SAP LOGISTICS
• SAP QUALITY MANAGEMENT
• SAP ABAP - PROGRAMMING MODULE
• SAP SALES AND DISTRIBUTION - SD
• SAP CUSTOMER SERVICE – CS
• SAP S4 HANA (SIMPLE FINANCE, SIMPLE LOGISTICS, ABAP,SUCCESS FACTORS)
• SAP FIORI
Real Time SAP Training with 100% Placement, Best Sap Fico Academy , Attitude Tally learning Institute offers Sap classes at Yamuna Vihar East Delhi NCR
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
What is greenhouse gasses and how many gasses are there to affect the Earth.moosaasad1975
What are greenhouse gasses how they affect the earth and its environment what is the future of the environment and earth how the weather and the climate effects.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
1. SAPFI/COGeneral LedgerAccounting:BasicSettings
Sl.No. Particulars Transaction
Code
I Enterprise Structure
1 Creationof Company OX15
2 Creationof CompanyCode OX02
3 AssignCompanyCode toCompany OX16
4 Creationof BusinessAreas OX03
II Fiscal Year
1 Creationof Fiscal Year Variant OB29
2 AssignCompanyCode toFiscal Year Variant OB37
III Chart of Accounts
1 Creationof Chart of Accounts OB13
2 AssignCompanyCode toChart of Accounts OB62
3 Define AccountGroups OBD4
4 Define RetainedEarningsAccount OB53
IV PostingPeriods
1 Define PostingPeriodVariant OBBO
2. 2 AssignCompanyCode toPostingPeriodVariant OBBP
3 Openand Close PostingPeriods OB52
V DocumentTypesand NumberRanges
1 Define DocumentTypes OBA7
2 Define NumberRanges FBN1
VI Tolerances
1 Define Tolerance GroupsforG/LAccounts OBA0
2 Define Tolerance GroupsforEmployees OBA4
3 AssignUsersto Tolerance Groups OB57
VII FieldStatus
1 Define FieldStatusVariants OBC4
2 AssignCompanyCode toFieldStatusVariants OBC5
VIII CalculationProcedures
1 AssignCountrytoCalculationProcedure OBBG
IX Global Parameters
1 Enter Global Parameters OBY6
X ForeignCurrencySettings
1 CheckExchange Rate Types OB07
3. 2 Define TranslationRatiosforCurrencyTranslation OBBS
3 Enter Exchange Rates OB08
4 SpecifyDefaultExchange Rate Type inDocument
Type
OBA7
XI Creationof G/L Accounts
1 Creationof G/L Account at Chart of AccountsLevel FSP0
2 Creationof G/L Account at CompanyCode Level FSS0
3 Creationof G/L Account Centrally FS00 DocumentPosting
and OtherTransactions
Sl.No. Particulars Transaction
Code
I DocumentPosting
1 G/L DocumentPosting F-02
2 PostOutgoingPaymentforG/L Accounts F-07
3 G/L Account Posting - EnjoyTransaction FB50
4 Postinga Documentwithreference toanother
Document
FBR2
5 DisplayDocument FB03
6 Change Document FB02
4. 7 DisplayG/L AccountBalances FS10N
8 DisplayG/L AccountBalancesforOpenItem
Managed A/cs
FBL3N
II Activationof Line ItemDisplay
1 Flag"Line ItemDisplay"Checkbox inG/LAccount FS00
2 BlockGL Account FS00
3 Run Program"RFSEPA01" for activationof Line Items SE38
4 UnblockGL Account FS00
III OtherTransactions
1 CopyCompanyCode Settingsfromone Company
Code to another
EC01
2 CopyNumberRangesfromone CompanyCode to
another
OBH1
3 CopyNumberRangesfromone Fiscal Year to another OBH2
4 To see the changesinthe G/L AccountMaster FS04
42. II Assessment- EC-PCA
1 MaintainAssessmentCostElement KA06
2 Define Actual AssessmentCycle forEC-PCA 3KE1
3 Actual Assessment 3KE5
III Distribution - EC-PCA
1 Define DistributionCycle 4KE1