1) Patellofemoral pain syndrome is a common condition caused by multiple factors affecting the patella, hip, trunk, and foot. 2) Theories for its pathogenesis include maltracking of the patella, weakness or timing issues of the vastus medialis muscle, altered hip and trunk muscle function, and pronated foot mechanics. 3) Treatment approaches aim to address these various local and proximal factors and may include taping, foot orthoses, and physiotherapy exercises. Short-term benefits have been seen from foot orthoses but combined physiotherapy may be most effective.