A 21-year old female marathon runner has begun experiencing knee pain around the patella after increasing her training from twice to 4-5 times per week on hills. This document provides an overview of patellofemoral pain syndrome (PFPS), including causes, risk factors, diagnosis, and treatment options. PFPS is caused by an imbalance of forces around the patella that leads to pain. Treatment focuses on strengthening the quadriceps and hips to correct biomechanics and management of pain. The prognosis is generally good if treatment addresses contributing factors and allows for gradual return to activity.