AKI is a common problem in ICU patients, occurring in up to 18% of hospitalized patients with normal kidney function. Risk factors include conditions that reduce blood flow to the kidneys like sepsis or hypotension. The kidneys are vulnerable to toxins and drugs due to their high blood flow and the tubules' role in reabsorbing and secreting materials. Early detection of AKI using markers like serum creatinine and urine output is important for management, which aims to treat the underlying cause, ensure proper fluid balance and nutrition, and consider renal replacement therapy for severe cases.

1. AKI in ICUAKI in ICU
An OverviewAn Overview
By
Dr. Ahmed Mohammed Abd El Wahab
Lecturer of internal medicine(Nephrology)

2. Epidemiology
Up to 18% of hospitalized
patients with baseline normal
renal function experience AKI
Up to 4% of hospital
admissions are due to AKI
Mortality may reach up to 70%
in AKI requiring RRT

5. Why kidney is easily exposed to
Toxin and Drug
 Blood flow 1/3 of cardiac output
 High energy demand
 Water reabsorption, increase
concentration of toxic materials
 Tubular reabsorption and secretion
of some drugs

7. Risk Factors contd.,

11. Contd.,

13. Pathophysiology

14. Contd.,

16. Presentation

17. Detection

18. New markers

19. Contd.,

20. Management

21. Contd.,