This document is the thesis submitted by Manoj Lohatepanont to the Department of Civil and Environmental Engineering at MIT in partial fulfillment of the requirements for the degree of Doctor of Science in Transportation and Logistics Systems. The thesis studies two elements of airline schedule generation: schedule design and fleet assignment. In the fleet assignment problem, the thesis investigates issues of network effects, spill, and recapture. Models developed capture these elements and can provide benefits of up to $100 million annually for a major US airline. The thesis also develops two models for schedule design, one assuming constant market share and one allowing variable market share with schedule changes.