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Advia centuar IMMUNOASSAY SYSTEM
The document describes the ADVIA Centaur XP system, an automated clinical chemistry analyzer that uses direct chemiluminescence to detect analytes in samples. It uses acridinium ester as the chemiluminescent label, which provides benefits like long reagent shelf life and fast reaction times without needing additional catalysts or substrates. The system can run up to 240 tests per hour using various immunoassay formats and has features like on-board reagent storage, quality control, and the ability to handle different sample types and volumes. It measures over 100 different analytes across various disease and condition areas.
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Advia centuar IMMUNOASSAY SYSTEM
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- 3. • Chemiluminescence isa chemical reaction that emits energy in the form of light. When used in combination with immunoassay technology, the light produced by the reaction indicates the amount of analyte in a sample. Direct chemiluminescent reactions directly measure the light energy without the use of added steps or amplifying molecules. The ADVIA Centaur XP assays use acridinium ester (AE) as the chemiluminescent label, because AE does not require the addition of a catalyst or substrate. • Direct Chemiluminescence It is easy to automate direct chemiluminescence using AE and provides many benefits, such as long reagent shelf life, fast reaction time, and assay sensitivity. The ADVIA Centaur XP assays use the dimethyl form of AE because its stability allows long reagent shelf life.
- 4. The system usesa variety of formats to detect antigens as well as antibodies. 1 sandwich format 2 competitive format 3 antibody- capture format
- 9. • 30 onboard reagents maximize test capacity
- 10. • 240 testsper hour • High-resolution touch screen for easy interaction • Expanded ancillary reagent and fluid capacity • Universal sample rack design eliminates manual tasks
- 11. • STAT portguarantees priority sampling at any time
- 12. Replenish Supplieswithout Pausing 840 tips
- 23. Sample Tubes • 1 mL,2 mL, 3 mL, 5 mL, 7 mL, 10 mL, micro container tubes Automatic Dilutions • Varies by assay, up to 1:1000
- 24. Sample Handling • Serum, plasma,urine - assay dependent Sample Volume • 10 uL to 200 uL assay dependent Sample Integrity Control • Pressure transducer technology with clot management, detection, and flagging.
- 26. Reagent Cooling • 30-position reagenttray cooled 4°C to 8°C Reagent Integrity Control • Barcode reagent identification, automatic inventory tracking and flagging, calibration validity tracked and flagged, reagent on board stability tracked and flagged, reagent expired/ reagent low flagging Reagent Mixing • ReadyPacks automatically rocked onboard
- 27. • Advanced QCpackage includes Levy- Jennings plots and Westgard rules; 65,000 control results can be stored • Results within ± 2SD accepted
- 29. Allergy • Total IgE Anemia •Ferritin • Folate • RBC Folate • Vitamin B12 Bone • Vitamin D
- 30. Tumor Markers/Oncology • AFP • BR •CA 15-3 • CA 19-9 • CA 125II • CEA • Complexed PSA • Free PSA • PSA • Serum HER-2/neu
- 31. ToRCH and Special ID •CMV IgG • CMV IgM • Rubella IgG • Rubella IgM • Syphilis • Toxo IgG • Toxo IgM
- 32. • BNP • CKMBII • D-Dimer • Myoglobin • Tnl-Ultra • C-Peptide (serum, urine) • Insulin
- 33. • Anti-HBe • Anti-HBs •Anti-HBs-2 • eHIV 1/O/2† • HAV IgM • HAV Total • HBc Total • HBc IgM • HBe Ag • HBs Ag • HBs Ag Confirmatory • HBs AgII • HCV† • HIV Combo (CHIV)†
- 34. TDM • Carbamazepine • Digitoxin •Digoxin • Gentamicin • Phenobarbital • Phenytoin • Theophylline • Tobramycin • Valproic Acid • Vancomycin
- 35. Liver Fibrosis • HA (ELFMarker) • TIMP (ELF Marker) • PIIINP (ELF Marker) Metabolic • Cortisol (serum, urine) • Homocysteine
- 36. Reproductive Endocrinology • AFP • DHEAS •Estradiol-6 • Estradiol-6 III • FSH • LH • Progesterone • Prolactin • SHBG • Testosterone • Total hCG
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- 38. Thyroid Function • Anti-TG Ab •Anti-TPO Ab • Free T3 • Free T4 • Intact PTH • TSH • Third Generation TSH • T Uptake • Total T3 • Total T4 • TSH 3-UL