Detecting and managing adverse drug reactions is important for patient safety. Adverse drug reactions can range from mild to life-threatening. Common causes include dose-related toxicity, drug-drug interactions, hypersensitivity reactions, and idiosyncratic reactions. Nurses play a key role in monitoring patients, recognizing signs and symptoms of adverse reactions, reporting them immediately, and managing the situation under a physician's guidance. Timely reporting helps increase understanding of medication risks and improve safe use.