This document discusses advanced optimization techniques used to solve large-scale problems that traditional techniques cannot handle effectively. It introduces several population-based metaheuristic algorithms inspired by natural phenomena, including genetic algorithms, artificial immune algorithms, and differential evolution. Genetic algorithms use operations like selection, crossover and mutation to evolve solutions over generations. Artificial immune algorithms are based on clonal selection to amplify high-affinity antibodies. Differential evolution generates trial vectors through mutation and crossover of randomly selected target vectors.