This document summarizes an experiment to synthesize the sulfa drug sulfanilamide through a multi-step process involving the acetylation of aniline and other reactions. The experiment had a very low yield of less than 1% sulfanilamide, likely due to product loss during filtration and some reactions not going to completion. While the target compound sulfanilamide was produced, as confirmed by its melting point and IR spectroscopy, improvements to the technique are needed to increase the yield. The synthesis of sulfanilamide and other sulfa drugs provides opportunities to study their antimicrobial mechanisms and develop new therapeutic agents.