This presentation was delivered over two days to second year pharmacy students enrolled in a course in pharmacology & toxicology. This lecture is designed to accompany Goodman & Gilman's (12e) chapter 11.
This presentation was delivered over two days to second year pharmacy students enrolled in a course in pharmacology & toxicology. This lecture is designed to accompany Goodman & Gilman's (12e) chapter 11.
This presentation deals with the beta blockers commonly used in day-to-day practice alongwith some interesting mnemonics to remember their names & site of action
This presentation contains drugs which blocks the adrenergic system e.g receptor blockers like alpha and beta receptor antagonists, adrenergic neuron blocking agents in details.various animated pictures are also included to make the presentation interesting as well as i have used various diagrams and tables to have better understanding of the topic. Thank you.
This presentation was given by me during my M.pharm.
It contains description, classification, mechanism of actions and therapeutic uses of Neuromuscular blockers.
By Dr. Vishal Pawar, MD pharmacology
considering the complex nature of this topic, i am hereby providing a comprehensive review of prostaglandins and its various effects in the body, which after a through go through should be enough for simplifying the understanding of prostaglandins
This presentation deals with the beta blockers commonly used in day-to-day practice alongwith some interesting mnemonics to remember their names & site of action
This presentation contains drugs which blocks the adrenergic system e.g receptor blockers like alpha and beta receptor antagonists, adrenergic neuron blocking agents in details.various animated pictures are also included to make the presentation interesting as well as i have used various diagrams and tables to have better understanding of the topic. Thank you.
This presentation was given by me during my M.pharm.
It contains description, classification, mechanism of actions and therapeutic uses of Neuromuscular blockers.
By Dr. Vishal Pawar, MD pharmacology
considering the complex nature of this topic, i am hereby providing a comprehensive review of prostaglandins and its various effects in the body, which after a through go through should be enough for simplifying the understanding of prostaglandins
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Rasamanikya is a excellent preparation in the field of Rasashastra, it is used in various Kushtha Roga, Shwasa, Vicharchika, Bhagandara, Vatarakta, and Phiranga Roga. In this article Preparation& Comparative analytical profile for both Formulationon i.e Rasamanikya prepared by Kushmanda swarasa & Churnodhaka Shodita Haratala. The study aims to provide insights into the comparative efficacy and analytical aspects of these formulations for enhanced therapeutic outcomes.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
263778731218 Abortion Clinic /Pills In Harare ,sisternakatoto
263778731218 Abortion Clinic /Pills In Harare ,ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group ABORTION WOMEN’S CLINIC +27730423979 IN women clinic we believe that every woman should be able to make choices in her pregnancy. Our job is to provide compassionate care, safety,affordable and confidential services. That’s why we have won the trust from all generations of women all over the world. we use non surgical method(Abortion pills) to terminate…Dr.LISA +27730423979women Clinic is committed to providing the highest quality of obstetrical and gynecological care to women of all ages. Our dedicated staff aim to treat each patient and her health concerns with compassion and respect.Our dedicated group of receptionists, nurses, and physicians have worked together as a teamof receptionists, nurses, and physicians have worked together as a team wwww.lisywomensclinic.co.za/
3. The sympathetic preganglionic fibers leave the
CNS through the thoracic and lumbar spinal nerves.
The sympathetic preganglionic neurons (first
neurons) project from the intermediolateral
column of the spinal gray matter to the paired
paravertebral ganglionic chain lying alongside
the vertebral column and to unpaired prevertebral
ganglia. These ganglia represent sites of synaptic
contact between preganglionic axons (1st
neurons)
and nerve cells (2nd
neurons) that emit postgan-
glionic axons terminating on cells in various end
organs. In addition, there are preganglionic neurons
that project either to peripheral ganglia in end organs
or to the adrenal medulla.
5. Activation of the
Sympathetic Nervous
System can be
considered a means
by which the body
achieves a state of
maximal work capacity
as required in fight
or flight situations.
6. Whereas ACh serves as the chemical transmitter at
ganglionic synapses between first and second neurons
Norepinephrine (NE, noradrenaline) is the mediator at
synapses of the second neuron. Excitation of the neuron
leads to activation of a larger aggregate of effector cells,
although the action of released NE may be confined to
the region of each junction. Excitation of preganglionic
neurons innervating the adrenal medulla causes
liberation of ACh. This, in turn, elicits a secretion
of epinephrine (adrenaline) into the blood, by
which it is distributed to body tissues as a hormone.
9. Adrenoceptors fall into two major
groups, designated alpha (α1, α2)
and beta (β1, β2, β3) within
each of which further subtypes can be
distinguished pharmacologically. The
different adrenoceptors are differentially
distributed according to region and
tissue. Agonists at adrenoceptors
(direct adrenomimetics) mimic the
actions of the naturally occurring
catecholamines, NA and epinephrine, and
are used for various therapeutic effects.
10. Within the varicosities, NE is stored in small
membrane-enclosed vesicles (granules,
0.05 to 0.2 µm in diameter). In the axoplasm,
L-tyrosine is converted via two intermediate
steps to dopamine (DA), which is taken up into
the vesicles and there converted to NE by
DA-beta-hydroxylase.
When stimulated electrically, the sympathetic
nerve discharges the contents of part of its
vesicles, including NE, into the extracellular
space. Liberated NE reacts with adrenoceptors
located postjunctionally on the membrane of
effector cells or prejunctionally on the membrane of
varicosities. Activation of presynaptic α2-receptors
inhibits NE (regulative negative feedback).
11. Presynaptic receptors in adrenergic synapse
and their role in the regulatory negative and
positive feedback
13. The effect of released NE wanes quickly,
because approximately 90% is actively
transported back into the axoplasm, then
into storage vesicles (neuronal re-uptake).
Small portions of NE are inactivated by the
enzyme catechol-O-methyltransferase
(COMT, present in the cytoplasm of
postjunctional cells, to yield normeta-
nephrine), and monoamine oxidase
(MAO, present in the mitochondria of nerve
cells and postjunctional cells) to yield
3,4-dihydroxymandelic acid).
14. The liver is richly endowed with
COMT and MAO. It therefore contri-
butes significantly to the degradation
of circulating NE and epinephrine.
The end productThe end product of the combinedof the combined
actions of MAO and COMT isactions of MAO and COMT is
vanillylmandelic acidvanillylmandelic acid..
20. • PLC (phospholipase C) catalyses the
formation of two intracellular messen-
gers − InsP3 and DAG, from memb-
rane phospholipids.
• InsP3 (inositol-triphosphate) increases
free cytosolic calcium by releasing
Ca2+
from the endoplasmic reticulum.
• Free calcium initiates contractions, se-
cretion, membrane hyperpolarization
• DAG activates protein kinase C.
21. Action on beta-adrenoceptors
•Arterioles and veins (β2): dilation and fall in BP
•Heart (β1): increased heart rate,
force, and conduction velocity
•Lung (β2): bronchodilation
•Eye (β2): enhanced aqueous secretion
•GIT (β2): intestinal relaxation
•Bladder detrusor (β2): relaxation
•Uterus (β2): relaxation
•Liver (β2): glycogenolysis
•Insulin and glucagon secretion (β2): augmented
•Fat (β3): lipolysis
•Kidney (β ): renin release
24. Agents which increase cAMP
(adrenaline, salbutamol,
and other beta-adrenoceptor
agonists) inhibit histamine
secretion and produce
bronchodilation
(antiasthmatic effect).
29. Norepinephrine (noradrenaline):
α1, α2, β1 and β3, but no β2 action
Epinephrine (adrenaline):
α1, α2, β1 and β2, and weak β3 action
Isoproterenol (isoprenaline):
β1 and β2, but no α action
--------------------------------------------------
Clonidine: presynaptic α2 agonist
(with antihypertensive action)
30. Direct-acting adrenomimetics
a) α-adrenomimetics (activators of phospholipase C)
- antihypotensive drugs: Etilefrinе, Midodrine, Noradrenaline
- local nasal decongestants: Naphazoline, Oxymetazoline,
Xylometazoline (0.1% nasal drops: 3 x 2 drops daily 5 days)
- eye drops in glaucoma: Phenylephrine
b) Cardioselective β1-adrenomimetics: Dobutamine
c) DA-ergic adrenomimetics: Dopamine
d) Selective β2-adrenomimetics: Clenbuterol, Fenoterol, Hexoprenaline,
Indacaterol, Levosalbutamol, Salbutamol, Salmeterol, Terbutaline
e) Non-selective β-adrenomimetics: Isoprenaline and Orciprenaline
f) α- and β-adrenomimetics: Adrenaline (antiallergic): sol. 0,1% 1 ml s.c.;
Anapen® or EpiPen® (0.3 mg/0.3 ml i.m.) in prefilled syringes
Indirect-acting adrenomimetics
Antihypotensive drugs
Ephedrine, Mephentermine
36. Dose-response curves of Adr (adrenaline), NA (noradrenaline)
and Iso (isoprenaline) on isolated aortic strip and isolated bron-
chial smooth muscle illustrating two distinct rank orders of po-
tencies respectively for α- and β-adrenergic receptors.
Isolated aortic strip Isolated bronchial
smooth muscle
37. Effect after 3 to 5 min
and duration 4–6 h:
•Salbutamol
•Fenoterol
Effect after 15–20 min
and duration 12 h:
•Salmeterol
40. The primary site of bronchodilation action of inhaled
β2-adrenergic agonists is mainly bronchiolar smooth muscle.
Atropinic drugs cause bronchodilation by blocking cholinergic
constrictor tone, act primarily in large airways.