The document discusses the case for personalized medicine and its benefits. It argues that personalized medicine can shift the focus to prevention, enable the selection of optimal therapies, make drugs safer by avoiding adverse reactions, improve quality of life, and help control overall healthcare costs. It also notes that major drugs are ineffective for many patients, wasting billions of dollars each year. The Personalized Medicine Coalition works to promote personalized medicine concepts to benefit patients and the healthcare system.

1. The Case for Personalized Medicine OSU Personalized Health Care Conference October 6, 2011 Columbus, Ohio Edward Abrahams, Ph.D. President Personalized Medicine Coalition

2. The Case for Personalized Medicine Shift emphasis in medicine from reaction to prevention Enable the selection of optimal therapy and reduce trial-and-error prescribing Make drugs safer by avoiding adverse drug reactions Increase patient adherence with treatment Improve quality of life Revive drugs that failed in clinical trials or were withdrawn from the market Help control the overall cost of health care

3. Major Drugs Ineffective for Many Source: Spear B, Heath-Chiozzi M, Huff J Clinical Trends Molecular Medicine 2001; 7(5):201-4.

4. Ineffective Therapies Waste Money Major Drug Hypertension Drugs Ace Inhibitors Heart Failure Drugs Beta Blockers Anti Depressants SSRIs Cholesterol Drugs Statins Asthma Drugs Beta-2-agonists Cost of Ineffectiveness to Healthcare System $390 million – $1.2 billion $345 million – $575 million $2.3 billion – $5.8 billion $3.8 billion – $8.8 billion $560 million – $1.0 billion

5. Personalized Medicine Coalition The Personalized Medicine Coalition, representing scientists, patients, providers and payers, promotes the understanding and adoption of personalized medicine concepts, services and products to benefit patients and the health system.