This document discusses ABO and Rh blood typing. It describes the discovery of the ABO blood group system by Dr. Karl Landsteiner in 1901. The four main blood types are A, B, AB, and O. Rh typing was discovered in 1940 after studying Rhesus monkeys. The Rh system includes over 45 antigens, with Rh(D) being the most significant. Sensitization to Rh(D) can be prevented by anti-D immunoglobulin in Rh(D) negative pregnant women. Antiglobulin testing can detect non-agglutinating antibodies or complement on red blood cells through direct or indirect methods.