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A tactical approach to writing
your grant proposal
Catherine A. Sarkisian, MD, MSHS
UCLA CTSI R Workshop
November 9, 2017
4-6 month time-line: 1st month
• Pick a high-impact topic you love and
get excited to be creative
– should be natural extension of your K work
• Draft specific aims
• Start to put together scientific team
• Map out calendar
– meet with your admin team to determine
key dates
– vacations, ward attending?
– set target dates to get drafts to Co-Is
3-4 months out:
Meet with your Program Official
• Remember that most PO’s love seeing K
awardees get R01s
– relationship evolves during your K
• Phone vs. email?
• Will he/she will read your specific aims?
• Suggestions re study section?
• Cover letter can mention your PO
• Send thank you email and copy of grant
Putting Together your Team: think
both as a reviewer and as PI
• Interdisciplinary teams increasingly
attractive
• Each team member needs to be making
unique/complimentary contribution
• Consider linking with strengths of your
institution
– Will be attractive to reviewers
– Good opportunity to expand your network
Putting Your Team Together
(Continued)
• Think carefully about subcontracts
(allow extra time)
• Balance of seniority levels
• Think about division needs
• Choose people you want to work with
Developing your Team
Leadership Style
• Embrace the role of PI (gradual process
evolving over K period)
• Be very clear to Co-I’s what is expected
– What is exact role?
– How many meetings? Format? Travel?
– What % time covered?
– Authorship?
Start Budget Early
• Tension between being economical and
practical (talk to your PO)
– Agencies like low-budget projects BUT
– Make sure you can do the work!
• (also likely to get across the board cut)
– Budget justification is CRITICAL
• Investigator time:
– As new investigator consider 35% time
– 5% time for Co-Is can be red flag to reviewers
Don’t under-budget:
• Project Director salary
• Ground transportation for staff
• Cell phones and service
• Translations
• Data storage (consider scanning)
Writing the Grant
• Approach (Methods) is MOST important
– Write first. Do not wait.
• Remember your audience
– Few MDs
– May know nothing about your area of research
– Make it easy on the reviewer
• White space, figures, tables, colors
– Always discuss trade-offs
Telling your Story:
Preliminary Studies
• Purpose:
– (Findings that support your hypotheses)
– Most important: to show the reviewer your
team has experience to do the project
Show that you have considered
potential obstacles/tradeoffs
and how you will address them
• Discuss trade-offs of design decisions
– Example: randomizing at individual vs.
cluster
– Can do throughout or in summary section
towards end of approach section
– How will you deal with potential problems?
• Refer to budget throughout
Make it Easy for the Reviewer
• Use exact language from program
announcement
– “the stated aim of this program
announcement is XXX and our project
addresses this by . . . . “
• Remind reviewer of specific review
criteria and state specifically how your
project addresses.
– Consider bulletted section at the end
– 1 bullet for each criteria
Avoid Grant Pitfalls
• Write face page (abstract) early and
circulate
• Don’t be unjustifiably overambitious
• Do not put essential elements in the
appendices
• Convince reviewer of feasibility
– Preliminary studies
– Benchmarks
– Alternative plans
– Institutional support

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A Tactical Approach to Writing Your Grant Application by Catherine Sarkisian, MD, MSPH

  • 1. A tactical approach to writing your grant proposal Catherine A. Sarkisian, MD, MSHS UCLA CTSI R Workshop November 9, 2017
  • 2. 4-6 month time-line: 1st month • Pick a high-impact topic you love and get excited to be creative – should be natural extension of your K work • Draft specific aims • Start to put together scientific team • Map out calendar – meet with your admin team to determine key dates – vacations, ward attending? – set target dates to get drafts to Co-Is
  • 3. 3-4 months out: Meet with your Program Official • Remember that most PO’s love seeing K awardees get R01s – relationship evolves during your K • Phone vs. email? • Will he/she will read your specific aims? • Suggestions re study section? • Cover letter can mention your PO • Send thank you email and copy of grant
  • 4. Putting Together your Team: think both as a reviewer and as PI • Interdisciplinary teams increasingly attractive • Each team member needs to be making unique/complimentary contribution • Consider linking with strengths of your institution – Will be attractive to reviewers – Good opportunity to expand your network
  • 5. Putting Your Team Together (Continued) • Think carefully about subcontracts (allow extra time) • Balance of seniority levels • Think about division needs • Choose people you want to work with
  • 6. Developing your Team Leadership Style • Embrace the role of PI (gradual process evolving over K period) • Be very clear to Co-I’s what is expected – What is exact role? – How many meetings? Format? Travel? – What % time covered? – Authorship?
  • 7. Start Budget Early • Tension between being economical and practical (talk to your PO) – Agencies like low-budget projects BUT – Make sure you can do the work! • (also likely to get across the board cut) – Budget justification is CRITICAL • Investigator time: – As new investigator consider 35% time – 5% time for Co-Is can be red flag to reviewers
  • 8. Don’t under-budget: • Project Director salary • Ground transportation for staff • Cell phones and service • Translations • Data storage (consider scanning)
  • 9. Writing the Grant • Approach (Methods) is MOST important – Write first. Do not wait. • Remember your audience – Few MDs – May know nothing about your area of research – Make it easy on the reviewer • White space, figures, tables, colors – Always discuss trade-offs
  • 10. Telling your Story: Preliminary Studies • Purpose: – (Findings that support your hypotheses) – Most important: to show the reviewer your team has experience to do the project
  • 11. Show that you have considered potential obstacles/tradeoffs and how you will address them • Discuss trade-offs of design decisions – Example: randomizing at individual vs. cluster – Can do throughout or in summary section towards end of approach section – How will you deal with potential problems? • Refer to budget throughout
  • 12. Make it Easy for the Reviewer • Use exact language from program announcement – “the stated aim of this program announcement is XXX and our project addresses this by . . . . “ • Remind reviewer of specific review criteria and state specifically how your project addresses. – Consider bulletted section at the end – 1 bullet for each criteria
  • 13. Avoid Grant Pitfalls • Write face page (abstract) early and circulate • Don’t be unjustifiably overambitious • Do not put essential elements in the appendices • Convince reviewer of feasibility – Preliminary studies – Benchmarks – Alternative plans – Institutional support