This document discusses the role of anticoagulation in neurocritical care. It notes that anticoagulation remains the mainstay for preventing and treating thrombosis. It then compares different anticoagulants and their properties. It provides dosing guidelines for prophylactic and therapeutic anticoagulation in various neurologic conditions and procedures. Finally, it discusses newer oral anticoagulants and their advantages over warfarin, though they lack reversal agents and are not useful in renal failure or pregnancy.