This document discusses various psychotropic drugs, including their classification, mechanisms of action, effects, and uses. It covers antipsychotic drugs, mood stabilizers like lithium, antidepressants, anti-anxiety drugs, and hallucinogens. Antipsychotics work primarily by blocking dopamine receptors in the brain and include first generation "typical" antipsychotics like chlorpromazine as well as newer "atypical" antipsychotics. Lithium is used to treat mania and bipolar disorder by stabilizing mood, though its exact mechanism is unknown. Hallucinogens can cause psychedelic experiences by mimicking serotonin and other neurotransmitters but are rarely used therapeutically.
Hello friends. In this PPT I am talking about CNS drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
Hello friends. In this PPT I am talking about CNS drugs. If you like it, please do let me know in the comments section. A single word of appreciation from you will encourage me to make more of such videos. Thanks. Enjoy and welcome to the beautiful world of pharmacology where pharmacology comes to life. This video is intended for MBBS, BDS, paramedical and any person who wishes to have a basic understanding of the subject in the simplest way.
Psychopharmacology is the study of drug-induced changes in mood, thinking, and behavior. These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical syntheses in the laboratory.
Major Categories of Drugs
1- Neuroleptics 2- Anxiolytics 3- Hypnotics 4- Antidepressants 5- Mood Stabilizers 6- Psychostimulants
A compiled Power point presentation on "Antipsychotic drugs" suitable for Undergraduate level medical students and also PG students in the subject of Pharmacology.
Second generation atypical anti-psychotic used for mental disorders more extensively for bipolar disorder. have very low side effects than other SGA Medications
Here is an overview of Antipsychotics,starting from basic pathophysiology of Psychosis and Schizophrenia,breifing the Neuropharmacology and lastly introduction of drugs with special reference to side effects and clincal uses.
Psychopharmacology is the study of drug-induced changes in mood, thinking, and behavior. These drugs may originate from natural sources such as plants and animals, or from artificial sources such as chemical syntheses in the laboratory.
Major Categories of Drugs
1- Neuroleptics 2- Anxiolytics 3- Hypnotics 4- Antidepressants 5- Mood Stabilizers 6- Psychostimulants
A compiled Power point presentation on "Antipsychotic drugs" suitable for Undergraduate level medical students and also PG students in the subject of Pharmacology.
Second generation atypical anti-psychotic used for mental disorders more extensively for bipolar disorder. have very low side effects than other SGA Medications
Here is an overview of Antipsychotics,starting from basic pathophysiology of Psychosis and Schizophrenia,breifing the Neuropharmacology and lastly introduction of drugs with special reference to side effects and clincal uses.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
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Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
2. Psychotropics
Neurotransmitters:
Dopamine: Pleasure, fine muscle movement, integration of emotion & thoughts, decision
making,
Norepinephrine: affects mood, fight/ flight response
Serotonin: sleep regulation, pain perception, sexual behavior & aggression
Gamma-aminobutyric acid (GABA): Plays role in inhibition, muscle relaxing properties
Acetylcholine: Role in learning, memory, regulates mood, sexual drive
3. Psychotropics
Neurotransmitters and psychiatric disorders
Serotonin: Depression or anxiety related.
Norepinephrine: Bipolar (deals with flight or fight response), mania, anxiety.
Dopamine: Schizophrenic disorders and ADHD.
Acetylcholine: Alzheimer's related.
GABA: Anxiety disorders, Schizophrenia.
4. Psychotropics
Psychoses These are severe psychiatric illness with serious distortion of thought, behavior,
capacity to recognize reality and of perception.
a) Acute and chronic organic brain syndromes (cognitive disorders) Such as delirium and
dementia with psychotic features.
b) Functional disorders No underlying cause can be defined.
• Schizophrenia (split mind),
• Paranoid states with marked persecutory or other kinds of fixed delusions (false beliefs) ,
• Mood (affective) disorders The primary symptom is change in mood state; may manifest as:
Mania—elation or irritable mood, reduced sleep, hyperactivity, uncontrollable thought and
speech, may be associated with reckless or violent behaviour,
Depression—sadness, loss of interest and pleasure, worthlessness, guilt, physical and mental
slowing, melancholia, self-destructive ideation.
5. Psychotropics
Neuroses These are less serious; ability to comprehend reality is not lost, though the patient may
undergo extreme suffering. Depending on the predominant feature, it may be labelled as:
(a) Anxiety - An unpleasant emotional state associated with uneasiness, worry, tension and concern for
the future.
(b) Phobic states - Phobic states Fear of the unknown or of some specific objects, person or situations.
(c) Obsessive-compulsive disorder Limited abnormality of thought or behaviour; recurrent intrusive
thoughts or ritual like behaviours
(d) Reactive depression due to physical illness, loss, blow to self-esteem
(e) Post-traumatic stress disorder Varied symptoms following distressing experiences like war.
(f) Hysterical Dramatic symptoms resembling serious physical illness, but situational, and always in the
presence of others.
6. Psychotropics
• The psychopharmacological agents or psychotropic drugs are those having primary effects
on psyche (mental processes) and are used for treatment of psychiatric disorders.
• Pathophysiology of mental illness is not clear
• Treatment is empirical, symptom oriented and not disease specific.
7. Psychotropics
Depending on the primary use, the psychotropic drugs may be grouped into:
1. Antipsychotic (neuroleptic, ataractic, major tranquillizer) useful in all types of functional
psychosis, especially schizophrenia.
2. Antimanic (mood stabilizer) used to control mania and to break into cyclic affective
disorders.
3. Antidepressants used for minor as well as major depressive illness, phobic states,
obsessive-compulsive behaviour, and certain anxiety disorders.
4. Antianxiety (anxiolytic-sedative, minor tranquillizer) used for anxiety and phobic stat
5. Psychotomimetic (psychedelic, psychodysleptic, hallucinogen). They are seldom used
therapeutically but produce psychosis-like states.
9. PHARMACOKINETICS
• Oral absorption of CPZ is somewhat unpredictable and bioavailability is low. More consistent
effects are produced after i.m. or i.v. administration
• Brain concentration is higher than plasma concentration.
• It is metabolized in liver, mainly by CYP 2D6 into a number of metabolites
• The elimination t½ is variable, but mostly is in the range of 18– 30 hours. The drug cumulates on
repeated administration, and it is possible to give the total maintenance dose once a day.
Psychotropics
10. Psychotropics
PHARMACOLOGICAL ACTIONS
1. CNS Effects differ in normal and psychotic individuals. - In normal individuals CPZ produces
indifference to surroundings, paucity of thought, psychomotor slowing, emotional quietening,
reduction in initiative,
In a psychotic CPZ reduces irrational behaviour, agitation and aggressiveness and controls
psychotic symptomatology.
Mechanism of action All antipsychotics (except clozapine-like atypical ones) have potent
dopamine D2 receptor blocking action.
2. ANS Neuroleptics have varying degrees of α adrenergic blocking activity.
3. Local anesthetic Chlorpromazine is as potent a local anaesthetic as procaine.
4. CVS Neuroleptics produce hypotension
11. Psychotropics
5. Skeletal muscle Neuroleptics have no direct effect on muscle fibres or neuromuscular
transmission. However, they reduce certain types of spasticity.
6. Endocrine Neuroleptics consistently increase prolactin release by blocking the inhibitory action of DA
on pituitary lactotropes. This may result in galactorrhoea and gynaecomastia.
Tolerance and dependence Tolerance to the sedative and hypotensive actions develops within
days or weeks, but maintenance doses for therapeutic effect in most psychotics remain
fairly unchanged over years, despite increased DA turnover in the brain.
12. Psychotropics
ADVERSE EFFECTS
I. Based on pharmacological actions (dose related)
1. CNS Drowsiness, lethargy, mental confusion; more with low potency typical antipsychotics and some
atypical ones like quetiapine and clozapine.
2. CVS Postural hypotension, palpitation, inhibition of ejaculation (especially with thioridazine) are due
to α adrenergic blockade;
3. Anticholinergic Dry mouth, blurring of vision, constipation, urinary hesitancy in elderly males
4. Endocrine Hyperprolactinemia (due to D2 blockade) is common with typical neuroleptics and
risperidone.
5. Metabolic effects Elevation of blood sugar and triglyceride levels as a consequence of chronic
therapy with certain antipsychotics is a major concern now.
13. Psychotropics
6. Extrapyramidal disturbances
The extrapyramidal effects may be categorized into:
(a) Parkinsonism
(b) Acute muscular dystonias
(c) Akathisia
(d) Malignant neuroleptic syndrome
7. Miscellaneous - Weight gain often occurs due to long-term antipsychotic therapy, sugar and
lipids may tend to rise.
8. Hypersensitivity reactions – Skin rashes, Myocarditis, Cholestatic jaundice
14. Psychotropics
2.ANTIMANIC AND MOOD STABILIZING DRUGS (Drugs for bipolar disorder)
LITHIUM CARBONATE
Lithium is a small monovalent cation. In 1949, it was found to be sedative in animals and to exert
beneficial effects in manic patients.
Actions and mechanism
1. CNS Lithium has practically no acute effects in normal individuals as well as in
bipolar patients. It is neither sedative nor euphorient; but on prolonged
administration, it acts as a mood stabiliser in bipolar disorder. Given to patients in
acute mania, it gradually suppresses the episode taking 1–2 weeks; continued treatment
prevents cyclic mood changes. The markedly reduced sleep time of manic patients is
normalized.
15. Psychotropics
(a) Li+ partly replaces body Na+ and is nearly equally distributed inside and outside the cells (contrast
Na+ and K+ which are unequally distributed); this may affect ionic fluxes across brain cells or modify the
property of cellular membranes
(b) Lithium decreases the presynaptic release of NA and DA in the brain of treated animals without
affecting 5-HT release.
(c) The above hypothesis cannot explain why Li+ has no effect on people not suffering from
mania.
Use
1. Acute mania (inappropriate cheerfullness or irritability, motor restlessness, high energy level, nonstop
talking, flight of ideas, little need for sleep and progressive loss of contact with reality;
2. Prophylaxis in bipolar disorder Lithium has proven efficacy in bipolar disorder:
• The mechanism of antimanic and mood stabilizing action of lithium is not known. However, the
following mechanisms have been proposed:
16. Psychotropics
3.HALLUCINOGENS (Psychotomimetics, Psychedelics, Psychodysleptics, Psychotogens)
• These are drugs which alter mood, behaviour, thought and perception in a manner similar to
that seen in psychosis. Many natural products having hallucinogenic property have been
discovered and used by man since prehistoric times.
I.INDOLE AMINES
1. Lysergic acid diethylamide (LSD) Synthesized by Hofmann (1938) who was working on
chemistry of ergot alkaloids, and himself experienced its hallucinogenic effect.
2. Lysergic acid amide A close relative of LSD but 10 times less potent
3.Psilocybin Found in a Mexican mushroom Psilocybe mexicana; it has been used by Red Indian
tribals during religious rituals.
4. Harmine It is present in a vine Banisteriopsis caapi, found in the Amazon region. The
Brazilian natives have used it as a snuff.
5. Bufotenin Isolated from skin of a toad (Bufo marinus). It is also found in ‘Cohaba Snuff’ and in
the mushroom Amanita muscaria.
The above are all Indolealkylamines related chemically to 5-HT. A number of other synthetic
derivatives like Dimethyltryptamine (DMT) are also hallucinogenic.
17. Psychotropics
II.PHENYLALKYL AMINES
Mescaline From Mexican ‘Peyote cactus’ Lophophora williamsi. It is a low potency hallucinogen used
by natives during rituals.
Ecstasy Methylene dioxy methamphetamine (MDMA, or tenamphetamine) is an amphetamine-like
synthetic compound with stimulant and hallucinogenic properties
Yaba This is a combination of methamphetamine with another stimulant methylhexanamine or
caffeine.
18. Psychotropics
III.ARYLCYCLOHEXYL AMINES
Phencyclidine It is an anticholinergic, which activates σ receptors in brain causing disorientation,
distortion of body image, hallucinations and an anaesthetic like state. Ketamine is a closely related
compound with lower hallucinogenic potential and is used in anaesthesia.
CANNABINOIDS
Tetrahydrocannabinol - It is the active principle of Cannabis indica (Marijuana), which has been the
most popular recreational and ritualistic intoxicant used for millennia. Its use has spread
worldwide.
personality and psychiatric problems are more common among cannabis users.
Young abusers may exhibit ‘amotivational syndrome’, i.e. loss of interest in work or self improvement
activities.
Hallucinogens have been rarely used in psychiatry to facilitate conversation and for opening up
the inner self in case of withdrawn patients.