This study examined the effects of implementing the 7E learning cycle model in online chemistry classes versus a direct instruction model. The 7E model includes eliciting prior knowledge, engagement, exploration, explanation, elaboration, evaluation, and extension. Data was collected from two 11th grade chemistry classes in Indonesia on student activities and critical thinking skills. Results from questionnaires, observations, and tests found that students in the 7E model class had significantly higher levels of learning participation and critical thinking abilities compared to the direct instruction class. The 7E learning cycle model was an effective approach for online chemistry teaching.