The document outlines 7 reasons why email subscribers may not respond to email campaigns: 1) They did not receive the email due to deliverability issues. 2) They do not know or trust the sender. 3) The subject line does not clearly state the offer or benefits. 4) The email does not clearly explain the benefits or what's in it for the subscriber. 5) The call to action is not clear about what the subscriber should do. 6) The landing page is not well optimized for conversion. 7) The offer may not be relevant to the subscriber's interests. The document provides tips on addressing each reason to improve response rates.