This lecture covers the 6 degree-of-freedom equations of motion for spacecraft and aircraft. It begins with a review of Newton's laws, rotating reference frames, and coordinate rotations. It then derives the equations of motion for linear and angular momentum in an inertial frame and body-fixed frame. Due to the body-fixed frame rotating, additional terms are needed in the equations of motion. Euler angles are also introduced to relate vectors between the inertial and body-fixed frames.