The 5-alpha reductase enzyme converts testosterone to dihydrotestosterone (DHT), which is thought to trigger male and female pattern baldness in genetically susceptible individuals. There are two types of 5-alpha reductase enzymes (type I and type II) that are responsible for producing DHT throughout the body, including in scalp hair follicles where it can disrupt hair growth and lead to hair loss. Studies show that type I 5-alpha reductase, which is highly active in the scalp hair follicles, produces 60-70% of the body's DHT, while type II produces the remaining 30-40%.

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2. What is 5-Alpha Reductase?
To medical specialists, the 5-alpha reductase enzyme is easily identified
as the enzyme which converts testosterone to Dihydrotestosterone or
DHT which is thought to be the hormone that triggers
Androgenetic alopecia in individuals who are genetically susceptible.
The 5 alpha reductase enzymes have been medically proven to convert
the hormone testosterone into a super and much potent hormone that is
Dihydrotestosterone. DHT is primarily the main cause of androgenetic
alopecia which is also known as the male and female pattern baldness.
History stated that 5-alpha reductase enzyme was initially discovered in
the prostate of most men where it modifies the conversion of the
hormone testosterone into a destructive hormone dihydrotestosterone.
This whole process is considerably blameful of why men endure an
enlargement of the prostate and when the modification happens, the
action can seemingly bind to the androgen receptor thus initiating the
progressing development of the external genitalia and prostate.
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3. In the long procedure, concerned doctors and specialists have also
found out that the 5-alpha reductase enzyme can also occur in the
scalp hair follicles of humans and somewhere in the area of the skin,
wherein it usually disseminates equivalent reaction as in the
prostate. It has been assessed that the disruption of the 5-alpha
reductase activity in the skin cells may contribute to male pattern
baldness and could provide a sufficient evidence in such hair loss
condition.
There are two 5-alpha reductase enzymes, the type I and the type II.
They are both active in different sectors of the body and are also
responsible in producing Dihydrotestosterone that can disperse
throughout the body and can inevitably burst effects in other organs.
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4. The two different types of 5-alpha reductase enzymes are
individually coded by a separate gene which is generated by
dissimilar and numerous tissues and the genes for 5-alpha
reductase has been totally outlined to chromosome 5. However,
both seem essentially significant in developing androgenetic
alopecia. Studies show that the first type of 5-alpha reductase is
considered to be more prominent because it is predominantly
vigorous in the human scalp and hair follicles in a very high manner.
The type I 5-alpha reductase enzyme abundantly produces 60% to
705 of Dihydrotestosterone in the human body while on the other
hand, the type II 5-alpha reductase enzyme only produces the extra
30% to 40% of DHT in the body.
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