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University of Puerto Rico - Cayey
RISE Program
Biol. 3095 Seminar Scientific Literature and Bibliography
Seminar Reflections
Félix Vallés
Seminar 4. October 22, 2013 Dr. Aixa Alfonso: The Use of C.elegans as a Model to Study Neural
Development, Function and Dysfunction

Central nervous system (CNS) neurons are incapable of regenerating whereas peripheral nervous system
(PNS) neurons are able to do so in adult warm-blooded vertebrates. The inhibitory environment,
essential axon promoting growth factors, and the low levels of endogenous cyclic adenosine
monophosphate (cAMP) in the CNS are responsible for this incapacity. The inability of regeneration in
the CNS occurs in the branch. Nevertheless, if the PNS and CNS braches are segregated consecutively,
the PNS promotes the levels of cAMP to rise, hence allowing the CNS branch to regrow. The purpose of
this research is to elaborate a genetically manageable model system that detects innovative molecules
responsible for regulate axon regeneration. C. elegans serves as a proper model system, because it has a
modest nervous system with recognizable axon trajectories and synaptic connections in addition to
optimal size and transparency. Their genes, regeneration patterns and molecular mechanisms share
similar characteristics with vertebrates.

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4 seminar reflection wordpress

  • 1. University of Puerto Rico - Cayey RISE Program Biol. 3095 Seminar Scientific Literature and Bibliography Seminar Reflections Félix Vallés Seminar 4. October 22, 2013 Dr. Aixa Alfonso: The Use of C.elegans as a Model to Study Neural Development, Function and Dysfunction Central nervous system (CNS) neurons are incapable of regenerating whereas peripheral nervous system (PNS) neurons are able to do so in adult warm-blooded vertebrates. The inhibitory environment, essential axon promoting growth factors, and the low levels of endogenous cyclic adenosine monophosphate (cAMP) in the CNS are responsible for this incapacity. The inability of regeneration in the CNS occurs in the branch. Nevertheless, if the PNS and CNS braches are segregated consecutively, the PNS promotes the levels of cAMP to rise, hence allowing the CNS branch to regrow. The purpose of this research is to elaborate a genetically manageable model system that detects innovative molecules responsible for regulate axon regeneration. C. elegans serves as a proper model system, because it has a modest nervous system with recognizable axon trajectories and synaptic connections in addition to optimal size and transparency. Their genes, regeneration patterns and molecular mechanisms share similar characteristics with vertebrates.