Advancements in Epigenetics have certainly given us huge breakthroughs in drug discovery, development and effective diagnosis of diseases. Scientists are working towards making new developments and address challenges in epigenetics for cancer, neurodegenerative diseases and other ailments. The Epigenetics Discovery Congress will provide a platform to such scientists to present their work, learn what their peers are doing, share experiences and overcome challenges that the industry is facing.....
Nanotechnology for Cancer therapy: Recent developmentsroshan telrandhe
This paper is an overview of advances and prospects in applications of nanotechnology for cancer treatment. Nanotechnology is an use for prevention, diagnosis, and treatment. nanotechnology offers a promise for the targeted delivery of drugs, genes and protein to tumer tissue and therefore alleviating the toxicity of anticancer agent in healthy tissues. Cancer is one of the leading causes of death worldwide. Nanotechnology is one of the most rapidly growing fields in the 21st centuryThese mainly include arrays of nanocantilevers, nanotubes and nanowires for multiplexing detection, multifunctional injectable nanovectors for therapeutics and diagnostics. This article review current nanotechnology platforms for anticancer drug delivery, including polymeric nanoparticles, liposomes, dendrimers, nanoshells, nuclear acid base nanoparticle [DNA, RNA interference (RNAi), and antisense oligonucleotide (ASO) ] The review increases awarnes of advantages in cancer therapy.
Nanotechnology for Cancer therapy: Recent developmentsroshan telrandhe
This paper is an overview of advances and prospects in applications of nanotechnology for cancer treatment. Nanotechnology is an use for prevention, diagnosis, and treatment. nanotechnology offers a promise for the targeted delivery of drugs, genes and protein to tumer tissue and therefore alleviating the toxicity of anticancer agent in healthy tissues. Cancer is one of the leading causes of death worldwide. Nanotechnology is one of the most rapidly growing fields in the 21st centuryThese mainly include arrays of nanocantilevers, nanotubes and nanowires for multiplexing detection, multifunctional injectable nanovectors for therapeutics and diagnostics. This article review current nanotechnology platforms for anticancer drug delivery, including polymeric nanoparticles, liposomes, dendrimers, nanoshells, nuclear acid base nanoparticle [DNA, RNA interference (RNAi), and antisense oligonucleotide (ASO) ] The review increases awarnes of advantages in cancer therapy.
Biochemistry: A pivotal aspects in forensic scienceVanshikaVarshney5
In the above presentation, you will know the importance of biochemistry in forensic science. Biochemistry is not all about the chemicals, it is about your life, your environment. Basically, it belongs to you.
in this presentation, you can know about the biochemical techniques which are majority used in forensic science and various research occurs in the field of forensic science which is related with biochemistry.
Viral metagenomics is the study of viral genetic material sourced directly from the environment rather than from a host or natural reservoir. The goal is to ascertain the viral diversity in the environment that is often missed in studies targeting specific potential reservoirs.
Contains the speakers details of the 23rd International Conference on Cancer Research and Pharmacology.
For more details, visit: https://cancer.cmesociety.com/
Antitumor applications of nano-traditional Chinese medicineLucyPi1
An article by Deng et al. [1] that was first published in ACS Nano in 2019 revealed that nanoparticles extracted from cuttlefish ink (CINPs) could inhibit tumor growth by synergizing immunotherapy and photothermal therapy. The researchers found that these CINPs, which had significant antitumor efficacy, could effectively reprogram tumor-associated macrophages (TAMs) from the immune-suppressive M2-like phenotype to the antitumor M1-like phenotype.
Sonogenetic Locale Specific Activation of Universal Vectors for Xenobiotics -...Nejc Draganjec
The final goal of the project is to develop “BioBrick” for liposome produced by means of synthetic biology, that
has a construct for disintegration embedded in its membrane. Xenobiotic packaged in a liposome is not part
of pharmacodynamics since it is biologically unavailable. Which makes liposomes interesting candidates for
universal drug delivery vectors. In our case, liposome disintegration is initiated by non-invasive sonic signal
and carried out by a construct of a sensor and an active part embedded in a membrane. Sensor part of a
construct is mechanoreceptor/mechanotransducer which activates protein representing the active part of a
construct. After activation, active part carries out the dissolution of a compartmentalization function by means
of total disintegration of vector or only membrane perforation. After an opening of a vector, previously packed
xenobiotic becomes locally available with a high concentration in locale and thus high effect and low systemic
concentration and thus smaller chance of side effect. This approach is very specific for both, time and space
factors and at the same time has a very broad area of potential biomedical applications. Vector would be, in
a hypothetical scenario of practical use in oncology, first packed with chemotherapeutics/biological drugs,
administered intravenously and then medical staff would have an option of drug activation in specific locations.
Activation is very precise and at the same time offers an option of easy switching among many different
targets, for example between dominant tumor to many potential metastasis. Since location of activation is
not tied to biomarker, but rather takes advantage of other rapidly developing medical technologies, vector
remains universally and directly applicable for any patient and for a broad spectrum of pathologies in fields of
oncology (chemotherapeutics/biological drugs and other payloads, like local immune response enhancers),
autoimmune diseases (local immune suppressors, diabetes), parasitology (malaria drugs and plasmodium
sporozoite), local pathologies (ulcer, trauma healing) . . .
Dr. Terry Dwelle - Antimicrobial Resistance: What Can We Do?John Blue
Antimicrobial Resistance: What Can We Do? - Dr. Terry Dwelle, State Health Officer, North Dakota Department of Health, from the 2013 NIAA Symposium Bridging the Gap Between Animal Health and Human Health, November 12-14, 2013, Kansas City, MO, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2013-niaa-antibiotics-bridging-the-gap-animal-health-human-health
Biochemistry: A pivotal aspects in forensic scienceVanshikaVarshney5
In the above presentation, you will know the importance of biochemistry in forensic science. Biochemistry is not all about the chemicals, it is about your life, your environment. Basically, it belongs to you.
in this presentation, you can know about the biochemical techniques which are majority used in forensic science and various research occurs in the field of forensic science which is related with biochemistry.
Viral metagenomics is the study of viral genetic material sourced directly from the environment rather than from a host or natural reservoir. The goal is to ascertain the viral diversity in the environment that is often missed in studies targeting specific potential reservoirs.
Contains the speakers details of the 23rd International Conference on Cancer Research and Pharmacology.
For more details, visit: https://cancer.cmesociety.com/
Antitumor applications of nano-traditional Chinese medicineLucyPi1
An article by Deng et al. [1] that was first published in ACS Nano in 2019 revealed that nanoparticles extracted from cuttlefish ink (CINPs) could inhibit tumor growth by synergizing immunotherapy and photothermal therapy. The researchers found that these CINPs, which had significant antitumor efficacy, could effectively reprogram tumor-associated macrophages (TAMs) from the immune-suppressive M2-like phenotype to the antitumor M1-like phenotype.
Sonogenetic Locale Specific Activation of Universal Vectors for Xenobiotics -...Nejc Draganjec
The final goal of the project is to develop “BioBrick” for liposome produced by means of synthetic biology, that
has a construct for disintegration embedded in its membrane. Xenobiotic packaged in a liposome is not part
of pharmacodynamics since it is biologically unavailable. Which makes liposomes interesting candidates for
universal drug delivery vectors. In our case, liposome disintegration is initiated by non-invasive sonic signal
and carried out by a construct of a sensor and an active part embedded in a membrane. Sensor part of a
construct is mechanoreceptor/mechanotransducer which activates protein representing the active part of a
construct. After activation, active part carries out the dissolution of a compartmentalization function by means
of total disintegration of vector or only membrane perforation. After an opening of a vector, previously packed
xenobiotic becomes locally available with a high concentration in locale and thus high effect and low systemic
concentration and thus smaller chance of side effect. This approach is very specific for both, time and space
factors and at the same time has a very broad area of potential biomedical applications. Vector would be, in
a hypothetical scenario of practical use in oncology, first packed with chemotherapeutics/biological drugs,
administered intravenously and then medical staff would have an option of drug activation in specific locations.
Activation is very precise and at the same time offers an option of easy switching among many different
targets, for example between dominant tumor to many potential metastasis. Since location of activation is
not tied to biomarker, but rather takes advantage of other rapidly developing medical technologies, vector
remains universally and directly applicable for any patient and for a broad spectrum of pathologies in fields of
oncology (chemotherapeutics/biological drugs and other payloads, like local immune response enhancers),
autoimmune diseases (local immune suppressors, diabetes), parasitology (malaria drugs and plasmodium
sporozoite), local pathologies (ulcer, trauma healing) . . .
Dr. Terry Dwelle - Antimicrobial Resistance: What Can We Do?John Blue
Antimicrobial Resistance: What Can We Do? - Dr. Terry Dwelle, State Health Officer, North Dakota Department of Health, from the 2013 NIAA Symposium Bridging the Gap Between Animal Health and Human Health, November 12-14, 2013, Kansas City, MO, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2013-niaa-antibiotics-bridging-the-gap-animal-health-human-health
Test drive the 2012 Ford Fusion and Fusion Hybrid at Mizell Ford serving Augusta Georgia. View our in stock selection of all 2012 Ford Fusions and Fusion Hybrids by visiting our website at www.mizellford.com
Gemini Type Fontpack™ Font Download
Download : http://myfonts.us/lvCgtN
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INTRODUCING THE GEMINI TYPE FONTPACK, an industrial-strength OpenType font bundle inspired by and optimized for dimensional type.
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Der Hako Citymaster 600 von Stangl Reinigungstechnik dient nicht nur als Kehrmaschine sondern ist auch als Rasenmäher und Fahrzeug im Winterdienst einsatzfähig. Zudem zeichnet sich das Gerät durch Multifunktionalität und Komfort aus. Alle Informationen zu dieser Kehrmaschine und Multifunktionsgerät von Stangl Reinigungstechnik finden Sie in dieser Broschüre.
Pegs Europe 2015 Protein & Antibody Engineering SummitNicole Proulx
PEGS Europe is the largest European event covering all aspects of protein and antibody engineering. With three consecutive years of 35% growth in attendance, and another year of expanded program coverage, this year’s event will feature:
700 attendees
175 technical presentations
125 scientific posters
Dedicated networking opportunities
Exclusive exhibit & poster viewing hours
Interactive roundtable, breakout & panel discussions
Tumour models London 1-3 December 2015 AgendaDiane McKenna
Tumour Models London 2015, now in its 4th year,is the leading meeting dedicated to improve preclinical predictability and translational success of oncology discoveries. Tackling clinical failures rates, preclinical strategies and translational challenges, this Summit will enable you to translate your discoveries from model to human studies with superior predictability to future proof clinical success. [Read More…]
Genomics is the study of an organism's entire genome, which is the complete set of genetic material present in its DNA. This includes all the genes, non-coding regions, and regulatory sequences. Genomics involves sequencing and analyzing the DNA to identify genes, variations (such as single nucleotide polymorphisms or SNPs), and other structural features of the genome.
2019 02-21 Oxford Global 14th Biomarker Congress, Manchester, Alain van GoolAlain van Gool
Outline of innovations in clinical X-omics approaches towards personalized diagnostics in our clinical laboratory, presented for an audience of experienced diagnostic and pharmaceutical biomarker scientists.
TCGC The Clinical Genome Conference 2015Nicole Proulx
Bio-IT World and Cambridge Healthtech Institute are again proud to host the Fourth Annual TCGC: The Clinical Genome Conference, inviting stakeholders impacting clinical genomics to share new findings and solutions for advancing the applications of clinical genome medicine.
4th International Conference on Biomarkers & Clinical Research, will be organized around the theme "Impact of Biomarker Developments in Health Diagnostics and Clinical Research."
Haapalinna the new modalities ecosystem project what is there for meAntti Haapalinna
The aim of this New Modalities Ecosystem is enable improved understanding of disease pathology related to the symptoms and disease progression and better treatments by applying large molecular drugs and diagnostic tools as well as digital wearable patient tools for disease symptom recording, to have real world evidence for treatment efficacy
I will show some news that are important to the understanding of the importance of the genetic transcription and how it provides important tools to the actual medicine
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Biomaterials & Tissue engineering - London - AgendaTony Couch
Designed for experts in academia and industry working in this exciting field, this conference will examine cutting-edge
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This expanding series attracts the leading authorities worldwide working in companion diagnostics, biomarkers, immuno-oncology, liquid biopsies, AI and other facets of precision medicine. It has been praised for its stimulating, interactive and engaging environment where it brings together a multi-disciplined community of researchers, leaders and innovators whose aim is to develop groundbreaking and impactful treatments for patients.
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Precision Medicine & Biomarkers Leaders Summit - Boston USA - 7th & 8th MayTony Couch
Global Engage is pleased to announce the 2018 Precision Medicine & Biomarkers Leaders Summit USA taking place on May 7-8th in Boston, MA. The event is part of our highly successful Drug Discovery Series which includes conferences on Biologics, Medicinal Chemistry, NASH, Pharmaceutical R&D IT and the Human Microbiome amongst others. It is also the sister meeting of the European Precision Medicine Summit which has run successfully since 2013.
The conference will provide an interactive networking forum to both further develop and answer your queries through a vibrant exhibition room full of technology providers showcasing their technologies and other solutions, poster presentation sessions, expert led case study presentations, a high-level panel discussion, a round table discussion session, and interactive Q&A sessions from a 40-strong speaker faculty examining topics on 4 separate tracks outlined below.
Designed to attract experts working in all areas of medicinal chemistry and molecular pharmacology the summit has five tracks focusing on key issues such as optimising hit to lead quality and timescale, protein degradation, DNA Encoded libraries, GPCR’s, small molecule Immuno-oncology research, FBDD, SBDD, CADD as well as best strategies for partnerships, collaborations, outsourcing and integration of research. The Summit will provide a forum to network, learn and engage with senior representatives of leading pharmaceutical and biotech companies worldwide. It is a gathering not to be missed!
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After the success of the previous edition - Bioprocessing of Advanced Cellular Therapies Congress 2016, MarketsandMarkets is pleased to announce the 2nd Annual Bioprocessing of Advanced Cellular Therapies Congress in London, UK.
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Last opportunity to get onto the programme.
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Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
A brief information about the SCOP protein database used in bioinformatics.
The Structural Classification of Proteins (SCOP) database is a comprehensive and authoritative resource for the structural and evolutionary relationships of proteins. It provides a detailed and curated classification of protein structures, grouping them into families, superfamilies, and folds based on their structural and sequence similarities.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
PRESENTATION ABOUT PRINCIPLE OF COSMATIC EVALUATION
2nd Epigenetics Discovery congress - Latest agenda
1. MnM CONFERENCES
FOR MORE INFORMATION PLEASE CONTACT
Tony at tony.couch@mnmconferences.com
MnM CONFERENCES
11
Review the importance of the strongly growing epigenetic market
Discuss the latest epigenetic breakthroughs in your field of epigenetic studies
Explore new avenues to network and showcase your epigenetic research work and discoveries
Discuss the use of Biomarkers as a tool for achieving optimal detection
Network with your academic and industry colleagues to brainstorm on latest epigenetic application
Review the latest epigenetic tools and technologies available in the market to aid your research
Why Attend?
2nd Annual
Epigenetics Discovery
Congress
Novel Inhibitors & Emerging Targets for Drug Discovery
8th
- 9th
September 2016, London, UK
MnM CONFERENCES
Epigenetics has flourished to become one of the most revolutionary areas of science over the past decade. Also, advances in the understanding
of epigenetic processes, have led to a burst in interest in this area as a potential source of new targets for the discovery of medicines.
While the promise of epigenetics is significant, it also presents some interesting challenges like pathways and mechanisms underlying epigenetics,
using right screening platforms, bottlenecks in translational and clinical phase, collating epigenetics data with proper analysis and finding the
right biomarkers.
At the 2nd
Annual Epigenetics Discovery Congress, which will be held on 8-9 September 2016 in London, UK aims to provide a
platform for researchers, academics and industry professionals working in epigenetic research to avail an opportunity & explore the potential of
epigenetics to contribute towards novel and existing therapeutics, current progress and trends in the inclusion of epigenetics in drug discovery
and development.
Along with the advancements in technologies and solutions, the conference will also focus on highlighting some of the emerging trends in terms of
drug discovery with respect to evolving targets, inhibitors, biomarkers and clinical success of epigenetics across various diseases.
2. MnM CONFERENCES
FOR MORE INFORMATION PLEASE CONTACT
Tony at tony.couch@mnmconferences.com
MnM CONFERENCES
2
Gold Sponsors:
Silver Sponsors:
Sponsor/Exhibitors:
Supporting Association:
THE EPIGENETICS SOCIETY
Media Partners:
3. MnM CONFERENCES
FOR MORE INFORMATION PLEASE CONTACT
Tony at tony.couch@mnmconferences.com
MnM CONFERENCES
3
Speakers:
Advisory Panel:
Dr. Tamara Maes
Chief Scientific Officer,
Oryzon, Spain
Dr. Paola B. Arimondo
Research Director,
CNRS EtaC, France
Dr. Hajji Nabil
Lecturer in epigenetics and
translational oncology, Imperial
College London, UK
Prof. A. Ganesan
Professor of Chemical Biology
University of East Anglia,
Norwich, UK
Dr. Brian Lohse
Associate Professor, EpiDiscoverY,
Faculty of Health and Medical
Sciences, Department of Drug Design
and Pharmacology, University of
Copenhagen, Denmark
Jenny Southgate
Professor of Molecular Carcinogenesis
Director, Jack Birch Unit,
Department of Biology,
University of York, UK
Prof. Dr. Gianluca Sbardella
Associate Professor of
Medicinal Chemistry, Head of
EpigeneticMedChemLab
Università di Salerno, Italy
Dr. Matthew Suderman
Senior Research Associate in
Epigenetics and Social Science
University of Bristol, UK
Prof. Guro Elisabeth Lind
Group leader Epigenetics, Department
of Molecular Oncology, Institute for
cancer research, Oslo University
Hospital, Norway
Dr. Manfred Koegl
Director Oncology Research
Boehringer Ingelheim, Vienna,
Austria
Dr. Tobias A. Knoch
Group Leader Biophysical Genomics,
Cell Biology & Genetics
Erasmus MC, Rotterdam,
The Netherlands
Dr. Gian Gaetano Tartaglia
Group Leader, Gene Function &
Evolution, Centre for Genomic
Regulation (CRG), Barcelona,
Spain
Prof. Irene Maeve Rea
MD, BSc (Hons), FRCP, FRCP(Ed), FHEA
| Professor Emeritus School of Medicine,
Dentistry and Biomedical Science
Queens University Belfast | Visiting
Professor, NI Centre for Translational
Research, Ulster University
Prof. Dr. F.J. (Frank) Dekker
Associate professor, Medicinal
Chemistry, University of
Groningen, Netherlands
Prof. Stephen J Shuttleworth
Chief Scientific Officer
Karus Therapeutics Ltd, England
Dr. Richard Chesworth
Senior Vice President Molecular
Discovery
Epizyme, USA
Prof. Richard Meehan
Programme Leader, Chromosomes
and Gene Expression MRC Human
Genetics Unit MRC IGMM,
University of Edinburgh, UK
Prof. Rosalind M John
Division Leader for Pathophysiology
and Repair
Cardiff School of Biosciences, UK
Prof. Dr. Reinhard Stöger
Associate Professor in Epigenetics
University of Nottingham,
England
Dr. Moshe Szyf
Glaxo Smith Kline and James McGill
Professor, Department of Pharmacology
and Therapeutics, McGill University
Medical School, Canada
Prof. Dr. Manon van Engeland
Dept. of Pathology, GROW-School for
Oncology and Developmental Biology,
Maastricht University Medical
Center, Netherlands
Dr. Paola B. Arimondo
Research Director
CNRS EtaC, France
Dr. Tamara Maes
Chief Scientific Officer
Oryzon, Spain
Dr. Daniel Vitt
CSO
4SC AG, Germany
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Conference Day One, Thursday, 8th
September 2016
08:00 Registration and Refreshments
08:50 MnM Conferences’ Welcome Address
08:55 Opening remarks by the Chair
Developmental Biology and Environment
09:00 Keynote address: Epigenetic regulation of the tumour micro environment (TME) - immuno oncology meets
epigenetics
• 4SC-202 is a new clinical stage epigenetic regulator of the TME
• Enhanced T-cell infiltration in tumours may offer a unique clinical boost of responses to checkpoint inhibitors
• Further approaches of epigenetic immune regulation - beyond HDAC inhibitors
Dr. Daniel Vitt, Vorstand, CSO, 4SC AG, Germany
09:25 Epigenetic profiling and environmental challenge
• 5mC/5hmC profiling tracks environmental exposure in model systems
• Allows identification of potential epigenetic predictors of end point pathologies
• Studying the effects of environmental triggers on the epigenome will enable identification of novel biomarkers
Prof. Richard Meehan, Programme Leader, Chromosomes and Gene Expression, MRC Human Genetics Unit MRC IGMM,
University of Edinburgh, UK
09:50 Stability and flux of DNA methylation patterns
• Genomic programs regulating energy balance evolved to be buffered or ‘canalised’ against genetic variation
• Large genetic regulatory networks can acquire novel epigenetic states in response to environmental challenges
• A new metric to quantify and compare epigenetic flexibility and stability across loci, cell types, and developmental stages
Prof. Dr. Reinhard Stöger, Associate Professor in Epigenetics, University of Nottingham, England
10:15 Presentation by NuGEN
10:45 Morning Refreshments | Networking | Poster presentation | One to One meetings
11:30 Environmental programming of maternal care and offspring behaviour by an epigenetic mechanism
• Prenatal environment and the developing placental epigenome
• Placental function and fetal growth
• Dual programming of maternal care and offspring behaviour
Prof. Rosalind M John, Division Leader for Pathophysiology and Repair, Cardiff School of Biosciences, UK
Translational Epigenetics
11:55 Epigenetic regulation of epithelial homeostasis: an emerging story of health and disease
• Urothelium is a transitional epithelium that functions as a self-repairing, urinary barrier within the bladder and associated urinary tract.
• I will present experimental evidence that at the cellular level, the homeostasis of human urothelium is regulated epigenetically
• I will further consider how local and environmental factors effecting epigenetic deregulation can create an imbalance in tissue
homeostasis, with chronic ulceration versus cancer at the extremes of chronic bladder disease
Prof. Jenny Southgate, Professor of Molecular Carcinogenesis, Director, Jack Birch Unit, Department of Biology, University of York, England
12:20 Presentation by Cell Signalling
12:50 Lunch | Networking | Poster presentation | One to One Meetings
13:50 Presentation by Roche/Kapa Biosystems Ltd.
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Clinical Epigenetics and Biomarkers
14:15 Findings in DNA methylation measured across the life-course in a large well-characterized human cohort
• Prenatal biomarkers that remain and disappear
• Static and changing biomarkers of phenotype
• Genetic influences and causal applications
Dr. Matthew Suderman, Senior Research Associate in Epigenetics and Social Science, University of Bristol, UK
14:40 DNA methylation biomarkers for early and non-invasive detection and monitoring of bladder cancer
• Using methylome sequencing (RRBS) to identify high performing DNA methylation biomarkers specific for bladder cancer
• Leveraging biomarkers to reduce the economic costs of bladder cancer
Prof. Guro Elisabeth Lind, Group leader Epigenetics, Department of Molecular Oncology, Institute for cancer research,
Oslo University hospital, Norway
15:05 Genetics or Lifestyle: Is Epigenetics the Missing link in the Longevity Phenotype?
• Human longevity is a complex trait and increasingly we recognise that both genes and lifestyle interact in the longevity
phenotype.
• Family clusters of nonagenarian and centenarian siblings, who show both exceptional age-span and health-span are likely to
have inherited facilitatory gene groups but also have nine decades of life experiences and behaviours which have interacted
with their genetic profiles.
• Although much remains to be discovered, this lecture will discuss some of the epigenetic and environmental factors which
appear important in good quality longevity and link known epigenetic mechanisms to themes identified by nonagenarians
themselves related to their longevity.
Prof. Irene Maeve Rea, Emeritus Professor School of Medicine, Dentistry and Biomedical Science, Ulster University, Ireland
15:30 Afternoon Refreshments | Poster Presentation | Networking | One to One Meetings
16:15 Solution Provider Presentation; contact steve.h@mnmconferences.com
16:45 DNA methylation markers for management of cancer: pitfalls and perspectives
• Discovery of DNA methylation markers
• Implementation of methylation markers into clinical practice
• Pitfalls and perspectives
Prof. Dr. Manon van Engeland, Dept. of Pathology, GROW-School for Oncology and Developmental Biology, Maastricht
University Medical Center, Netherlands
17:10 Decoding the 3D Multi-Loop Aggregate/Rosette Chromatin Architecture, Dynamics, and Functional Epigenetics of
Genomes
• Novel combination of chromosome interaction capture (T2C) and fluorescence correlation spectroscopy (FCS)
• Final architecture and dynamics of genome organization
• The tight entanglement of sequence, structure, and functional epigenetics
Dr. Tobias A. Knoch, Group Leader Biophysical Genomics, Cell Biology Genetics, Erasmus MC, Rotterdam, The
Netherlands
17:35 Closing Remarks by the Chair
17:45 Networking and Drinks Reception
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Conference Day Two, Friday, 9th
September 2016
08:15 Registration and Refreshments
08:50 MnM Conferences’ Welcome Address
08:55 Opening remarks by the Chair
09:00 Keynote: Drug Discovery and HMTs
• Overview of Histone Methyl transferases
• Drug discovery of HMTs
• Clinical Data of HMTs so far
Dr. Richard Chesworth, Senior Vice President Research, Epizyme, USA
Epigenetics Inhibitors and Emerging Targets
09:25 KATching lysine acetylations in inflammation
• Role of lysine acetylation in inflammation
• Development of histone acetyltransferase inhibitors
• Selective HDAC inhibitors in inflammation
Prof. Dr. Frank Dekker, Associate professor, Medicinal Chemistry, University of Groningen, Netherlands
09:50 Targeting DNA methylation in cancer cells with non-nucleoside inhibitors
• We have designed novel non-nucleoside inhibitors of DNA methyltransferases able to demethylate and reactive tumor
suppressor genes.
• We applied three chemical strategies: High-Throughput Screening of chemical libraries, rational drug design based on
molecular modeling and the pharmacomodulation of known inhibitors.
• The cellular consequences of this DNA demethylation are studied in comparison to nucleoside inhibitor decitabine.
Dr. Paola B. Arimondo, CNRS, ETaC, France
10:15 Panel discussion
Fostering the culture of collaborations between industry and academic researchers to deliver innovation, translation and impact of
epigenetics on a global scale
• Nurturing translational research
• Initiating drug discovery projects in collaboration with industry
• Improving clinical development
-Dr. Moshe Szyf, Glaxo Smith Kline and James McGill Professor, Department of Pharmacology and Therapeutics,
McGill University Medical School, Canada
-Prof. Jenny Southgate, Professor of Molecular Carcinogenesis, Director, Jack Birch Unit, Department of Biology,
University of York, England
-Dr. Richard Chesworth, Senior Vice President Research, Epizyme, USA
10:45 Morning Refreshments – Networking – Poster presentation and One to One meetings
11:30 Solution Provider Presentation; Please contact Steve Hambrook at steve.h@mnmconferences.com
12:00 Strategies to identify new inhibitor scaffolds for Histone Demethylases and Methylases
• Strategies to discover new scaffolds: small molecules and peptides
• DNA encoded peptide libraries
• Fluorescence Assay development and testing on epigenetic targets
Dr. Brian Lohse, Associate Professor, EpiDiscoverY, Faculty of Health and Medical Sciences, Department of Drug Design and
Pharmacology, University of Copenhagen, Denmark
12:25 Is two better than one? Multitarget epigenetic inhibitors
• Dual HDAC plus kinase inhibitors
• Dual HDAC inhibitor plus receptor ligand
• Dual epigenetic targeting
Prof. A. Ganesan, Professor of Chemical Biology, University of East Anglia, Norwich, UK
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12:50 Probing genome readers: the generation of an in vivo active bromodomain inhibitor for BRD9
• The BAF complex is a potential target in cancer therapy
• Structure based drug design of a selective inhibitor of BRD9
• On-target chemical inhibition of Brd9 limits the proliferation of acute myeloid leukemia cells
Dr. Manfred Koegl, Director Oncology Research, Boehringer Ingelheim, Vienna, Austria
13:15 Lunch – Networking – Poster presentation and One to One Meetings
14:15 Presentation by Diagenode
Cancer and Neurodevelopment
14:45 Targeting DNA methylation in neuropsychiatric disease; instructions from cancer epigenetics
• DNA methylation mediating the impact of early exposures on behavioral phenotypes
• Strategies of epigenetic therapeutics in cancer guiding approaches to neuropsychiatry
• Epigenetic strategies towards treatment of behavioral disorders: addiction as a model
Dr. Moshe Szyf, Glaxo Smith Kline and James McGill Professor, Department of harmacology and Therapeutics,
McGill University Medical School, Canada
15:10 Development of LSD1 inhibitors for the treatment of oncological and neurodegenerative disease
• Development of ORY-1001 and ORY-2001
• Identification of the drugs’ modes of action
• Status of ongoing clinical research
Dr. Tamara Maes, Chief Scientific Officer, Oryzon, Spain
15:35 Design and Development of a Novel HDAC6-Selective Inhibitor, KA2507, for Hematological Cancer Treatment
and Solid Tumor Immunotherapy
• Orally-active, selective small molecule HDAC6 inhibitor
• Cancer Immunotherapy
Prof. Stephen Shuttleworth, CSO, Karus Therapeutics, UK
16:00 Afternoon Refreshments | Poster Presentation | Networking
16:40 A “library-on-library” screening approach to identify small-molecule ligands of methyl-lysine reader proteins
• Methyllysine readers
• Chemical probes
• Protein arrays
Prof. Dr. Gianluca Sbardella, Associate Professor of Medicinal Chemistry, Head of EpigeneticMedChemLab, Università di
Salerno, Italy
Bioinformatics Development in Epigenetics
17:05 A computational approach for identification of protein-RNA interactions uncovers direct binders of Xist lncRNA
• Global Score algorithm to calculate interactions of proteins and lncRNAs at nucleotide and amino acid resolution
• Investigating protein binding to the Xist lncRNA, which orchestrates X Chromosome inactivation
• Validating calculations by means of enhanced individual nucleotide CLIP method (eCLIP)
• Testing method against a number of nucleotide-binding proteins
Dr. Gian Gaetano Tartaglia, Group Leader, gene Function Evolution, Centre for Genomic Regulation (CRG), Barcelona, Spain
17:30 Closing Remarks by the Chair
17:35 End of Conference