4th International Conference on Biomarkers & Clinical Research, will be organized around the theme "Impact of Biomarker Developments in Health Diagnostics and Clinical Research."
The most complete map of oncogenes to date a summary of 568 oncogenes in 66 c...DoriaFang
By analyzing the genomes of 28,076 tumor samples from 66 types of cancer, 568 cancer driver genes were identified. This is the most complete map of cancer driver genes to date. The research data has been updated on the IntOGen platform.
As an uncommon malignant tumor, hypopharyngeal cancer accounts for 3–5% of head and neck tumors [1]. Most pathological types of hypopharyngeal cancer are squamous cell carcinoma. Due to the occult anatomical location of hypopharyngeal cancer and poor surgical effect, local recurrence or distant metastasis often occurs in patients with hypopharyngeal cancer following surgery.
The most complete map of oncogenes to date a summary of 568 oncogenes in 66 c...DoriaFang
By analyzing the genomes of 28,076 tumor samples from 66 types of cancer, 568 cancer driver genes were identified. This is the most complete map of cancer driver genes to date. The research data has been updated on the IntOGen platform.
As an uncommon malignant tumor, hypopharyngeal cancer accounts for 3–5% of head and neck tumors [1]. Most pathological types of hypopharyngeal cancer are squamous cell carcinoma. Due to the occult anatomical location of hypopharyngeal cancer and poor surgical effect, local recurrence or distant metastasis often occurs in patients with hypopharyngeal cancer following surgery.
Differences in microRNA expression during tumor development in the transition...Enrique Moreno Gonzalez
The prostate is divided into three glandular zones, the peripheral zone (PZ), the transition zone (TZ), and the central zone. Most prostate tumors arise in the peripheral zone (70-75%) and in the transition zone (20-25%) while only 10% arise in the central zone. The aim of this study was to investigate if differences in miRNA expression could be a possible explanation for the difference in propensity of tumors in the zones of the prostate.
The use of genetic engineering technology in animals has been associated with ethical issues, some of which relate to animal welfare. Discuss examples of genetically engineering animals and evaluate the ethical concerns of genetic engineering.
Acute myeloid leukemia (AML) is a hematopoietic malignancy with a dismal outcome in the majority of cases. A detailed understanding of the genetic alterations and gene expression changes that contribute to its pathogenesis is important to improve prognostication, disease monitoring, and therapy. In this context, leukemia-associated misexpression of microRNAs (miRNAs) has been studied, but no coherent picture has emerged yet, thus warranting further investigations.
Multicentric and multifocal versus unifocal breast cancer: differences in the...Enrique Moreno Gonzalez
The aim of this study was to evaluate the expression of the cell adhesion-related glycoproteins MUC-1, β-catenin and E-cadherin in multicentric/multifocal breast cancer in comparison to unifocal disease in order to identify potential differences in the biology of these tumor types.
Overexpression of YAP 1 contributes to progressive features and poor prognosi...Enrique Moreno Gonzalez
Yes-associated protein 1 (YAP 1), the nuclear effector of the Hippo pathway, is a key regulator of organ size and a candidate human oncogene in multiple tumors. However, the expression dynamics of YAP 1 in urothelial carcinoma of the bladder (UCB) and its clinical/prognostic significance are unclear.
Objective: To analyze the sonographic features of different histopathological subtypes of borderline ovarian tumors (BOTs) confirmed by pathology, and to study the ultrasound performances of various types in borderline ovarian tumors.
Study Design: Retrospective analysis was performed on the pathological results and ultrasound projection findings of 129 patients diagnosed as BOTs by ultrasound department of our hospital from January 2012 to November 2019. All patients were confirmed by surgical pathology and scanned consecutively by the investigators using transabdominal or transvaginal ultrasound examination.
Results: Serous borderline tumors (SBOTs) were observed, and the prevalence rate (53%) was significantly higher than that of other subtypes, and the probability of bilateral lesions was higher (40%). The sonogram often showed ultrasound features of papillary neoplasm in the lesion and good internal echo (p<0.05). Mucinous borderline ovarian tumors (MBOTs) were mostly unilateral lesions (86%). The prevalence was second only to SBOTs. Histomorphological examinations were divided into gastrointestinal-type and endocervical-type. Among them, the gastrointestinal type of MBOTs were mostly unilateral, and their incidence was higher than that of endocervical-type of MBOTs. Compared with other pathological subtypes, the gastrointestinal type is more likely to show the sonographic characteristics of huge space occupying in the pelvic and abdominal cavity (mean diameter >10 cm), polycystic, multiple septums, and poor internal echo (p<0.05). The ultrasonographic features of the endocervical-type of MBOTs were similar to those of SBOTs. Compared with gastrointestinal type, the sonographic images showed smaller lesion diameter, less septal or cyst, and more papillary excrescences in the tumor (p<0.05). The borderline clear cell tumor is the intermediate transition between the clear cell adenofibroma and the clear cell carcinoma. The clinical manifestations are diverse and lack specificity. The histology of sonography was mainly solid, and the multiple microcapsules were honeycomb-like. It can also be shown as cystic. Among the 169 patients with BOTs, 20 cases of SBOTs, 17 cases of MBOTs, and 10 cases of other rare subtypes were complicated with other diseases or multiple subtypes. This study did not find significant ultrasonic characteristics were used for distinguish them from other subtypes.
Conclusion: BOTs is a common disease in women during the reproductive period. It is characterized by the development of malignant tumors. Its clinical and pathological subtypes are complex and diverse. It leads many doctors to use the terms “large pelvic mass” and “solid ovarian mass” for diagnosis because of their lack of experience and understanding.
Keywords: adenocarcinoma, mucinous; adenocarcinoma, serous; borderline ovarian tumors; diagnostic imaging; ovarian neoplasms; papillary neoplasms; prognosis; transvaginal ultrasound, ultrasonography
Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical experimental data explaining the interaction mechanism(s) are lacking. Our objective is to investigate the anticancer efficacy and mechanism of combined sorafenib and 5-FU therapy in vitro in HCC cell lines MHCC97H and SMMC-7721.
Presentation by Scott Woodman, MD, PhD. Presented at the 2018 Eyes on a Cure: Patient & Caregiver Symposium, hosted by the Melanoma Research Foundation's CURE OM initiative.
Clinical and experimental studies regarding the expression and diagnostic val...Enrique Moreno Gonzalez
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions. According to previous reports, serum CEACAM1 is dysregulated in different malignant tumours and associated with tumour progression. However, the serum CEACAM1 expression in nonsmall-cell lung carcinomas (NSCLC) is unclear. The different expression ratio of CEACAM1-S and CEACAM1-L isoform has seldom been investigated in NSCLC. This research is intended to study the serum CEACAM1 and the ratio of CEACAM1-S/L isoforms in NSCLC.
Objective: The association between telomerase reverse transcriptase (TERT) promoter mutation and outcome of melanoma is unclear and controversial. We aim to conduct a meta-analysis and investigate whether the TERT promoter mutation is a prognostic factor of melanoma.
Study Design: Appropriate studies were searched in 3 databases: PubMed, Web of Science, and Embase. Pooled hazard ratios (HRs) were counted through random effects model.
Results: Heterogeneity was moderate in overall survival (OS) (I2=43.7%, p=0.059) and low in disease-free survival (DFS) (I2=0.0%, p=0.587). Sensitivity analysis indicated that the removal of any of the study did not affect the final results. Evidence for publication bias was not found (Begg’s test, p=0.281; Egger’s test, p=0.078). The pooled OS HRs from combined effects analysis was determined (HR 1.07; 95% CI 0.83–1.39, p=0.585), together with the pooled HRs of DFS (HR 1.65; 95% CI 1.02–2.66, p=0.042). TERT promoter mutation predicted a good outcome in meta-static melanoma patients (HR 0.66; 95% CI 0.46–0.96, p=0.042). The pooled HRs of combined mutation in TERT promoter and BRAF (HR 6.27; 95% CI 2.7–14.58, p=0.000) predicted a bad outcome in melanoma patients.
Conclusion: TERT promoter mutation significantly predicted poor DFS outcome but, on the contrary, predicted a good outcome in metastatic melanoma patients. The combined TERT promoter and BRAF mutation was a significant independent factor of OS in melanoma patients.
Keywords: melanoma; meta-analysis; mutation; prognosis; promoter regions, genetic; skin neoplasms; telomerase; TERT promoter mutation; TERT protein, human
2D CAT Based Modeling of Tumour Growth and Drug TransportEditor IJMTER
The transition of normal cells in the tissue that leads into tumour and spreads throughout
depending upon its behavioural conditions is a complex biological process studied through the use of
both in vivo and in vitro experimentation. Mathematical models provide the approach by using a
controlled environment in which a system can be described quantitatively. This can also yield data
which predicts the behaviour of cells and likely medical conditions after thorough analysis by the
modeller. In an effort to study the characteristics that increase cell fitness, the paper presents a 2D
Cellular Automaton model that uses computer simulation to describe the invasion of healthy tissue
by cancer cells. The growth process is simulated and it was found that movement of cells affects
tumour growth rate. It was also found that the relative distance of the tumour initiation area from
neighbouring vessels influences the growth of tumour. The model and the simulation software
developed thus can be used to understand the dynamics of early tumour growth and to explore
various hypotheses of tumour growth relevant to drug delivery in chemotherapy. Importantly, this
approach highlights that vessel displacement should not be neglected in tumour growth models. The
paper thus presents two models i.e cancer growth model and drug transport model for tumour growth
and treatment that will help to diagnose the early tumour growth. Though cancer is uncurable;early
and quick detection of cancer will help doctors in better way by suggesting quick remedial action
against it.
Lung cancer is one of the most common types of cancer in the world and accounts for the most cancer-related deaths. Because of this, it is continuously studied for advancements in how to treat and manage it. This involves improved detection, which facilitates better treatment outcomes, and developments in the direct treatment of lung cancer.
This ppt will provide you a brief yet effective information about major types of biomarkers, their definitions, their significance in disease dignosis & treatment, how they are being & are developed to be used as an effective dignostic tool for Cancer & their other future implications in other fields of medicine.
Differences in microRNA expression during tumor development in the transition...Enrique Moreno Gonzalez
The prostate is divided into three glandular zones, the peripheral zone (PZ), the transition zone (TZ), and the central zone. Most prostate tumors arise in the peripheral zone (70-75%) and in the transition zone (20-25%) while only 10% arise in the central zone. The aim of this study was to investigate if differences in miRNA expression could be a possible explanation for the difference in propensity of tumors in the zones of the prostate.
The use of genetic engineering technology in animals has been associated with ethical issues, some of which relate to animal welfare. Discuss examples of genetically engineering animals and evaluate the ethical concerns of genetic engineering.
Acute myeloid leukemia (AML) is a hematopoietic malignancy with a dismal outcome in the majority of cases. A detailed understanding of the genetic alterations and gene expression changes that contribute to its pathogenesis is important to improve prognostication, disease monitoring, and therapy. In this context, leukemia-associated misexpression of microRNAs (miRNAs) has been studied, but no coherent picture has emerged yet, thus warranting further investigations.
Multicentric and multifocal versus unifocal breast cancer: differences in the...Enrique Moreno Gonzalez
The aim of this study was to evaluate the expression of the cell adhesion-related glycoproteins MUC-1, β-catenin and E-cadherin in multicentric/multifocal breast cancer in comparison to unifocal disease in order to identify potential differences in the biology of these tumor types.
Overexpression of YAP 1 contributes to progressive features and poor prognosi...Enrique Moreno Gonzalez
Yes-associated protein 1 (YAP 1), the nuclear effector of the Hippo pathway, is a key regulator of organ size and a candidate human oncogene in multiple tumors. However, the expression dynamics of YAP 1 in urothelial carcinoma of the bladder (UCB) and its clinical/prognostic significance are unclear.
Objective: To analyze the sonographic features of different histopathological subtypes of borderline ovarian tumors (BOTs) confirmed by pathology, and to study the ultrasound performances of various types in borderline ovarian tumors.
Study Design: Retrospective analysis was performed on the pathological results and ultrasound projection findings of 129 patients diagnosed as BOTs by ultrasound department of our hospital from January 2012 to November 2019. All patients were confirmed by surgical pathology and scanned consecutively by the investigators using transabdominal or transvaginal ultrasound examination.
Results: Serous borderline tumors (SBOTs) were observed, and the prevalence rate (53%) was significantly higher than that of other subtypes, and the probability of bilateral lesions was higher (40%). The sonogram often showed ultrasound features of papillary neoplasm in the lesion and good internal echo (p<0.05). Mucinous borderline ovarian tumors (MBOTs) were mostly unilateral lesions (86%). The prevalence was second only to SBOTs. Histomorphological examinations were divided into gastrointestinal-type and endocervical-type. Among them, the gastrointestinal type of MBOTs were mostly unilateral, and their incidence was higher than that of endocervical-type of MBOTs. Compared with other pathological subtypes, the gastrointestinal type is more likely to show the sonographic characteristics of huge space occupying in the pelvic and abdominal cavity (mean diameter >10 cm), polycystic, multiple septums, and poor internal echo (p<0.05). The ultrasonographic features of the endocervical-type of MBOTs were similar to those of SBOTs. Compared with gastrointestinal type, the sonographic images showed smaller lesion diameter, less septal or cyst, and more papillary excrescences in the tumor (p<0.05). The borderline clear cell tumor is the intermediate transition between the clear cell adenofibroma and the clear cell carcinoma. The clinical manifestations are diverse and lack specificity. The histology of sonography was mainly solid, and the multiple microcapsules were honeycomb-like. It can also be shown as cystic. Among the 169 patients with BOTs, 20 cases of SBOTs, 17 cases of MBOTs, and 10 cases of other rare subtypes were complicated with other diseases or multiple subtypes. This study did not find significant ultrasonic characteristics were used for distinguish them from other subtypes.
Conclusion: BOTs is a common disease in women during the reproductive period. It is characterized by the development of malignant tumors. Its clinical and pathological subtypes are complex and diverse. It leads many doctors to use the terms “large pelvic mass” and “solid ovarian mass” for diagnosis because of their lack of experience and understanding.
Keywords: adenocarcinoma, mucinous; adenocarcinoma, serous; borderline ovarian tumors; diagnostic imaging; ovarian neoplasms; papillary neoplasms; prognosis; transvaginal ultrasound, ultrasonography
Recently, a phase II clinical trial in hepatocellular carcinoma (HCC) has suggested that the combination of sorafenib and 5-fluorouracil (5-FU) is feasible and side effects are manageable. However, preclinical experimental data explaining the interaction mechanism(s) are lacking. Our objective is to investigate the anticancer efficacy and mechanism of combined sorafenib and 5-FU therapy in vitro in HCC cell lines MHCC97H and SMMC-7721.
Presentation by Scott Woodman, MD, PhD. Presented at the 2018 Eyes on a Cure: Patient & Caregiver Symposium, hosted by the Melanoma Research Foundation's CURE OM initiative.
Clinical and experimental studies regarding the expression and diagnostic val...Enrique Moreno Gonzalez
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is a multifunctional Ig-like cell adhesion molecule that has a wide range of biological functions. According to previous reports, serum CEACAM1 is dysregulated in different malignant tumours and associated with tumour progression. However, the serum CEACAM1 expression in nonsmall-cell lung carcinomas (NSCLC) is unclear. The different expression ratio of CEACAM1-S and CEACAM1-L isoform has seldom been investigated in NSCLC. This research is intended to study the serum CEACAM1 and the ratio of CEACAM1-S/L isoforms in NSCLC.
Objective: The association between telomerase reverse transcriptase (TERT) promoter mutation and outcome of melanoma is unclear and controversial. We aim to conduct a meta-analysis and investigate whether the TERT promoter mutation is a prognostic factor of melanoma.
Study Design: Appropriate studies were searched in 3 databases: PubMed, Web of Science, and Embase. Pooled hazard ratios (HRs) were counted through random effects model.
Results: Heterogeneity was moderate in overall survival (OS) (I2=43.7%, p=0.059) and low in disease-free survival (DFS) (I2=0.0%, p=0.587). Sensitivity analysis indicated that the removal of any of the study did not affect the final results. Evidence for publication bias was not found (Begg’s test, p=0.281; Egger’s test, p=0.078). The pooled OS HRs from combined effects analysis was determined (HR 1.07; 95% CI 0.83–1.39, p=0.585), together with the pooled HRs of DFS (HR 1.65; 95% CI 1.02–2.66, p=0.042). TERT promoter mutation predicted a good outcome in meta-static melanoma patients (HR 0.66; 95% CI 0.46–0.96, p=0.042). The pooled HRs of combined mutation in TERT promoter and BRAF (HR 6.27; 95% CI 2.7–14.58, p=0.000) predicted a bad outcome in melanoma patients.
Conclusion: TERT promoter mutation significantly predicted poor DFS outcome but, on the contrary, predicted a good outcome in metastatic melanoma patients. The combined TERT promoter and BRAF mutation was a significant independent factor of OS in melanoma patients.
Keywords: melanoma; meta-analysis; mutation; prognosis; promoter regions, genetic; skin neoplasms; telomerase; TERT promoter mutation; TERT protein, human
2D CAT Based Modeling of Tumour Growth and Drug TransportEditor IJMTER
The transition of normal cells in the tissue that leads into tumour and spreads throughout
depending upon its behavioural conditions is a complex biological process studied through the use of
both in vivo and in vitro experimentation. Mathematical models provide the approach by using a
controlled environment in which a system can be described quantitatively. This can also yield data
which predicts the behaviour of cells and likely medical conditions after thorough analysis by the
modeller. In an effort to study the characteristics that increase cell fitness, the paper presents a 2D
Cellular Automaton model that uses computer simulation to describe the invasion of healthy tissue
by cancer cells. The growth process is simulated and it was found that movement of cells affects
tumour growth rate. It was also found that the relative distance of the tumour initiation area from
neighbouring vessels influences the growth of tumour. The model and the simulation software
developed thus can be used to understand the dynamics of early tumour growth and to explore
various hypotheses of tumour growth relevant to drug delivery in chemotherapy. Importantly, this
approach highlights that vessel displacement should not be neglected in tumour growth models. The
paper thus presents two models i.e cancer growth model and drug transport model for tumour growth
and treatment that will help to diagnose the early tumour growth. Though cancer is uncurable;early
and quick detection of cancer will help doctors in better way by suggesting quick remedial action
against it.
Lung cancer is one of the most common types of cancer in the world and accounts for the most cancer-related deaths. Because of this, it is continuously studied for advancements in how to treat and manage it. This involves improved detection, which facilitates better treatment outcomes, and developments in the direct treatment of lung cancer.
This ppt will provide you a brief yet effective information about major types of biomarkers, their definitions, their significance in disease dignosis & treatment, how they are being & are developed to be used as an effective dignostic tool for Cancer & their other future implications in other fields of medicine.
International Conference on Integrative Biology Summit, will be organized around the theme "Accelerating Computational Approaches to Biological Research."
The Journal of Biomarkers in Drug Development (JBDD) promotes rigorous research that makes a significant contribution in advancing knowledge for Biomarkers in Drug Development. JBDD includes all major themes pertaining to Biomarkers used in Drug Development.
Biomarkers – in Toxicology and Clinical Researchsuruchi71088
A small presentation on growing use of Biomarkers in the field of toxicology and Clinical Research... basically use of various types of bio-markers and its role in drug development process...
5 Cutting-Edge Trends in Molecular DiagnosticsBruce Carlson
Despite the focus on novelty in this field, it is near 2 decades old. Yet a lot is changing. A look at a few trends that could change molecular diagnostics.
What is biomarker?
What is the purpose of biomarker
Processes of biomarker development?
Types of Biomarkers
What is biomarker testing for cancer treatment?
Uses of Biomarkers in Cancer Medicine
Uses of Biomarkers in Cancer Drug Discovery
introduction
What is biomarker?
What is the purpose of biomarker
Processes of biomarker development?
Types of Biomarkers
What is biomarker testing for cancer treatment?
Uses of Biomarkers in Cancer Medicine
Uses of Biomarkers in Cancer Drug Discovery
Biomarker is an objective measure that has been evaluated and confirmed either as an indicator of physiologic health, a pathogenic process or a pharmacologic response to a therapeutic intervention. Biomarkers, whether produces by normal healthy individuals or by individuals affected by specific systemic diseases, are tell tale molecules that could be used to monitor health status, disease onset, treatment response and outcome.The biomarkers can help for the determination of present as well as future disease activity along with diagnosis and previous periodontal diseases.
CHI's Bioassays for Immuno-Oncology Symposium, Oct. 23, 2017 in Washington, DCJames Prudhomme
Biological assays demonstrating drug characteristics such as potency, mechanism-of-action, and stability, are one of the most critical components of an FDA biologic submission. However, with more complex mechanisms-of-action, immunotherapies add a layer of difficulty to bioassay selection and development. At Cambridge Healthtech Institute's Inaugural Bioassays for Immuno-Oncology symposium, experts in bioassays for immuno-oncology therapies will discuss selection, development, and standards for bioassays and immunoassays. Special attention will be given to understanding the mechanism-of-action for immunotherapies, whether they be antibody- or cell-based. Overall, this one-day immersive symposium will outline a product life cycle approach for developing and implementing biological assays from preclinical studies to clinical development. This symposium is part of the Immunogenicity & Bioassay Summit.
Macroeconomics- Movie Location
This will be used as part of your Personal Professional Portfolio once graded.
Objective:
Prepare a presentation or a paper using research, basic comparative analysis, data organization and application of economic information. You will make an informed assessment of an economic climate outside of the United States to accomplish an entertainment industry objective.
Normal Labour/ Stages of Labour/ Mechanism of LabourWasim Ak
Normal labor is also termed spontaneous labor, defined as the natural physiological process through which the fetus, placenta, and membranes are expelled from the uterus through the birth canal at term (37 to 42 weeks
Read| The latest issue of The Challenger is here! We are thrilled to announce that our school paper has qualified for the NATIONAL SCHOOLS PRESS CONFERENCE (NSPC) 2024. Thank you for your unwavering support and trust. Dive into the stories that made us stand out!
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...Levi Shapiro
Letter from the Congress of the United States regarding Anti-Semitism sent June 3rd to MIT President Sally Kornbluth, MIT Corp Chair, Mark Gorenberg
Dear Dr. Kornbluth and Mr. Gorenberg,
The US House of Representatives is deeply concerned by ongoing and pervasive acts of antisemitic
harassment and intimidation at the Massachusetts Institute of Technology (MIT). Failing to act decisively to ensure a safe learning environment for all students would be a grave dereliction of your responsibilities as President of MIT and Chair of the MIT Corporation.
This Congress will not stand idly by and allow an environment hostile to Jewish students to persist. The House believes that your institution is in violation of Title VI of the Civil Rights Act, and the inability or
unwillingness to rectify this violation through action requires accountability.
Postsecondary education is a unique opportunity for students to learn and have their ideas and beliefs challenged. However, universities receiving hundreds of millions of federal funds annually have denied
students that opportunity and have been hijacked to become venues for the promotion of terrorism, antisemitic harassment and intimidation, unlawful encampments, and in some cases, assaults and riots.
The House of Representatives will not countenance the use of federal funds to indoctrinate students into hateful, antisemitic, anti-American supporters of terrorism. Investigations into campus antisemitism by the Committee on Education and the Workforce and the Committee on Ways and Means have been expanded into a Congress-wide probe across all relevant jurisdictions to address this national crisis. The undersigned Committees will conduct oversight into the use of federal funds at MIT and its learning environment under authorities granted to each Committee.
• The Committee on Education and the Workforce has been investigating your institution since December 7, 2023. The Committee has broad jurisdiction over postsecondary education, including its compliance with Title VI of the Civil Rights Act, campus safety concerns over disruptions to the learning environment, and the awarding of federal student aid under the Higher Education Act.
• The Committee on Oversight and Accountability is investigating the sources of funding and other support flowing to groups espousing pro-Hamas propaganda and engaged in antisemitic harassment and intimidation of students. The Committee on Oversight and Accountability is the principal oversight committee of the US House of Representatives and has broad authority to investigate “any matter” at “any time” under House Rule X.
• The Committee on Ways and Means has been investigating several universities since November 15, 2023, when the Committee held a hearing entitled From Ivory Towers to Dark Corners: Investigating the Nexus Between Antisemitism, Tax-Exempt Universities, and Terror Financing. The Committee followed the hearing with letters to those institutions on January 10, 202
Operation “Blue Star” is the only event in the history of Independent India where the state went into war with its own people. Even after about 40 years it is not clear if it was culmination of states anger over people of the region, a political game of power or start of dictatorial chapter in the democratic setup.
The people of Punjab felt alienated from main stream due to denial of their just demands during a long democratic struggle since independence. As it happen all over the word, it led to militant struggle with great loss of lives of military, police and civilian personnel. Killing of Indira Gandhi and massacre of innocent Sikhs in Delhi and other India cities was also associated with this movement.
Welcome to TechSoup New Member Orientation and Q&A (May 2024).pdfTechSoup
In this webinar you will learn how your organization can access TechSoup's wide variety of product discount and donation programs. From hardware to software, we'll give you a tour of the tools available to help your nonprofit with productivity, collaboration, financial management, donor tracking, security, and more.
Synthetic Fiber Construction in lab .pptxPavel ( NSTU)
Synthetic fiber production is a fascinating and complex field that blends chemistry, engineering, and environmental science. By understanding these aspects, students can gain a comprehensive view of synthetic fiber production, its impact on society and the environment, and the potential for future innovations. Synthetic fibers play a crucial role in modern society, impacting various aspects of daily life, industry, and the environment. ynthetic fibers are integral to modern life, offering a range of benefits from cost-effectiveness and versatility to innovative applications and performance characteristics. While they pose environmental challenges, ongoing research and development aim to create more sustainable and eco-friendly alternatives. Understanding the importance of synthetic fibers helps in appreciating their role in the economy, industry, and daily life, while also emphasizing the need for sustainable practices and innovation.
1. Impact of Biomarkers
Development in Health
Diagnostics and Clinical
Research
OMICS Group Clinical
Conferences: 4th International
Conference on Biomarkers &
Clinical Research, during July 15-
17, 2013 at Philadelphia, USA
2. • OMICS Group invites scientific
communities, students, delegates and business
executives to give their latest biomarker
developments and its application in health
diagnostics and in clinical research through oral and
poster presentations and clinical case studies across
the globe to attend 4th International Conference on
Biomarkers & Clinical Research, during July 15-
17, 2013 at Philadelphia, USA, that can demonstrate
the evidence from research and clinical application
in Biomarker discovery and its potential application
in clinical practice. Special interest and theme of this
conference is “Impact of Biomarkers Development in
Health Diagnostics and Clinical Research”.
3. • Biomarkers-2013 focuses on the development and
application of biomarkers as key role indicators in
health diagnostics, has become a central strategy in
a general re-evaluation of drug discovery processes
and points the way to major changes in health
diagnostics and clinical research. This three days
conference, assembles leading
scientists, researchers, decision-makers and other
players across the industry spectrum, that provides
a unique opportunity to gain the latest biomarker
developments and its application in health
diagnostics, oncology and in clinical research.
th
4. • Biomarkers-2013 focuses on the
development and application of biomarkers
as key role indicators in health
diagnostics, has become a central strategy in
a general re-evaluation of drug discovery
processes and points the way to major
changes in health diagnostics and clinical
research.
• This three days conference, assembles
leading scientists, researchers, decision-
5. • The conference has also gathered support
from Bentham Science Publishers, Eoro
Science Con, US Biomarkers, Molecular
Targeting Technology Inc
(MTTI), Biomarkers Profile
Corporation, Genome Web, Pharma Phorum
as the media partners.
• MTTI has already published the conference
description in two of its press release; also
the citing can be viewed at webpages of
6. Prominent speakers present
at the meet
• Dr. Lawrence Greenfield from Affymetrix delivered a
talk highlighting the application and implementation
of Affymetrix OncoScan into the basis of genomic
treatments for cancer.
• The caner is a matter fact from the distortion of cell
cycle and thus the genome irregularities. The most
common method to identify these irregularities is by
SNP Genotyping. The technology uses the Molecular
Inversion Probe (MIP) assay and has successfully
performed well with high degradable DNA in
addition to the genomic deletions, additions and
copy number alterations.
7. • Challenges and advances in absolute quantization of
peptide hormones by Eduard Rogatsky. Typical method of
choice for quantitative LC/MS analysis of small molecules
and tryptic digests is MRM or SRM. The deciding factors
include post-translation modifications, influence of
tertiary structure on electrospray ionization and
especially different fragmentation pathways of peptides
by collision-induced dissociation.
• Using 2D LC for C-peptide analysis we are able to use
isotopic labeling to define previously inaccessible aspects
of insulin secretion and biosynthesis in vivo. Specifically
we have defined a method using deuterated Leucine
infusion combined with isotopic analysis of incorporated
Leucine into C-peptide for calculation of denovo insulin
8. • Dr. Tao Chen, Food and Drug Administration, USA
discussed about how multiple studies have revealed
the presence of miRNAs and relatively stable in
clinically accessible biofluids such as blood and
urine.
• In our studies, microRNA profiling and individual
miRNAs in rodent blood and urine have been
evaluated for biomarkers to predict toxicities
induced by several chemicals and drugs. The
microRNA induction resulted from the release of the
damaged heart cells.
9. • Protein biomarker discovery and validation by Ruo-
Pan Huang, RayBiotech, Inc., USA. Protein
biomarkers could be used for early diagnosis of life-
threatening diseases, such as cancer, identifying
novel drug targets, uncovering mechanisms of drug
action or adverse responses to a drug, and
monitoring or predicting patientsʼ responses to
treatment.
• The ability to semi-quantitatively and quantitatively
measure the expression levels of multiple proteins
from a variety of biological samples provides a
powerful tool for identification of new biomarkers
10. • Stabilizing proteins and peptides in human plasma
sample for biomarker development by Jizu Yi, BD
Diagnostics, USA. Proteins and peptides in serum
and plasma samples contain status information of a
ariety of diseases.
• However, these proteins and peptides are subject to
proteolytic and other enzymatic degradation
intrinsic to plasma sample, resulting in preanalytical
variability and a barrier in translating the discovered
biomarkers from batch-side research into bedside
applications.
• One major challenge is to stabilize these peptides in
11. • Yaping Tian, PLA General Hospital, China explained
the clinical significance of serum cytokine profile in
variety of cancers, The study confirmed that
inflammation were involved in the development of
cancer. In this study serum cytokines and tumor
markers have been studies and explore their clinical
utility of biomarker profile.
• The results showed that serum levels of interleukin-
8 and monocyte chemoattractant protein1 (MCP-1)
were both significantly higher in cervical diseases
patients. IL-1β and IL-2 is obviously increased in
pancreatic cancer, and compared to benign
diseases, MCP-1 decreased and GM-CSF increased.
12. • Carlo Trugenberger, InfoCodex AG, Semantic
Technologies, Switzerland presented a talk on Discovery
of biomarkers by text mining The discovery of relevant
biomarkers is aided by in silico techniques based on
applying data mining and computational chemistry on
large molecular databases. However, there is an even
larger source of valuable information available that can
potentially be tapped for such discoveries: repositories
constituted by research documents.
• The study is a pilot experiment to discover potential
novel biomarkers and phenotypes for diabetes and
obesity by self-organized text mining of about 120,000
PubMed abstracts, public clinical trial summaries, and
internal Merck research documents. The reported
13. • Osteopontin splice variants are cancer progression
markers, Georg F. Weber, University of
Cincinnati, USA. The early detection of tumor
dissemination is a challenge in cancer diagnosis
because biomarkers for invasiveness are largely
lacking in clinical medicine.
• Osteopontin is frequently secreted by cancer cells
and plays important roles in their ability to
metastasize. Osteopontin is subject to alternative
splicing, which yields three messengers; We have
developed a realtime RT-PCR blood test and
evaluated it in a pilot study of
14. Protein Biomarkers and Cancer
Biomarkers
• Biomarker discovery using proteins
identified across disease. Biomarker
discovery is a difficult series of
experiments due to the number of
different molecules in clinical
samples, the wide dynamic range of
these molecules, their fluctuations and
modifications.
• Biomarkers can be used as indicators of
15. • The diagnosis of ductal carcinoma in situ
(DCIS) is increasing worldwide. there is a
need for developing tissue biomarkers to
determine the likelihood that initial breast
tumor identified on diagnostic biopsy
remains contained in situ, as opposed to
becoming invasive.
• Measurements in DCIS revealed previously
unidentified quantitative differences in the
insulin-like growth factor I receptor, Ras
16. • The status of estrogen receptor (ER) in
breast cancer is the cornerstone of endocrine
therapy. Two isoforms of ER are known - ERα
and ERβ, the breast tumors are characterized
based on the status of ERα. Despite the
expression of ERα some patients develop
tamoxifen resistance and 50% present de
novo tamoxifen resistance. Mammalian
target of rapamycin (mTOR) is a central hub
of signaling pathways impacting cell
growth, proliferation, metabolism and
protein synthesis.
17. Institutions, Universities and
Research bodies at the
conference• The whole sessions was thoroughly
enjoyed by attendees of the
conference. Biomarkers-2013
represented more than 70 US
universities and 50 reputed Universities
from different corners of the world.
18. Venue & Hospitality
• The Official Attendee Housing Site for
the 4th International Conference on
Biomarkers & Clinical Research which will be
held in the county seat of Philadelphia, USA. The
conference will take place in the following dates
and locations.
• Conference Dates: July 15-17, 2013
• Courtyard by Marriott Philadelphia Downtown
21 N Juniper Street
Philadelphia, Pennsylvania 19107, USA
Phone:+1-215-496-3200
19. For further details contact
• Michael Smith
Biomarkers-2013 Organizing Committee
OMICS Group Clinical Conferences
5716 Corsa Ave., Suite 110,
Westlake, Los Angeles, CA 91362-7354, USA
Tel: 1-650-268-9744
Fax: 1-650-618-1414
Toll Free: +1-800-216-6499
Email: biomarkers2013@omicsonline.com
http://www.omicsonline.org/contact.php
• Michael Smith
OMICS Group Clinical Conferences
+1-650-268-9744
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