Hospital pharmacy is a service department of a hospital that receives, stores, dispenses and supplies drugs and medications to patients under the supervision of a qualified pharmacist. The key functions of a hospital pharmacy include dispensing drugs and preparing medications, maintaining drug inventories, ensuring drug quality, providing drug information to medical staff, and manufacturing drugs in-house when necessary. An effective hospital pharmacy aims to provide the right medication to patients at the right time, in the right dose and at minimum cost, while maintaining high professional standards. It requires qualified pharmacists and adequate space and facilities to fulfill its important clinical and administrative roles safely and effectively within the hospital.
hospital formulary is developed under the guidance of pharmacy and therapeutic commitee of the hospital.pharmacist working in a hospital should play an important role in the preparation of the hospital formulary
Definition, Types of drug distribution systems, Dispensing of drugs to ambulatory (outdoor) patients, Distribution of controlled drug, Novel drug distribution methods
hospital formulary is developed under the guidance of pharmacy and therapeutic commitee of the hospital.pharmacist working in a hospital should play an important role in the preparation of the hospital formulary
Definition, Types of drug distribution systems, Dispensing of drugs to ambulatory (outdoor) patients, Distribution of controlled drug, Novel drug distribution methods
In this slides included clinical pharmacy introduction and pharmaceutical care, also explanation about the goals and objectives of the clinical pharmacy requirements
Formulary is an official or authorised publication of an approved list of medicines for use in a hospital, a group of hospitals a society a state or a region a country or a number of countries.
Hospital Formulary is a continually revised compilation of pharmaceuticals dosage agents and their forms that reflects the current clinical view of the medical staff.
Function of community pharmacy, Organization and structure of retail and wholesale drug store, Legal requirement for establishment, Maintenance of records
In this slides included clinical pharmacy introduction and pharmaceutical care, also explanation about the goals and objectives of the clinical pharmacy requirements
Formulary is an official or authorised publication of an approved list of medicines for use in a hospital, a group of hospitals a society a state or a region a country or a number of countries.
Hospital Formulary is a continually revised compilation of pharmaceuticals dosage agents and their forms that reflects the current clinical view of the medical staff.
Function of community pharmacy, Organization and structure of retail and wholesale drug store, Legal requirement for establishment, Maintenance of records
Hospital Pharmacy And Its Organization -Ravinandan A PRavinandan A P
Hospital pharmacy is the department, service, or domain in the hospital organization managed under the direction of a professionally competent, legally qualified pharmacist.
Hospital pharmacy: Hospital and Clinical Pharmacy SHIVANEE VYAS
The hospital pharmacy may be defined as that department of the hospital that deals with procurement, storage, compounding, dispensing, manufacturing, testing, packaging, and distribution of drugs. It is also concerned with education and research in pharmaceutical services. A hospital pharmacy is controlled by a qualified pharmacist.
The hospital pharmacy exerts a great deal of influence on the professional status of the hospital as well as the economics of the total operational cost of the institution. Modern-day hospital pharmacy also provides clinical pharmacy services of drug monitoring and drug information system.
Hospital pharmacy near me and general anaesthetic and general anaesthetic drugs and the rest is a lot better than yesterday and I was in the rest of my life with the kids and I was thinking of going to bed and I was in the rest of your day to do the rest and general issues and I was thinking about it when you were on the
Successful treatment of hypertension is possible with limited side effects
given the availability of multiple antihypertensive drug classes. The translation of
pharmacological research to the treatment of hypertension has been a continuous
process, starting with drugs discovered 60 years ago, such as thiazide diuretics
(1958) and currently finishing with the newest antihypertensive agent available
on the market, the orally active direct renin-inhibitor aliskiren, discovered more
than 10 years ago (2000) (Laurent, 2017).
In between, there has been a continuous rate of discovery, including
spironolactone (1957), beta-blockers (propranolol, 1973), centrally acting alpha-
2 adrenergic receptor agonists (clonidine, 1970s), alpha1- adrenergic receptor
blocker (prazosin, 1975), angiotensin converting enzyme inhibitors (captopril,
1977), calcium channel blockers (verapamil, 1977), and angiotensin II receptor
blockers (losartan, 1993) (Kotchen, 2011).
Therapeutic considerations regarding the treatment of hypertension in
patients with diabetes mellitus are reviewed. Good blood pressure control is
essential in diabetic patients to prevent morbidity and mortality associated with
Hospital pharmacy-Organisation and management
a) Organizational structure-Staff, Infrastructure & work load statistics
b) Management of materials and finance
c) Roles & responsibilities of hospital pharmacist
THE IMPORTANCE OF MARTIAN ATMOSPHERE SAMPLE RETURN.Sérgio Sacani
The return of a sample of near-surface atmosphere from Mars would facilitate answers to several first-order science questions surrounding the formation and evolution of the planet. One of the important aspects of terrestrial planet formation in general is the role that primary atmospheres played in influencing the chemistry and structure of the planets and their antecedents. Studies of the martian atmosphere can be used to investigate the role of a primary atmosphere in its history. Atmosphere samples would also inform our understanding of the near-surface chemistry of the planet, and ultimately the prospects for life. High-precision isotopic analyses of constituent gases are needed to address these questions, requiring that the analyses are made on returned samples rather than in situ.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Astronomy Update- Curiosity’s exploration of Mars _ Local Briefs _ leadertele...
2.hospital pharmacist
1. 2. Hospital pharmacy
Prepared By: Mr. Anand P Kakde
Assistant Professor RMDIPER
Definition:
Hospital Pharmacy-It is service department of hospital which receives drugs and supplies, stores,
dispenses them to inpatients and outpatients under supervision of qualified registered pharmacist.
Function:
1. The dispensing of drugs ,chemicals and pharmaceuticals preparations.
2. The filling and labeling of drug container.
3. The inspection of all pharmaceutical supplies .
4. The dispensing of all narcotic drugs and alcohol and the maintenance of perpetual
inventory of them.
5. Specification of the quality of drugs, chemicals ,antibiotics ,biological and
pharmaceutical supplies used in the treatment of patient.
6. Sources to get above products.
7. To maintain adequate control over requitioning and dispensing of all drugs and
pharmaceutical supplies.
8. To make large volume injection fluids and other parenterals, and to maintain aseptic
condition while doing so.
9. To do inhouse production of drugs ,the buying of which from outside sources is not
prudent.
10. To furnish information concerning medications to physicians , interns and nurses
Objective:
1. To professionalize the functioning of pharmaceutical services in a hospital.
2. To ensure the availability of the right medication at the right time, in the right dose, at the
minimum possible cost.
3. To teach the hospital pharmacist about the philosophy and ethics of hospital pharmacy and
guide them to take responsibility of professional practice.
4. To strengthen the management skills of hospital pharmacist working as the head of the
department
5. To strengthen the scientific and professional aspects of practice of hospital pharmacy such as
his consulting, teaching role and research activities.
6. To utilize the resources of hospital pharmacy for the development of profession.
7. To attract the greater number of pharmacist to work in the hospital.
8. To promote the payment of good salaries to pharmacist.
9.To establish drug information services
10. To participate in research projects carried out in hospital.
11. To implement decisions of Pharmacy and Therapeutics Committee
Location and layout of Hospital Pharmaceutical service:
• Location on first or ground floor of hospital.
• If hospital has OPD then it should be near to department.
• Departments should be vertically separated.
2. 2. Hospital pharmacy
Prepared By: Mr. Anand P Kakde
Assistant Professor RMDIPER
• OPP must have waiting room with professional look and display educated posters on
health & hygiene.
• Manufacturing room adjacent to pharmacy or can be located in the basement directly
below the pharmacy.
PHARMACIST REQUIRMENT:
BED STRENGTH NO.OF PHARMACIST
UP TO 50 BEDS 3
100 Beds 5
200 beds 8
300 beds 10
500 beds 15
3. 2. Hospital pharmacy
Prepared By: Mr. Anand P Kakde
Assistant Professor RMDIPER
Functions Area requirements(Sq.feet)
100 beds 300 beds 700 beds
Dispensary 350 500 800
Preparation room 100 400 650
Store room 450 1000 2400
Office 110 150 200
Manufacturing of pills & tablet - - 900
Capsulation - - 200
Manufacturing unit for aseptic
preparation and other
- 250 250
Repacking operation - - 300
Parenteral - 600 600
Total area in sq.feet 1010 2900 6300
Avg.area per bed in sq.feet 10 9.6 9.00
4. 2. Hospital pharmacy
Prepared By: Mr. Anand P Kakde
Assistant Professor RMDIPER
Abilities Required of Hospital Pharmacist
Requirements in qualification:
• Head of hospital pharmacy should be PG in pharmacology or Hospital pharmacy.
• He should be co-ordinate other pharmacist and non-pharmacist.
Abilities Required:
1) Administrative ability:
• Ability to plan, organise, direct & control the hospital pharmacy.
• Maintain good human relation with other departments.
• Work as personal manager for his own staff.
• He should select ,guide,train,evaluate & prepare working schedule for them
• He should keep legal& administrative data records.
• Develop policy for prescription.
• Maintain professional environment.
2) Technical ability:
• He well-versed in pharmaceutical science ,expert on drug and their ADME, Storage
condition according to stability.
• Skill in drug handling than counter working.
• Inspire confidence in his medical colleagues.
• He has to Ensure the quality of pharmaceutical products specially generic preparations.
3) Ability to developed manufacturing section:
• Manufacture those preparation in hospital which commercially not available in market.
• Control over supply , quality and cost.
• Attract M. Pharm (pharmaceutics) for this purpose.
4) Ability to control:
• Total quality control over the drugs and other suppliers.
• Keep good relations with suppliers.
5) Academic ability:
• Act as trainer for nursing staff.
• Practical training to pharmacist.
• Participation in medical research regarding used of drug.
• Also participate in product development and evalution.