Over 60% of girls in the Rukungiri District of Uganda miss at least one day of school per month due to lack of access to feminine hygiene products and sanitary facilities. As the new Global Advocacy Adviser for Girls Empowered International, you have been tasked with developing a 5-year, $2 million proposal to address this issue. Your proposal must include objectives, strategies, budgets, timelines, and plans for sustainability, education, product distribution, and addressing cultural stigma. It should leverage local partnerships and resources to create an intervention that is effective, culturally appropriate, and feasible for improving menstrual health and education in the Rukungiri District.
International Journal of Humanities and Social Science Invention (IJHSSI) is an international journal intended for professionals and researchers in all fields of Humanities and Social Science. IJHSSI publishes research articles and reviews within the whole field Humanities and Social Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
International Journal of Humanities and Social Science Invention (IJHSSI) is an international journal intended for professionals and researchers in all fields of Humanities and Social Science. IJHSSI publishes research articles and reviews within the whole field Humanities and Social Science, new teaching methods, assessment, validation and the impact of new technologies and it will continue to provide information on the latest trends and developments in this ever-expanding subject. The publications of papers are selected through double peer reviewed to ensure originality, relevance, and readability. The articles published in our journal can be accessed online.
Effect of Mothers Working and Non Working Status on the Nutritional Status of...YogeshIJTSRD
Health and nutritional status are two crucial and interlinked aspects of human development, which in to interact with demographic variables Malnutrition a condition that occurs due to intake of inadequate amount of nutrients leading to insufficient nourishment continues to be a problem of considerable magnitude in most of the developing countries in the world. Preschool children are one of the most nutritionally vulnerable segments of the population. Nutrition during the first 5 years has not only an impact on growth and morbidity during childhood, but also acts as a determinant of nutritional status in adolescent and adult life. Global comparative data indicate that contrary to common perception, prevalence of under nutrition is highest in South Asian children. India has the highest occurrence of childhood malnutrition in the world. Malnutrition is responsible for 55 percent of all deaths of children younger than 5 years of age globally. Malnutrition makes a child susceptible to infections and delayed recovery, thus increasing mortality and morbidity. It is therefore logical to direct attention to the quality of life of the survivors Bose and Das, 2010 . Joyeeta Bhattacharyya "Effect of Mothers Working and Non-Working Status on the Nutritional Status of Pre School Children" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd41167.pdf Paper URL: https://www.ijtsrd.comhome-science/food-and-nutrition/41167/effect-of-mothers-working-and-nonworking-status-on-the-nutritional-status-of-pre-school-children/joyeeta-bhattacharyya
Dr. Andrew Pipe provided a keynote presentation to the Healthy Children Healthy Spaces Initiative in Ottawa in November, 2010. As the Medical Director of Prevention and Rehab at the University of Ottawa Heart Institute, Dr Pipe speaks to the critical need to shift our children away from sedentary screen based time to outdoor, active, unstructured play.
Achievements and Implications of Care and Support Programme among Orphans and...QUESTJOURNAL
Background: In Nigeria, children who need special protection on the account of being in vulnerable situations are observably increasing due to growing levels of poverty and the poor socio-economic situation of the country and it is necessary to ameliorate the problem by strengthening the capacity of families. This article therefore presents the achievements of care and support programme among orphans and vulnerable children (OVC) in Bayelsa State, Nigeria as well as the implications for future programming. Methods: The project was an intervention study carried out among OVC in Bayelsa State, Nigeria. Four civil society organizations were engaged by Bayelsa State Agency for the Control of AIDS (BYSACA) under HIV and AIDS Fund (HAF) II project to provide care and support services for OVC. The target population consisted of paternal orphan or maternal orphan, double orphan and vulnerable children whose parents are infected with HIV but alive in six local government areas. A total of 3000 was an estimated sample size for this intervention and data were collected using various data reporting tools and analyzed using Microsoft Excel. Results: The total number of OVC reached during the project period was 5410 given a target reached of 180.3%. Among these, 87.7% of the children were reached with at least one service, 74.9% were reached with psychosocial services, nutrition (37.4%), educational services (33.3%), healthcare services (9.5%) and protection services (4.4%). Thirty-five children withdrawn from the programme and two children reported died during this project. Conclusion: Efforts to care, support and protect vulnerable children should not only focus on their immediate survival needs such as food, education, water, shelter and clothing, but also on long-term developmental needs that reduce children's vulnerability such as life skills, child protection, vocational training, food security, and household economic strengthening.
Child survival strategies- interventions that lead to a childhood mortality reduction in line with the SDG(in children under 5)
The proposed SDG target for child mortality aims to end, by 2030, preventable deaths of newborns and children under 5 years of age, with all countries aiming to reduce neonatal mortality to at least as low as 12 deaths per 1,000 live births and under-5 mortality to at least as low as 25 deaths per 1,000 live births.
the recent data on child mortality are well covered.
follow the GOBIFF for seurity of the future.
Students awareness on Reproductive Health Education in Sri LankaAyomi Irugalbandara
Reproductive Health (RH) is among the most fundamental aspects of life. Yet they often receive little attention in public policy discussions because of cultural and political sensitivities. In Sri Lanka, traditional religious and family values, designed to protect adolescents, can restrict RH education for youth. Some Sri Lankan parents assume that adolescents do not need to know about RH issues until they are married. This idea is rooted in traditional values and long-standing taboos surrounding sexuality that need to be examined in light of protecting health.This study examines the knowledge and perception regarding reproductive health and opinion toward reproductive health education among adolescents in Sri Lanka. The Main outcome measures were adolescent’s knowledge of reproductive health concepts, pregnancy and abortion.
Under Five Child Mortality Experience from Bangladeshijtsrd
Under five mortality rates is a key indicator for several development policies, targets and programs. However, relevant source of data on causes of death are not available in developing countries, including Bangladesh. Because sometimes the information is hidden with the various causes of risk. The main purpose of this study is to find out some different cases of child mortality with the various causes. The paper reveals that several characteristics socioeconomic, demographic, health related disease and non disease are affecting child mortality. Juliet Reberio "Under Five Child Mortality: Experience from Bangladesh" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42601.pdf Paper URL: https://www.ijtsrd.combiological-science/other/42601/under-five-child-mortality-experience-from-bangladesh/juliet-reberio
Putting Children First: Identifying solutions and taking action to tackle poverty and inequality in Africa.
Addis Ababa, Ethiopia, 23-25 October 2017
This three-day international conference aimed to engage policy makers, practitioners and researchers in identifying solutions for fighting child poverty and inequality in Africa, and in inspiring action towards change. The conference offered a platform for bridging divides across sectors, disciplines and policy, practice and research.
Effect of Mothers Working and Non Working Status on the Nutritional Status of...YogeshIJTSRD
Health and nutritional status are two crucial and interlinked aspects of human development, which in to interact with demographic variables Malnutrition a condition that occurs due to intake of inadequate amount of nutrients leading to insufficient nourishment continues to be a problem of considerable magnitude in most of the developing countries in the world. Preschool children are one of the most nutritionally vulnerable segments of the population. Nutrition during the first 5 years has not only an impact on growth and morbidity during childhood, but also acts as a determinant of nutritional status in adolescent and adult life. Global comparative data indicate that contrary to common perception, prevalence of under nutrition is highest in South Asian children. India has the highest occurrence of childhood malnutrition in the world. Malnutrition is responsible for 55 percent of all deaths of children younger than 5 years of age globally. Malnutrition makes a child susceptible to infections and delayed recovery, thus increasing mortality and morbidity. It is therefore logical to direct attention to the quality of life of the survivors Bose and Das, 2010 . Joyeeta Bhattacharyya "Effect of Mothers Working and Non-Working Status on the Nutritional Status of Pre School Children" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd41167.pdf Paper URL: https://www.ijtsrd.comhome-science/food-and-nutrition/41167/effect-of-mothers-working-and-nonworking-status-on-the-nutritional-status-of-pre-school-children/joyeeta-bhattacharyya
Dr. Andrew Pipe provided a keynote presentation to the Healthy Children Healthy Spaces Initiative in Ottawa in November, 2010. As the Medical Director of Prevention and Rehab at the University of Ottawa Heart Institute, Dr Pipe speaks to the critical need to shift our children away from sedentary screen based time to outdoor, active, unstructured play.
Achievements and Implications of Care and Support Programme among Orphans and...QUESTJOURNAL
Background: In Nigeria, children who need special protection on the account of being in vulnerable situations are observably increasing due to growing levels of poverty and the poor socio-economic situation of the country and it is necessary to ameliorate the problem by strengthening the capacity of families. This article therefore presents the achievements of care and support programme among orphans and vulnerable children (OVC) in Bayelsa State, Nigeria as well as the implications for future programming. Methods: The project was an intervention study carried out among OVC in Bayelsa State, Nigeria. Four civil society organizations were engaged by Bayelsa State Agency for the Control of AIDS (BYSACA) under HIV and AIDS Fund (HAF) II project to provide care and support services for OVC. The target population consisted of paternal orphan or maternal orphan, double orphan and vulnerable children whose parents are infected with HIV but alive in six local government areas. A total of 3000 was an estimated sample size for this intervention and data were collected using various data reporting tools and analyzed using Microsoft Excel. Results: The total number of OVC reached during the project period was 5410 given a target reached of 180.3%. Among these, 87.7% of the children were reached with at least one service, 74.9% were reached with psychosocial services, nutrition (37.4%), educational services (33.3%), healthcare services (9.5%) and protection services (4.4%). Thirty-five children withdrawn from the programme and two children reported died during this project. Conclusion: Efforts to care, support and protect vulnerable children should not only focus on their immediate survival needs such as food, education, water, shelter and clothing, but also on long-term developmental needs that reduce children's vulnerability such as life skills, child protection, vocational training, food security, and household economic strengthening.
Child survival strategies- interventions that lead to a childhood mortality reduction in line with the SDG(in children under 5)
The proposed SDG target for child mortality aims to end, by 2030, preventable deaths of newborns and children under 5 years of age, with all countries aiming to reduce neonatal mortality to at least as low as 12 deaths per 1,000 live births and under-5 mortality to at least as low as 25 deaths per 1,000 live births.
the recent data on child mortality are well covered.
follow the GOBIFF for seurity of the future.
Students awareness on Reproductive Health Education in Sri LankaAyomi Irugalbandara
Reproductive Health (RH) is among the most fundamental aspects of life. Yet they often receive little attention in public policy discussions because of cultural and political sensitivities. In Sri Lanka, traditional religious and family values, designed to protect adolescents, can restrict RH education for youth. Some Sri Lankan parents assume that adolescents do not need to know about RH issues until they are married. This idea is rooted in traditional values and long-standing taboos surrounding sexuality that need to be examined in light of protecting health.This study examines the knowledge and perception regarding reproductive health and opinion toward reproductive health education among adolescents in Sri Lanka. The Main outcome measures were adolescent’s knowledge of reproductive health concepts, pregnancy and abortion.
Under Five Child Mortality Experience from Bangladeshijtsrd
Under five mortality rates is a key indicator for several development policies, targets and programs. However, relevant source of data on causes of death are not available in developing countries, including Bangladesh. Because sometimes the information is hidden with the various causes of risk. The main purpose of this study is to find out some different cases of child mortality with the various causes. The paper reveals that several characteristics socioeconomic, demographic, health related disease and non disease are affecting child mortality. Juliet Reberio "Under Five Child Mortality: Experience from Bangladesh" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-5 | Issue-4 , June 2021, URL: https://www.ijtsrd.compapers/ijtsrd42601.pdf Paper URL: https://www.ijtsrd.combiological-science/other/42601/under-five-child-mortality-experience-from-bangladesh/juliet-reberio
Putting Children First: Identifying solutions and taking action to tackle poverty and inequality in Africa.
Addis Ababa, Ethiopia, 23-25 October 2017
This three-day international conference aimed to engage policy makers, practitioners and researchers in identifying solutions for fighting child poverty and inequality in Africa, and in inspiring action towards change. The conference offered a platform for bridging divides across sectors, disciplines and policy, practice and research.
The U.S. Agency for International Development (USAID) is committed to providing development assistance that improves the lives of women, men, and children around the world. USAID has a special interest in the advancement of women worldwide. Women’s health, education, economic opportunity and human rights are at the core of successful, stable societies and economic growth.
One of the fundamental principles of the Department of State/USAID strategic plan is that “all citizens, men and women, are vital to meeting the critical challenges of today and reaching the goals of equality, peace and security.” USAID’s commitment to the full inclusion of women dates back to 1973, when the United States Congress passed the “Percy Amendment” to the Foreign Assistance Act, requiring that particular attention be given to integrating women into national economies to improve the status of women and to assist the overall development effort.
Today, USAID embraces this goal, and seeks to understand the different needs of men and women, to improve the efficiency and overall impact of its programs, and to ensure that both women and men have equitable access to development activities and their benefits. This document profiles USAID efforts to address barriers to full access to opportunity for women and men throughout the developing world. The success stories are a testament to the progress women and men have made. The selected examples illustrate the many efforts made by the USAID field missions, the Office of Women in Development, and other operating units in USAID to fully integrate women into development programs and policies throughout USAID. It is important to note that women’s leadership is not treated as a separate category in this report, but is reflected in all the examples.
Women are becoming political leaders, grassroots leaders, leaders in their professions, leaders in their communities, and heads of households, especially in regions ravaged by HIV/AIDS and conflict, and are growing into leaders in many other ways. As a result, all USAID efforts to support women’s skills, opportunities and rights contribute to “women’s leadership.” WOMEN, MEN AND DEVELOPMENT 1
Impacts of Cash Transfers on Adolescents' & Young Women's Well-Being Globally...The Transfer Project
Tia Palermo's presentation for the joint UNICEF & Gates Foundation Tanzania Adolescent Symposium in Dar es Salaam on 7 February 2018.
Using evidence from around the world, Tia outlines what we know about cash transfers impacts on youth and young women's well-being.
Educational achievement is a significant indicator of children’s wellbeing and future life opportunities. It can predict growth potential and economic viability of a country. While this is an ideal situation for all children, the case may be different for orphans and vulnerable children (OVC) due to the psychosocial challenges they go through on a daily basis. It is even worse for children attending public primary schools in Kenya. This paper aims to advance a debate on the relationship between psychosocial support and educational support provided for OVC through a critical engagement on the challenges experienced and the intervention measures to be taken in Kenyan public primary schools context. The study is based on the critical review of related literature materials. Findings suggest that, although the Kenyan government has put mechanisms in place to support OVC attain basic education, numerous challenges are found to be hindering some OVC from attaining quality education. Based on the findings, the paper recommends that there is need for various interventions to address psychosocial needs of orphans and children attending primary schools.
THE BREAKTHROUGH STRATEGY FOR ACHIEVING ALL THE MDGS INVESTING IN WOMEN AND GIRLS THE BREAKTHROUGH STRATEGY FOR ACHIEVING ALL THE MDGS Based on a speech by Jon Lomoy, Director of the OECD’s Development Co-operation Directorate, at the Helsinki High-level Symposium, United Nations 2010 Development Co-operation Forum, 4 June 2010 KEEP GIRLS IN SCHOOL 1 I believe that investing in women and girls in itself constitutes a breakthrough strategy for achieving the MDGs, and that almost any investment we make in women and girls will have multiplier effects across the Goals —Helen Clark, UNDP Administrator, 25 March 2010. W ithout a great leap forward towards achieving greater equality between women and men and increased empowerment of women and girls, none of the MDGs will be achieved. It is time to back up political promises with the investments and resources needed to do the job. Investing in women and girls has a powerful impact. It will make the world a better place for all – both women and men. Helen Clark has called it the breakthrough strategy for achieving the MDGs. The challenge is to identify how and where donor money can fuel that breakthrough strategy. There are four key areas where increased investments and attention could have catalytic and multiplier impacts on the lives of women and girls – and of future generations: • Keep girls in school to complete a quality secondary education • Urgently improve reproductive health, including access to family planning services • Increase women’s control over productive and financial assets (not just microcredit), and • Identify and support women leaders at all levels. Studies have shown that women with even a few years of primary education have better economic prospects, have fewer and healthier children, and are more likely to ensure that their own children go to school. Development would be accelerated if girls were kept in school to complete a quality secondary education. Education of girls is one of the most powerful tools for women’s empowerment, but discrimination continues to keep girls out of school. • In 2007, only 53 of the 171 countries with available data had achieved gender parity in both primary and secondary education1 . • Secondary school enrolment is very low in sub-Saharan Africa (24 percent of girls and 33 percent of boys). That means that girls are missing out – particularly when they live in rural areas and in poor households. Removing school fees and providing financial incentives for girls to attend school have proven to be effective. At the same time we need to build schools closer to remote communities, ensure that schools have quality teachers and adequate sanitary facilities and that they are safe places for girls. 1. United Nations (2009). The Millennium Development Goals Report 2009
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html